Gene-Environment Interactions in Schizophrenia: Review of Epidemiological Findings and Future Directions

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works

Psychosis as a state of aberrant salience: a framework linking biology, phenomenology and pharmacology in schizophrenia

Kapur, S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.13 · Cited by 2,813 · see citing works

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works

Strategy for Investigating Interactions Between Measured Genes and Measured Environments

Moffitt, T. E., Caspi, A., & Rutter, M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.473 · Cited by 784 · see citing works

Emotional Reactivity to Daily Life Stress in Psychosis

Myin-Germeys, I., van Os, J., Schwartz, J. E., Stone, A. A., & Delespaul, P. A. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.12.1137 · Cited by 653 · see citing works

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Meyer-Lindenberg, A., Miletich, R. S., Kohn, P. D., Esposito, G., Carson, R. E., Quarantelli, M., Weinberger, D. R., & Berman, K. F. (2002) · Nature Neuroscience · doi:10.1038/nn804 · Cited by 652 · see citing works

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

Smith, G. D., & Ebrahim, S. (2005) · BMJ · doi:10.1136/bmj.330.7499.1076 · Cited by 545 · see citing works

Substantia nigra/ventral tegmental reward prediction error disruption in psychosis

Murray, G. K., Corlett, P. R., Clark, L., Pessiglione, M., Blackwell, A. D., Honey, G., Jones, P. B., Bullmore, E. T., Robbins, T. W., & Fletcher, P. C. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002058 · Cited by 532 · see citing works

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: A meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

Barnett, J. H., Jones, P. B., Robbins, T. W., & Müller, U. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001973 · Cited by 274 · see citing works

The formation of abnormal associations in schizophrenia: Neural and behavioral evidence

Jensen, J., Willeit, M., Zipursky, R. B., Savina, I., Smith, A. J., Menon, M., Crawley, A. P., & Kapur, S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301437 · Cited by 225 · see citing works

Evidence that moment‐to‐moment variation in positive emotions buffer genetic risk for depression: a momentary assessment twin study

Wichers, M. C., Myin‐Germeys, I., Jacobs, N., Peeters, F., Kenis, G., Derom, C., Vlietinck, R., Delespaul, P., & Van Os, J. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00924.x · Cited by 165 · see citing works

How dopamine dysregulation leads to psychotic symptoms? Abnormal mesolimbic and mesostriatal prediction error signalling in psychosis

Murray, G. K., Corlett, P. R., Clark, L., Pessiglione, M., Blackwell, A. D., Honey, G., Jones, P. B., Bullmore, E. T., Robbins, T. W., & Fletcher, P. C. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002157 · Cited by 119 · see citing works

Genetic and environmental influences on schizotypy: a community-based twin study

MacDonald, A. W., Pogue-Geile, M. F., Debski, T. T., & Manuck, S. (2001) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006859 · Cited by 75 · see citing works

The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway

Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693 · see citing works

Autoimmune Diseases and Severe Infections as Risk Factors for Schizophrenia: A 30-Year Population-Based Register Study

Benros, M. E., Nielsen, P. R., Nordentoft, M., Eaton, W. W., Dalton, S. O., & Mortensen, P. B. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11030516 · Cited by 582 · see citing works

Autoimmune Diseases and Severe Infections as Risk Factors for Mood Disorders: A Nationwide Study

Benros, M. E., Waltoft, B. L., Nordentoft, M., Østergaard, S. D., Eaton, W. W., Krogh, J., & Mortensen, P. B. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1111 · Cited by 572 · see citing works

What causes psychosis? An umbrella review of risk and protective factors

Radua, J., Ramella‐Cravaro, V., Ioannidis, J. P. A., Reichenberg, A., Phiphopthatsanee, N., Amir, T., Yenn Thoo, H., Oliver, D., Davies, C., Morgan, C., et al. (2018) · World Psychiatry · doi:10.1002/wps.20490 · Cited by 553 · see citing works

Psychosocial Stress and Psychosis. A Review of the Neurobiological Mechanisms and the Evidence for Gene-Stress Interaction

van Winkel, R., Stefanis, N. C., & Myin-Germeys, I. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn101 · Cited by 489 · see citing works

Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis

Agerbo, E., Sullivan, P. F., Vilhjálmsson, B. J., Pedersen, C. B., Mors, O., Børglum, A. D., Hougaard, D. M., Hollegaard, M. V., Meier, S., Mattheisen, M., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0346 · Cited by 319 · see citing works

Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality

García-Gutiérrez, M. S., Navarrete, F., Sala, F., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00432 · Cited by 331 · see citing works

Systematic reviews of categorical versus continuum models in psychosis: evidence for discontinuous subpopulations underlying a psychometric continuum. Implications for DSM-V, DSM-VI, and DSM-VII

Linscott, R. J., & van Os, J. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.032408.153506 · Cited by 324 · see citing works

Epigenetic regulation in the pathophysiology of Alzheimer's disease

Chouliaras, L., Rutten, B. P. F., Kenis, G., Peerbooms, O., Visser, P. J., Verhey, F., van Os, J., Steinbusch, H. W. M., & van den Hove, D. L. A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.01.002 · Cited by 262 · see citing works

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.022 · Cited by 255 · see citing works

Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders

Rutten, B. P. F., & Mill, J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp104 · Cited by 244 · see citing works

Use of the experience sampling method in the context of clinical trials

Verhagen, S. J. W., Hasmi, L., Drukker, M., van Os, J., & Delespaul, P. A. E. G. (2016) · Evidence Based Mental Health · doi:10.1136/ebmental-2016-102418 · Cited by 208 · see citing works

Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence

Harley, M., Kelleher, I., Clarke, M., Lynch, F., Arseneault, L., Connor, D., Fitzpatrick, C., & Cannon, M. (2010) · Psychological Medicine · doi:10.1017/s0033291709991966 · Cited by 206 · see citing works

From maps to multi-dimensional network mechanisms of mental disorders

Braun, U., Schaefer, A., Betzel, R. F., Tost, H., Meyer-Lindenberg, A., & Bassett, D. S. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.007 · Cited by 177 · see citing works

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci

GROUP investigators, Børglum, A. D., Demontis, D., Grove, J., Pallesen, J., Hollegaard, M. V., Pedersen, C. B., Hedemand, A., Mattheisen, M., Uitterlinden, A., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.2 · Cited by 186 · see citing works

Translational perspectives for computational neuroimaging

Stephan, K. E., Iglesias, S., Heinzle, J., & Diaconescu, A. O. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.008 · Cited by 169 · see citing works

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0601-3 · Cited by 168 · see citing works

Methamphetamine use and schizophrenia: A population-based cohort study in California

Callaghan, R. C., Cunningham, J. K., Allebeck, P., Arenovich, T., Sajeev, G., Remington, G., Boileau, I., & Kish, S. J. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10070937 · Cited by 150 · see citing works

Prenatal Immune Activation Interacts with Genetic<i>Nurr1</i>Deficiency in the Development of Attentional Impairments

Vuillermot, S., Joodmardi, E., Perlmann, T., Ove Ögren, S., Feldon, J., & Meyer, U. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4831-11.2012 · Cited by 127 · see citing works

Alteration of the gut microbiome in first-episode drug-naive and chronic medicated schizophrenia correlate with regional brain volumes

Ma, X., Asif, H., Dai, L., He, Y., Zheng, W., Wang, D., Ren, H., Tang, J., Li, C., Jin, K., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.02.005 · Cited by 114 · see citing works

The psychoses: Cluster 3 of the proposed meta-structure for DSM-V and ICD-11: Paper 4 of 7 of the thematic section: ‘A proposal for a meta-structure for DSM-V and ICD-11’

Carpenter, W. T., Bustillo, J. R., Thaker, G. K., van Os, J., Krueger, R. F., & Green, M. J. (2009) · Psychological Medicine · doi:10.1017/s0033291709990286 · Cited by 99 · see citing works

Neurobiological effects of physical exercise in schizophrenia: a systematic review.

Vancampfort, D., Probst, M., De Hert, M., Soundy, A., Stubbs, B., Stroobants, M., & De Herdt, A. (2014) · Disability and Rehabilitation · doi:10.3109/09638288.2013.874505 · Cited by 80 · see citing works

Association of a reproducible epigenetic risk profile for schizophrenia with brain methylation and function

Chen, J., Zang, Z., Braun, U., Schwarz, K., Harneit, A., Kremer, T., Ma, R., Schweiger, J., Moessnang, C., Geiger, L., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4792 · Cited by 69 · see citing works

Can epigenetics shine a light on the biological pathways underlying major mental disorders?

Alameda, L., Trotta, G., Quigley, H., Rodriguez, V., Gadelrab, R., Dwir, D., Dempster, E., Wong, C. C. Y., & Forti, M. D. (2022) · Psychological Medicine · doi:10.1017/s0033291721005559 · Cited by 60 · see citing works

Prognostic accuracy and clinical utility of psychometric instruments for individuals at clinical high-risk of psychosis: a systematic review and meta-analysis

Oliver, D., Arribas, M., Radua, J., Salazar de Pablo, G., De Micheli, A., Spada, G., Mensi, M. M., Kotlicka-Antczak, M., Borgatti, R., Solmi, M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01611-w · Cited by 49 · see citing works

Misconceptions about gene-environment interactions in psychiatry

Zammit, S., Owen, M. J., & Lewis, G. (2010) · Evidence Based Mental Health · doi:10.1136/ebmh1056 · Cited by 50 · see citing works

The study of gene environment interactions in psychiatry: Limited gains at a substantial cost?

Zammit, S., Wiles, N., & Lewis, G. (2010) · Psychological Medicine · doi:10.1017/s0033291709991280 · Cited by 25 · see citing works

Interaction of genotype and environment: effect of strain and housing conditions on cognitive behavior in rodent models of schizophrenia

Turner, K. M., & Burne, T. H. J. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00097 · Cited by 16 · see citing works

Enhancement of Function of the Prefrontal Cortex to Improve Symptoms of Schizophrenia

Sarma Bardoloi, P. (2020) · Acta Scientific Neurology · doi:10.31080/asne.2020.03.0183 · Cited by 4 · see citing works