Immunological Effects of Probiotics and their Significance to Human Health

Arzneimittelforschung

Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works

Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works

Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial

Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,434 · see citing works

Genetics of Mouse Behavior: Interactions with Laboratory Environment

Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666 · see citing works

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584 · see citing works

Dendritic-cell control of pathogen-driven T-cell polarization

Kapsenberg, M. L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1246 · Cited by 1,440 · see citing works

Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial

Kalliomäki, M. A., Salminen, S., Poussa, T. A., Arvilommi, H. S., & Isolauri, E. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13490-3 · Cited by 1,340 · see citing works

Allergy development and the intestinal microflora during the first year of life

Björkstén, B., Sepp, E., Julge, K., Voor, T., & Mikelsaar, M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118130 · Cited by 1,203 · see citing works

The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction

Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C., & Koga, Y. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1739 · Cited by 1,070 · see citing works

Probiotics in the management of atopic eczema

Isolauri, E., Arvola, T., Sütas, Y., Moilanen, E., & Salminen, S. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00943.x · Cited by 977 · see citing works

Cytokines in acute and chronic inflammation

Wright, T. M. (1997) · Frontiers in bioscience · doi:10.2741/a171 · Cited by 965 · see citing works

Lactobacilli Differentially Modulate Expression of Cytokines and Maturation Surface Markers in Murine Dendritic Cells

Christensen, H. R., Frøkiær, H., & Pestka, J. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.171 · Cited by 905 · see citing works

Meta-Analysis of Probiotics for the Prevention of Antibiotic Associated Diarrhea and the Treatment of Clostridium difficile Disease

McFarland, L. V. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00465.x · Cited by 872 · see citing works

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis

Rachmilewitz, D., Katakura, K., Karmeli, F., Hayashi, T., Reinus, C., Rudensky, B., Akira, S., Takeda, K., Lee, J., Takabayashi, K., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.019 · Cited by 859 · see citing works

Selective probiotic bacteria induce IL-10–producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell–specific intercellular adhesion molecule 3–grabbing nonintegrin

Smits, H. H., Engering, A. J., van der Kleij, D., de Jong, E. C., Schipper, K., van Capel, T. M. M., Zaat, B. A. J., Yazdanbakhsh, M., Wierenga, E. A., & van Kooyk, Y. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.03.036 · Cited by 765 · see citing works

Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled trial

Kukkonen, A. K., Savilahti, E., Haahtela, T., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., & Kuitunen, M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.09.009 · Cited by 708 · see citing works

Enhancement of the Circulating Antibody Secreting Cell Response in Human Diarrhea by a Human Lactobacillus Strain

Kaila, M., Isolauri, E., Soppi, E. T., Virtanen, E., Laine, S., & Arvilommi, H. S. (1992) · Pediatric Research · doi:10.1203/00006450-199208000-00002 · Cited by 700 · see citing works

Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial

Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J. H., Poussa, T., Näse, L., Saxelin, M., & Korpela, R. (2001) · BMJ · doi:10.1136/bmj.322.7298.1327 · Cited by 645 · see citing works

Epithelial cells as sensors for microbial infection.

Kagnoff, M. F., & Eckmann, L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119522 · Cited by 619 · see citing works

Effect of probiotic strains in children with atopic dermatitis

Rosenfeldt, V., Benfeldt, E., Nielsen, S. D., Michaelsen, K. F., Jeppesen, D. L., Valerius, N. H., & Pærregaard, A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.389 · Cited by 614 · see citing works

LactobacillusTherapy for Acute Infectious Diarrhea in Children: A Meta-analysis

Niel, C. W. V., Feudtner, C., Garrison, M. M., & Christakis, D. (2002) · PEDIATRICS · doi:10.1542/peds.109.4.678 · Cited by 599 · see citing works

Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients

Rafter, J. J., Bennett, M., Caderni, G., Clune, Y., Hughes, R., Karlsson, P. C., Klinder, A., O'Riordan, M., O’Sullivan, G. C., Pool-Zobel, B. L., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.488 · Cited by 591 · see citing works

Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant

Rautava, S., Kalliomäki, M. A., & Isolauri, E. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.120273 · Cited by 566 · see citing works

Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials

Sazawal, S., Hiremath, G. S., Dhingra, U., Malik, P., Deb, S., & Black, R. E. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70495-9 · Cited by 557 · see citing works

Modulation of human dendritic cell phenotype and function by probiotic bacteria

Hart, A. L., Lammers, K., Brigidi, P., Vitali, B., Rizzello, F., Gionchetti, P., Campieri, M., Kamm, M. A., Knight, S. C., & Stagg, A. J. (2004) · Gut · doi:10.1136/gut.2003.037325 · Cited by 555 · see citing works

Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bacteria

Schiffrin, E. J., Rochat, F., Link‐Amster, H., Aeschlimann, J., & Donnet‐Hughes, A. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76659-0 · Cited by 553 · see citing works

Lactic Acid Bacteria in the Treatment of Acute Rotavirus Gastroenteritis

Majamaa, H., Isolauri, E., Saxelin, M., & Vesikari, T. (1995) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199504000-00012 · Cited by 551 · see citing works

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial

Taylor, A. L., Dunstan, J. A., & Prescott, S. L. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.08.036 · Cited by 538 · see citing works

Probiotics Ameliorate Recurrent Th1-Mediated Murine Colitis by Inducing IL-10 and IL-10-Dependent TGF-β-Bearing Regulatory Cells

Giacinto, C. D., Marinaro, M., Sanchez, M., Strober, W., & Boirivant, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3237 · Cited by 522 · see citing works

Probiotics in the Treatment and Prevention of Acute Infectious Diarrhea in Infants and Children: A Systematic Review of Published Randomized, Double-Blind, Placebo-Controlled Trials

Szajewska, H., & Mrukowicz, J. Z. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200110002-00004 · Cited by 509 · see citing works

Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019

Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485 · see citing works

Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double‐blind placebo‐controlled trial

Viljanen, M., Savilahti, E., Haahtela, T., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., & Kuitunen, M. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00514.x · Cited by 478 · see citing works

Probiotics in prevention of IgE-associated eczema: A double-blind, randomized, placebo-controlled trial

Abrahamsson, T., Jakobsson, T., Böttcher, M. F., Fredrikson, M. G., Jenmalm, M. C., Björkstén, B., & Oldæus, G. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.01.007 · Cited by 476 · see citing works

Cytokines and Their Roles in Pancreatic Islet β-Cell Destruction and Insulin-Dependent Diabetes Mellitus

Rabinovitch, A., & Suarez‐Pinzon, W. L. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00492-9 · Cited by 466 · see citing works

Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures

Haller, D., Bode, C., Hammes, W. P., Pfeifer, A. M. A., Schiffrin, E. J., & Blum, S. (2000) · Gut · doi:10.1136/gut.47.1.79 · Cited by 466 · see citing works

Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance

McCarthy, J., O’Mahony, L., O’Callaghan, L., Sheil, B., Vaughan, E. E., Fitzsimons, N., Fitzgibbon, J., O’Sullivan, G. C., Kiely, B., Collins, J. K., et al. (2003) · Gut · doi:10.1136/gut.52.7.975 · Cited by 462 · see citing works

Interleukin‐10 generation in atopic children following oral Lactobacillus rhamnosus GG

Pessi, T., Sütas, Y., Hurme, M., & Isolauri, E. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00948.x · Cited by 432 · see citing works

Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake

Link‐Amster, H., Rochat, F., Saudan, K.-Y., Mignot, O., & Aeschlimann, J. (1994) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1994.tb00011.x · Cited by 432 · see citing works

A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial

Wickens, K. L., Black, P., Stanley, T., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.07.011 · Cited by 430 · see citing works

Meta-analysis of probiotics for the prevention of traveler's diarrhea

McFarland, L. V. (2005) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2005.10.003 · Cited by 412 · see citing works

Effects of probiotics on atopic dermatitis: a randomised controlled trial

Weston, S. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2004.060673 · Cited by 408 · see citing works

Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria

Miettinen, M., Vuopio‐Varkila, J., & Varkila, K. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5403-5405.1996 · Cited by 402 · see citing works

Probiotics for treating infectious diarrhoea

Allen, S. J., Okoko, B. J., Martinez, E. G., Gregorio, G. V., & Dans, L. F. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003048.pub2 · Cited by 400 · see citing works

The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans

Spanhaak, S., Havenaar, R., & Schaafsma, G. (1998) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600663 · Cited by 399 · see citing works

The gnotobiotic animal as a tool in the study of host microbial relationships

Gordon, H. A., & Pesti, L. (1971) · Bacteriological Reviews · doi:10.1128/br.35.4.390-429.1971 · Cited by 393 · see citing works

Randomized, Double-Blind, Placebo-Controlled Trial of Probiotics for Primary Prevention: No Clinical Effects of Lactobacillus GG Supplementation

Kopp, M., Hennemuth, I., Heinzmann, A., & Urbanek, R. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1492 · Cited by 386 · see citing works

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis

Rachmilewitz, D., Karmeli, F., Takabayashi, K., Hayashi, T., Leider–Trejo, L., Lee, J., Leoni, L. M., & Raz, E. (2002) · Gastroenterology · doi:10.1053/gast.2002.32994 · Cited by 380 · see citing works

Preventive Effect of a Lactobacillus casei Preparation on the Recurrence of Superficial Bladder Cancer in a Double-Blind Trial

Aso, Y., Akaza, H., Kotake, T., Tsukamoto, T., Imai, K., Naito, S., & and the BLP Study Group (1995) · European Urology · doi:10.1159/000475138 · Cited by 373 · see citing works

Probiotic immunomodulation in health and disease

Erickson, K. L., & Hubbard, N. E. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.2.403s · Cited by 372 · see citing works

Improved immunogenicity of oral D x RRV reassortant rotavirus vaccine by Lactobacillus casei GG

Isolauri, E., Joensuu, J., Suomalainen, H., Luomala, M., & Vesikari, T. (1995) · Vaccine · doi:10.1016/0264-410x(95)93319-5 · Cited by 370 · see citing works

Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse

Calcinaro, F., Dionisi, S., Marinaro, M., Candeloro, P., Bonato, V., Marzotti, S., Corneli, R. B., Ferretti, E., Gulino, A., Grasso, F., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1831-2 · Cited by 353 · see citing works

Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens

Cross, M. L. (2002) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2002.tb00632.x · Cited by 350 · see citing works

Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells

Miettinen, M., Matikainen, S., Vuopio‐Varkila, J., Pirhonen, J., Varkila, K., Kurimoto, M., & Julkunen, I. (1998) · Infection and Immunity · doi:10.1128/iai.66.12.6058-6062.1998 · Cited by 343 · see citing works

Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases

Vanderpool, C., Yan, F., & Polk, B. D. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20525 · Cited by 340 · see citing works

Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019)

Arunachalam, K. D., Gill, H., & Chandra, R. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600938 · Cited by 336 · see citing works

Lactobacillus GG effect in increasing IFN-γ production in infants with cow's milk allergy

Pohjavuori, E., Viljanen, M., Korpela, R., Kuitunen, M., Tiittanen, M., Vaarala, O., & Savilahti, E. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.036 · Cited by 335 · see citing works

Microbes, immunoregulation, and the gut: Figure 1

Rook, G. A. W., & Brunet, L. R. (2005) · Gut · doi:10.1136/gut.2004.053785 · Cited by 334 · see citing works

Probiotics and human health: a clinical perspective

Gill, H. S., & Guarner, F. (2004) · Postgraduate Medical Journal · doi:10.1136/pgmj.2003.008664 · Cited by 334 · see citing works

Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children

Fukushima, Y., Kawata, Y., Hiroyoshi, H. A. R. A., Terada, A., & MITSUOKA, T. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00056-7 · Cited by 333 · see citing works

DNA from probiotic bacteria modulates murine and human epithelial and immune function

Jijon, H. B., Backer, J., Díaz, H., Yeung, H. P., Thiel, D., McKaigney, C. J., Simone, C. D., & Madsen, K. L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.003 · Cited by 318 · see citing works

Mechanisms of Disease: the hygiene hypothesis revisited

Guarner, F., Bourdet‐Sicard, R., Brandtzæg, P., Gill, H. S., McGuirk, P., van Eden, W., Versalovic, J. A., Weinstock, J. V., & Rook, G. A. W. (2006) · Nature Clinical Practice Gastroenterology &#38 Hepatology · doi:10.1038/ncpgasthep0471 · Cited by 315 · see citing works

Dietary Probiotic Supplementation Enhances Natural Killer Cell Activity in the Elderly: An Investigation of Age-Related Immunological Changes

Gill, H. S., Rutherfurd, K. J., & Cross, M. L. (2001) · Journal of Clinical Immunology · doi:10.1023/a:1010979225018 · Cited by 304 · see citing works

Randomized trial of dietary fiber andLactobacillus casei administration for prevention of colorectal tumors

Ishikawa, H., Akedo, I., Otani, T., Suzuki, T., Nakamura, T., Takeyama, I., Ishiguro, S., Miyaoka, E., Sobue, T., & Kakizoe, T. (2005) · International Journal of Cancer · doi:10.1002/ijc.21115 · Cited by 291 · see citing works

Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis

Stadlbauer, V., Mookerjee, R. P., Hodges, S. J., Wright, G. A. K., Davies, N. A., & Jalan, R. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.02.015 · Cited by 288 · see citing works

Viable versus inactivated lactobacillus strain GG in acute rotavirus diarrhoea.

Kaila, M., Isolauri, E., Saxelin, M., Arvilommi, H. S., & Vesikari, T. (1995) · Archives of Disease in Childhood · doi:10.1136/adc.72.1.51 · Cited by 287 · see citing works

Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells

Lammers, K. M., Brigidi, P., Vitali, B., Gionchetti, P., Rizzello, F., Caramelli, E., Matteuzzi, D., & Campieri, M. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00144-5 · Cited by 282 · see citing works

Probiotic bacteria down‐regulate the milk‐induced inflammatory response in milk‐hypersensitive subjects but have an immunostimulatory effect in healthy subjects

Pelto, Isolauri, Lilius, Nuutila, & Salminen (1998) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1998.00449.x · Cited by 275 · see citing works

Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0–6 months

Grönlund, M., Arvilommi, H., Kero, P., Lehtonen, O.-P., & Isolauri, E. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.83.3.f186 · Cited by 269 · see citing works

Oral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination

Olivares, M. M., Díaz-Ropero, M. P., Sierra, S., Lara‐Villoslada, F., Fonollá, J., Navas, M., Rodríguez, J. M., & Xaus, J. (2007) · Nutrition · doi:10.1016/j.nut.2007.01.004 · Cited by 264 · see citing works

No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch‐pollen allergy: a placebo‐controlled double‐blind study

Helin, T., Haahtela, S., & Haahtela, T. (2002) · Allergy · doi:10.1034/j.1398-9995.2002.1s3299.x · Cited by 245 · see citing works

Use of Lactobacillus probiotics for bacterial genitourinary infections in women: A review

Barrons, R., & Tassone, D. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.03.013 · Cited by 240 · see citing works

Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses

Chiang, B., Sheih, Y.-H., Wang, L. H., Liao, C., & Gill, H. S. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601093 · Cited by 238 · see citing works

Systemic Immunity-Enhancing Effects in Healthy Subjects Following Dietary Consumption of the Lactic Acid BacteriumLactobacillus rhamnosusHN001

Sheih, Y.-H., Chiang, B., Wang, L.-H., Liao, C.-K., & Gill, H. S. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719027 · Cited by 237 · see citing works

Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis – a pilot study

Hatakka, K., Martio, J., Korpela, M. M., Herranen, M., Poussa, T. A., Laasanen, T., Saxelin, M., Vapaatalo, H., Moilanen, E., & Korpela, R. (2003) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740310003695 · Cited by 235 · see citing works

Modulation of humoral immune response through probiotic intake

He, F., Tuomola, E., Arvilommi, H. S., & Seppo, S. (2000) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2000.tb01504.x · Cited by 226 · see citing works

Identification of strong interleukin‐10 inducing lactic acid bacteria which down‐regulate T helper type 2 cytokines

Niers, L. E. M., Timmerman, H. M., Rijkers, G. T., van Bleek, G. M., van Uden, N. O. P., Knol, E. F., Kapsenberg, M. L., Kimpen, J. L. L., & Hoekstra, M. O. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02375.x · Cited by 226 · see citing works

Probiotics to enhance anti-infective defences in the gastrointestinal tract

Gill, H. S. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00074-x · Cited by 224 · see citing works

Prophylactic Effect of a Lactobacillus casei Preparation on the Recurrence of Superficial Bladder Cancer

Aso, Y., & Akazan, H. (2010) · Urologia Internationalis · doi:10.1159/000282409 · Cited by 219 · see citing works

Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum

Lee, J. W., Shin, J. G., Kim, E. H., Kang, H. E., Yim, I. B., Kim, J. Y., Joo, H. G., & Woo, H. J. (2004) · Journal of Veterinary Science · doi:10.4142/jvs.2004.5.1.41 · Cited by 218 · see citing works

Bacterial Probiotic Modulation of Dendritic Cells

Drakes, M. L., Blanchard, T. G., & Czinn, S. J. (2004) · Infection and Immunity · doi:10.1128/iai.72.6.3299-3309.2004 · Cited by 218 · see citing works

Modulation of Nonspecific Mechanisms of Defense by Lactic Acid Bacteria: Effective Dose

Donnet‐Hughes, A., Rochat, F., Serrant, P., Aeschlimann, J., & Schiffrin, E. J. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75304-x · Cited by 215 · see citing works

Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon‐γ and breast milk transforming growth factor‐β and immunoglobin A detection

Prescott, S. L., Wickens, K. L., Westcott, L., Jung, W., Currie, H., Black, P., Stanley, T., Mitchell, E. A., Fitzharris, P., Siebers, R. W. L., et al. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03061.x · Cited by 213 · see citing works

Probiotics, Immunomodulation, and Health Benefits

Gill, H., & Prasad, J. (2007) · Springer eBooks · doi:10.1007/978-0-387-74087-4_17 · Cited by 213 · see citing works

Probiotic administration in patients with ileal pouch–anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells

Pronio, A., Montesani, C., Butteroni, C., Vecchione, S., Mumolo, G. M., Vestri, A., Vitolo, D., & Boirivant, M. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20369 · Cited by 212 · see citing works

Effects of probiotic on intestinal mucosa of patients with ulcerative colitis

Cui, H.-H. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i10.1521 · Cited by 209 · see citing works

Habitual Intake of Lactic Acid Bacteria and Risk Reduction of Bladder Cancer

Ohashi, Y., Nakai, S., Tsukamoto, T., Masumori, N., Akaza, H., Miyanaga, N., Kitamura, T., Kawabe, K., Kotake, T., Kuroda, M., et al. (2002) · Urologia Internationalis · doi:10.1159/000058450 · Cited by 208 · see citing works

Cytokine Response Patterns, Exposure to Viruses, and Respiratory Infections in the First Year of Life

Copenhaver, C. C., Gern, J. E., Li, Z., Shult, P. A., Rosenthal, L. A., Mikus, L. D., Kirk, C. J., Roberg, K. A., Anderson, E. L., Tisler, C. J., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200312-1647oc · Cited by 207 · see citing works

Probiotic and Prebiotic Influence Beyond the Intestinal Tract

Lenoir‐Wijnkoop, I., Sanders, M. E., Cabana, M. D., Çağlar, E., Corthier, G., Rayes, N., Sherman, P. M., Timmerman, H. M., Vaneechoutte, M., Loo, J. V., et al. (2007) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00272.x · Cited by 205 · see citing works

The gnotobiotic animal as a tool in the study of host microbial relationships.

Gordon, H. A., & Pesti, L. (1971) · Bacteriological Reviews · doi:10.1128/mmbr.35.4.390-429.1971 · Cited by 205 · see citing works

Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial

de Vrese, M., Winkler, P., Rautenberg, P., Harder, T., Noah, C., Laue, C., Ott, S., Hampe, J., Schreiber, S., Heller, K., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.05.048 · Cited by 201 · see citing works

Faecal SIgA secretion in infants fed on pre‐ or probiotic infant formula

Bakker‐Zierikzee, A. M., van Tol, E. A. F., Kroes, H., Alles, M., Kok, F. J., & BINDELS, J. G. (2006) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2005.00370.x · Cited by 199 · see citing works

Effects of a Fermented Milk Drink Containing Lactobacillus casei Strain Shirota on the Immune System in Healthy Human Subjects

Nagao, F., NAKAYAMA, M., Muto, T., & Okumura, K. (2000) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.64.2706 · Cited by 193 · see citing works

The acquisition of tolerance toward cow's milk through probiotic supplementation: A randomized, controlled trial

Hol, J., van Leer, E. H. G., Schuurman, B. E. E. E., de Ruiter, L. F., Samsom, J. N., Hop, W. C. J., Neijens, H. J., de Jongste, J. C., & Nieuwenhuis, E. E. S. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.018 · Cited by 192 · see citing works

Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and β-hemolytic streptococci)

Glück, U., & Gebbers, J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.517 · Cited by 192 · see citing works

Probiotic bacteria stimulate virus-specific neutralizing antibodies following a booster polio vaccination

de Vrese, M., Rautenberg, P., Laue, C., Koopmans, M., Herremans, T., & Schrezenmeir, J. (2005) · European Journal of Nutrition · doi:10.1007/s00394-004-0541-8 · Cited by 190 · see citing works

Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials

Johnston, B. C. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.051603 · Cited by 189 · see citing works

Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis

Sheil, B., McCarthy, J., O’Mahony, L., Bennett, M. W., Ryan, P., Fitzgibbon, J. J., Kiely, B., Collins, J. K., & Shanahan, F. (2004) · Gut · doi:10.1136/gut.2003.027789 · Cited by 187 · see citing works

T Helper 1/T Helper 2 Cytokine Imbalance in Respiratory Syncytial Virus Infection Is Associated With Increased Endogenous Plasma Cortisol

Pinto, R. A., Arredondo, S. M., Bono, M. R., Gaggero, A. A., & DÍAZ, P. V. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2119 · Cited by 180 · see citing works

Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions

So, J., Kwon, H., Lee, C., Yi, H., Park, J., Lim, S., Hwang, K., Jeon, Y. H., & Im, S. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2007.12.010 · Cited by 178 · see citing works

Lactobacilluscasei reduces CD8+ T cell‐mediated skin inflammation

Chapat, L., Chemin, K., Dubois, B., Bourdet‐Sicard, R., & Kaiserlian, D. (2004) · European Journal of Immunology · doi:10.1002/eji.200425139 · Cited by 175 · see citing works

Is the effect of probiotics on atopic dermatitis confined to food sensitized children?

Sistek, D., Kelly, R. S., Wickens, K. L., Stanley, T., Fitzharris, P., & Crane, J. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02485.x · Cited by 175 · see citing works

Stimulation of the Immune System by Lactic Cultures

Gill, H. S. (1998) · International Dairy Journal · doi:10.1016/s0958-6946(98)00074-0 · Cited by 175 · see citing works

Interleukin-12 is involved in the enhancement of human natural killer cell activity byLactobacillus caseiShirota

Takeda, K., Suzuki, T., Shimada, S.-I., Shida, K., Nanno, M., & Okumura, K. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03165.x · Cited by 171 · see citing works

Inflammatory bowel disease: Current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics

Geier, M. S., Butler, R. N., & Howarth, G. S. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.10.006 · Cited by 170 · see citing works

Prospective, randomized controlled trial onLactobacillus rhamnosusin infants with moderate to severe atopic dermatitis

Fölster‐Holst, R., Müller, F. C., Schnopp, N., Abeck, D., Kreiselmaier, I., Lenz, T., von Rüden, U., Schrezenmeir, J., Christophers, E., & Weichenthal, M. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07558.x · Cited by 166 · see citing works

Randomized, placebo‐controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy

Grüber, C., Wendt, M., Sulser, C., Lau, S., Kulig, M., Wahn, U., Werfel, T., & Niggemann, B. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01543.x · Cited by 165 · see citing works

Protection against translocating Salmonella typhimurium infection in mice by feeding the immuno-enhancing probiotic Lactobacillus rhamnosus strain HN001

Gill, H. S., Shu, Q., Lin, H., Rutherfurd, K. J., & Cross, M. L. (2001) · Medical Microbiology and Immunology · doi:10.1007/s004300100095 · Cited by 163 · see citing works

Probiotics in the treatment of Japanese cedar pollinosis: a double‐blind placebo‐controlled trial

Xiao, J., Kondo, S., Yanagisawa, N., Takahashi, N., Odamaki, T., Iwabuchi, N., Miyaji, K., Iwatsuki, K., Togashi, H., Enomoto, K., et al. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02575.x · Cited by 163 · see citing works

The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention

Roessler, A., Friedrich, U., Vogelsang, H., Bauer, A., Kaatz, M., Hipler, U. ‐., Schmidt, I., & Jahreis, G. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02876.x · Cited by 162 · see citing works

Immune and Clinical Impact of Lactobacillus acidophilus on Asthma

Wheeler, J. G., Shema, S. J., Bogle, M. L., Shirrell, M. A., Burks, A. W., Pittler, A., & Helm, R. M. (1997) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63007-4 · Cited by 161 · see citing works

Effects of a Fermented Milk Drink Containing Lactobacillus casei Strain Shirota on the Human NK-Cell Activity1,

Takeda, K., & Okumura, K. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.791s · Cited by 161 · see citing works

Lactic acid bacteria and cancer: mechanistic perspective

Rafter, J. J. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002633 · Cited by 161 · see citing works

ProbioticLactobacillusspp. DiminishHelicobacter hepaticus-Induced Inflammatory Bowel Disease in Interleukin-10-Deficient Mice

Peña, J. A., Rogers, A. B., Ge, Z., Ng, V., Li, S. Y., Fox, J. G., & Versalovic, J. A. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.912-920.2005 · Cited by 160 · see citing works

Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study.

Turchet, P., Laurenzano, M., Auboiron, S., & Antoine, J. M. (2003) · PubMed · Cited by 158 · see citing works

Increased Poliovirus-Specific Intestinal Antibody Response Coincides with Promotion of Bifidobacterium longum-infantis and Bifidobacterium breve in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial

Mullié, C., Yazourh, A., Thibault, H., Odou, M., Singer, E., Kalach, N., Kremp, O., & Romond, M. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000141955.47550.a0 · Cited by 151 · see citing works

Natural Killer Cells in the Late Decades of Human Life

Ogata, K., Yokose, N., Tamura, H., An, E., Nakamura, K., Dan, K., & Nomura, T. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4401 · Cited by 147 · see citing works

Clinical effects of probiotics are associated with increased interferon‐γ responses in very young children with atopic dermatitis

Prescott, S. L., Dunstan, J. A., Hale, J., Breckler, L., Lehmann, H. S., Weston, S., & Richmond, P. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02376.x · Cited by 146 · see citing works

Immune protection mediated by the probioticLactobacillus rhamnosusHN001 (DR20™) againstEscherichia coliO157:H7 infection in mice

Shu, Q., & Gill, H. S. (2002) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2002.tb00603.x · Cited by 146 · see citing works

Lactobacillus GG Bacteria Ameliorate Arthritis in Lewis Rats

Baharav, E., Weinberger, A., Mor, F., & Halpern, M. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.8.1964 · Cited by 144 · see citing works

Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice

Goudy, K., Song, S., Wasserfall, C. H., Zhang, Y. C., Kapturczak, M., MUIR, A. B., Powers, M. A., Scott-Jorgensen, M., Campbell‐Thompson, M., Crawford, J. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251532298 · Cited by 141 · see citing works

Enhancement of natural killer cytotoxicity delayed murine carcinogenesis by a probiotic microorganism

Takagi, A., Matsuzaki, T., Sato, M., Nomoto, K., Morotomi, M., & Yokokura, T. (2001) · Carcinogenesis · doi:10.1093/carcin/22.4.599 · Cited by 134 · see citing works

Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-Dependent Fashion

Goudy, K., Burkhardt, B. R., Wasserfall, C. H., Song, S., Campbell‐Thompson, M., Brusko, T. M., Powers, M. A., Clare-Salzler, M. J., Sobel, E. S., Ellis, T. M., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2270 · Cited by 131 · see citing works

Suppressive effects of the oral administration of Lactobacillus casei on type II collagen-induced arthritis in DBA/1 mice

Kato, I., Endo-Tanaka, K., & Yokokura, T. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00315-4 · Cited by 130 · see citing works

Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines

Lee, D. K., Jang, S., Kim, M. J., Kim, J. H., Chung, M. J., Kim, K. J., & Ha, N. J. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-310 · Cited by 130 · see citing works

Effect of Milk Fermented withLactobacillus acidophilusStrain L-92 on Symptoms of Japanese Cedar Pollen Allergy: A Randomized Placebo-Controlled Trial

ISHIDA, Y., Nakamura, F., Kanzato, H., Sawada, D., Yamamoto, N., Kagata, H., Ohida, M., Takeuchi, H., & FUJIWARA, S. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.1652 · Cited by 121 · see citing works

Natural Health Products, Modulation of Immune Function and Prevention of Chronic Diseases

Haddad, P. S., Azar, G. A., Groom, S., & Boivin, M. (2005) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/neh125 · Cited by 118 · see citing works

The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans.

Olivares, M. M., Díaz-Ropero, M. P., Gómez, N., Lara‐Villoslada, F., Sierra, S., Maldonado, J. A., Martı́n, R., Rodríguez, J. M., & Xaus, J. (2006) · PubMed · Cited by 117 · see citing works

Hypoxia inhibits macrophage migration

Turner, L., Scotton, C. J., Negus, R. P. M., & Balkwill, F. R. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199907)29:07 · Cited by 117 · see citing works

The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114001 on the immune response of subjects under academic examination stress

Marcos, A., W�rnberg, J., Nova, E., Gómez‐Martínez, S., Alvarez, A. M., Alvarez, R., Mateos, J. A., & Cobo, J. M. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0517-8 · Cited by 116 · see citing works

Dietary Bifidobacterium lactis (HN019) Enhances Resistance to Oral Salmonella typhimurium Infection in Mice

Shu, Q., Lin, H., Rutherfurd, K. J., Fenwick, S., Prasad, J., Gopal, P. K., & Gill, H. S. (2000) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2000.tb02486.x · Cited by 116 · see citing works

Effect of a dietary supplement containing probiotic bacteria plus vitamins and minerals on common cold infections and cellular immune parameters

Winkler, P., de Vrese, M., Laue, C., & Schrezenmeir, J. (2005) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp43318 · Cited by 115 · see citing works

Probiotics for the Treatment or Prevention of Atopic Dermatitis

Betsi, G. I., Papadavid, E., & Falagas, M. E. (2008) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200809020-00002 · Cited by 115 · see citing works

Viability and dose–response studies on the effects of the immunoenhancing lactic acid bacteriumLactobacillus rhamnosusin mice

Gill, H. S., & Rutherfurd, K. J. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001402 · Cited by 114 · see citing works

Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probioticLactobacillus johnsoniiLa1 (NCC533)

Fukushima, Y., Miyaguchi, S., Yamano, T., Kaburagi, T., Iino, H., Ushida, K., & Sato, K. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507764723 · Cited by 114 · see citing works

Probiotics and immunology: separating the wheat from the chaff

Shida, K., & Nanno, M. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.07.011 · Cited by 109 · see citing works

Effect of probiotics on vaccine antibody responses in infancy – a randomized placebo‐controlled double‐blind trial

Kukkonen, A. K., Nieminen, T., Poussa, T. A., Savilahti, E., & Kuitunen, M. (2006) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2006.00420.x · Cited by 106 · see citing works

Effects of feeding probiotics during weaning on infections and antibody responses to diphtheria, tetanus and Hib vaccines

West, C. E., Gothefors, L., Granström, M., Käyhty, H. M., Hammarström, M., & Hernell, O. (2008) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2007.00583.x · Cited by 105 · see citing works

Fermented Milks, Probiotic Cultures, and Colon Cancer

Saikali, J., Picard, C., Freitas, M., & Holt, P. R. (2004) · Nutrition and Cancer · doi:10.1207/s15327914nc4901_3 · Cited by 104 · see citing works

Intestinal microflora: probiotics and autoimmunity.

Matsuzaki, T., Takagi, A., Ikemura, H., Matsuguchi, T., & Yokokura, T. (2007) · Journal of NutriLife · doi:10.1093/jn/137.3.798s · Cited by 104 · see citing works

Effect of the oral administration of Lactobacillus brevis subsp. coagulans on interferon-alpha producing capacity in humans.

Kishi, A., Uno, K., Matsubara, Y., Okuda, C., & Kíshida, T. (1996) · Journal of the American College of Nutrition · doi:10.1080/07315724.1996.10718617 · Cited by 100 · see citing works

Induction of human cytokines by bacteria used in dairy foods

Pereyra, B., & Lemonnier, D. (1993) · Nutrition Research · doi:10.1016/s0271-5317(05)80737-7 · Cited by 99 · see citing works

Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse

Williams, A. M., Probert, C. S., Štëpánková, R., Tlaskalová‐Hogenová, H., Phillips, A. C., & Bland, P. W. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02458.x · Cited by 98 · see citing works

The adjuvant effect of yogurt on production of gamma-interferon by con a-stimulated human peripheral blood lymphocytes

Simone, C., Salvadori, B. B., Negri, R., Ferrazzi, M., Baldinelli, L., & Veselý, R. (1986) · Nutrition reports international · Cited by 97 · see citing works

Increasing work-place healthiness with the probiotic Lactobacillus reuteri: A randomised, double-blind placebo-controlled study

Tubelius, P., Stan, V., & Zachrisson, A. (2005) · Environmental Health · doi:10.1186/1476-069x-4-25 · Cited by 96 · see citing works

Influence of long-term yoghurt consumption in young adults

HALPERN, G. M., Vruwink, K. G., de Water, J. A. V., Keen, C. L., & Gershwin, M. E. (1991) · International journal of immunotherapy · Cited by 96 · see citing works

Role of food in the stimulation of cytokine production

Pereyra, B., Aattouri, N., & Lemonnier, D. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.421s · Cited by 91 · see citing works

Suppression of Autoimmune Diabetes by Viral IL-10 Gene Transfer

Yang, Z., Chen, M., Wu, R., Fialkow, L. B., Bromberg, J. S., MCDUFFIE, M. J., Naji, A., & Nadler, J. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6479 · Cited by 89 · see citing works

Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in habitual smokers

Morimoto, K., Takeshita, T., Nanno, M., Tokudome, S., & Nakayama, K. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2004.07.019 · Cited by 85 · see citing works

Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves innate defense capacity in healthy middle-aged people

Parra, M. D., de Morentin, B. E. M., Cobo, J., Mateos, A., & Martínez, J. A. (2004) · Journal of Physiology and Biochemistry · doi:10.1007/bf03168444 · Cited by 82 · see citing works

Probiotic Lactobacilli for Urogenital Health in Women

Reid, G. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31817f1298 · Cited by 79 · see citing works

Immunomodulating potential of supplementation with probiotics: a dose–response study in healthy young adults

Christensen, H. R., Larsen, C. N., Kæstel, P., Rosholm, L. B., Sternberg, C., Michaelsen, K. F., & Frøkiær, H. (2006) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2006.00109.x · Cited by 79 · see citing works

EFFECTS OF THE NORMAL MICROBIAL FLORA ON VARIOUS TISSUE ELEMENTS OF THE SMALL INTESTINE

Gordon, H. A., & Bruckner-Kardoss, E. (2008) · Acta Anatomica · doi:10.1159/000141723 · Cited by 76 · see citing works

Dietary probiotic supplementation to enhance cellular immunity in the elderly.

Gill, H. S., Cross, M. L., Rutherfurd, K. J., & Gopal, P. K. (2001) · PubMed · Cited by 74 · see citing works

Probiotic Therapy in the Prevention of Pouchitis Onset: Decreased Interleukin-1β, Interleukin-8, and Interferon-γ Gene Expression

Lammers, K. M., Vergopoulos, A., Babel, N., Gionchetti, P., Rizzello, F., Morselli, C., Caramelli, E., Fiorentino, M., D’Errico, A., Volk, H., et al. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mpa.0000160302.40931.7b · Cited by 73 · see citing works

Preliminary Human Study for Possible Alteration of Serum Immunoglobulin E Production in Perennial Allergic Rhinitis with Fermented Milk Prepared with Lactobacillus gasseri TMC0356

Morita, H., He, F., Kawase, M., Kubota, A., Hiramatsu, M., Kurisaki, J., & Salminen, S. (2006) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2006.tb03842.x · Cited by 72 · see citing works

Antitumour activity of yogurt: study of possible immune mechanisms

Perdigón, G., Valdéz, J. C., & Rachid, M. (1998) · Journal of Dairy Research · doi:10.1017/s0022029997002604 · Cited by 68 · see citing works

Dietary deprivation of fermented foods causes a fall in innate immune response. Lactic acid bacteria can counteract the immunological effect of this deprivation

Olivares, M., Paz Díaz-Ropero, M., Gómez, N., Sierra, S., Lara-Villoslada, F., Martín, R., Miguel Rodríguez, J., & Xaus, J. (2006) · Journal of Dairy Research · doi:10.1017/s0022029906002068 · Cited by 68 · see citing works

Interaction of Mucosal Microbiota with the Innate Immune System

Tlaskalová‐Hogenová, H., Tučková, L., Mestecky, J. F., Kolinska, J., Rossmann, P., Stepankova, R., Kozáková, H., Hudcovic, T., Hrnčíř, T., Frolová, L., et al. (2005) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2005.01618.x · Cited by 66 · see citing works

Probiotics for the Prevention of Beta Cell Autoimmunity in Children at Genetic Risk of Type 1 Diabetes—the PRODIA Study

Ljungberg, M., Korpela, R., Ilonen, J., Ludvigsson, J., & Vaarala, O. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1375.055 · Cited by 66 · see citing works

Modulation of Cellular Responses by Plasmid CD40L: CD40L Plasmid Vectors Enhance Antigen-Specific Helper T Cell Type 1 CD4 + T Cell-Mediated Protective Immunity against Herpes Simplex Virus Type 2 in Vivo

Sin, J., Kim, J. J., Zhang, D., & Weiner, D. B. (2001) · Human Gene Therapy · doi:10.1089/104303401750214302 · Cited by 66 · see citing works

A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis

Matsuzaki, T., Saito, M., Usuku, K., Nose, H., Izumo, S., Arimura, K., & Osame, M. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.05.011 · Cited by 65 · see citing works

Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei DN114001 in lactating mothers and their children

Ortiz‐Andrellucchi, A., Sánchez‐Villegas, A., Rodríguez‐Gallego, C., Lemes, A., Molero, T., Soria, A., Quintana, L. P., Santana, M., Ramirez, O., García, J. B., et al. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508959183 · Cited by 63 · see citing works

Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula.

Phuapradit, P., Varavithya, W., Vathanophas, K., Sangchai, R., Podhipak, A., Suthutvoravut, U., Nopchinda, S., Chantraruksa, V., & Haschke, F. (1999) · PubMed · Cited by 60 · see citing works

Effect of oral administration of Lactobacillus casei on alloxan‐induced diabetes in mice

Matsuzaki, T., Nagata, Y., KADO, S., UCHIDA, K., Hashimoto, S., & Yokokura, T. (1997) · Apmis · doi:10.1111/j.1699-0463.1997.tb05065.x · Cited by 58 · see citing works

Probiotic supplementation to enhance natural immunity in the elderly: effects of a newly characterized immunostimulatory strain Lactobacillus rhamnosus HN001 (DR20™) on leucocyte phagocytosis

Gill, H. S., & Rutherfurd, K. J. (2001) · Nutrition Research · doi:10.1016/s0271-5317(00)00294-3 · Cited by 57 · see citing works

Probiotics and the incidence of colorectal cancer: when evidence is not evident

Capurso, G., Marignani, M., & Fave, G. D. (2006) · Digestive and Liver Disease · doi:10.1016/s1590-8658(07)60010-3 · Cited by 55 · see citing works

Role of food in the stimulation of cytokine production

Solis-Pereyra, B., Aattouri, N., & Lemonnier, D. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.521s · Cited by 55 · see citing works

Protective Effect of Bifidobacterium-Monoassociation against Lethal Activity of Escherichia coli

Yamazaki, S., KAMIMURA, H., Momose, H., KAWASHIMA, T., & Ueda, K. (1982) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.1.1_55 · Cited by 52 · see citing works

How dietary antigens access the mucosal immune system

Heyman, M. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns2001117 · Cited by 51 · see citing works

Production of interferon induced by Streptococcus thermophilus: role of CD4+ and CD8+ lymphocytes

Aattouri, N., & Lemonnier, D. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(96)00147-7 · Cited by 47 · see citing works

Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNFα and IL18 but not CXCL12

van Oosterhout, M., Levarht, E. W. N., Sont, J. K., Huizinga, T. W. J., Toes, R. E. M., & van Laar, J. M. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.024927 · Cited by 45 · see citing works

Hypocholesterolemic and immunostimulatory effects of orally appliedEnterococcus fœcium M-74 in man

Mikeś, Z., Ferencĭk, M., Jahnova, E., Ebringer, L., & Ciznar, I. (1995) · Folia Microbiologica · doi:10.1007/bf02818522 · Cited by 44 · see citing works

Human and microbe: united we stand

Sekirov, I., & Finlay, B. B. (2006) · Nature Medicine · doi:10.1038/nm0706-736 · Cited by 42 · see citing works

[Effect of Lactobacillus casei on the incidence of infectious conditions in children].

Sanz, J. M., Mateos, J. A., & Conejo, A. M. (2006) · PubMed · Cited by 41 · see citing works

Bacillus clausii exerts immuno-modulatory activity in allergic subjects: a pilot study.

Ciprandi, G., Vizzaccaro, A., Cirillo, I., & Tosca, M. A. (2005) · PubMed · Cited by 38 · see citing works

Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: A pilot study

Ciprandi, G., Tosca, M. A., Milanese, M., Caligo, G., & Ricca, V. (2004) · Pediatric Allergy and Immunology · doi:10.1046/j.1399-3038.2003.00102.x · Cited by 36 · see citing works

Indigenous bacteria that influence the number of Salmonella typhimurium in the spleen of intravenously challenged mice

Roach, S., & Tannock, G. W. (1980) · Canadian Journal of Microbiology · doi:10.1139/m80-068 · Cited by 34 · see citing works

Induction of 2'-5' A synthetase activity and interferon in humans by bacteria used in dairy products.

Solis Pereyra, B., & Lemonnier, D. (1992) · PubMed · Cited by 32 · see citing works

Immunomodulatory agents in the laboratory and clinic

Nussler, A. K., & Thomson, A. W. (1992) · Parasitology · doi:10.1017/s0031182000075326 · Cited by 26 · see citing works

Bioecological control of inflammatory bowel disease

Bengmark, S. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.10.001 · Cited by 25 · see citing works

Einfluß eines bakteriellen Immunstimulans (humane Enterococcus faecalis-Bakterien) auf die Rezidivhäufigkeit bei Patienten mit chronischer Bronchitis

Habermann, W., Zimmermann, K., Skarabis, H., Kunze, R., & Rusch, V. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300140 · Cited by 25 · see citing works

Combination Treatment of Rat Adjuvant-Induced Arthritis with Methotrexate, Probiotic BacteriaEnterococcus faecium, and Selenium

Rovenský, J., Švík, K., Maťha, V., Istok, R., KAMARÁD, V., Ebringer, L., Ferencĭk, M., & Stančíková, M. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.101 · Cited by 20 · see citing works

Trial of Oral Administration of Bifidobacterium breve for the Prevention of Rotavirus Infections

Araki, K., Shinozaki, T., Yoshiko, I. R. I. E., & Miyazawa, Y. (1999) · Kansenshogaku zasshi · doi:10.11150/kansenshogakuzasshi1970.73.305 · Cited by 14 · see citing works

Lactobacillus fermentum exerts a beneficial effect in an experimental model of rheumatoid arthritis in mice

Rodríguez‐Cabezas, M. E., Fisac, F., Bailón, E., Comalada, M., Camuesco, D., Xaus, J., Concha, Á., Talavera, P., Nieto, A., Zarzuelo, A., et al. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006757 · Cited by 6 · see citing works

[Impaired interferon status in children with acute respiratory infection and its correction with bifidumbacterin-forte].

Lykova, E. A., Vorob'ev, A. A., Bokovoĭ, A. G., & Murashova, A. O. (2001) · PubMed · Cited by 6 · see citing works

[Disruption of microbiocenosis of the large intestine and the immune and interferon status in children with bacterial complications of acute viral infections of the respiratory tract and their correction by high doses of bifidumbacterin forte].

Lykova, E. A., Vorob'ev, A. A., Bokovoĭ, A. G., Pobedinskaia, I. N., Gevondian, V. S., Gevondyan, N. M., Дмитриевич, М. С., Vi, M., Dzis, N. B., Makkaveeva, L. F., et al. (2000) · PubMed · Cited by 5 · see citing works

[The lymphoid tissue of human gastrointestinal mucous membrane. II. Its role].

Crabbé, P. A. (1968) · PubMed · Cited by 4 · see citing works

Discovering probiotic microorganisms: in vitro, in vivo, genetic and omics approaches

Papadimitriou, K., Ζουμποπούλου, Γ., Foligné, B., Alexandraki, V., Κάζου, Μ., Pot, B., & Tsakalidou, E. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00058 · Cited by 388 · see citing works

Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions

Coelho, M. C., Malcata, F. X., & Silva, C. C. G. (2022) · Foods · doi:10.3390/foods11152276 · Cited by 276 · see citing works

Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis

Ma, C., Sun, Z., Zeng, B., Huang, S. W., Zhao, J., Zhang, Y., Su, X., Xu, J., Hong Kui, W. E. I., & Zhang, H. (2018) · Microbiome · doi:10.1186/s40168-018-0578-1 · Cited by 173 · see citing works

Are probiotics useful for therapy of Helicobacter pylori diseases?

Eslami, M., Yousefi, B., Kokhaei, P., Moghadas, A. J., Moghadam, B. S., Arabkari, V., & Niazi, Z. (2019) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2019.02.010 · Cited by 100 · see citing works

Might patients with immune-related diseases benefit from probiotics?

Rad, A. H., Torab, R., Ghalibaf, M., Norouzi, S., & Mehrabany, E. V. (2013) · Nutrition · doi:10.1016/j.nut.2012.10.008 · Cited by 47 · see citing works

Effects of supplemental copper-methionine chelate and copper-soy proteinate on the performance, blood parameters, liver mineral content, and intestinal microflora of broiler chickens

Kim, G.-B., Seo, Y. M., Shin, K.-J., Rhee, A. R., Han, J., & Paik, I. K. (2011) · The Journal of Applied Poultry Research · doi:10.3382/japr.2010-00177 · Cited by 41 · see citing works

Fruit Juices as Probiotic Foods

Pimentel, T. C., Klososki, S. J., Rosset, M., Barão, C. E., & Marcolino, V. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815851-7.00014-0 · Cited by 35 · see citing works

Healing with microbial Allies: Exploration of probiotics in wound management

Kadwaikar, M., & Shinde, V. M. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107906 · Cited by 9 · see citing works

The Mechanisms of Immune System Regulation by Probiotics in Immune-Related Diseases

Bastani, P., Rad, A. H., Norouzi-Panahi, L., Tondhoush, A., Norouzi, S., Mehrabany, E. V., & Kasaie, Z. (2016) · Journal of Pharmacy and Nutrition Sciences · doi:10.6000/1927-5951.2016.06.03.4 · Cited by 5 · see citing works

Health Benefits of Probiotic Consumption

Bastani, P., Akbarzadeh, F., Rad, A. H., Javadi, M., & Khalili, L. (2016) · Springer eBooks · doi:10.1007/978-3-319-25277-3_9 · Cited by 5 · see citing works

Exploring gut microbiota and spinal cord injury: pathogenesis, treatment strategies and prospects

Chen, Q., Zhong, M., & Ye, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1693883 · Cited by 3 · see citing works

Probiotics selection for low-lactose fermented goat milk products

Antsyperova, M. А., Арсеньева, Т. П., Fedorov, A., Lemeshonok, E., Забодалова, Л. А., & Baranenko, D. (2025) · Sustainable Food Technology · doi:10.1039/d5fb00668f · Cited by 2 · see citing works

In Vitro assessment of the probiotic properties of lactic acid bacteria isolated from sorghum mahewu

Mugwanda, K. (2016) · University of Zimbabwe Institutional Repository (University of Zimbabwe) · Cited by 1 · see citing works

Immune Modulation by Probiotics

Tan, P., Eor, J. Y., Chun, T., & Kim, S. H. (2015) · Microbiology monographs · doi:10.1007/978-3-319-23213-3_5 · Cited by 5 · see citing works

Probiotics and Immunomodulation

Donkor, O. N., Vasiljevic, T., & Gill, H. S. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-061-8_34 · Cited by 7 · see citing works

Application of Probiotics and Fermented Foods in Immunostabilization

Hati, S., Das, S., & Basu, S. (2021) · CRC Press eBooks · doi:10.1201/9781003242604-13

The Immunomodulatory Role of Probiotics

Siddique, F., Akram, K., Al-Ghamdi, E. S., Arshad, Q., & Siddique, A. (2022) · Greater South Information System · doi:10.60692/ey8jh-rmc51

Immunomodulation of gastrointestinal tract by probiotics: an insight into the role of Lactobacillus sp. and Bacillus sp. on immunity

D’Rose, V., & Bhat, S. G. (2023) · Journal of BioScience and Biotechnology