The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Improved Plasma Glucose Control, Whole-Body Glucose Utilization, and Lipid Profile on a Low-Glycemic Index Diet in Type 2 Diabetic Men
Open accessAbstract
OBJECTIVE—To determine whether a chronic low-glycemic index (LGI) diet, compared with a high-glycemic index (HGI) diet, has beneficial effects on plasma glucose control, lipid metabolism, total fat mass, and insulin resistance in type 2 diabetic patients. RESEARCH DESIGN AND METHODS—Twelve type 2 diabetic men were randomly allocated to two periods of 4 weeks of an LGI or HGI carbohydrate diet separated by a 4-week washout interval, in a crossover design. RESULTS—The LGI diet induced lower postprandial plasma glucose and insulin profiles and areas under the curve than after the HGI diet. At the end of the two dietary periods, the 7-day dietary records demonstrated equal daily total energy and macronutrient intake. Body weight and total fat mass were comparable. Four-week LGI versus HGI diet induced improvement of fasting plasma glucose (P < 0.01, Δ changes during LGI vs. HGI), HbA1c (P < 0.01), and whole-body glucose utilization measured by the euglycemic-hyperinsulinemic clamp (P < 0.05). LGI diet induced a decrease in fasting plasma total and LDL cholesterol (Δ changes LGI vs. HGI, P < 0.01), free fatty acids (P < 0.01), apolipoprotein B, and plasminogen activator inhibitor 1 activity. CONCLUSIONS—Only 4 weeks of an LGI diet was able to improve glycemic control, glucose utilization, some lipid profiles, and the capacity for fibrinolysis in type 2 diabetes. Even if changes in glycemic control were modest during the 4-week period, the use of an LGI diet in a longer-term manner might play an important role in the treatment and prevention of diabetes and related disorders.
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“Over the last 3 decades, clinical trials have demonstrated that reducing the GI or glycemic load (GL), the product of GI and the available carbohydrate content of a food,13 in the context of diets low in saturated fat, can improve CHD risk factors including body mass index (BMI), blood pressure, and serum cholesterol.14–24”
From Associations of Glycemic Index and Load With Coronary Heart Disease Events: A Systematic Review and Meta‐Analysis of Prospective Cohorts (2012) · cites this paper as [20]
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Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Glycemic index of foods: a physiological basis for carbohydrate exchange
Jenkins, D. J., Wolever, T. M., Taylor, R. H., Barker, H., Fielden, H., Baldwin, J. M., Bowling, A. C., Newman, H. C., Jenkins, A. L., & Goff, D. V. (1981) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.3.362 · Cited by 3,857
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435
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“and insulin excursions are assumed (1,2)”
Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus.
Chandalia, M., Garg, A., Lütjohann, D., von Bergmann, K., Grundy, S., & Brinkley, L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421903 · Cited by 1,158
Low–Glycemic Index Diets in the Management of Diabetes
Brand-Miller, J., Hayne, S., Petocz, P., & Colagiuri, S. (2003) · Diabetes Care · doi:10.2337/diacare.26.8.2261 · Cited by 951
Groop, L. C., Bonadonna, R. C., DelPrato, S., Ratheiser, K., Zyck, K., Ferrannini, E., & DeFronzo, R. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114142 · Cited by 812 · cited 1×
“During the infusion of this high insulin dose of 6 mU kg 1 min (1), hepatic glucose production was supposed to be zero (19), so that the exogenous glucose infusion provides a measurement of the total-body glucose disposal.”
BackgroundJärvi, A. E., Karlström, B. E., Granfeldt, Y. E., Björck, I. E., Asp, N. G., & Vessby, B. O. (1999) · Diabetes Care · doi:10.2337/diacare.22.1.10 · Cited by 484 · cited 5×
“(12) could be because, first, in our study, the GI of the LGI diet was lower (GI 39) than that in the study of Jarvi et al.”
BackgroundResultInfluentialBonora, E., & Muggeo, M. (2001) · Diabetologia · doi:10.1007/s001250100020 · Cited by 418
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Bantle (2008) · doi:10.2337/dc08-s061 · Cited by 1,795
Brouns, F., Bjorck, I., Frayn, K. N., Gibbs, A. L., Lang, V., Slama, G., & Wolever, T. M. S. (2005) · Nutrition Research Reviews · doi:10.1079/nrr2005100 · Cited by 1,093
Self-citationAugustin, L. S. A., Kendall, C. W. C., Jenkins, D. J. A., Willett, W. C., Astrup, A., Barclay, A. W., Björck, I., Brand-Miller, J. C., Brighenti, F., Buyken, A. E., et al. (2015) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.05.005 · Cited by 707
Self-citationEvidence-based nutritional approaches to the treatment and prevention of diabetes mellitus
Mann, J. I., Leeuw, I. D., Hermansen, K., Karamanos, B. G., Karlström, B., Katsilambros, N. L., Riccardi, G., Rivellese, A. A., Rizkalla, S. W., Slama, G., et al. (2004) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/s0939-4753(04)80028-0 · Cited by 524
Self-citationTHE INSULIN RESISTANCE SYNDROME: Definition and Dietary Approaches to Treatment
Reaven, G. M. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132155 · Cited by 516
Metadata
- Authors
- Rizkalla, S. W., Taghrid, L., Laromiguiere, M., Huet, D., Boillot, J., Rigoir, A., Elgrably, F., & Slama, G.
- Affiliations
- Inserm (FR)
- Hôtel-Dieu de Paris (FR)
- Laboratory of Biochemistry, Hôtel-Dieu Hospital, Paris, France
- Department of Diabetes, Hôtel-Dieu Hospital, Paris, France
- ORCID
- Rizkalla, Salwa W.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2004-08-01
- Volume
- 27
- Issue
- 8
- Pages
- 1866-1872
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2059885017
- Cited by
- 263
- References
- 42
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 12 · 2015: 12 · 2014: 16 · 2013: 21 · 2012: 18
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Université Pierre et Marie Curie
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- low glycemic index diet, high glycemic index diet, type 2 diabetes, glycemic control, postprandial blood glucose, insulin resistance, lipid profile, LDL cholesterol, free fatty acids, apolipoprotein B, plasminogen activator inhibitor-1, fibrinolysis, dietary carbohydrates
- MeSH terms
- Blood Glucose, Cholesterol, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Fibrinolysis, Glucose, Humans, Lipids, Male, Middle Aged, Triglycerides, Glycemic Index
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