Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats
Open accessAbstract
Aluminium (Al) is a potent neurotoxic metal known to cause neurodegeneration. Al exposure causes oxidative stress by accumulation of reactive oxygen species, followed by the activation of neuronal cell death in the brain. Asiatic acid (AA), the major bioactive compound of Centella asiatica (a medicinal plant), act as multifunctional drug as well as an antioxidant. Thus, the present study aimed to investigate the potential neuroprotective effect of AA against Al neurotoxicity. Rats were orally administered aluminium chloride (AlCl 3; 100 mg/kg b. wt.) dissolved in distilled water for 8 weeks or AA (75 mg/kg b. wt.) in combination with AlCl 3. The results showed that AlCl 3-intoxication causes significant impairment of memory, enhances anxiety-like behavior, acetyl cholinesterase (AChE) activity, malondialdehydes (MDA) level, and concomitant decrease in the activities of superoxide dismutase (SOD) and catalase (CAT) in the cortex and hippocampus regions of rat brain. In addition, AlCl 3-intoxication enhanced neuronal loss and reactive astrogliosis in both regions. However, co-administration of AA with AlCl 3 significantly attenuated the behavioral alterations, restored SOD and CAT activities, while reduced AChE activity and MDA content. Further, the study demonstrated that AA attenuates neuronal loss and reactive astrogliosis in rat brain. In conclusion, the study suggests that AA protects rat brain from Al neurotoxicity by inhibiting oxidative stress, neuronal loss and reactive astrogliosis.
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Asiatic acid from Centella asiatica (75 mg/kg) enhanced antioxidant activity and reduced AChE activity, oxidative stress, and brain damage in the cortex and hippocampus of AlCl3-exposed rats (p≤0.05 and p≤0.01).
“Asiatic acid (AA) from Centella asiatica (75 mg/kg) enhanced antioxidant activity and reduced AChE activity, oxidative stress, and brain damage, especially in the cortex and hippocampus of AlCl3-exposed rats (p ≤ 0.05 and p ≤ 0.01, respectively) [66].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [66]
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- Authors
- Suryavanshi, J., Prakash, C., & Sharma, D.
- Affiliations
- Jawaharlal Nehru University (IN)
- Corresponding author
- Sharma, Deepak
- ORCID
- Sharma, Deepak
- Venue
- Metabolic Brain Disease
- Published
- 2022-05-13
- Volume
- 37
- Issue
- 6
- Pages
- 1773-1785
- ISSN
- 0885-7490 (ISSN-L)
- 1573-7365
- OpenAlex
- W4280496067
- Cited by
- 27
- References
- 62
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 5
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Metabolic Brain Disease (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India (09/263(1124)2017-EMR-I)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- asiatic acid, aluminum chloride, aluminum neurotoxicity, neuroprotection, oxidative stress, reactive astrogliosis, neuronal loss, memory impairment, anxiety-like behavior, acetylcholinesterase, lipid peroxidation, superoxide dismutase, catalase, Centella asiatica, hippocampus, cortex
- MeSH terms
- Aluminum Chloride, Animals, Antioxidants, Astrocytes, Mental Disorders, Gliosis, Superoxide Dismutase, Rats, Wistar, Oxidative Stress, Neuroprotective Agents, Neurotoxicity Syndromes, Rats, Pentacyclic Triterpenes
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