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Cited by 330Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityCytokine Signaling Pathways and Interactions

Role of Leptin in Inflammation and Vice Versa

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Pérez-Pérez, Antonio, Sánchez-Jiménez, Flora, Vilariño-García, Teresa, Sánchez-Margalet, Víctor·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21165887PMC PMC7460646
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Abstract

Inflammation is an essential immune response for the maintenance of tissue homeostasis. In a general sense, acute and chronic inflammation are different types of adaptive response that are called into action when other homeostatic mechanisms are insufficient. Although considerable progress has been made in understanding the cellular and molecular events that are involved in the acute inflammatory response to infection and tissue injury, the causes and mechanisms of systemic chronic inflammation are much less known. The pathogenic capacity of this type of inflammation is puzzling and represents a common link of the multifactorial diseases, such as cardiovascular diseases and type 2 diabetes. In recent years, interest has been raised by the discovery of novel mediators of inflammation, such as microRNAs and adipokines, with different effects on target tissues. In the present review, we discuss the data emerged from research of leptin in obesity as an inflammatory mediator sustaining multifactorial diseases and how this knowledge could be instrumental in the design of leptin-based manipulation strategies to help restoration of abnormal immune responses. On the other direction, chronic inflammation, either from autoimmune or infectious diseases, or impaired microbiota (dysbiosis) may impair the leptin response inducing resistance to the weight control, and therefore it may be a cause of obesity. Thus, we are reviewing the published data regarding the role of leptin in inflammation, and the other way around, the role of inflammation on the development of leptin resistance and obesity

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Authors
Pérez-Pérez, A., Sánchez-Jiménez, F., Vilariño-García, T., & Sánchez-Margalet, V.
Affiliations
  • Department of Medical Biochemistry and Molecular Biology, and Immunology, Virgen Macarena University Hospital, University of Seville, 41009 Seville, Spain
  • Hospital Universitario Virgen Macarena (ES)
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-08-16
Volume
21
Issue
16
Pages
5887
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms21165887
PMC
PMC7460646
OpenAlex
W3049167578
Cited by
330
References
21
Citations by year
2026: 51 · 2025: 76 · 2024: 67 · 2023: 54 · 2022: 43 · 2021: 33 · 2020: 6
FWCI
4.96
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by-nc-nd)
Funders
Instituto de Salud Carlos III (PI19/01741)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
leptin, inflammation, chronic inflammation, obesity, leptin resistance, adipokines, dysbiosis, microbiota, type 2 diabetes, cardiovascular disease, autoimmune disease, weight management
MeSH terms
Animals, Autoimmune Diseases, Communicable Diseases, Humans, Immunity, Innate, Obesity, Leptin, Adaptive Immunity

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