Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer’s Disease1
Abstract
Alzheimer's disease (AD) is a common neurodegenerative disorder that mainly affects the aged population and is characterized by the progressive loss of the hippocampal and cortical neurons, which results in memory and cognitive impairments. Trigonella foenum-graecum (fenugreek) has been reported to have hypoglycemic, hypocholesterolemic, hyperinsulinemic and anti-diabetic properties. Traditionally, it was used as a galactagogue and to treat anorexia, fever gastritis, gastric ulcers, and various nervous disorders. However, the neuroprotective effect of fenugreek seed powder against aluminum chloride (AlCl3) induced AD rats has not been analyzed. The result of the present study indicated that the chronic administration of AlCl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of IDE and CDK5 (enzymes involved in the metabolism of tau and amyloid proteins), pTau, GFAP and Iba-1, IL-1β, IL-6, TNF-α, iNOS, NF-κB, COX-2, CDK5, BDNF, and STAT3. Our behavioral, biochemical, and molecular studies revealed that the co-administration of fenugreek seed powder significantly attenuated the AlCl3 induced memory deficits, amyloid and tau pathology, oxidative stress, and inflammation in AD rats could be due to the synergistic action of its active components.
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Trigonella foenum-graecum attenuated aluminum chloride-induced tau pathology, oxidative stress, and inflammation in AlCl3-induced Alzheimer rats.
“Concerning neuroprotection, it was shown to attenuate aluminum chloride-induced tau pathology, oxidative stress, and inflammation in AlCl 3 -induced Alzheimer rats (Prema et al., 2017).”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Prema et al., 2017
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- Authors
- Prema, A., Justin Thenmozhi, A., Manivasagam, T., Mohamed Essa, M., & Guillemin, G. J.
- Affiliations
- Annamalai University (IN)
- Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India
- Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman
- Macquarie University (AU)
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2017-09-15
- Volume
- 60
- Issue
- s1
- Pages
- S209-S220
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2593745455
- Cited by
- 90
- References
- 68
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 7 · 2023: 12 · 2022: 22 · 2021: 6 · 2020: 8 · 2019: 12 · 2018: 6 · 2017: 1
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Keywords
- fenugreek seed powder, fenugreek
- MeSH terms
- Aluminum Chloride, Alzheimer Disease, Animals, Catalase, Chlorides, Disease Models, Animal, Encephalitis, Glutathione, Glutathione Peroxidase, Plant Extracts, Superoxide Dismutase, Cytokines, tau Proteins, Thiobarbituric Acid Reactive Substances, Aluminum Compounds, Oxidative Stress, Neuroprotective Agents, Maze Learning, Brain-Derived Neurotrophic Factor, Trigonella, STAT3 Transcription Factor, Rats
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