Impact of an orally administered insect growth regulator (lufenuron) on flea infestations of dogs in a controlled simulated home environment
Open accessAbstract
Objective: To evaluate the ability of lufenuron to control cat flea (Ctenocephalides felis felis) populations on dogs under conditions simulating a naturally infested home environment. Design: 2 treatment and 2 control groups of dogs. Treated dogs received lufenuron in tablet form monthly, and controls received excipient. Dogs had unrestricted access to indoor (carpeted) and outdoor (grassy) environments in which self-propagating flea populations had been established. Animals: 17 adult female Beagles. Procedure: Dogs were monitored for 77 days after initial infestation with fleas and 70 days after initial treatment. Efficacy of the drug was calculated on the basis of absolute reduction in flea counts and as a percentage of control. Results: Lufenuron administration caused a statistically significant (P < 0.05) reduction in flea burdens in treated dogs, compared with controls. Initiation of treatment 7 days after infestation resulted in 75% control of F 1-generation and 97% control of F 2-generation fleas over a 70-day posttreatment period. Conclusions: Lufenuron was highly effective in reducing flea populations on dogs. The time required for control will vary with the duration (generation time) of the flea reproductive cycle and, hence, the geographic area in which the product will be used. The experimental results are most relevant to use of the product for control of an existing flea population in the Midwest. (Am J Vet Res 1996;57:502–504)
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lufenuron is highly effective when used alone in simulated home environments with induced flea infestations.
“Lufenuron proved to be highly effective when used alone in simulated home environments with induced flea infestations [129-131]”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [130]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cited by
Sorted by citations
Therapy, control and prevention of flea allergy dermatitis in dogs and cats
Carlotti, D., & Jacobs, D. E. (2000) · Veterinary Dermatology · doi:10.1046/j.1365-3164.2000.00204.x · Cited by 84 · see citing works
Toxicology of newer pesticides for use in dogs and cats
Hovda, L. R., & Hooser, S. B. (2002) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(01)00013-4 · Cited by 65 · see citing works
Junquera, P., Hosking, B. C., Gameiro, M., et al. (2019) · Parasite · doi:10.1051/parasite/2019026 · Cited by 58 · see citing works
“High preventative efficacy lasting for about one month after a single treatment and proportionally longer after repeated treatments has been shown in vivo after oral administration to experimentally infested dogs [20, 113, 114, 138, 220, 267] and cats [21, 22, 108, 220].”
BackgroundFleas infesting pets in the era of emerging extra-intestinal nematodes
Traversa, D. (2013) · Parasites & Vectors · doi:10.1186/1756-3305-6-59 · Cited by 53 · see citing works
“used alone in simulated home environments with induced flea infestations [129-131], but a fast acting”
MethodSlowik, T. J., Lane, R. S., & Davis, R. M. (2001) · Journal of Medical Entomology · doi:10.1603/0022-2585-38.1.75 · Cited by 28 · see citing works
Davis, R. M. (1999) · Journal of Medical Entomology · doi:10.1093/jmedent/36.5.562 · Cited by 25 · see citing works
Systemic insecticides used in dogs: potential candidates for phlebotomine vector control?
Ares‐Gómez, S., & Picado, A. (2017) · Tropical Medicine & International Health · doi:10.1111/tmi.12870 · Cited by 23 · see citing works
Chemical modification of nodulisporic acid A: preliminary structure–activity relationships
Meinke, P. T., Ayer, M. B., Colletti, S. L., et al. (2000) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00469-8 · Cited by 24 · see citing works
Marsella, R. (1999) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(99)50135-6 · Cited by 22 · see citing works
Ritzhaupt, L. K., Rowan, T. G., Jones, R. L., Cracknell, V. C., Murphy, M. G., & Shanks, D. J. (2002) · Veterinary Parasitology · doi:10.1016/s0304-4017(02)00051-1 · Cited by 17 · see citing works
Campbell, B., Baldwin, R. W., & koehler, P. G. (2017) · Insects · doi:10.3390/insects8030094 · Cited by 12 · see citing works
Woodward, K. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849733007-00348 · Cited by 11 · see citing works
White, W. H., Riggs, K. L., Totten, M., Snyder, D. E., McCoy, C. M., & Young, D. R. (2016) · Veterinary Parasitology · doi:10.1016/j.vetpar.2016.11.018 · Cited by 5 · see citing works
Moog, F., Plichart, G. V., Blua, J.-L., et al. (2020) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2020.02.001 · Cited by 4 · see citing works
“Nevertheless, Bioticks® acted more rapidly than lufenuron, an insect growth regulator given alone to dogs living in infested households, which took between two to three months (Smith et al., 1996; Cadiergues et al., 1999), to achieve full efficacy, albeit at an ultimately higher ceiling than that reported for Bioticks…”
BackgroundFeline flea allergy dermatitis
Horvath, C., & van den Broek, A. (2006) · Companion animal · doi:10.1111/j.2044-3862.2006.tb00083.x · Cited by 3 · see citing works
Veterinary Products Containing Pesticide Active Ingredients
Woodward, K. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735483-00150 · Cited by 2 · see citing works
Chapter 29. New developments in animal healthcare
Fenwick, A. E. (2001) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(01)36069-4
Craig, S. L. (2000) · PubMed
Can Lufenuron be an alternative treatment option in small animal dermatomycosis?
Bilgiç, B., Dokuzeylül, B., Bakay, B. B., & Or, M. E. (2021) · GMPC Thesis & Opinions Platform · doi:10.51585/gtop.2021.2.0009
- Authors
- Smith, R. D., Paul, A. J., Kitron, U. D., Philip, J. R., Barnett, S., Piel, M. J., Ness, R. W., & Evilsizer, M.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- ORCID
- Kitron, Uriel D.
- Venue
- American Journal of Veterinary Research
- Published
- 1996-04-01
- Volume
- 57
- Issue
- 4
- Pages
- 502-504
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W186836235
- Cited by
- 19
- References
- 0
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Keywords
- lufenuron, insect growth regulators, flea infestation, Ctenocephalides felis, dogs, flea control, oral administration
- MeSH terms
- Administration, Oral, Analysis of Variance, Animals, Benzamides, Cats, Dog Diseases, Dogs, Ectoparasitic Infestations, Female, Siphonaptera, Fluorocarbons, Insecticides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
