Correlation between Perceived Asthma Control and Thoraco-Abdominal Asynchrony in Primary Care Patients Diagnosed with Asthma
Abstract
Objective Thoraco-abdominal asynchrony (TAA), the discordant movement of the abdomen and thorax, may impact upon health-related variables. Here, we investigated the extent to which TAA is associated with health-related variables, particularly perceived asthma control and quality of life. Methods Ambulatory respiratory data from 43 patients diagnosed with asthma and 43 healthy age and sex-matched controls were recorded over 4 hours. Phase relation (Ph Rel Total), the percentage of time that the effects of rib cage (RC) and diaphragmatic movement result in opposite effects on intra-thoracic volume, quantified TAA. Subjects completed the Mini Asthma Quality of Life Questionnaire (AQLQ), Asthma Control Questionnaire (ACQ), Nijmegen questionnaire (NQ), Hospital Anxiety and Depression Scale (HADS), Spielberger State-Trait Anxiety Inventory (STAI), and General Health Perception (GHP) subscale of the short form 36 questionnaire'. Capnography profiling, breath-hold time (BHT), and standard spirometry were performed. Results The time in asynchrony was significantly greater in the asthma than in the healthy control group (Ph Rel Total = 14% (interquartile range (IQR) 8.5-20.7%) versus 10.4% (IQR 7.1-14.5%), p = .012). In patients with asthma, Ph Rel Total was weakly associated with poorer ACQ scores (r = 0.33, p = .03), and in the healthy control group with GHP (r = 0.319, p = .037). Post-hoc exploratory analysis revealed a moderate relationship in the female asthma subgroup between Ph…
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Thoraco-abdominal asynchrony is linked to obstruction, neuromuscular disease and respiratory failure.
“| Thoraco-abdominal asynchrony | 6 | [52–54] | Obstruction Neuromuscular disease Respiratory failure |”
From Dysfunctional breathing: a review of the literature and proposal for classification (2016) · cites this paper as [52]
Thoraco-abdominal asynchrony is sometimes seen as a normal physiological response in upper airway obstruction, neuromuscular disorders and acute respiratory failure, but may be seen in patients without evidence of these, and therefore considered dysfunctional.
“Thoraco-abdominal asynchrony is sometimes seen as a normal physiological response in upper airway obstruction, neuromuscular disorders and in patients with acute respiratory failure, but may be seen in patients without evidence of these, and therefore considered dysfunctional [52].”
From Dysfunctional breathing: a review of the literature and proposal for classification (2016) · cites this paper as [52]
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Dysfunctional breathing: a review of the literature and proposal for classification
Boulding, R., Stacey, R., Niven, R., & Fowler, S. J. (2016) · European Respiratory Review · doi:10.1183/16000617.0088-2015 · Cited by 372 · see citing works
- Authors
- Upton, J., Brodie, D., Beales, D., Richardson, J., Jack, S., Warburton, C., Thomas, M., & Kendrick, A.
- Affiliations
- University of Birmingham (GB)
- Buckinghamshire New University (GB)
- University of Plymouth (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Aintree University Hospital (GB)
- University of Southampton (GB)
- Corresponding author
- Upton, Jane
- Venue
- Journal of Asthma
- Publisher
- Informa UK Limited
- Published
- 2012-09-10
- Volume
- 49
- Issue
- 8
- Pages
- 822-829
- ISSN
- 0277-0903 (ISSN-L)
- 1532-4303
- OpenAlex
- W2041515989
- Cited by
- 11
- References
- 6
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Asthma (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- Bucks New University
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- asthma, quality of life, respiratory mechanics, diaphragm, rib cage movement, phase equilibria, anxiety, sex differences, primary care patients
- MeSH terms
- Abdomen, Adolescent, Adult, Aged, Asthma, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Respiratory Muscles, Spirometry, Thorax, Respiratory Mechanics, Case-Control Studies, Statistics, Nonparametric, Young Adult
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