Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer rsquo s disease

Justin Thenmozhi, Arokiasamy

doi:10.2741/s514

Cited by 87Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsAluminum toxicity and tolerance in plants and animals

Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer rsquo s disease

Justin Thenmozhi, Arokiasamy·2018·Frontiers in Bioscience

DOI 10.2741/s514

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia, characterized by memory loss, cognitive impairment and personality disorders accompanied by diffuse structural abnormalities in the brain of elderly people. The current investigation explored the neuroprotective potential of asiatic acid (AA), a natural triterpene of Centella asiatica on aluminium chloride (AlCl3) induced rat model of AD. Oral administration of AlCl3 (100 mg/kg b.w.) for 42 days significantly elevated the levels of Al, activity of acetyl cholinesterase and expressions of amyloid precursor protein, amyloid beta1–42, beta and gamma secretases, glial fibrillary acidic protein, ionized calcium binding adaptor molecule 1, interleukins -1β, 6, 4, 2, tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor- k beta and cyclooxygenase-2 in the hippocampus and cortex compared to the control group. Our observations suggested that AA treatment mitigated AlCl3 induced AD associated pathologies, which might be due to its multiple pharmacological actions. Further studies are necessary in order to explore the link between AlCl3-mediated oxidative stress and associated apoptosis to establish its neuroprotective role in AD.

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“In addition, previous studies have shown that asiatic acid (AA) (major bioactive triterpene) may be helpful in reducing Aβ levels in the AD brain with subsequent reduction in the pathologies associated with AD [112].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [112]

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Authors: Justin Thenmozhi, A.
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2018
Volume: 10
Issue: 1
Pages: 262-275
ISSN: 1944-7906 (ISSN-L)
1945-0516
1945-0524
DOI: 10.2741/s514
OpenAlex: W2756660947
Cited by: 84
References: 11
Citations by year: 2026: 9 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 7 · 2018: 3
FWCI: 9.34
Type: journal article
Language: en
Open access: closed
Locations: Frontiers in Bioscience-Scholar (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
Keywords: asiatic acid, Centella asiatica, Alzheimer's disease, aluminum chloride, neuroprotection, triterpenoids, amyloid-beta, acetylcholinesterase, gamma-secretase, amyloid precursor protein, neuroinflammation, oxidative stress, apoptosis, hippocampus, cerebral cortex, NF-κB, cyclooxygenase-2, nitric oxide synthase, glial fibrillary acidic protein
MeSH terms: Aluminum Chloride, Alzheimer Disease, Amyloid, Animals, Chlorides, Disease Models, Animal, Male, Random Allocation, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Rats, Wistar, Apoptosis, Aluminum Compounds, Oxidative Stress, Neuroprotective Agents, Rats, Amyloid Precursor Protein Secretases, Pentacyclic Triterpenes

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Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer rsquo s disease

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