Retinal pigment epithelial cells play a central role in the conservation of docosahexaenoic acid by photoreceptor cells after shedding and phagocytosis
Abstract
The involvement of retinal pigment epithelial (RPE) cells in the recycling of docosahexaenoic acid (DHA), from phagocytized disc membranes back to the retina, was studied in frogs subsequent to injection of [3H]DHA via the dorsal lymph sac. Rod outer segments (ROS) gradually accumulated [3H]DHA as a dense, heavily labeled region that arrived at the distal tips by 28 days post-injection. Autoradiographic analysis at the time of maximal shedding and phagocytosis (1-2 hr after the onset of light) showed diffusely (before 28 days) and heavily (after 28 days) labeled phagosomes in RPE cells. Biochemical analysis of the [3H]DHA-containing lipids of discs that contribute to the labeling of RPE cells after phagocytosis was also performed. Between 27 and 34 days, when 12% of retinal [3H]DHA-lipids present in disc membranes are phagocytized by RPE cells, total retinal labeling remained unchanged. Taken together, these data suggest that the [3H]DHA of the densely labeled region of the ROS was recycled back to the photoreceptor cells only after it had reached the RPE cells following 28 days post-injection. We conclude that, following daily phagocytosis of ROS tips, RPE cells play a central role in the conservation and redelivery of ROS-derived DHA back to photoreceptor cells through the interphotoreceptor matrix.
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RPE cells play a central role in the conservation and delivery of rod outer segment-derived DHA back to PRCs through the interphotoreceptor matrix following daily phagocytosis of ROS tips.
“By participating in the recycling of DHA, from phagocytized disc membranes back to the retina, RPE cells play a central role in the conservation and delivery of rod outer segment (ROS)-derived DHA back to PRCs through the interphotoreceptor matrix following daily phagocytosis of ROS tips (Gordon et al., 1992).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Gordon et al., 1992
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Cheng, S.-Y., & Punzo, C. (2024) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-981-99-4436-1_12
Analyse du phénotype visuel d'un modèle de souris déficiente pour la protéine FATP1
Chekroud, K. (2010) · theses.fr (ABES) · doi:10.70675/c75f05c9z2e99z4ef6zbf97zd0a0bc550339
Global approach of lipid metabolism in Age-Related Macular Degeneration (AMD)
Vasku, G. (2023) · theses.fr (ABES) · doi:10.70675/67696aa5z9b6fz41c5zb63cz082c93383791
McKinney, J. R. (2026) · Patient Education and Counseling · doi:10.1016/j.pec.2026.109843
- Authors
- Gordon, W. C., de Turco, E. B. R., & Bazan, N. G.
- Affiliations
- Louisiana State University (US)
- Venue
- Current Eye Research
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 11
- Issue
- 1
- Pages
- 73-83
- ISSN
- 0271-3683 (ISSN-L)
- 1460-2202
- OpenAlex
- W1993464867
- Cited by
- 89
- References
- 24
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 3
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ey004428-07)
- National Eye Institute (EY-02377, EY04428, P30EY002377)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- retinal pigment epithelium, docosahexaenoic acid, phagocytosis, fatty acid recycling, rod outer segments, interphotoreceptor matrix, frog retina, fatty acid metabolism
- MeSH terms
- Animals, Autoradiography, Docosahexaenoic Acids, Phagocytosis, Phagosomes, Phospholipids, Photoreceptor Cells, Pigment Epithelium of Eye, Rana pipiens, Rod Cell Outer Segment
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