Fat Consumption and HbA1c Levels
Open accessAbstract
OBJECTIVE—To describe the relationship between total dietary fat and the pattern of fat intake and HbA1c. RESEARCH DESIGN AND METHODS—In this cross-sectional study, 2,759 men and 3,464 women (40–78 years of age) without a previous diagnosis of type 2 diabetes were recruited from a population-based sampling frame. Diet was assessed using a self-reported semiquantitative food frequency questionnaire. RESULTS—The HbA1c level was negatively associated with the polyunsaturated fat–to–saturated fat ratio (P:S ratio) of the diet (β = −0.0338 HbA1c% per SD change in P:S ratio; P < 0.001) and positively associated with the total level of fat intake (β = 0.0620 HbA1c% per SD change in total fat intake; P < 0.001), adjusted for age and total energy intake. The associations remained significant when adjusted for each other and for total energy, protein, age, sex, family history of diabetes, BMI, waist-to-hip ratio, physical activity, and smoking (for P:S ratio, β = −0.0200 HbA1c% per SD change in P:S ratio, P = 0.013; for total fat, β = 0.420% HbA1c% per SD change in total fat intake, P < 0.001). The benefits from a high P:S ratio were attributed to a lower saturated fat intake. CONCLUSIONS—These findings demonstrate independent associations between HbA1c concentration across the normal range of HbA1c and both total fat intake and the pattern of dietary fat intake. They provide further support to efforts promoting modifications in the intake of dietary fat.
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Epidemiologic data indicate a link between high saturated fat intake and elevated HbA1c.
“Epidemiologic data showed a relation between a high intake of saturated fat and raised glycated hemoglobin (Hb A 1c ) (15)”
From Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes (2013) · cites this paper as [15]
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- Authors
- Harding, A.-H., Sargeant, L. A., Welch, A., Oakes, S., Luben, R. N., Bingham, S., Day, N. E., Khaw, K.-T., & Wareham, N. J.
- Affiliations
- University of Cambridge (GB)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2001-11-01
- Volume
- 24
- Issue
- 11
- Pages
- 1911-1916
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2047236185
- Cited by
- 86
- References
- 39
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 3
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- dietary fat, HbA1c, saturated fat intake, total fat intake, type 2 diabetes risk, glycemic control, older adults
- MeSH terms
- Adult, Aged, Energy Intake, Cross-Sectional Studies, Dietary Carbohydrates, Dietary Fats, Dietary Fats, Unsaturated, Dietary Proteins, Female, Glycated Hemoglobin, Humans, Life Style, Male, Middle Aged, Surveys and Questionnaires, Regression Analysis, Smoking, Cohort Studies, Exercise, Body Mass Index, Age Distribution
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