Hypoglycemm Increases the Gastric Emptying Rate in Healthy Subjects
Abstract
OBJECTIVES: To compare the gastric emptying rate during normoglycemia with that during insulin-induced hypoglycemia in healthy subjects. RESEARCH DESIGN AND METHODS: In eight healthy subjects, the rate of gastric emptying of an isotope-labeled meal was assessed by a scintigraphic technique during normoglycemia and hypoglycemia, both controlled by an insulin-glucose clamp. RESULTS: The mean time taken to empty 50% of the test meal from the stomach (Tg0) for the solid phase was 43.0 ± 20.0 min during normoglycemia, compared with 16.3 ± 6.6 min during hypoglycemia, P < 0.001. The mean T50 for the liquid phase was 38.0 ± 21.2 and 15.4 ± 10.6 min, respectively, P < 0.001. CONCLUSIONS: Insulin-induced hypoglycemia increases the gastric emptying rate in healthy subjects.
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Low blood glucose accelerates gastric emptying in healthy individuals.
“An elevation of blood glucose concentrations, even including concentrations within the physiologic range, reduces the GER in healthy subjects (16), and hypoglycemia increases the GER (17,18).”
From Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects (2007) · cites this paper as [17]
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- Authors
- Schvarcz, E., Palmér, M., Åman, J., & Berne, C.
- Affiliations
- Örebro University Hospital (SE)
- Uppsala University Hospital (SE)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1995-05-01
- Volume
- 18
- Issue
- 5
- Pages
- 674-676
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W1989659505
- Cited by
- 87
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- hypoglycemia, gastric emptying, insulin-induced hypoglycemia, gastric emptying rate
- MeSH terms
- Adult, Blood Glucose, Gastric Emptying, Humans, Hypoglycemia, Infusions, Intravenous, Insulin, Male, Reference Values, Time Factors, Glucose Clamp Technique
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