Levels of C-reactive protein (CRP) in elderly patients with unipolar depression—Case control analysis
Abstract
AIM: C-reactive protein (CRP) is the major acute-phase plasma protein. Studies show that patients with depression have elevated levels of CRP. The aim of the study was to determine differences in CRP serum level in elderly patients with unipolar depression (DEP) compared with non-depressed elderly patients (nonDEP) using case-control analysis. METHODS: Serum level of CRP was measured in 404 (DEP: n = 202, nonDEP: n = 202) Caucasian inpatients aged ≥60 (350 women, 86.7%; mean age = 76.7 years). RESULTS: Mean CRP level in the study groups was: DEP 2.67 ± 2.56 mg/dL, nonDEP 2.41 ± 2.19 mg/dL, the difference was not significant (p = 0.96). The overall rate of being above the high level of CRP (set at 3.0 mg/L) was 33.2% for DEP and 29.2% for nonDEP groups (p = 0.39). It was also found that, in the whole study group, CRP level was not correlated with age (p = 0.10). CONCLUSIONS: Elderly patients with depression have no increased CRP levels. A high percentage (∼30%) of all subjects had a CRP level >3 mg/L, which is the cut-off point for increased cardiovascular risk.
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CRP levels were not associated with age and about 30% of the sample showed CRP level >3 mg/L.
“In addition, the authors reported that CRP levels were not associated with age and about 30% of the sample showed CRP level > 3 mg/L [86].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [86]
In 202 elderly depressed patients and 202 healthy elderly individuals, no significant differences between CRP levels in the two groups were found.
“A case control study investigating the differences in serum CRP levels between elderly (≥60 years) depressed patients and healthy elderly individuals (202 with unipolar depression and 202 healthy subjects), found no significant differences between CRP levels in the two groups [86].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [86]
About one-third of depressed patients show a low-grade inflammatory state (CRP > 3.0 mg/L).
“Indeed, about a third of all depressed patients seem to express CRP levels > 3.0 mg/L [86,119,120].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [86]
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C-Reactive protein as a biomarker for major depressive disorder?
Orsolini, L., Pompili, S., Tempia Valenta, S., Salvi, V., & Volpe, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031616 · Cited by 171 · see citing works
- Authors
- Wysokiński, A., Socha, K., Sołtysik, B. K., Kłoszewska, I., Sobów, T., & Kostka, T.
- Affiliations
- Medical University of Lodz (PL)
- Corresponding author
- Wysokiński, Adam
- Venue
- Nordic Journal of Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2016-04-27
- Volume
- 70
- Issue
- 7
- Pages
- 503-507
- ISSN
- 0029-1455 (ISSN-L)
- 0803-9488
- 1502-4725
- OpenAlex
- W2343034011
- Cited by
- 5
- References
- 50
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2018: 1 · 2017: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nordic Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- FP7 Research Potential of Convergence Regions
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- C-reactive protein, major depressive disorder, elderly patients, acute phase response, inflammation, cardiovascular risk, age differences
- MeSH terms
- Aged, Aged, 80 and over, Aging, C-Reactive Protein, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Risk Factors, Case-Control Studies
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