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Cited by 578

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

The Association Between Cardiovascular Autonomic Neuropathy and Mortality in Individuals With Diabetes

Maser, Raelene E., Mitchell, Braxton D., Vinik, Aaron I., Freeman, Roy·2003·Diabetes Care
DOI 10.2337/diacare.26.6.1895
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Abstract

OBJECTIVE—To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes. RESEARCH DESIGN AND METHODS—We searched Medline for English-language articles published from 1966 to 2001. Fifteen studies having a baseline assessment of cardiovascular autonomic function and mortality follow-up were identified. The analyses were stratified according to whether a single abnormality or two or more measures of cardiovascular autonomic function were used to define CAN. A global measure of association (i.e., relative risk) was generated for each group by pooling estimates across the studies using the Mantel-Haenszel procedure. RESULTS—CAN was significantly associated with subsequent mortality in both groups, although the magnitude of the association was stronger for those studies for which two or more measures were used to define CAN. The pooled relative risk for studies that defined CAN with the presence of two or more abnormalities was 3.45 (95% CI 2.66–4.47; P < 0.001) compared with 1.20 (1.02–1.41; P = 0.03) for studies that used one measure. CONCLUSIONS—These results support an association between CAN and increased risk of mortality. The stronger association observed in studies defining CAN by the presence of two or more abnormalities may be due to more severe autonomic dysfunction in these subjects or a higher frequency of other comorbid complications that contributed to their higher mortality risk. Future studies should evaluate whether early identification of subjects with CAN can lead to a reduction in mortality.

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Research works printed but not linked: 24

  1. Maser RE, Lenhard MJ, DeCherney GS: Cardiovascular autonomic neuropathy: the clinical significance of its determination. Endocrinologist 10: 27–33, 2000 · DOI
  2. Freeman R: Cardiovascular autonomic neuropathy. In Diabetic Neuropathy. 2nd ed. Dyck PJ, Thomas PK, Eds. Philadelphia, W.B. Saunders, 1999, p. 541–554
  3. Hilsted J, Low PA: Diabetic autonomic neuropathy. In Clinical Autonomic Disorders. 2nd ed. Low PA, Ed. Philadelphia, Lippincott-Raven, 1997, p. 487–508
  4. Orchard TJ, Lloyd CE, Maser RE, Kuller LH: Why does diabetic autonomic neuropathy predict IDDM mortality? An analysis from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Res Clin Pract 34 (Suppl.): S165–S171, 1996 · DOI
  5. Ewing DJ, Martyn CN, Young RJ, Clarke BF: The value of cardiovascular autonomic function tests: 10 years’ experience in diabetes. Diabetes Care 8: 491–498, 1985 · DOI · Paper page
  6. Ewing DJ, Boland O, Neilson JMM, Cho CG, Clarke BF: Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients. Diabetologia 34: 182–185, 1991 · DOI · Paper page
  7. Rathmann W, Ziegler D, Jahnke M, Haastert B, Gries FA: Mortality in diabetic patients with cardiovascular autonomic neuropathy. Diabet Med 10: 820–824, 1993 · DOI · Paper page
  8. Hathaway DK, El-Gebely S, Cardoso SS, Elmer DS, Gaber AO: Autonomic cardiac dysfunction in diabetic transplant recipients succumbing to sudden cardiac death. Transplantation 59: 634–637, 1995 · DOI
  9. Navarro X, Kennedy WR, Aeppli D, Sutherland DER: Neuropathy and mortality in diabetes: influence of pancreas transplantation. Muscle Nerve 19: 1009–1016, 1996 · DOI
  10. Veglio M, Sivieri R, Chinaglia A, Scaglione L, Cavallo-Perin P for the Neuropathy Study Group of the Italian Society of the Study of Diabetes, Piemonte Affiliate: QT interval prolongation and mortality in type 1 diabetic patients: a 5-year cohort prospective study. Diabetes Care 23: 1381–1383, 2000 · DOI
  11. Chen HS, Hwu CM, Kuo BI, Chiang SC, Kwok CF, Lee SH, Lee YS, Weih MJ, Hsiao LC, Lin SH, Ho LT: Abnormal cardiovascular reflex tests are predictors of mortality in type 2 diabetes mellitus. Diabet Med 18: 268–273, 2001 · DOI
  12. Sawicki PT, Dahne R, Bender R, Berger M: Prolonged QT interval as a predictor of mortality in diabetic nephropathy. Diabetologia 39: 77–81, 1996 · DOI
  13. Toyry JP, Niskanen LK, Mantysaari MJ, Lansimies EA, Uusitupa MIJ: Occurrence, predictors, and clinical significance of autonomic neuropathy in NIDDM: ten-year follow-up from the diagnosis. Diabetes 45: 308–315, 1996 · DOI
  14. Sawicki PT, Kiwitt S, Bender R, Berger M: The value of QT interval dispersion for identification of total mortality risk in non-insulin-dependent diabetes mellitus. J Intern Med 243: 49–56, 1998 · DOI
  15. Wirta O, Pasternack A, Mustonen J, Laippala P: Renal and cardiovascular predictors of 9-year total and sudden cardiac mortality in non-insulin-dependent diabetic subjects. Nephrol Dial Transplant 12: 2612–2617, 1997 · DOI
  16. Levitt NS, Stansberry KB, Wynchank S, Vinik AI: The natural progression of autonomic neuropathy and autonomic function tests in a cohort of people with IDDM. Diabetes Care 19: 751–754, 1996 · DOI
  17. Charlson ME, MacKenzie CR, Gold JP: Preoperative autonomic function abnormalities in patients with diabetes mellitus and patients with hypertension. J Am Coll Surg 179: 1–10, 1994 · DOI
  18. Gaede P, Vedel P, Parving HH, Pedersen O: Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomized study. Lancet 353: 617–622, 1999 · DOI · Paper page
  19. Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M: Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Prac 28: 103–117, 1995 · DOI · Paper page
  20. Ebbehoj E, Poulsen PL, Hansen KW, Knudsen ST, Molgaard H, Mogensen CE: Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in type 1 diabetic patients with abnormal albuminuria. Diabeteologia 45: 965–975, 2002 · DOI
  21. Malik RA, Williamson S, Abbott C, Carrington AL, Iqbal J, Schady W, Boulton AJM: Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: randomized double-blind controlled trial. Lancet 352: 1978–1981, 1998 · DOI · Paper page
  22. Kontopoulos AG, Athyros VG, Didangelos TP, Papageorgiou AA, Avramidis MJ, Mayroudi MC, Karamitsos DT: Effect of chronic quinapril administration on heart rate variability in patients with diabetic autonomic neuropathy. Diabetes Care 20: 355–361, 1997 · DOI
  23. Ziegler D, Schatz H, Conrad F, Gries FA, Ulrich H, DEKAN Study Group, Reichel G: Effects of treatment with the antioxidant α-lipoic acid on cardiac autonomic neuropathy in NIDDM patients: a 4-month randomized controlled multicenter trial (DEKAN Study). Diabetes Care 20: 369–373, 1997 · DOI · Paper page
  24. Vinik AI, Erbas T: Recognizing and treating diabetic autonomic neuropathy. Cleveland Clinic J Med 68: 928–944, 2001 · DOI

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Metadata

Authors
Maser, R. E., Mitchell, B. D., Vinik, A. I., & Freeman, R.
Affiliations
  • Department of Medical Technology, University of Delaware, Newark, Delaware
  • Department of Medicine, Division of Endocrinology, Diabetes & Nutrition, University of Maryland School of Medicine, Baltimore, Maryland
  • Department of Medicine and Pathology/Anatomy/Neurobiology, the Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia
  • Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2003-06-01
Volume
26
Issue
6
Pages
1895-1901
ISSN
  • 0149-5992
  • 1935-5548
DOI
10.2337/diacare.26.6.1895
Cited by
578
References
4
Language
en

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