Enhancement of Function of the Prefrontal Cortex to Improve Symptoms of Schizophrenia
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A case report suggests guanfacine may be especially helpful in young adults with schizophrenia and a childhood history of abuse, and can improve insight.
“a case report by Bardoloi (2020) suggests that guanfacine may be especially helpful in young adults with schizophrenia and a childhood history of abuse, and that it can improve insight”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Bardoloi (2020)
The Clinical history says the patient had no history of emotional or physical abuse, contrary to the claimed childhood-abuse history. The Conclusion does report improved insight after guanfacine was added, but this case cannot support the claim about young adults with schizophrenia and a history of abuse. (LLM, conf=0.88)
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Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Lewis DA and Lieberman JA. "Catching up on schizophrenia: Natural history and neurobiology". Neuron 28.2 (2000): 325- 334.
- Wang M., et al. "α2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex". Cell 129.2 (2007): 397-410.
Cited by
Sorted by citations
Arnsten, A. F. T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107327 · Cited by 75 · see citing works
“However, a case report by Bardoloi (2020) suggests that guanfacine may be especially helpful in young adults with schizophrenia and a childhood history of abuse, and that it can improve insight, and thus have global benefits (Bardoloi, 2018).”
Management of Aggressive Behaviors in Neurodevelopmental Disorders - Role of α 2 Agonists
Bardoloi, P. S. (2023) · Acta Scientific Neurology · doi:10.31080/asne.2023.06.0590 · Cited by 3 · see citing works
- Authors
- Sarma Bardoloi, P.
- Venue
- Acta Scientific Neurology
- Published
- 2020-04-28
- Volume
- 3
- Issue
- 5
- Pages
- 19-23
- ISSN
- 2582-1121 (ISSN-L)
- OpenAlex
- W3021581771
- Cited by
- 4
- References
- 32
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 2
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Acta Scientific Neurology (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
- Keywords
- prefrontal cortex, schizophrenia, symptom improvement
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