The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Mucosal Tumor Necrosis Factor-or, Interleukin-1/3, and Interleukin-8 Production in Patients with Helicobacter pylori Infection
Abstract
We investigated whether tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-8 (IL-8) are involved in the inflammatory reaction of Helicobacter pylori infection. In 23 patients with H. pylori infection and 16 patients with negative cultures for H. pylori and normal antral mucosa, the mucosal production of TNF-alpha, IL-1 beta, and IL-8 was measured in antral biopsy specimens after 23 h of in vitro culture. The levels of TNF-alpha and IL-1 beta appeared to be significantly higher in H. pylori-positive patients (p = 0.0002 for both TNF-alpha and IL-1 beta). IL-8 production was also higher in H. pylori-infected subjects, but this difference did not reach statistical significance (p = 0.057). No significant differences were found between the level of the cytokines in H. pylori-infected patients with or without duodenal ulcer disease. A strong correlation was found between the production of IL-1 beta and IL-8. The biologic effects of these cytokines may explain the conspicuous recruitment, influx, and activation of neutrophils in the gastric mucosa during H. pylori infection.
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Cites
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
March, C. J., Mosley, B., Larsen, A., Cerretti, D. P., Braedt, G., Price, V., Gillis, S., Henney, C. S., Kronheim, S. R., Grabstein, K., et al. (1985) · Nature · doi:10.1038/315641a0 · Cited by 1,579
Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
Le, J., & Vilček, J. (1987) · PubMed · Cited by 1,327
Interleukin-1 and the Pathogenesis of the Acute-Phase Response
Epstein, F. H., & Dinarello, C. A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411293112205 · Cited by 1,146
Cure of duodenal ulcer associated with eradication of Helicobacter pylori
Rauws, E. A. J., & Tytgat, G. N. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)91301-p · Cited by 922
Self-citationEndothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β
Strieter, R. M., Kunkel, S. L., Showell, H. J., Remick, D. G., Phan, S. H., Ward, P. A., & Marks, R. M. (1989) · Science · doi:10.1126/science.2648570 · Cited by 775
Rauws, E. A. J., Langenberg, W., Houthoff, H. J., et al. (1988) · PubMed · Cited by 772
Cytotoxic activity in broth-culture filtrates of Campylobacter pylori
Leunk, R. D., Johnson, P. T., David, B. C., Kraft, W. G., & Morgan, D. R. (1988) · Journal of Medical Microbiology · doi:10.1099/00222615-26-2-93 · Cited by 671
(2011) · Hepatogastroenterology · doi:10.5754/hge11470 · Cited by 646
Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation
Blaser, M. J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90126-j · Cited by 612
Yoshimura, T., Matsushima, K., Oppenheim, J. J., & Leonard, E. J. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.3.788 · Cited by 610
Cited by
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
El-Omar, E. M., Carrington, M., Chow, W.-H., McColl, K. E. L., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C.-C., Rothman, N., et al. (2000) · Nature · doi:10.1038/35006081 · Cited by 2,366
Chronic inflammation and cytokines in the tumor microenvironment
Landskron, G., De la Fuente, M., Thuwajit, P., Thuwajit, C., & Hermoso, M. A. (2014) · Journal of Immunology Research · doi:10.1155/2014/149185 · Cited by 1,765
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
Wroblewski, L. E., Peek, R. M., & Wilson, K. T. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00011-10 · Cited by 1,442
Inflammation: Gearing the journey to cancer
KUNDU, J., & SURH, Y. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.03.002 · Cited by 803
Role of Leptin in Inflammation and Vice Versa
Pérez-Pérez, A., Sánchez-Jiménez, F., Vilariño-García, T., & Sánchez-Margalet, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165887 · Cited by 330
Metadata
- Authors
- Noach, L. A., Bosma, N. B., Jansen, J., Hoek, F. J., Van Deventer, S. J. H., & Tytgat, G. N. J.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 29
- Issue
- 5
- Pages
- 425-429
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2071129528
- Cited by
- 521
- References
- 23
- FWCI
- 22.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mucosal Tumor Necrosis Factor-or, Interleukin-1/3, and Interleukin-8 Production in Patients with Helicobacter pylori Infection. https://app.cochat.ai/papers/10.3109/00365529409096833
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- Noach, L. A., Bosma, N. B., Jansen, J., Hoek, F. J., Van Deventer, S. J. H., & Tytgat, G. N. J. (1994). Mucosal Tumor Necrosis Factor-or, Interleukin-1/3, and Interleukin-8 Production in Patients with Helicobacter pylori Infection. Scandinavian Journal of Gastroenterology. https://doi.org/10.3109/00365529409096833
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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