Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms

Tissue sulfhydryl groups

Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824 · see citing works

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061 · see citing works

Mechanisms of lipid peroxide formation in animal tissues

Wills, E. D. (1966) · Biochemical Journal · doi:10.1042/bj0990667 · Cited by 1,348 · see citing works

Mitochondrial dysfunction in neurodegenerative diseases

Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 608 · see citing works

Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology

Frautschy, S. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00300-1 · Cited by 514 · see citing works

3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin

Ludolph, A. C., He, F., Spencer, P. S., Hammerstad, J. P., & Sabri, M. I. (1991) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100032212 · Cited by 484 · see citing works

Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats

Sinha, K., Chaudhary, G., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01691-0 · Cited by 356 · see citing works

Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats

Sharma, M., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02083-0 · Cited by 326 · see citing works

Neuroprotective effects of resveratrol against β‐amyloid‐induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C

Han, Y.-S., Zheng, W., Bastianetto, S., Chabot, J., & Quirion, R. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705688 · Cited by 300 · see citing works

Efficiency and Mechanism of the Antioxidant Action of trans-Resveratrol and Its Analogues in the Radical Liposome Oxidation

Stojanović, S., SPRINZ, H., & Brede, O. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2388 · Cited by 275 · see citing works

Effects of resveratrol on the rat brain respiratory chain.

Zini, R., Morin, C., Bertelli, A., Bertelli, A., & Tillement, J. P. (1999) · PubMed · Cited by 252 · see citing works

Resveratrol Is a Selective Human Cytochrome P450 1A1 Inhibitor

Chun, Y. J., Kim, M. Y., & Guengerich, F. P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1152 · Cited by 243 · see citing works

Resveratrol is a Peroxidase-mediated Inactivator of COX-1 but Not COX-2

Szewczuk, L. M., Forti, L., Stivala, L. A., & Penning, T. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314302200 · Cited by 240 · see citing works

Resveratrol inhibition of lipid peroxidation

Tadolini, B., Juliano, C., Piu, L., Franconi, F., & Cabrini, L. (2000) · Free Radical Research · doi:10.1080/10715760000300661 · Cited by 220 · see citing works

Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice

Sharma, A. C., & Kulkarni, S. K. (1992) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(92)90014-6 · Cited by 208 · see citing works

Potential Mechanism by Which Resveratrol, a Red Wine Constituent, Protects Neurons

Zhuang, H., Kim, Y., Koehler, R. C., & Doré, S. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07534.x · Cited by 186 · see citing works

Red Wine Ingredient Resveratrol Protects from β-Amyloid Neurotoxicity

Savaskan, E., Olivieri, G., Meier, F., Seifritz, E., Wirz‐Justice, A., & Müller-Spahn, F. (2003) · Gerontology · doi:10.1159/000073766 · Cited by 182 · see citing works

3‐Nitropropionic Acid Neurotoxicity Is Attenuated in Copper/Zinc Superoxide Dismutase Transgenic Mice

Beal, M. F., Ferrante, R. J., Henshaw, R., Matthews, R. T., Chan, P. H., Kowall, N. W., Epstein, C. J., & Schulz, J. B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020919.x · Cited by 162 · see citing works

Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats

Gupta, Y. K., Briyal, S., & Chaudhary, G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00663-3 · Cited by 158 · see citing works

INVOLVEMENT OF OXIDATIVE STRESS IN 3-NITROPROPIONIC ACID NEUROTOXICITY

Schulz, J. B., Henshaw, D. R., MacGarvey, U. M., & Beal, M. F. (1996) · Neurochemistry International · doi:10.1016/0197-0186(95)00122-0 · Cited by 145 · see citing works

The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat

Dawson, D. A., Masayasu, H., Graham, D. I., & Macrae, I. M. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(94)11226-9 · Cited by 145 · see citing works

Effects of trans-Resveratrol on Copper-Dependent Hydroxyl-Radical Formation and DNA Damage: Evidence for Hydroxyl-Radical Scavenging and a Novel, Glutathione-Sparing Mechanism of Action

Burkitt, M. J., & Duncan, J. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1973 · Cited by 144 · see citing works

Protective effect of melatonin on 3‐nitropropionic acid‐induced oxidative stress in synaptosomes in an animal model of Huntington's disease

Túnez, I., Montilla, P., Muñoz, M. D. C., Feijóo, M., & Salcedo, M. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00163.x · Cited by 141 · see citing works

Brain Oxidative Stress in Animal Models of Accelerated Aging and the Age-related Neurodegenerative Disorders, Alzheimers Disease and Huntingtons Disease

Butterfield, D. A., Howard, B. J., & LaFontaine, M. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373048 · Cited by 134 · see citing works

Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury

Hurley, S. D., Olschowka, J. A., & O'Banion, M. K. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753460196 · Cited by 110 · see citing works

Quercetin, a bioflavonoid, attenuates haloperidol-induced orofacial dyskinesia

Naidu, P. S., Singh, A., & Kulkarni, S. K. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00101-1 · Cited by 94 · see citing works

Resveratrol, a polyphenolic phytoalexin protects against cyclosporine-induced nephrotoxicity through nitric oxide dependent mechanism

Chander, V., Tirkey, N., & Chopra, K. (2005) · Toxicology · doi:10.1016/j.tox.2005.01.011 · Cited by 64 · see citing works

Inhibitors of Cyclooxygenase-2, but Not Cyclooxygenase-1 Provide Structural and Functional Protection against Quinolinic Acid-Induced Neurodegeneration

Brenhouse, H. C., Chen, E., Emerich, D. F., Baldwin, S., Hogeland, K., Ranelli, S., Lafreniere, D., Perdomo, B., Novak, L., Kladis, T., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049700 · Cited by 60 · see citing works

Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum

Kim, G. W., & Chan, P. H. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0327 · Cited by 59 · see citing works

A review of the treatment options for Huntington?s disease

Bonelli, R. M., & Hofmann, P. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.4.767 · Cited by 55 · see citing works

Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease

Saydoff, J. A., Liu, L. S., Garcia, R. A. G., Hu, Z., Li, D., & von Borstel, R. W. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.049 · Cited by 54 · see citing works

Resveratrol-induced limitation of dysfunction of mitochondria isolated from rat brain in an anoxia-reoxygenation model

Zini, R., Morin, C., Bertelli, A., Bertelli, A. A. E., & Tillement, J. P. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02161-6 · Cited by 45 · see citing works

Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess

Fass, U., Panickar, K. S., Personett, D. A., Bryan, D., Williams, K., Gonzales, J., Sugaya, K., & McKinney, M. (2000) · Neuroreport · doi:10.1097/00001756-200004070-00007 · Cited by 38 · see citing works

Effect of glucocorticoids on 3-nitropropionic acid-induced oxidative stress in synaptosomes

Montilla, P., Túnez, I., Muñoz, M. C., Salcedo, M., Feijóo, M., Muñoz-Castañeda, J. R., & Bujalance, I. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.004 · Cited by 37 · see citing works

3-Nitropropionic Acid and Similar Nitrotoxins

Patočka, J., Bielavský, J., Cabal, J., & Fusek, J. (2000) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2019.110 · Cited by 22 · see citing works

Injections of an opioid antagonist into the locus coeruleus and periaqueductal gray but not the amygdala precipitates morphine withdrawal in the 7‐day‐old rat

Jones, K. L., & Barr, G. A. (2000) · Synapse · doi:10.1002/1098-2396(200102)39:2 · Cited by 11 · see citing works

SIRT1 in Neurodevelopment and Brain Senescence

Herskovits, A. Z., & Guarente, L. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.028 · Cited by 493 · see citing works

Herbal extracts and phytochemicals: Plant secondary metabolites and the enhancement of human brain function

Kennedy, D. O., & Wightman, E. L. (2011) · Advances in Nutrition · doi:10.3945/an.110.000117 · Cited by 684 · see citing works

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

Tomé‐Carneiro, J., Larrosa, M., González‐Sarrías, A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990407 · Cited by 451 · see citing works

Resveratrol: French Paradox Revisited

Catalgol, B., Batirel, S., Taga, Y., & Ozer, N. K. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00141 · Cited by 449 · see citing works

What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

Vang, O., Ahmad, N., Baile, C. A., Baur, J. A., Brown, K., Csiszár, A., Das, D. K., Delmas, D., Gottfried, C., Lin, H., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019881 · Cited by 433 · see citing works

Mitochondrial Diseases of the Brain

Chaturvedi, R. K., & Beal, M. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.018 · Cited by 416 · see citing works

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., & Haskell, C. F. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28641 · Cited by 415 · see citing works

Resveratrol: Its Biologic Targets and Functional Activity

Pervaiz, S., & Holme, A. L. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2412 · Cited by 411 · see citing works

The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

Athauda, D., & Foltynie, T. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.013 · Cited by 383 · see citing works

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

Sun, A. Y., Wang, Q., Simonyi, Á., & Sun, G. Y. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8111-y · Cited by 330 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease

Khan, M. M., Ahmad, A., Ishrat, T., Khan, M. B., Hoda, M. N., Khuwaja, G., Raza, S. S., Khan, A., Javed, H., Vaibhav, K., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.031 · Cited by 279 · see citing works

Neuroprotective Strategies for Neurological Disorders by Natural 
Products: An update

Rehman, M., Wali, A., Ahmad, A., Shakeel, S., Rasool, S., Ali, R., Rashid, S. M., Madkhali, H. A., Ganaie, M., & Khan, R. (2019) · Current Neuropharmacology · doi:10.2174/1570159x16666180911124605 · Cited by 202 · see citing works

Anti-inflammatory activities of resveratrol in the brain: Role of resveratrol in microglial activation

Zhang, F., Liu, J., & Shi, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.043 · Cited by 265 · see citing works

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Pallos, J., Bodai, L., Lukácsovich, T., Purcell, J. M., Steffan, J. S., Thompson, L. M., & Marsh, J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn273 · Cited by 265 · see citing works

Resveratrol supplementation: Where are we now and where should we go?

Novelle, M. G., Wahl, D., Diéguez, C., Bernier, M., & de Cabo, R. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.002 · Cited by 247 · see citing works

Mitochondrial Dysfunction as a Driver of Cognitive Impairment in Alzheimer’s Disease

Sharma, C., Kim, S., Nam, Y., Jung, U. J., & Kim, S. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094850 · Cited by 242 · see citing works

Resveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia

Candelario-Jalil, E., de Oliveira, A. C. P., Gräf, S., Bhatia, H. S., Hüll, M., Muñoz, E., & Fiebich, B. L. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-25 · Cited by 223 · see citing works

PGC-1α, mitochondrial dysfunction, and Huntington's disease

Johri, A., Chandra, A., & Beal, M. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.016 · Cited by 223 · see citing works

Sirtuin deacetylases in neurodegenerative diseases of aging

Herskovits, A. Z., & Guarente, L. (2013) · Cell Research · doi:10.1038/cr.2013.70 · Cited by 222 · see citing works

Energy deficit in Huntington disease: why it matters

Mochel, F., & Haller, R. G. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45691 · Cited by 220 · see citing works

Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease

Rahman, M. H., Akter, R., Bhattacharya, T., Abdel‐Daim, M. M., Alkahtani, S. H., Arafah, M. W., AL–Johani, N. S., Alhoshani, N. M., Alkeraishan, N., Alhenaky, A., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.619024 · Cited by 194 · see citing works

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

Manjula, R., Anuja, K., & Alcain, F. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.585821 · Cited by 193 · see citing works

Resveratrol: A Natural Compound with Pharmacological Potential in Neurodegenerative Diseases

Rocha-­González, H. I., Ambriz‐Tututi, M., & Granados‐Soto, V. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00045.x · Cited by 187 · see citing works

Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

Neal, M. P., & Richardson, J. R. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.004 · Cited by 185 · see citing works

Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection

Pallàs, M., Casadesús, G., Smith, M. A., Coto‐Montes, A. M., Pelegrı́, C., Vilaplana, J., & Camins, A. (2009) · Current Neurovascular Research · doi:10.2174/156720209787466019 · Cited by 183 · see citing works

Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?

Liddell, J. R. (2017) · Antioxidants · doi:10.3390/antiox6030065 · Cited by 167 · see citing works

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

Ho, D. J., Calingasan, N. Y., Wille, E. J., Dumont, M., & Beal, M. F. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.05.006 · Cited by 147 · see citing works

Resveratrol as a Therapeutic Agent for Alzheimer’s Disease

Ma, T., Tan, M., Yu, J., & Tan, L. (2014) · BioMed Research International · doi:10.1155/2014/350516 · Cited by 144 · see citing works

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

Chaturvedi, R. K., & Beal, M. F. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.11.011 · Cited by 139 · see citing works

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease

Divino da Rocha, M., Pereira Dias Viegas, F., Cristina Campos, H., Carolina Nicastro, P., Calve Fossaluzza, P., Alberto Manssour Fraga, C., J. Barreiro, E., & Viegas, C. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794480429 · Cited by 126 · see citing works

Possible Neuroprotective Effect of <i>Withania somnifera</i> Root Extract Against 3-Nitropropionic Acid-Induced Behavioral, Biochemical, and Mitochondrial Dysfunction in an Animal Model of Huntington's Disease

Kumar, P., & Kumar, A. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0028 · Cited by 120 · see citing works

Expression of Concern: Role of LOX/COX pathways in 3‐nitropropionic acid‐induced Huntington's Disease‐like symptoms in rats: protective effect of licofelone

Kumar, P., Kalonia, H., & Kumar, A. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01418.x · Cited by 108 · see citing works

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

Sadagurski, M., Cheng, Z., Rozzo, A., Palazzolo, I., Kelley, G. R., Dong, X., Krainc, D., & White, M. F. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46305 · Cited by 107 · see citing works

Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid–rich plant foods

Willis, L., Shukitt‐Hale, B., & Joseph, J. A. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.26736j · Cited by 105 · see citing works

Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

Chao, J., Li, H., Cheng, K., Yu, M.-S., Chang, R. C., & Wang, M. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.02.004 · Cited by 104 · see citing works

Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease

Gao, Y., Chu, S., Li, J., Zhang, Z., Yan, J., Wen, Z.-L., Xia, C., Mou, Z., Wang, Z., He, W., et al. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.107 · Cited by 98 · see citing works

Neuroprotective and metabolic effects of resveratrol: Therapeutic implications for Huntington's disease and other neurodegenerative disorders

Pasinetti, G. M., Wang, J., Marambaud, P., Ferruzzi, M. G., Gregor, P., Knable, L. A., & Ho, L. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.014 · Cited by 96 · see citing works

Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain

Kumar, P., & Kumar, A. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.013 · Cited by 95 · see citing works

Anti-Oxidative Effects of Rooibos Tea (Aspalathus linearis) on Immobilization-Induced Oxidative Stress in Rat Brain

Hong, I., Lee, H., & Kim, H.-P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087061 · Cited by 92 · see citing works

Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex

Schweiger, S., Matthes, F., Posey, K. L., Kickstein, E., Weber, S. S., Hettich, M. M., Pfurtscheller, S., Ehninger, D., Schneider, R., & Krauß, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-12974-4 · Cited by 92 · see citing works

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

Pierzynowska, K., Gaffke, L., Cyske, Z., Puchalski, M., Rintz, E., Bartkowski, M., Osiadły, M., Pierzynowski, M., Mantej, J., Piotrowska, E., et al. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0214-6 · Cited by 89 · see citing works

Effects of pterostilbene and resveratrol on brain and behavior

Poulose, S. M., Thangthaeng, N., Miller, M. G., & Shukitt‐Hale, B. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.017 · Cited by 89 · see citing works

Resveratrol: botanical origin, pharmacological activity and applications

Wu, C., Yang, J., Wang, F., & Wang, X. (2013) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(13)60001-1 · Cited by 85 · see citing works

Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro

Walter, C., Clemens, L. E., Müller, A. J., Fallier‐Becker, P., Proikas‐Cezanne, T., Rieß, O., Metzger, S., & Nguyen, H. P. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.041 · Cited by 84 · see citing works

Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review

Tabeshpour, J., Mehri, S., Behbahani, F. S., & Hosseinzadeh, H. (2018) · Phytotherapy Research · doi:10.1002/ptr.6168 · Cited by 82 · see citing works

Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats

Orsu, P., Murthy, B. V. S. N., & Akula, A. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-0982-4 · Cited by 78 · see citing works

Olive oil reduces oxidative damage in a 3-nitropropionic acid-induced Huntington's disease-like rat model

Tasset, I., Pontes, A. J., Hinojosa, A. J., de la Torre, R., & Túnez, I. (2011) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000005 · Cited by 77 · see citing works

Sirtuin Acetylation and Deacetylation: a Complex Paradigm in Neurodegenerative Disease

Khan, H., Tiwari, P., Kaur, A., & Singh, T. G. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02387-w · Cited by 75 · see citing works

Neuroprotective Effect of Lutein Against 3-Nitropropionic Acid–Induced Huntington's Disease–Like Symptoms: Possible Behavioral, Biochemical, and Cellular Alterations

Binawade, Y., & Jagtap, A. G. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2698 · Cited by 75 · see citing works

Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: Possible behavioural, biochemical and cellular alterations

Kumar, P., & Kumar, A. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.058 · Cited by 75 · see citing works

Neuroprotective activity of<scp>L</scp>-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum

Thangarajan, S., Deivasigamani, A., Natarajan, S. S., Krishnan, P., & Mohanan, S. K. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2013.872642 · Cited by 71 · see citing works

Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity

Kumar, P., Kalonia, H., & Kumar, A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.11.030 · Cited by 69 · see citing works

Protective Effect of Natural Products against Huntington’s Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Lum, P. T., Sekar, M., Gan, S. H., Bonam, S. R., & Shaikh, M. F. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00824 · Cited by 68 · see citing works

Neuroprotective effects of resveratrol in Alzheimer rsquo s disease

Murlimanju, B. V. (2019) · Frontiers in Bioscience-Elite · doi:10.2741/e863 · Cited by 67 · see citing works

Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity

Kumar, P., Kalonia, H., & Kumar, A. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.10.001 · Cited by 66 · see citing works

Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders

Mehan, S., Parveen, S., & Kalra, S. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.200812 · Cited by 65 · see citing works

Neuroprotective effect of cyclosporine and FK506 against 3-nitropropionic acid induced cognitive dysfunction and glutathione redox in rat: Possible role of nitric oxide

Kumar, P., & Kumar, A. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.01.005 · Cited by 63 · see citing works

Stilbenes and Anthocyanins Reduce Stress Signaling in BV-2 Mouse Microglia

Carey, A. N., Fisher, D. R., Rimando, A. M., Gomes, S. M., Bielinski, D. F., & Shukitt‐Hale, B. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400342g · Cited by 60 · see citing works

Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: Possible neuroprotective mechanisms

Bhateja, D., Dhull, D. K., Gill, A., Sidhu, A., Sharma, S., Reddy, B. V. K., & Padi, S. S. V. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.10.029 · Cited by 60 · see citing works

Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study

Anton, S. D., Ebner, N. C., Dzierzewski, J. M., Zlatar, Z. Z., Gurka, M. J., Dotson, V. M., Kirton, J. W., Mankowski, R. T., Marsiske, M., & Manini, T. M. (2018) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2017.0398 · Cited by 60 · see citing works

Minocycline modulates neuroprotective effect of hesperidin against quinolinic acid induced Huntington's disease like symptoms in rats: Behavioral, biochemical, cellular and histological evidences

Kumar, A., Chaudhary, T., & Mishra, J. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.057 · Cited by 59 · see citing works

Quercetin Protects Against Acute Immobilization Stress-Induced Behaviors and Biochemical Alterations in Mice

Kumar, A., & Goyal, R. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2006.0207 · Cited by 58 · see citing works

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations.

Kumari, B., Kumar, A., & Dhir, A. (2007) · PubMed · Cited by 58 · see citing works

Targeting Sirtuin-1 in Huntington’s Disease: Rationale and Current Status

Duan, W. (2013) · CNS Drugs · doi:10.1007/s40263-013-0055-0 · Cited by 54 · see citing works

Protective Effect of Sesamol against 3‐Nitropropionic Acid‐Induced Cognitive Dysfunction and Altered Glutathione Redox Balance in Rats

Kumar, P., Kalonia, H., & Kumar, A. (2010) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2010.00537.x · Cited by 54 · see citing works

Histone deacetylases as targets for the treatment of human neurodegenerative diseases

D’Mello, S. R. (2009) · Drug News & Perspectives · doi:10.1358/dnp.2009.22.9.1437959 · Cited by 53 · see citing works

Estrogens of multiple classes and their role in mental health disease mechanisms

Watson, C. S. (2010) · International Journal of Women s Health · doi:10.2147/ijwh.s6907 · Cited by 52 · see citing works

Sirtuins Expression and Their Role in Retinal Diseases

Balaiya, S., Abu‐Amero, K. K., Kondkar, A. A., & Chalam, K. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3187594 · Cited by 52 · see citing works

Sesamol attenuate 3-nitropropionic acid-induced Huntington-like behavioral, biochemical, and cellular alterations in rats

Kumar, P., Kalonia, H., & Kumar, A. (2009) · Journal of Asian Natural Products Research · doi:10.1080/10286020902862194 · Cited by 52 · see citing works

Antioxidant Intervention to Improve Cognition in the Aging Brain: The Example of Hydroxytyrosol and Resveratrol

Terracina, S. A., Petrella, C., Francati, S., Lucarelli, M., Barbato, C., Minni, A., Ralli, M., Greco, A., Tarani, L., Fiore, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415674 · Cited by 51 · see citing works

Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer’s Disease in Rats

Dhull, D. K., Jindal, A., Dhull, R. K., Aggarwal, S., Bhateja, D., & Padi, S. S. V. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9583-6 · Cited by 50 · see citing works

Nitric oxide mechanism in the protective effect of antidepressants against 3-nitropropionic acid-induced cognitive deficit, glutathione and mitochondrial alterations in animal model of Huntington's disease

Kumar, P., Kalonia, H., & Kumar, A. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833a5bf4 · Cited by 47 · see citing works

Effect of resveratrol on scopolamine-induced cognitive impairment in mice

Rachna, G., Lalit, K., Pramod, K. M., & Swapan, K. B. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70785-5 · Cited by 46 · see citing works

Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation, and apoptosis in rats

Gendy, A. M., El-Sadek, H. M., Amin, M. M., Ahmed, K. A., El-Sayed, M. K., El-Haddad, A. E., & Soubh, A. A. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121317 · Cited by 45 · see citing works

Protective effects of epigallocatechin gallate following 3-nitropropionic acid-induced brain damage: possible nitric oxide mechanisms

Kumar, P., & Kumar, A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1652-y · Cited by 43 · see citing works

l-Theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory cytokines and oxidative stress in rat brain

Sumathi, T., Asha, D., Nagarajan, G., Sreenivas, A., & Nivedha, R. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.01.008 · Cited by 40 · see citing works

Resveratrol: A Natural Compound Targeting the PI3K/Akt/mTOR Pathway in Neurological Diseases

Utpal, B. K., Mokhfi, F. Z., Zehravi, M., Sweilam, S. H., Gupta, J. K., Kareemulla, S., Ronald Darwin, C., Rao, A. A., Kumar, V. V., Krosuri, P., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04608-4 · Cited by 37 · see citing works

Berberine Ameliorate Haloperidol and 3-Nitropropionic Acid-Induced Neurotoxicity in Rats

Kadir, A., Singh, J., Rahi, V., & Kumar, P. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03677-y · Cited by 36 · see citing works

An Overview of the Pathophysiological Mechanisms of 3-Nitropropionic Acid (3-NPA) as a Neurotoxin in a Huntington's Disease Model and Its Relevance to Drug Discovery and Development

Upadhayay, S., Yedke, N. G., Rahi, V., Singh, S., Kumar, S., Arora, A., Chandolia, P., Kaur, P., Kumar, M., Koshal, P., et al. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03868-1 · Cited by 36 · see citing works

Protective effect ofConvolvulus pluricaulisstandardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats

Malik, J., Choudhary, S., & Kumar, P. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2014.984856 · Cited by 35 · see citing works

Effect of Licofelone—A Dual COX/5-LOX Inhibitor in Intracerebroventricular Streptozotocin-Induced Behavioral and Biochemical Abnormalities in Rats

Kumar, A., Sharma, S., Prashar, A., & Deshmukh, R. R. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0414-4 · Cited by 33 · see citing works

Resveratrol Delivery from Implanted Cyclodextrin Polymers Provides Sustained Antioxidant Effect on Implanted Neural Probes

Haley, R. M., Zuckerman, S. T., Dakhlallah, H., Capadona, J. R., von Recum, H. A., & Ereifej, E. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103579 · Cited by 32 · see citing works

Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats

Dhir, A., Akula, K. K., & Kulkarni, S. K. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.12.017 · Cited by 31 · see citing works

The neuroprotective attribution of Ocimum basilicum: a review on the prevention and management of neurodegenerative disorders

Ali‐Seyed, M., Ayesha, S., Azmi, N., Al-Rabae, F. M., Alalawy, A. I., Alzahrani, O. R., & Hawsawi, Y. M. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00295-3 · Cited by 30 · see citing works

Possible nitric oxide modulation in protective effect of FK-506 against 3-nitropropionic acid-induced behavioral, oxidative, neurochemical, and mitochondrial alterations in rat brain

Kumar, P., Kalonia, H., & Kumar, A. (2010) · Drug and Chemical Toxicology · doi:10.3109/01480541003642050 · Cited by 30 · see citing works

Role of neurosteroids in experimental 3-nitropropionic acid induced neurotoxicity in rats

Kumar, P., Kumar, P., Khan, A. G., Deshmukh, R. R., & Sharma, P. L. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.036 · Cited by 29 · see citing works

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Socała, K., Żmudzka, E., Lustyk, K., Zagaja, M., Brighenti, V., Costa, A., Andres-Mach, M., Pytka, K., Martinelli, I., Mandrioli, J., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8101 · Cited by 24 · see citing works

Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi’s Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics

Szalárdy, L., Zádori, D., Klivènyi, P., Toldi, J., & Vécsei, L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/498401 · Cited by 28 · see citing works

ADIOL protects against 3-NP-induced neurotoxicity in rats: Possible impact of its anti-oxidant, anti-inflammatory and anti-apoptotic actions

Hanna, D. M. F., Tadros, M. G., & Khalifa, A. E. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.02.005 · Cited by 28 · see citing works

Anacardic Acids from Cashew Nuts Prevent Behavioral Changes and Oxidative Stress Induced by Rotenone in a Rat Model of Parkinson’s Disease

Linard, C. F. B. M., Andrade‐da‐Costa, B. L. D. S., Augusto, R. L., Sereniki, A., Trevisan, M. T. S., Perreira, R. D. C. R., de Souza, F. T. C., Braz, G. R. F., Lagranha, C. J., de Souza, I. A., et al. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9882-6 · Cited by 28 · see citing works

Effects of Mediterranean Diet Components on Neurodegenerative Diseases

Farooqui, A. A., & Farooqui, T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00001-8 · Cited by 28 · see citing works

Mitochondrial Effects of Plant-Made Compounds

Biasutto, L., Szabó, I., & Zoratti, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4021 · Cited by 25 · see citing works

Animal models of Huntington’s disease and their applicability to novel drug discovery and development

Upadhayay, S., Jamwal, S., & Kumar, P. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2201493 · Cited by 24 · see citing works

Chronic treatment with resveratrol, a natural polyphenol found in grapes, alleviates oxidative stress and apoptotic cell death in ovariectomized female rats subjected to chronic cerebral hypoperfusion

ÖZAÇMAK, V. H., ÖZAÇMAK, H. S., & Barut, F. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000027 · Cited by 24 · see citing works

Organoselenium Bis Selenide Attenuates 3-Nitropropionic Acid-Induced Neurotoxicity in Rats

Bortolatto, C. F., Jessé, C. R., Wilhelm, E. A., Chagas, P. M., & Nogueira, C. W. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9336-5 · Cited by 24 · see citing works

Polyphenol Compounds as Antioxidants for Disease Prevention: Reactive Oxygen Species Scavenging, Enzyme Regulation, and Metal Chelation Mechanisms inE. coliand Human Cells

Wang, H. C., & Brumaghim, J. L. (2011) · ACS symposium series · doi:10.1021/bk-2011-1083.ch005 · Cited by 24 · see citing works

A Novel Pharmacological Protective Role for Safranal in an Animal Model of Huntington’s Disease

Fotoohi, A., Moloudi, M. R., Hosseini, S., Hassanzadeh, K., Feligioni, M., & Izadpanah, E. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03271-8 · Cited by 24 · see citing works

Improved neuroprotective activity of Fisetin through SNEDDS in ameliorating the behavioral alterations produced in rotenone-induced Parkinson’s model

Kumar, R., Kumar, R., Khurana, N., Singh, S. K., Khurana, S., Verma, S., Sharma, N., Vyas, M., Dua, K., Khursheed, R., et al. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-19428-z · Cited by 24 · see citing works

Neuroprotective effect of MK-801 against intra-striatal quinolinic acid induced behavioral, oxidative stress and cellular alterations in rats.

Kalonia, H., Kumar, P., Nehru, B., & Kumar, A. (2009) · PubMed · Cited by 23 · see citing works

Resveratrol alleviates neurological disorders and motor dysfunction in 3-NP induced- Huntington's Disease in rats: Role of activating AMPK/SIRT1/ULK1 autophagy pathway

Fahmy, M. I., Rizk, N. I., Eitah, H. E., Arab, H. H., Alsufyani, S. E., Arafa, E. A., & Azzam, H. N. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111084 · Cited by 1 · see citing works

Nicotinamide reverses behavioral impairments and provides neuroprotection in 3˗nitropropionic acid induced animal model ofHuntington’s disease: implication of oxidative stress˗ poly(ADP˗ ribose) polymerase pathway

Sidhu, A., Diwan, V., Kaur, H., Bhateja, D., Singh, C. K., Sharma, S., & Padi, S. S. V. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0297-0 · Cited by 32 · see citing works

Ellagic acid prevents 3-nitropropionic acid induced symptoms of Huntington’s disease

Sharma, P., Kumar, M., & Bansal, N. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02106-1 · Cited by 42 · see citing works

Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington’s disease model in rats

Suganya, S., & Sumathi, T. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9929-4 · Cited by 84 · see citing works

Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: Possible behavioural, biochemical and cellular alterations

Kumar, P., & Kumar, A. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.058 · Cited by 75 · see citing works