Metabolomic biomarkers of polycystic ovary syndrome related-obesity: a review of the literature
Open accessAbstract
Background and objectives : Polycystic ovary syndrome (PCOS) displays a phenotype-dependent cardio-metabolic risk. By performing a systematic search of the literature, we aimed to summarize metabolomic signatures associated with obesity in PCOS women. Data sources and study eligibility criteria : We conducted a comprehensive search including: Embase, PubMed, and Web of Science until 31st of May 2019. We used the terms: metabolomics and polycystic ovary syndrome. We excluded the following papers: animal studies, studies that included only lean PCOS women, reviews, meta-analyses, results of interventional studies, those that did not apply metabolomic techniques. Results : The lipid signature in obese women with PCOS showed increased levels of free fatty acids (carnitine, adipic acid, linoleic acid, oleic acid) and lower levels of lysophosphatidylcholines and glycerolphosphocholine compared with non-obese PCOS women. Regarding carbohydrate metabolism, a decrease in citric and lactic acid levels characterized obese PCOS women. Decreased lactic acid in obese PCOS women suggests augmented insulin stimulated glucose muscle use in lean, but not in obese women. Considering amino acid metabolomic markers, valine, glycine, serine, threonine, isoleucine and lysine were higher in obese PCOS women. Patients with visceral obesity presented a diminished uptake of essential amino acids, BCAA, leucine and serine in the skeletal muscle. α-ketoglutarate was significantly higher in obese women with PCOS in comparison with lean women with PCOS, distinguishing these 2 subgroups of PCOS with high ‘predictive accuracy’. Limitations : Overall, a small number of studies have focused on the impact of obesity on the metabolic fingerprints of PCOS women. There is need for properly controlled, high-quality studies. Conclusions : There is compelling evidence of significant alterations in carbohydrate, lipid, and amino acid metabolism in women with PCOS and obesity. Metabolomics may identify new metabolic pathways involved in PCOS and improve our understanding of the complex relation between PCOS and obesity in order to personalize PCOS therapy.
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In women with PCOS and obesity, significant alterations in carbohydrate, lipid, and amino acid metabolism with specific metabolomic signatures have been identified.
“Moreover, in women with PCOS and obesity, significant alterations in carbohydrate, lipid, and amino acid metabolism with specific metabolomic signatures have been identified (e.g., decrease in citric and lactic acid levels, lysophosphatidylcholines, and glycerolphosphocholine and increase in free fatty acids (carnitine, adipic acid, linoleic acid, oleic acid) etc.) [14].”
From Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [14]
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Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS)
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- Authors
- Vonica, C. L., Farcas, A. D., Roman, G., Muresan, A. A., Fodor, A., Cernea, S., & Georgescu, C. E.
- Affiliations
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- “Iuliu Hatieganu” University of Medicine and Pharmacy , Department of Cardiology and Internal Medicine I , Cluj-Napoca , Romania
- ”Iuliu Hatieganu” University of Medicine and Pharmacy , 6th Department of Medical specialities, Diabetes and Nutrition Diseases , Cluj-Napoca , Romania
- Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș (RO)
- Venue
- Revista Romana de Medicina de Laborator
- Publisher
- Walter de Gruyter GmbH
- Published
- 2020-07-01
- Volume
- 28
- Issue
- 3
- Pages
- 241-255
- ISSN
- 1841-6624 (ISSN-L)
- 2284-5623
- OpenAlex
- W3070360959
- Cited by
- 5
- References
- 47
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Revista română de medicină de laborator (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, obesity, metabolomic biomarkers, lipid metabolism, free fatty acids, lysophosphatidylcholine, carbohydrate metabolism, lactic acid, amino acid metabolism, branched-chain amino acids, alpha-ketoglutarate, visceral obesity, skeletal muscle, insulin-stimulated glucose uptake, cardiometabolic risk
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