The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity
Abstract
Flavonoids are a group of polyphenols that provide health-promoting benefits upon consumption. However, poor bioavailability has been a major hurdle in their use as drugs or nutraceuticals. Low bioavailability has been associated with flavonoid interactions at various stages of the digestion, absorption and distribution process, which is strongly affected by their molecular structure. In this review, we use structure-activity/property relationship to discuss various flavonoid interactions with food matrices, digestive enzymes, intestinal transporters and blood proteins. This approach reveals specific bioactive properties of flavonoids in the gastrointestinal tract as well as various barriers for their bioavailability. In the last part of this review, we use these insights to determine the effect of different structural characteristics on the overall bioavailability of flavonoids. Such information is crucial when flavonoid or flavonoid derivatives are used as active ingredients in foods or drugs.
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Cites
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Cited by
Plant Flavonoids: Chemical Characteristics and Biological Activity
Dias, M. C., Pinto, D. C. G. A., & Silva, A. M. S. (2021) · Molecules · doi:10.3390/molecules26175377 · Cited by 1,512
Flavonoids as Anticancer Agents
Kopustinskiene, D. M., Jakstas, V., Savickas, A., & Bernatoniene, J. (2020) · Nutrients · doi:10.3390/nu12020457 · Cited by 1,295
Flavonoids and the gastrointestinal tract: local and systemic effects
Oteiza, P. I., Fraga, C. G., Mills, D. A., & Taft, D. H. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.001 · Cited by 281
Fuentes-Rios, D., Sanchez-Rodriguez, A., Lopez-Rios, L., Garcia-Gonzalez, E., Martinez-Canton, M., Galvan-Alvarez, V., Gallego-Selles, A., Martin-Rincon, M., Calbet, J. A. L., & Vega-Morales, T. (2025) · Molecules · doi:10.3390/molecules30030461 · Cited by 7
Metadata
- Authors
- Gonzales, G. B., Smagghe, G., Grootaert, C., Zotti, M., Raes, K., & Camp, J. V.
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 2015-01-30
- Volume
- 47
- Issue
- 2
- Pages
- 175-190
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2041100273
- Cited by
- 254
- References
- 101
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gonzales, G. B., Smagghe, G., Grootaert, C., Zotti, M., Raes, K., & Camp, J. V. (2015). Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity. Drug Metabolism Reviews. https://doi.org/10.3109/03602532.2014.1003649
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