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Cited by 160Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Dynamic network connectivity: a new form of neuroplasticity

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Arnsten, Amy F.T., Paspalas, Constantinos D., Gamo, Nao J., Yang, Yang, Wang, Min·2010·Trends in Cognitive Sciences
DOI 10.1016/j.tics.2010.05.003PMC PMC2914830
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Abstract

Prefrontal cortical (PFC) working memory functions depend on pyramidal cell networks that interconnect on dendritic spines. Recent research has revealed that the strength of PFC network connections can be rapidly and reversibly increased or decreased by molecular signaling events within slender, elongated spines: a process we term Dynamic Network Connectivity (DNC). This newly discovered form of neuroplasticity provides great flexibility in mental state, but also confers vulnerability and limits mental capacity. A remarkable number of genetic and/or environmental insults to DNC signaling cascades are associated with cognitive disorders such as schizophrenia and age-related cognitive decline. These insults can dysregulate network connections and erode higher cognitive abilities, leading to symptoms such as forgetfulness, susceptibility to interference, and disorganized thought and behavior.

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Crossref · 10.1016/j.tics.2010.05.003

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  • The PFC is especially sensitive to its neurochemical environment; relatively small changes in norepinephrine and dopamine levels can produce significant changes in PFC function.

    “The PFC is known to be especially sensitive to its neurochemical environment; relatively small changes in the levels of norepinephrine and dopamine can produce significant changes in its function.”

    From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Arnsten et al., 2010

    In “Pathways that strengthen network connections” and “Pathways that weaken network connections” (page unavailable), the paper says that norepinephrine and dopamine help determine PFC functional state, with optimal levels strengthening network firing and excessive levels impairing it. It does not establish that relatively small changes in their levels produce significant changes in PFC function. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Recurrent PFC network activity is fragile and extremely sensitive to the neurochemical environment; small changes in arousal systems can markedly alter the connectivity of PFC networks.

    “However, recurrent PFC network activity is fragile, and extremely sensitive to the neurochemical environment. Thus, small changes in the arousal systems can markedly alter the connectivity of PFC networks (Arnsten et al., 2010).”

    From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Arnsten et al., 2010

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Cited by

Sorted by citations

Authors
Arnsten, A. F. T., Paspalas, C. D., Gamo, N. J., Yang, Y., & Wang, M.
Affiliations
Yale University (US)
Corresponding author
Arnsten, Amy F.T.
ORCID
Venue
Trends in Cognitive Sciences
Publisher
Elsevier BV
Published
2010-08
Volume
14
Issue
8
Pages
365-375
ISSN
1364-6613 (ISSN-L)
DOI
10.1016/j.tics.2010.05.003
PMC
PMC2914830
OpenAlex
W2034673701
Cited by
160
References
16
Citations by year
2026: 2 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 13 · 2020: 8 · 2019: 9 · 2018: 11 · 2017: 13 · 2016: 8 · 2015: 16 · 2014: 16 · 2013: 15 · 2012: 22
FWCI
1.33
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Cognitive Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institute on Alcohol Abuse and Alcoholism (RL1AA017536)
  • National Institute on Aging (R37AG006036, P01AG030004, R01AG006036, AG06036)
  • National Center for Research Resources (U54RR024350)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
neuroplasticity, prefrontal cortex, working memory, dendritic spines, synaptic plasticity, schizophrenia, age-related cognitive decline, cognitive disorders, molecular signaling
MeSH terms
Aging, Animals, Cognition Disorders, Dopamine, Humans, Models, Neurological, Neural Pathways, Neuronal Plasticity, Neurons, Schizophrenia, Neural Networks, Computer, Prefrontal Cortex, Nonlinear Dynamics

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