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Cited by 112Nutritional Studies and DietFatty Acid Research and HealthDiet, Metabolism, and Disease

Dietary Fat and the Risk of Clinical Type 2 Diabetes: The European Prospective Investigation of Cancer-Norfolk Study

Harding, A.-H.·2004·American Journal of Epidemiology
DOI 10.1093/aje/kwh004
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Abstract

The role of dietary fat in the etiology of type 2 diabetes remains uncertain. The authors investigated the association between dietary fat composition and risk of clinical type 2 diabetes in the European Prospective Investigation of Cancer-Norfolk study and identified food consumption patterns associated with dietary fat composition. Diet was assessed at baseline (1993-1997) using a semiquantitative food frequency questionnaire. From multiple sources of information, 414 incident cases of diabetes were identified among 23,631 men and women aged 40-78 years during 3-7 years of follow-up. The capture-recapture ascertainment level was 99%. The energy-adjusted dietary polyunsaturated:saturated fat ratio was inversely associated with the risk of diabetes (odds ratio (OR) = 0.84 per standard deviation change, 95% confidence interval (CI): 0.75, 0.94). Adjustment for age, sex, family history of diabetes, smoking, physical activity, total fat, protein, and alcohol attenuated the association (OR = 0.88, 95% CI: 0.78, 0.99), and it was no longer statistically significant after including body mass index and the waist:hip ratio (OR = 0.91, 95% CI: 0.81, 1.03). This prospective study showed that an increased dietary polyunsaturated:saturated fat ratio was associated with a reduced risk of diabetes, independent of age, sex, family history of diabetes, and other lifestyle factors.

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  • Combination therapy with any two glucose-lowering agents is effective for lowering glucose levels.

    “While combination therapy with any two agents has been shown to be effective for lowering glucose levels 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , combination therapy with three or more agents (other than SU/glinide or DPP‐4 inhibitor/GLP‐1 receptor agonist combinations) has also been shown to be effective for lowering glucose levels 47 , 48 , 49 , 50 , 51 .”

    From Japanese clinical practice guideline for diabetes 2019 (2020) · cites this paper as [37]

  • Poor working environments or social environments may constitute an important risk factor for type 2 diabetes.

    “Poor working environments 35 , 36 , 37 , 38 , 39 or social environments 40 , 41 may constitute an important risk factor for type 2 diabetes.”

    From Japanese clinical practice guideline for diabetes 2019 (2020) · cites this paper as [37]

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Authors
Harding, A.-H.
Affiliations
MRC Epidemiology Unit (GB)
Corresponding author
Harding, A.-H.
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2004-01-01
Volume
159
Issue
1
Pages
73-82
ISSN
0002-9262 (ISSN-L)
DOI
10.1093/aje/kwh004
OpenAlex
W2100883391
Cited by
112
References
39
Citations by year
2024: 5 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 5 · 2012: 7
FWCI
4.06
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Funders
  • Stroke Association
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
dietary fat, type 2 diabetes, dietary fat composition, food consumption patterns, diabetes risk, body mass index, waist-to-hip ratio, lifestyle factors
MeSH terms
Adult, Aged, Diabetes Mellitus, Type 2, Diet, Dietary Fats, Dietary Fats, Unsaturated, Europe, Female, Glycated Hemoglobin, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk Factors, Diet Records, Odds Ratio

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