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Cited by 105Retinal Diseases and TreatmentsRetinal Imaging and AnalysisRetinal Development and Disorders

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Bruch’s membrane age-related changes vary by region

Newsome, David A., Huh, Warne, Green, W. Richard·1987·Current Eye Research
DOI 10.3109/02713688709025231
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Abstract

Aging changes known to occur in Bruch's membrane may be associated with drusen formation and retinal pigment epithelial mottling, which often have a peripheral as well as a macular distribution. Few details of peripheral Bruch's membrane aging changes have been reported. We conducted a histochemical investigation of Bruch's membrane in 31 postmortem donor eyes and an ultrastructural morphometric investigation of these regional changes in a subgroup of 22 eyes. The age of our donors ranged from 12 days to 80 years. When we reacted 5 micron paraffin embedded sections of chorio-retinal complex fixed in 2% glutaraldehyde-1% paraformaldehyde, we observed increased PAS positivity, and staining with Weigert's elastin and alcian blue at pH 2.5 in Bruch's membranes from donors over 46 years. In this older group, the macula showed increased histochemical reactivity for glycoconjugates, glycosaminoglycans, collagen and elastin as compared with the equator and periphery. Thickening of Bruch's membrane was first detected in the periphery in tissue from donors aged 10 to 45. Thickening of macular Bruch's membrane was first detected in tissue from donors older than 45. The major proportion of thickening, which appears to be due to the deposition of fibrillar and amorphous material, occurred earlier in the inner than the outer collagenous zone. The equatorial region was relatively spared. Our findings confirm and extend the observations of the timing, regional predeliction, and extent of Bruch's membrane aging changes.

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Citations

Cites

Show all 31 references

Research works printed but not linked: 15

  1. Bruch C, 1844, Untersuchungen zur Kenntniss des Kornigen Pigments der Wirbelthiere
  2. Kuhnt H, 1877, Heidelberg. Klin. Monatsbl. Augenheilkd, 15, 72
  3. Verhoeff F. H, 1926, Arch. Ophthalmol, 55, 125
  4. Lerche W, 1963, Ber. Dtsch. Ophthalmol. Ges, 65, 384
  5. Garron L. K, 1963, Trans. Am. Ophthalmol. Soc, 61, 545
  6. Hogan M. J, 1967, Role of elastic tissue and collagen. Trans. Ophthalmol. Soc. U.K, 87, 113
  7. Hollenberg M. J., 1969, Can. J. Ophthalmol, 4, 296
  8. Gass J. D.M, 1972, Trans. Am. Ophthalmol. Soc, 70, 409
  9. Garner A, 1975, Trans. Ophthalmol. Soc. U.K, 95, 54
  10. Green W. R., 1977, Trans. Am. Ophthalmol. Soc, 75, 180
  11. Mishima H., 1978, Jpn. J. Ophthalmol, 22, 476
  12. Grindle C. E.J., 1978, Trans. Ophthalmol. Soc. U.K, 98, 172
  13. Burns R. P., 1980, Trans. Am. Ophthalmol. Soc, 78, 206
  14. Lewis H., 1986, Multiple extramacular drusen. Ophthalmology, 93, 1098
  15. Newsome D. A., 1987, Exp. Eye Res

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Metadata

Authors
Newsome, D. A., Huh, W., & Green, W. R.
Affiliations
  • Johns Hopkins University (US)
  • The Catholic University of Korea Seoul St. Mary's Hospital (KR)
Venue
Current Eye Research
Publisher
Informa UK Limited
Published
1987-01
Volume
6
Issue
10
Pages
1211-1221
ISSN
  • 0271-3683 (ISSN-L)
  • 1460-2202
DOI
10.3109/02713688709025231
OpenAlex
W1980685924
Cited by
105
References
31
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 3
FWCI
2.54
Type
journal article
Language
en
Open access
closed
Locations
  • Current Eye Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute for Health and Care Research
  • National Institutes of Health
  • National Eye Institute (EY06677, EY-02377)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
  • Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords
Bruch's membrane, aging, regional variation, drusen, macula, periphery, collagen deposition, elastin, glycosaminoglycans, glycoconjugates, ultrastructural morphometry
MeSH terms
Adolescent, Adult, Aged, Aging, Child, Choroid, Histocytochemistry, Humans, Microscopy, Electron, Middle Aged

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