The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Oxidative Stress, Gene Expression, and Protein Changes Induced in the Human Placenta during Labor
Open accessAbstract
Malperfusion of the placenta has been implicated as a cause of oxidative stress in complications of human pregnancy, leading to release of pro-inflammatory cytokines and anti-angiogenic factors into the maternal circulation. Uterine contractions during labor are known to be associated with intermittent utero-placental perfusion. We therefore tested whether oxidative stress, pro-inflammatory cytokines and angiogenic regulators were increased in placentas subjected to short (<5hrs) and long (>15hrs) labor compared with non-labored controls delivered by caesarean section. In addition, broader changes in gene transcripts were assessed by microarray analysis. Oxidative stress, activation of the nuclear factor-κB pathway, tumor necrosis factor α and interleukin 1β all increased in placental tissues following labor. Stabilization of hypoxia inducible factor 1α and increased vascular endothelial growth factor soluble receptor-1 were also observed. By contrast, tissue levels of placenta growth factor decreased. Apoptosis was also activated in labored placentas. The magnitude of these changes related to the duration of labor. Following labor, 55 gene transcripts were up-regulated and 35 down-regulated, and many of these changes were reflected at the protein level. In conclusion, labor is a powerful inducer of placental oxidative stress, inflammatory cytokines and angiogenic regulators. Our findings are consistent with intermittent perfusion being the initiating cause. Placentas subjected to labor do not reflect the normal in vivo state at the molecular level.
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Cites
Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101
Circulating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720
Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes
Gerber, H.-P., Condorelli, F., Park, J., & Ferrara, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23659 · Cited by 794
Placental oxidative stress: from miscarriage to preeclampsia
Burton, G. J., & Jauniaux, E. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.03.003 · Cited by 673
Self-citationRajakumar, A., & Conrad, K. P. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.2.559 · Cited by 177
Brar, H. S., Platt, L. D., DeVore, G. R., Horenstein, J., & Medearis, A. L. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90100-7 · Cited by 119
Uterine and umbilical artery velocimetry during normal labor
Fleischer, A., Anyaegbunam, A. A., Schulman, H., Farmakides, G., & Randolph, G. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80342-3 · Cited by 103
Oxidative Stress and the Induction of Cyclooxygenase Enzymes and Apoptosis in the Murine Placenta
Burdon, C., Mann, C., Cindrova-Davies, T., Ferguson-Smith, A. C., & Burton, G. J. (2007) · Placenta · doi:10.1016/j.placenta.2006.12.001 · Cited by 71 · cited 1×
“between oxidative stress and increased concentrations of COX enzymes has recently been reported in the murine placenta.(33) Table 2.”
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Cited by
The effects of oxidative stress on female reproduction: a review
Agarwal, A., Aponte-Mellado, A., Premkumar, B. J., Shaman, A., & Gupta, S. (2012) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-10-49 · Cited by 1,637
Pre-eclampsia: pathophysiology and clinical implications
Burton, G. J., Redman, C. W., Roberts, J. M., & Moffett, A. (2019) · BMJ · doi:10.1136/bmj.l2381 · Cited by 1,250
Self-citationPathophysiology of placental-derived fetal growth restriction
Burton, G. J., & Jauniaux, E. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.577 · Cited by 1,070
Self-citationBurton, G. J., & Jauniaux, E. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2010.10.016 · Cited by 988
Self-citationBurton, G. J., Yung, H.-W., Cindrova-Davies, T., & Charnock-Jones, D. S. (2009) · Placenta · doi:10.1016/j.placenta.2008.11.003 · Cited by 502
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Metadata
- Authors
- Cindrova-Davies, T., Yung, H.-W., Johns, J., Spasic-Boskovic, O., Korolchuk, S., Jauniaux, E., Burton, G. J., & Charnock-Jones, D. S.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 171
- Issue
- 4
- Pages
- 1168-1179
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W2137248860
- Cited by
- 297
- References
- 8
- FWCI
- 16.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
