Epidemiology of Ischemic Stroke in Patients With Diabetes
Abstract
Objective Diabetes is a well known risk factor for stroke, but the impact of diabetes on stroke incidence rates is not known. This study uses a population-based study to describe the epidemiology of ischemic stroke in diabetic patients. Research design and methods Hospitalized cases were ascertained by ICD-9 discharge codes, prospective screening of emergency department admission logs, and review of coroner's cases. A sampling scheme was used to ascertain cases in the out-of-hospital setting. All potential cases underwent detailed chart abstraction by study nurses followed by physician review. Diabetes-specific incidence rates, case fatality rates, and population-attributable risks were estimated. Results Ischemic stroke patients with diabetes are younger, more likely to be African American, and more likely to have hypertension, myocardial infarction, and high cholesterol than nondiabetic patients. Age-specific incidence rates and rate ratios show that diabetes increases ischemic stroke incidence at all ages, but this risk is most prominent before age 55 in African Americans and before age 65 in whites. One-year case fatality rates after ischemic stroke are not different between those patients with and without diabetes. Conclusions Given the "epidemic" of diabetes, with substantially increasing diabetes prevalence each year across all age- and race/ethnicity groups, the significance of diabetes as a risk factor for stroke is becoming more evident. Diabetes is clearly one of t…
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Efforts that succeed in halting the rise in diabetes could mitigate or delay associated health complications if implemented early.
“Furthermore, efforts that succeed in halting the rise in diabetes could mitigate or delay associated health complications if implemented early.76, 77, 78, 79, 80”
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- Authors
- Kissela, B. M., Khoury, J., Kleindorfer, D., Woo, D., Schneider, A., Alwell, K., Miller, R., Ewing, I., Moomaw, C. J., Szaflarski, J. P., Gebel, J., Shukla, R., & Broderick, J. P.
- Affiliations
- Department of Neurology, University of Cincinnati, Cincinnati, Ohio
- University of Cincinnati (US)
- Jewish Hospital (US)
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2005-02-01
- Volume
- 28
- Issue
- 2
- Pages
- 355-359
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2023590207
- Cited by
- 330
- References
- 1
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 17 · 2021: 9 · 2020: 7 · 2019: 13 · 2018: 27 · 2017: 30 · 2016: 23 · 2015: 26 · 2014: 23 · 2013: 25 · 2012: 20
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS030678, K23NS045054)
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- ischemic stroke, diabetes mellitus, stroke incidence, case fatality, population attributable risk, hypertension, African Americans, young adults, stroke risk factors, age-specific incidence
- MeSH terms
- Adult, Aged, Aged, 80 and over, Black or African American, Brain Ischemia, Diabetes Mellitus, Female, Humans, Kentucky, Male, Middle Aged, Ohio, Incidence, Prevalence, Age Distribution, Stroke, Black People, White People
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