Cited by 261Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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A Dynamic Relationship between Intracellular and Extracellular Pools of Aβ

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Oddo, Salvatore, Caccamo, Antonella, Smith, Ian F., Green, Kim N., LaFerla, Frank M.·2006·The American Journal of Pathology

DOI 10.2353/ajpath.2006.050593PMC PMC1592652

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Abstract

The accumulation of the amyloid-beta peptide (Abeta) in the brain is considered to have a primary role in Alzheimer's disease (AD). In addition to the extracellular accumulation of Abeta in the parenchyma and cerebrovasculature, emerging evidence indicates that intraneuronal Abeta also plays a pathophysiological role in AD. It is unclear, however, if the intracellular and extracellular pools of Abeta are unrelated or connected. In these studies, we sought to establish a relationship between these two pools of Abeta. We identified an inverse relationship between intracellular and extracellular Abeta in the 3xTg-AD transgenic model of AD. Using an immunotherapy approach, we further found that extracellular Abeta was cleared before intracellular Abeta. After the antibody dissipated, however, the reappearance of extracellular plaques was preceded by the accumulation of intraneuronal Abeta. Taken together, these results provide strong experimental evidence that intraneuronal Abeta may serve as a source for some of the extracellular amyloid deposits.

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Authors: Oddo, S., Caccamo, A., Smith, I. F., Green, K. N., & LaFerla, F. M.
Affiliations: University of California, Irvine (US)
Corresponding author: LaFerla, Frank M.
ORCID: Oddo, Salvatore
Caccamo, Antonella
Smith, Ian F.
Green, Kim N.
LaFerla, Frank M.
Venue: The American Journal of Pathology
Publisher: Elsevier BV
Published: 2006-01
Volume: 168
Issue: 1
Pages: 184-194
ISSN: 0002-9440 (ISSN-L)
DOI: 10.2353/ajpath.2006.050593
PMC: PMC1592652
OpenAlex: W2110998913
Cited by: 261
References: 45
Citations by year: 2026: 4 · 2025: 11 · 2024: 21 · 2023: 12 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 14 · 2018: 15 · 2017: 8 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 11
FWCI: 16.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal Of Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association
National Institute on Aging (AG0212982)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta, intraneuronal amyloid-beta, Alzheimer's disease, immunotherapy, amyloid plaques, amyloid clearance
MeSH terms: Age Factors, Alzheimer Disease, Animals, Brain Chemistry, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Intracellular Fluid, Mice, Transgenic, Neurons, Blotting, Western, Amyloid beta-Peptides, Extracellular Fluid, Mice

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A Dynamic Relationship between Intracellular and Extracellular Pools of Aβ

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