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Tomoregulin (TMEFF2) binds alzheimer’s disease amyloid-β (aβ) oligomer and AβPP and protects neurons from Aβ-induced toxicity.

Hong, Hyun-Seok, Maezawa, Izumi, Petrlova, Jitka, Zhao, Xiao-Yan, C. Voss, John, Jin, Lee-Way·2015·Journal of Alzheimer's Disease
DOI 10.3233/jad-150318PMC PMC5533101
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Crossref · 10.3233/jad-150318

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  • Elevation of Tomoreguilin-1 by TPE is expected to have positive effects; it antagonizes Nodal and Junk signaling, combats cardiac hypertrophy, is needed for CNS formation and maintenance, and is neuroprotective by binding toxic Alzheimer's Disease amyloid beta.

    “Similarly, a general positive effects are expected from the elevation by TPE of Tomoreguilin-1, which antagonizes Nodal and Junk signaling, was shown to combat cardiac hypertrophy [81], to be needed for CNS formation and maintenance [82], and to be neuroprotective, by binding toxic Alzheimer’s Disease amyloid beta [83].”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [83]

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Research works printed but not linked: 37

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Metadata

Authors
Hong, H.-S., Maezawa, I., Petrlova, J., Zhao, X.-Y., C. Voss, J., & Jin, L.-W.
Affiliations
  • Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA
  • Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA
  • Biologics Research-USIC, Bayer Healthcare Pharmaceuticals, San Francisco, CA, USA
Venue
Journal of Alzheimer's Disease
Publisher
SAGE Publications
Published
2015-10-01
Volume
48
Issue
3
Pages
731-743
ISSN
  • 1387-2877
  • 1875-8908
DOI
10.3233/jad-150318
PMC
PMC5533101
Cited by
23
References
9

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