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Cytokines in acute and chronic inflammation
Open accessAbstract
Inflammation is mediated by a variety of soluble factors, including a group of secreted polypeptides known as cytokines. Inflammatory cytokines can be divided into two groups: those involved in acute inflammation and those responsible for chronic inflammation. This review describes the role played in acute inflammation by IL-1, TNF-alpha, IL-6, IL-11, IL-8 and other chemokines, G-CSF, and GM-CSF. It also describes the involvement of cytokines in chronic inflammation. This latter group can be subdivided into cytokines mediating humoral responses such as IL-4, IL-5, IL-6, IL-7, and IL-13, and those mediating cellular responses such as IL-1, IL-2, IL-3, IL-4, IL-7, IL-9, IL-10, IL-12, interferons, transforming growth factor-beta, and tumor necrosis factor alpha and beta. Some cytokines, such as IL-1, significantly contribute to both acute and chronic inflammation. This review also summarizes features of the cell-surface receptors that mediate the inflammatory effects of the described cytokines.
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Metadata
- Authors
- Wright, T. M.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 1997
- Volume
- 2
- Issue
- 4
- Pages
- d12-26
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/a171
- OpenAlex
- W1935912749
- Cited by
- 963
- References
- 0
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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