Cited by 383Nutritional Studies and DietFatty Acid Research and HealthDiet, Metabolism, and Disease

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Dietary Fat and Incidence of Type 2 Diabetes in Older Iowa Women

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Meyer, Katie A., Kushi, Lawrence H., Jacobs, David R., Folsom, Aaron R.·2001·Diabetes Care

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Abstract

OBJECTIVE: To examine the associations between reported intakes of dietary fat and incident type 2 diabetes. RESEARCH DESIGN AND METHODS: We studied the relation between dietary fatty acids and diabetes in a prospective cohort study of 35,988 older women who initially did not have diabetes. Diet was assessed with a food frequency questionnaire at baseline, and 1,890 incident cases of diabetes occurred during 11 years of follow-up. RESULTS: After adjusting for age, smoking, alcohol consumption, BMI, waist-to-hip ratio, physical activity, demographic factors, and dietary magnesium and cereal fiber, diabetes incidence was negatively associated with dietary polyunsaturated fatty acids, vegetable fat, and trans fatty acids and positively associated with omega-3 fatty acids, cholesterol, and the Keys score. After simultaneous adjustment for other dietary fat, only vegetable fat remained clearly related to diabetes risk. Relative risks across quintiles of vegetable fat intake were 1.00, 0.90, 0.87, 0.84, and 0.82 (P = 0.02). Diabetes risk was also inversely related to substituting polyunsaturated fatty acids for saturated fatty acids and positively correlated to the Keys dietary score. CONCLUSIONS: These data support an inverse relation between incident type 2 diabetes and vegetable fat and substituting polyunsaturated fatty acids for saturated fatty acids and cholesterol.

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Authors: Meyer, K. A., Kushi, L. H., Jacobs, D. R., & Folsom, A. R.
Affiliations: Harvard University (US)
Columbia University (US)
University of Minnesota (US)
ORCID: Meyer, Katie A.
Kushi, Lawrence H.
Jacobs, David R.
Folsom, Aaron R.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2001-09-01
Volume: 24
Issue: 9
Pages: 1528-1535
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.24.9.1528
OpenAlex: W2116871514
Cited by: 382
References: 49
Citations by year: 2026: 3 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 14 · 2021: 10 · 2020: 13 · 2019: 16 · 2018: 10 · 2017: 8 · 2016: 17 · 2015: 24 · 2014: 19 · 2013: 18 · 2012: 23
FWCI: 17.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA039742)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: type 2 diabetes, dietary fat, vegetable fats, polyunsaturated fatty acids, saturated fatty acids, omega-3 fatty acids, trans fatty acids, cholesterol, older women, dietary fatty acids, diabetes risk
MeSH terms: Age Factors, Aged, Animals, Body Constitution, Edible Grain, Cholesterol, Dietary, Demography, Diabetes Mellitus, Type 2, Dietary Fats, Dietary Fats, Unsaturated, Dietary Fiber, Feeding Behavior, Female, Humans, Magnesium, Middle Aged, Plant Oils, Prospective Studies, Surveys and Questionnaires, Risk, Risk Factors, Smoking, Cohort Studies, Body Mass Index

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Dietary Fat and Incidence of Type 2 Diabetes in Older Iowa Women

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