The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies
Open accessAbstract
Reactive oxygen species (ROS) are signaling molecules that influence many physiological processes. Increased ROS bioavailability and altered redox signaling (oxidative stress) have been implicated in chronic diseases including hypertension. Although oxidative stress may not be the sole cause of hypertension, it amplifies blood pressure elevation in the presence of other prohypertensive factors (salt, renin-angiotensin system, sympathetic hyperactivity). A major source for cardiovascular ROS is a family of non-phagocytic NADPH oxidases (Nox1, Nox2, Nox4, Nox5). Other sources of ROS involve mitochondrial electron transport enzymes, xanthine oxidase, and uncoupled nitric oxide synthase. Although evidence from experimental and animal studies supports a role for oxidative stress in the pathogenesis of hypertension, there is still no convincing proof that oxidative stress is a cause of human hypertension. However, what is clear is that oxidative stress is important in the molecular mechanisms associated with cardiovascular and renal injury in hypertension and that hypertension itself can contribute to oxidative stress. The present review addresses the putative function of ROS in the pathogenesis of hypertension and focuses on the role of Noxs in ROS generation in vessels and the kidney. Implications of oxidative stress in human hypertension are discussed, and clinical uncertainties are highlighted.
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Cites
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters
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Self-citationNox1 Is Involved in Angiotensin II–Mediated Hypertension: A Study in Nox1-Deficient Mice
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Mechanisms of Disease: oxidative stress and inflammation in the pathogenesis of hypertension
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Zhang, Z., Zhao, L., Zhou, X., Meng, X., & Zhou, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1098725 · Cited by 382
Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies
Montezano, A. C., Dulak-Lis, M., Tsiropoulou, S., Harvey, A., Briones, A. M., & Touyz, R. M. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.02.008 · Cited by 323
Self-citationEndothelial NADPH oxidases: which NOX to target in vascular disease?
Drummond, G. R., & Sobey, C. G. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.06.012 · Cited by 315
Redox activation of Nrf2 & NF-κB: A double end sword?
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Metadata
- Authors
- Montezano, A. C., & Touyz, R. M.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2012-06
- Volume
- 44
- Issue
- sup1
- Pages
- S2-S16
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2050983405
- Cited by
- 193
- References
- 19
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Montezano, A. C., & Touyz, R. M. (2012). Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies. Annals of Medicine. https://doi.org/10.3109/07853890.2011.653393
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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