Flavonoids and the gastrointestinal tract: local and systemic effects
Open accessAbstract
The gastrointestinal (GI) tract plays a central role in the absorption, distribution, metabolism, and excretion of flavonoids, which ultimately define the health effects of these bioactives. These aspects are modulated by the interactions of flavonoids with other dietary components, environmental factors, the host, and the GI microbiota. Flavonoid can target molecules in the luminal content, the different GI tract cell types, and the microbiota. Importantly, flavonoid actions at the GI tract can have an impact systemically, e.g. on glucose homeostasis, lipid and energy metabolism, or cardiovascular risk factors. The beneficial actions of flavonoids at the GI include their capacity to: i) protect the intestinal epithelium against pharmacological insults and food toxins; ii) modulate the activity of enzymes involved in lipid and carbohydrate absorption; iii) maintain the intestinal barrier integrity; iv) modulate the secretion of gut hormones; v) modulate the GI tract immune system; vi) exert potential anti-colorectal cancer activity; and vii) shape microbiota composition and function. Further understanding of the mechanisms mediating the effects of flavonoids on the intestine (and its microbiota) is of critical importance given the relevance of the GI tract on sustaining overall health and of the widespread recommendations of increasing the intake of plant bioactives.
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Flavonoids shape gut microbiota membership and function.
“Flavonoids also shape gut microbiota membership and function (Oteiza et al., 2018).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Oteiza et al., 2018
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Important Flavonoids and Their Role as a Therapeutic Agent
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- Authors
- Oteiza, P. I., Fraga, C. G., Mills, D. A., & Taft, D. H.
- Affiliations
- University of California, Davis (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Oteiza, P.I.
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 61
- Pages
- 41-49
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2782739033
- Cited by
- 281
- References
- 112
- Citations by year
- 2026: 28 · 2025: 25 · 2024: 41 · 2023: 41 · 2022: 36 · 2021: 39 · 2020: 34 · 2019: 25 · 2018: 12
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 378 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Molecular Aspects of Medicine (acceptedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- NIFA-USDA (CA-D*-XXX-7244-H)
- Universidad de Buenos Aires (20020130100760BA)
- Consejo Nacional de Investigaciones Científicas y Técnicas (PIP0612)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Keywords
- flavonoids, gastrointestinal tract, gut microbiota, intestinal barrier integrity, intestinal epithelium, gastrointestinal hormones, intestinal immunity, glucose homeostasis, cardiovascular risk factors, food toxins, phytochemicals
- MeSH terms
- Gastrointestinal Microbiome, Flavonoids, Gastrointestinal Diseases, Health, Humans, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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