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Cited by 42Tissue Engineering and Regenerative MedicineLiver Disease and TransplantationMechanical Circulatory Support Devices

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Artificial Liver Support: State of the Art

Dixit, V., Gitnick, G.·1996·Scandinavian Journal of Gastroenterology
DOI 10.3109/00365529609094760
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Abstract

Severe liver disease is very often life-threatening and dramatically diminishes quality of life. Liver support systems based on detoxification alone have proven ineffective because they cannot correct biochemical disorders. An effective artificial liver support system should be capable of carrying out the liver's essential processes such as synthetic and metabolic functions, detoxification, and excretion. It should be capable of sustaining patients with fulminant hepatic failure, preparing patients for liver transplantation when a donor liver is not readily available (i.e., bridge to transplantation), and improving the survival and quality of life for patients for whom transplantation is not a therapeutic option. Recent advances in cell biology, tissue culture techniques, and biotechnology have led the way for the potential use of isolated hepatocytes in treating an array of liver disorders. Isolated hepatocytes may be transplanted to replace liver-specific deficiencies or as an important element of an auxiliary hybrid, bioartificial extracorporeal liver support device, which are important therapeutic applications for treating severe liver disease. Although several hepatocyte-based liver support systems have been proposed, there is no current consensus on its eventual design configuration. Furthermore, application of tissue engineering technology, based on cell-surface interaction studies proposed by our group and others, has enhanced interest in the development of highly efficient hybrid, bioartificial, liver support devices.

Overview

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Crossref · 10.3109/00365529609094760

Cites

73 of 73 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 73 references

Research works printed but not linked: 25

  1. Martin P, 1992, Am J Gastroenterol, 87, 409
  2. Ebata H, 1978, Surg Forum, 29, 338
  3. Opolon P, 1976, Trans Am Soc Artif Intern Organs, 22, 701
  4. Lopore M J, 1972, Kansas Med Soc J, 129, 900
  5. Starzl T E, 1983, Trans Am Soc Artif Intern Organs, 29, 795
  6. Wolf C FW, 1976, Trans Am Soc Artif Intern Organs, 21, 16
  7. Matsumura K M, 1987, Surgery, 101, 99
  8. Uchino J, 1988, ASAIO Trans, 34, 972
  9. Dixit V, 1992, Artif Organs, 16, 336, 10.1111/j.1525-1594.1992.tb00528.x · DOI
  10. Chang T MS, 1983, Int J Artif Organs, 6, 178
  11. Neuzil D F, 1993, Surgery, 113, 340
  12. Dixit V, 1995, J Invest Med, 43, 148A
  13. Dixit V, 1995, ASAIO Abstracts
  14. Dixit V, 1995, Gastroenterology, 108, 1058A
  15. Dixit V, 1995, Hepatology, 22, 212A
  16. Dixit V, 1990, ASAIO Trans, 36, 21
  17. Demetriou A A, 1986, Science, 233, 1190, 10.1126/science.2426782 · DOI · Paper page
  18. Dixit V, 1992, Cell Transplantation, 1, 275, 10.1177/096368979200100404 · DOI
  19. Dixit V, 1993, Biomat Artif Cells Immob Biotech, 21, 119
  20. Cobourne C S, 1987, Transplant Proc, 19, 1002
  21. Sun A M, 1981, Artif Organs, 5, 784
  22. Guillouzo A, 1986, Research in isolated and cultured hepatocytes, 155
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  24. Yeary R A, 1971, Lab Anim Sci, 21, 362
  25. Guguen-Guillouzo C, 1983, Mol Cell Biochem, 53, 35

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Metadata

Authors
Dixit, V., & Gitnick, G.
Affiliations
University of California, Los Angeles (US)
ORCID
Dixit, V.
Venue
Scandinavian Journal of Gastroenterology
Publisher
Informa UK Limited
Published
1996-01
Volume
31
Issue
sup220
Pages
101-114
ISSN
  • 0036-5521 (ISSN-L)
  • 1502-7708
DOI
10.3109/00365529609094760
OpenAlex
W2077246325
Cited by
42
References
73
Citations by year
2025: 1 · 2024: 1 · 2020: 1 · 2015: 1
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Locations
  • Scandinavian Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
Keywords
artificial liver support, bioartificial liver, isolated hepatocytes, hepatocyte transplantation, acute liver failure, bridge to transplant, tissue engineering, cell-surface interactions, severe liver disease, detoxification
MeSH terms
Animals, Equipment Design, Humans, Liver, Artificial, In Vitro Techniques

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CoChat. (2026). Citation check: Artificial Liver Support: State of the Art. https://app.cochat.ai/papers/10.3109/00365529609094760
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Dixit, V., & Gitnick, G. (1996). Artificial Liver Support: State of the Art. Scandinavian Journal of Gastroenterology. https://doi.org/10.3109/00365529609094760

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.