Cited by 196Gut microbiota and healthPolyamine Metabolism and ApplicationsGastrointestinal motility and disorders

The exogenous origin of trimethylamine in the mouse

Al-Waiz, M., Mikov, M., Mitchell, S.C., Smith, R.L.·1992·Metabolism

Abstract

Although it is now generally regarded that the origin of urinary trimethylamine (TMA) is via the action of intestinal microflora on precursors such as choline, little direct evidence exists. The normal production of urinary TMA was shown to be absent in germ-free mice and greatly reduced in antibiotic-pretreated animals. Cohabitation of germ-free mice with conventional animals restored their ability to excrete TMA. This study invokes a fundamental role for the intestinal microflora in the provision of TMA from precursors within the food.

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Crossref · 10.1016/0026-0495(92)90140-6

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  • Gut microbiota are necessary for dietary choline, choline-containing compounds, betaine, and L-carnitine to be converted to TMA.

    “We know that gut microbiota are required for these nutrients to be converted to TMA because gnotobiotic mice do not produce such TMA (1,96), and antibiotic treatment of standard mice decreases TMA formation (1).”

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Authors
Al-Waiz, M., Mikov, M., Mitchell, S. C., & Smith, R. L.
Affiliations
St Mary's Hospital (GB)
Corresponding author
Mitchell, S.C.
Venue
Metabolism
Publisher
Elsevier BV
Published
1992-02
Volume
41
Issue
2
Pages
135-136
ISSN
0026-0495 (ISSN-L)
OpenAlex
W2089502105
Cited by
196
References
11
Citations by year
2026: 6 · 2025: 14 · 2024: 9 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 19 · 2019: 16 · 2018: 14 · 2017: 9 · 2016: 12 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 9
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
trimethylamine, gut microbiota, germ-free mice, antibiotic therapy, choline metabolism, dietary precursors
MeSH terms
Animals, Germ-Free Life, Male, Methylamines, Mice, Inbred Strains, Neomycin, Reference Values, Mice

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