Associations of high sensitivity C-reactive protein levels in schizophrenia and comparison groups
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Schizophrenia is characterized by physical (mainly metabolic and cardiovascular) comorbidity and shortened lifespan. High sensitivity C-reactive protein (hs-CRP), an inflammatory marker of hepatic origin linked to metabolic and cardiovascular diseases and mortality in the general population, has been reported to be elevated in people with schizophrenia. However, the relationship of hs-CRP to psychiatric and medical risk factors, after controlling for potentially confounding variables such as smoking, is not well established in schizophrenia. We assessed hs-CRP levels along with various demographic, psychiatric, and metabolic measures in 88 clinically stable outpatients with schizophrenia or schizoaffective disorder and 71 age epoch-matched comparison subjects with no history of a major psychiatric illness. hs-CRP levels were significantly higher in individuals with schizophrenia than in comparison subjects. Higher hs-CRP levels in the schizophrenia group were associated with female gender, more severe negative symptoms, greater medical comorbidity, and worse metabolic risk factors including BMI, fasting glucose, and hemoglobin A1c levels. hs-CRP was not related to age, race, education, smoking status, antipsychotic dosage, or cognitive impairment. Longitudinal studies are needed to investigate the relationship between hs-CRP and long-term health outcomes including metabolic syndrome, cardiovascular disease, and mortality in schizophrenia.
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CRP is used in clinical practice mainly as a biomarker of infection, chronic disease state, and chronic low-grade inflammation.
“and used in clinical practice mainly as a biomarker of infection, chronic disease state, and chronic low-grade inflammation [30,32].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [32]
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Prediction of coronary heart disease using risk factor categories
Wilson, P. W. F., D’Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H., & Kannel, W. B. (1998) · Circulation · doi:10.1161/01.cir.97.18.1837 · Cited by 9,581 · see citing works
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18921 · Cited by 4,576 · see citing works
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318921 · Cited by 3,436 · see citing works
Scale for the Assessment of Negative Symptoms (SANS)*
(1989) · The British Journal of Psychiatry · doi:10.1192/s0007125000291502 · Cited by 2,706 · see citing works
Clinical application of C-reactive protein for cardiovascular disease detection and prevention
Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000053730.47739.3c · Cited by 2,513 · see citing works
Scale for Assessment of Positive Symptoms (SAPS) 1984
Andreasen, N. C. (1995) · Open Scholarship Institutional Repository (Washington University in St. Louis) · Cited by 2,423 · see citing works
Scale for the Assessment of Negative Symptoms
Andreasen, N. C. (1982) · PsycTESTS Dataset · doi:10.1037/t12696-000 · Cited by 1,878 · see citing works
Black, S., Kushner, I., & Samols, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400025200 · Cited by 1,844 · see citing works
Shunk, A. W., Davis, A. S., & Dean, R. S. (2006) · Applied Neuropsychology · doi:10.1207/s15324826an1304_9 · Cited by 1,528 · see citing works
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Validation of the Cumulative Illness Rating Scale in a Geriatric Residential Population
Parmelee, P. A., THURAS, P. D., Katz, I. R., & Lawton, M. P. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb06377.x · Cited by 948 · see citing works
Andreasen, N. C., Pressler, M., Nopoulos, P., Miller, D. D., & Ho, B. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.040 · Cited by 944 · see citing works
Socioeconomic status and health: the role of subjective social status
Demakakos, P., Nazroo, J., Breeze, E., & Marmot, M. (2008) · Social Science & Medicine · doi:10.1016/j.socscimed.2008.03.038 · Cited by 719 · see citing works
Socioeconomic Status And Health
(2002) · Health Affairs · doi:10.1377/hlthaff.21.2.47 · Cited by 667 · see citing works
C-Reactive Protein and the Prediction of Cardiovascular Events Among Those at Intermediate Risk
Ridker, P. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.052 · Cited by 622 · see citing works
Zeyda, M., Farmer, D., Todoric, J., Aszmann, O. C., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 553 · see citing works
Tracy, R. P., Psaty, B. M., Macy, E., Bovill, E. G., Cushman, M., Cornell, E. S., & Kuller, L. H. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.10.2167 · Cited by 539 · see citing works
Tsimikas, S., Willerson, J. T., & Ridker, P. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.066 · Cited by 335 · see citing works
Is schizophrenia a syndrome of accelerated aging?
Kirkpatrick, B., Messias, E., Harvey, P. D., Fernandez-Egea, E., & Bowie, C. R. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm140 · Cited by 335 · see citing works
Ruiz‐Canela, M., Zazpe, I., Shivappa, N., Hébert, J. R., Sánchez‐Tainta, A., Corella, D., Salas‐Salvadó, J., Fitó, M., Lamuela-Raventós, R. M., Rekondo, J., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004401 · Cited by 280 · see citing works
C-Reactive Protein Levels in Schizophrenia
Miller, B. J., Culpepper, N. H., & Rapaport, M. H. (2013) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.micu.020813 · Cited by 263 · see citing works
Lopresti, A. L., & Drummond, P. D. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.005 · Cited by 231 · see citing works
Dickerson, F., Stallings, C. R., Origoni, A. E., Boronow, J. J., & Yolken, R. H. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.03.022 · Cited by 205 · see citing works
Osborn, D. P. J., Hardoon, S., Omar, R. Z., Holt, R. I. G., King, M., Larsen, J., Marston, L., Morris, R. W., Nazareth, I., Walters, K., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2133 · Cited by 200 · see citing works
Fucetola, R. P., Seidman, L. J., Kremen, W. S., Faraone, S. V., Goldstein, J. M., & Tsuang, M. T. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00240-7 · Cited by 167 · see citing works
Jones, A. L., Mowry, B. J., Pender, M. P., & Greer, J. M. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01305.x · Cited by 155 · see citing works
Cognition in schizophrenia : impairments, importance, and treatment strategies
Sharma, T., & Harvey, P. D. (2000) · Oxford University Press eBooks · Cited by 146 · see citing works
Toomey, R., Kremen, W. S., Simpson, J. C., SAMSON, J. A., Seidman, L. J., Lyons, M. J., Faraone, S. V., & Tsuang, M. T. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.3.371 · Cited by 135 · see citing works
Inflammation and schizophrenia
Fan, X., GOFF, D. C., & Henderson, D. C. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.7.789 · Cited by 117 · see citing works
Hinze‐Selch, D., Däubener, W., Eggert, L., Erdag, S., Stoltenberg, R. L., & Wilms, S. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm010 · Cited by 117 · see citing works
Wellness within illness: Happiness in schizophrenia
Palmer, B. W., Martin, A. S., Depp, C. A., Glorioso, D. K., & Jeste, D. V. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.027 · Cited by 113 · see citing works
Self-citationCognitive impairment of executive function as a core symptom of schizophrenia
Wobrock, T., Ecker, U. K. H., Scherk, H., Schneider-Axmann, T., Falkai, P., & Gruber, O. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701849986 · Cited by 102 · see citing works
García‐Rizo, C., Fernández-Egea, E., Oliveira, C., Justicia, A., Bernardo, M., & Kirkpatrick, B. W. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.08.014 · Cited by 90 · see citing works
C-reactive protein serum level in drug-free male Egyptian patients with schizophrenia
Fawzi, M. H., Fawzi, M. M., Fawzi, M. M., & Said, N. S. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.05.010 · Cited by 89 · see citing works
Hefner, G., Shams, M. E. E., Unterecker, S., Falter, T., & Hiemke, C. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3976-0 · Cited by 83 · see citing works
Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., Norman, P. E., & Flicker, L. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111882 · Cited by 82 · see citing works
Dickerson, F., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., & Yolken, R. H. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.10.003 · Cited by 81 · see citing works
Akanji, A. O., OHAERI, J. U., Al-Shammri, S., & Fatania, H. R. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.010 · Cited by 68 · see citing works
Jin, H., Folsom, D. P., Sasaki, A., Mudaliar, S. R. D., Henry, R. R., Torres, M., Golshan, S., Glorioso, D., & Jeste, D. V. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.10.029 · Cited by 55 · see citing works
Self-citationMortality in schizophrenia: clinical and serological predictors
Dickerson, F., Stallings, C., Origoni, A., Schroeder, J., Khushalani, S., & Yolken, R. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt113 · Cited by 50 · see citing works
Body Mass Index Identified as an Independent Predictor of Psychiatric Readmission
Manu, P., Khan, S., Radhakrishnan, R., Russ, M. J., Kane, J. M., & Correll, C. U. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08795 · Cited by 45 · see citing works
Executive dysfunction in schizophrenia
Leicester, S. (2002) · Research Online (University of Wollongong) · Cited by 44 · see citing works
Executive Dysfunction in Schizophrenia
Palmer, B. W., & Heaton, R. K. (2000) · doi:10.1093/oso/9780192629937.003.0003 · Cited by 39 · see citing works
Self-citationDietrich, T., García, R. I., de Pablo, P., Schulze, P. C., & Hoffmann, K. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e328270b913 · Cited by 36 · see citing works
Increased Framingham 10-year CVD risk in Chinese patients with schizophrenia
Tay, Y. H., Nurjono, M., & Lee, J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.03.023 · Cited by 34 · see citing works
Sicras‐Mainar, A., Rejas, J., Navarro‐Artieda, R., & Blanca-Tamayo, M. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.07.003 · Cited by 34 · see citing works
Rossi, I. A., Bochud, M., Bovet, P., Paccaud, F. M., Waeber, G., Vollenweider, P., & Taffé, P. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9671-0 · Cited by 33 · see citing works
Miller, B. J., Kandhal, P. K., Rapaport, M. H., Mellor, A. L., & Buckley, P. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.12.005 · Cited by 31 · see citing works
Fawzi, M. H., Fawzi, M. M., Said, N. S., Fawzi, M. M., Fouad, A. A., & Abdel-Moety, H. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.057 · Cited by 25 · see citing works
Protopopová, D., Masopust, J., Malý, R., Vališ, M., & Bažant, J. (2012) · PubMed · Cited by 23 · see citing works
Rogowski, O., Shapira, I., Toker, S., Melamed, S., Shirom, A., Berliner, S. A., & Zeltser, D. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802939 · Cited by 22 · see citing works
Onat, A., Can, G., Hergenç, G., Uğur, M., & Yüksel, H. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.010 · Cited by 17 · see citing works
Foley, D. L., Mackinnon, A. J., Morgan, V. A., Watts, G. F., Shaw, J. E., Magliano, D. J., Castle, D. J., McGrath, J. J., Waterreus, A. J., & Galletly, C. A. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414565476 · Cited by 12 · see citing works
Saatçioğlu, Ö., Kalkan, M., Fıstikçı, N., Erek, Ş., & Kılıc, K. C. (2015) · Psychiatric Quarterly · doi:10.1007/s11126-015-9384-0 · Cited by 10 · see citing works
Konishi, S., Parajuli, R. P., Takane, E., Maharjan, M., Tachibana, K., Jiang, H., Pahari, K., Inoue, Y., Umezaki, M., & Watanabe, C. (2014) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22470 · Cited by 9 · see citing works
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- First MB Spitzer RL Miriam G Williams JBW 2002 Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P) Biometrics Research New York State Psychiatric Institute New York
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Sorted by citations
Lee, E. E., Depp, C., Palmer, B. W., Glorioso, D., Daly, R., Liu, J., Tu, X. M., Kim, H.-C., Tarr, P., Yamada, Y., et al. (2019) · International Psychogeriatrics · doi:10.1017/s1041610218002120 · Cited by 286 · see citing works
Self-citationSocioeconomic status and inflammation: a meta-analysis
Muscatell, K. A., Brosso, S. N., & Humphreys, K. L. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0259-2 · Cited by 276 · see citing works
Nguyen, T. T., Kosciolek, T., Maldonado, Y., Daly, R. E., Martin, A. S., McDonald, D., Knight, R., & Jeste, D. V. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2018.09.014 · Cited by 260 · see citing works
Self-citationMisiak, B., Stańczykiewicz, B., Kotowicz, K., RYBAKOWSKI, J. K., Samochowiec, J., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.015 · Cited by 198 · see citing works
C-Reactive protein as a biomarker for major depressive disorder?
Orsolini, L., Pompili, S., Tempia Valenta, S., Salvi, V., & Volpe, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031616 · Cited by 171 · see citing works
Bora, E. (2019) · Psychological Medicine · doi:10.1017/s0033291719001685 · Cited by 150 · see citing works
Neuroinflammation in schizophrenia: the role of nuclear factor kappa B
Murphy, C. E., Walker, A. K., & Weickert, C. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01607-0 · Cited by 128 · see citing works
Patlola, S. R., Donohoe, G. J., & McKernan, D. P. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110668 · Cited by 122 · see citing works
Lee, E., Hong, S., Martin, A. S., Eyler, L. T., & Jeste, D. V. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.09.009 · Cited by 113 · see citing works
Self-citationProtein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review
Orsolini, L., Sarchione, F., Vellante, F., Fornaro, M., Matarazzo, I., Martinotti, G., Valchera, A., Nicola, M. D., Carano, A., Giannantonio, M. D., et al. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180119144538 · Cited by 102 · see citing works
Bulzacka, E., Boyer, L., Schürhoff, F., Godin, O., Berna, F. S., Brunel, L., Andrianarisoa, M., Aouizerate, B., Capdevielle, D., Chéreau, I., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw029 · Cited by 99 · see citing works
Joseph, J., Depp, C. A., Shih, P.-A. B., Cadenhead, K. S., & Schmid‐Schönbein, G. W. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00155 · Cited by 95 · see citing works
Self-citationCampeau, A., Mills, R. H., Stevens, T. W., Rossitto, L.-A. M., Meehan, M. J., Dorrestein, P. C., Daly, R., Nguyen, T. T., Gonzalez, D. J., Jeste, D. V., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01339-z · Cited by 94 · see citing works
Self-citationC-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review
Fond, G. B., Lançon, C., Auquier, P., & Boyer, L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00392 · Cited by 95 · see citing works
Lyall, A. E., Pasternak, O., Robinson, D. G., Newell, D., Trampush, J. W., Gallego, J. A., D, M. F. M., Malhotra, A. K., Karlsgodt, K. H., Kubicki, M. R., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.43 · Cited by 91 · see citing works
Abnormalities in chemokine levels in schizophrenia and their clinical correlates
Hong, S., Lee, E., Martin, A. S., Soontornniyomkij, B., Soontornniyomkij, V., Achim, C. L., Reuter, C., Irwin, M. R., Eyler, L. T., & Jeste, D. V. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.09.019 · Cited by 91 · see citing works
Self-citationMorrens, M., Overloop, C., Coppens, V., Loots, E., Noortgate, M. V. D., Vandenameele, S., Leboyer, M., & Picker, L. D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01582-y · Cited by 70 · see citing works
Abnormal levels of vascular endothelial biomarkers in schizophrenia
Nguyen, T. T., Dev, S. I., Chen, G., Liou, S. C., Martin, A. S., Irwin, M. R., Carroll, J., Tu, X. M., Jeste, D. V., & Eyler, L. T. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0842-6 · Cited by 66 · see citing works
Self-citationChildhood Adversity and Schizophrenia
Lee, E., Martin, A. S., Tu, X. M., Palmer, B. W., & Jeste, D. V. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17m11776 · Cited by 64 · see citing works
Self-citationSleep disturbances and inflammatory biomarkers in schizophrenia: focus on sex differences
Lee, E. E., Ancoli-Israel, S., Eyler, L. T., Tu, X. M., Palmer, B. W., Irwin, M. R., & Jeste, D. V. (2019) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.09.017 · Cited by 58 · see citing works
Self-citationNettis, M. A., Pergola, G., Kolliakou, A., O’Connor, J. A., Bonaccorso, S., David, A. S., Gaughran, F., Forti, M. D., Murray, R. M., Marques, T. R., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.005 · Cited by 56 · see citing works
García-Álvarez, L., Caso, J. R., García‐Portilla, M. P., de la Fuente-Tomás, L., González-Blanco, L., Sáiz, P. A., Leza, J. C., & Bobes, J. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.09.007 · Cited by 56 · see citing works
Psomiades, M., Fonteneau, C., Mondino, M., Luck, D., Haesebaert, F., Suaud‐Chagny, M., & Brunelin, J. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.04.013 · Cited by 52 · see citing works
iTRAQ technology-based identification of human peripheral serum proteins associated with depression
Wang, Q., Su, X., Jiang, X., Dong, X., Fan, Y., Zhang, J., Yu, C., Gao, W., Shi, S., Jiang, J., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.055 · Cited by 49 · see citing works
Cognitive impairment in psychiatric diseases: Biomarkers of diagnosis, treatment, and prevention
Wang, Y., Meng, W., Liu, Z., An, Q., & Hu, X. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1046692 · Cited by 49 · see citing works
Leukocyte telomere length: Effects of schizophrenia, age, and gender
Wolkowitz, O. M., Jeste, D. V., Martin, A. S., Lin, J., Daly, R. E., Reuter, C., & KRAEMER, H. C. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.10.015 · Cited by 47 · see citing works
Self-citationMisiak, B., Łaczmański, Ł., Słoka, N. K., Szmida, E., Piotrowski, P., Loska, O., Ślężak, R., Kiejna, A., & Frydecka, D. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.01.077 · Cited by 46 · see citing works
A significant causal association between C-reactive protein levels and schizophrenia
Inoshita, M., Numata, S., Tajima, A., Kinoshita, M., Umehara, H., Nakataki, M., Ikeda, M., Maruyama, S., Yamamori, H., Kanazawa, T., et al. (2016) · Scientific Reports · doi:10.1038/srep26105 · Cited by 42 · see citing works
RetractedLee, E., Winston-Gray, C., Barlow, J. W., Rissman, R. A., & Jeste, D. V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.532624 · Cited by 39 · see citing works
Self-citationZhang, Q., Hong, W., Li, H., Peng, F., Wang, F., Li, N., Xiang, H., Zhang, Z., Su, Y., Huang, Y., et al. (2017) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.02.001 · Cited by 39 · see citing works
Fond, G. B., Resseguier, N., Schürhoff, F., Godin, O., Andrianarisoa, M., Brunel, L., Bulzacka, E., Aouizerate, B., Berna, F. S., Capdevielle, D., et al. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0847-1 · Cited by 38 · see citing works
Kozłowska, E., Agier, J., Wysokiński, A., Łucka, A., Sobierajska, K., & Brzezińska‐Błaszczyk, E. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.138 · Cited by 36 · see citing works
Sapra, M., Lawson, D. M., Iranmanesh, A., & Varma, A. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.04.051 · Cited by 33 · see citing works
Relation of inflammatory markers with symptoms of psychotic disorders: a large cohort study
Liemburg, E. J., Nolte, I. M., Klein, H. C., & Knegtering, H. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.04.006 · Cited by 32 · see citing works
Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients
Liu, Y., Tao, H., Yang, X., Huang, K., Zhang, X., & Li, C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00217 · Cited by 32 · see citing works
Elevated plasma F2-isoprostane levels in schizophrenia
Lee, E., Eyler, L. T., Wolkowitz, O. M., Martin, A. S., Reuter, C., KRAEMER, H. C., & Jeste, D. V. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.06.011 · Cited by 31 · see citing works
Self-citationWei, L., Du, Y., Wu, W., Fu, X., & Xia, Q. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.002 · Cited by 31 · see citing works
Bahrami, A., Bahrami‐Taghanaki, H., Khorasanchi, Z., Tayefi, M., Ferns, G. A., Sadeghnia, H. R., & Ghayour‐Mobarhan, M. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01288-x · Cited by 21 · see citing works
Improvement of adjunctive berberine treatment on negative symptoms in patients with schizophrenia
Li, M., Qiu, Y., Zhang, J., Zhang, Y., Liu, Y., Zhao, Y., Jia, Q., Fan, X., & Li, J. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01359-4 · Cited by 21 · see citing works
Bolu, A., Aydın, M. S., Akgün, A., Coşkun, A., Garip, B., Öznur, T., Çelik, C., & Uzun, Ö. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.2.244 · Cited by 21 · see citing works
Soontornniyomkij, V., Lee, E. E., Jin, H., Martin, A., Daly, R., Liu, J., Tu, X., Eyler, L., & Jeste, D. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00251 · Cited by 19 · see citing works
Self-citationPan, L.-H., Qian, M. D., Qu, W., Tang, Q., & Yan, Y. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s284149 · Cited by 18 · see citing works
Adamowicz, D. H., Shilling, P. D., Palmer, B. W., Nguyen, T. T., Wang, E., Liu, C., Tu, X. M., Jeste, D. V., Irwin, M. R., & Lee, E. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.029 · Cited by 17 · see citing works
Self-citationLee, E. E., Martin, A., Kaufmann, C. N., Liu, J., Kangas, J. L., Daly, R., Tu, X., Depp, C., & Jeste, D. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.02.067 · Cited by 18 · see citing works
Self-citationC-Reactive Protein (CRP): A Potent Inflammation Biomarker in Psychiatric Disorders
Orsolini, L., Pompili, S., & Volpe, U. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_7 · Cited by 17 · see citing works
Nishimon, S., Ohnuma, T., Takebayashi, Y., Katsuta, N., Takeda, M., Nakamura, T., Sannohe, T., Higashiyama, R. I., Kimoto, A., Shibata, N., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.03.006 · Cited by 16 · see citing works
Klaus, F., Guetter, K., Schlegel, R., Spiller, T. R., Seifritz, E., Cathomas, F., & Kaiser, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-98769-0 · Cited by 17 · see citing works
Zeng, J., Zhang, W., Lu, X., Zhou, H., Huang, J. H., Xu, Z., Liao, H., Liang, J., Liang, M., Ye, C., et al. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01679-7 · Cited by 15 · see citing works
Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
Kumar, P., Millischer, V., Villaescusa, J. C., Nilsson, I. A. K., Östenson, C., Schalling, M., Ösby, U., & Lavebratt, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-07503-2 · Cited by 16 · see citing works
Boozalis, T., Devaraj, S., & Okusaga, O. O. (2018) · Psychiatric Quarterly · doi:10.1007/s11126-018-9606-3 · Cited by 15 · see citing works
Tang, S. X., Oliver, L. D., Hänsel, K., DeRosse, P., John, M., Khairullah, A., Gold, J. M., Buchanan, R. W., Voineskos, A. N., & Malhotra, A. K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02002-z · Cited by 15 · see citing works
Pan, S., Tan, Y., Yao, S., Zhao, X., & Xiong, J. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.09.033 · Cited by 15 · see citing works
Fathian, F., Gjestad, R., Kroken, R. A., Løberg, E., Reitan, S. K., Fleichhacker, W. W., Rettenbacher, M. A., Larsen, T. K., Joa, I., Stabell, L. A., et al. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.01.049 · Cited by 15 · see citing works
Challa, F., Seifu, D., Sileshi, M., Getahun, T., Geto, Z., Kassa, D., Alemayehu, M., Mesfin, M., Fekadu, A., & Woldeamanuel, Y. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03443-4 · Cited by 14 · see citing works
Orsolini, L., Ricci, L., Pompili, S., Cicolini, A., & Volpe, U. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.004 · Cited by 13 · see citing works
González-Blanco, L., García‐Portilla, M. P., García-Álvarez, L., de la Fuente-Tomás, L., García, C. I., Sáiz, P. A., & Bobes, J. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.042 · Cited by 12 · see citing works
Galectin-1 and Galectin-3 Levels in Patients with Schizophrenia and their Unaffected Siblings
Yüksel, R. N., Göverti, D., Kahve, A. C., Çakmak, I. B., Yücel, Ç., & Göka, E. (2020) · Psychiatric Quarterly · doi:10.1007/s11126-020-09731-8 · Cited by 12 · see citing works
Milewski, K. P., Żurakowski, A., Pająk, J., Pajak-Zielinska, E., Liszka, Ł., Buszman, P. P., Bis, J., Dębiński, M., & Buszman, P. E. (2010) · PubMed · Cited by 11 · see citing works
Santo, F. D., González-Blanco, L., García-Álvarez, L., de la Fuente-Tomás, L., Velasco, Á., Alvarez-Vázquez, C., Martínez-Cao, C., Sáiz, P. A., García‐Portilla, M. P., & Bobes, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-73043-x · Cited by 11 · see citing works
Cannabis Cessation, Inflammatory Markers and Schizophrenia
Roméo, B., Lestra, V., Martelli, C., Benyamina, A., & Hamdani, N. (2022) · Journal of Dual Diagnosis · doi:10.1080/15504263.2021.2013697 · Cited by 11 · see citing works
Interplay of inflammatory biomarkers in heart disease patients with depressive symptoms: An update
Varghese, T. P., Chand, S., Varghese, N. M., Singh, R., & Yadav, S. K. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102352 · Cited by 12 · see citing works
Chang, C.-H., Lane, H., Liu, C., Cheng, P.-C., Chen, S.-J., & Lin, C. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s223278 · Cited by 11 · see citing works
Palmer, B. W., Moore, R. C., Eyler, L. T., Pinto, L. L., Saks, E. R., & Jeste, D. V. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.052 · Cited by 10 · see citing works
Self-citationWhat can we learn about brain donors? Use of clinical information in human postmortem brain research
Sullivan, K., Pantazopoulos, H., Liebson, E. S., Woo, T., Baldessarini, R. J., Hedreen, J. C., & Berretta, S. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00014-1 · Cited by 8 · see citing works
Zhu, J., Hu, W., Zhou, Y., Qiao, J., Chang, X., & Tong, Z. (2019) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2019.152118 · Cited by 10 · see citing works
Oracz, A. J., Zwierz, M., Naumowicz, M., Modzelewski, S., Suprunowicz, M., & Waszkiewicz, N. (2025) · Biomedicines · doi:10.3390/biomedicines13092308 · Cited by 9 · see citing works
Berdeville, C. H. D. S. F., Silva-Amaral, D., Dalgalarrondo, P., Banzato, C. E. M., & Martins‐de‐Souza, D. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105949 · Cited by 9 · see citing works
Levihn‐Coon, A., Smits, J. A. J., & Beevers, C. G. (2025) · PLOS mental health. · doi:10.1371/journal.pmen.0000211 · Cited by 8 · see citing works
Adamowicz, D. H., Wu, T., Daly, R., Irwin, M. R., Jeste, D. V., Tu, X. M., Eyler, L. T., & Lee, E. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110866 · Cited by 7 · see citing works
Self-citationQuality of Life and C-Reactive Protein in Patients with Schizophrenia: A Cross-Sectional Study
Kachouchi, A., Laatabi, A., Saadia, K., Imane, A., & Fatiha, M. (2024) · ALPHA PSYCHIATRY · doi:10.5152/alphapsychiatry.2024.231437 · Cited by 7 · see citing works
Nimgaonkar, V. L., Dickerson, F., Pouget, J. G., Chowdari, K. V., O’Dushlaine, C. T., Wood, J. A., Klei, L., Devlin, B., & Yolken, R. H. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.025 · Cited by 6 · see citing works
Ferns, G. A. (2018) · Translational Metabolic Syndrome Research · doi:10.1016/j.tmsr.2018.04.003 · Cited by 6 · see citing works
Wysokiński, A., Socha, K., Sołtysik, B. K., Kłoszewska, I., Sobów, T., & Kostka, T. (2016) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2016.1174298 · Cited by 5 · see citing works
Longitudinal relationships between BMI and hs-CRP among people with schizophrenia
Dyne, A. V., Wu, T., Adamowicz, D. H., Lee, E., Tu, X. M., & Eyler, L. T. (2024) · Schizophrenia Research · doi:10.1016/j.schres.2024.07.050 · Cited by 5 · see citing works
Kozłowska, E., Żelechowska, P., Wysokiński, A., Rasmus, P., Łucka, A., & Brzezińska‐Błaszczyk, E. (2019) · Journal of Investigative Medicine · doi:10.1136/jim-2018-000964 · Cited by 5 · see citing works
Kachouchi, A., Sebbani, M., Akammar, S., Berghalout, M., Adali, I., Manoudi, F., Amine, M., & Asri, F. (2020) · L Encéphale · doi:10.1016/j.encep.2019.11.007 · Cited by 5 · see citing works
Ayari, F., Chaaben, A. B., Ammar, H. B., Nefzi, R., Ouni, N., Mihoub, O., Abaza, H., Aissa, A., Douik, H., Gara, S., et al. (2020) · L Encéphale · doi:10.1016/j.encep.2019.10.001 · Cited by 5 · see citing works
Ramsey, M., Govind, T., Lam, J. A., Palmer, B. W., Jeste, D. V., & Lee, E. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.03.017 · Cited by 5 · see citing works
Self-citationPeripheral immune cell markers and cognitive function in patients with schizophrenia
Karahan, A., Saka, I. M., Aykut, D. S., Arslan, F. C., Özmen, E. S., & Karagüzel, E. Ö. (2024) · The International Journal of Psychiatry in Medicine · doi:10.1177/00912174241266059 · Cited by 4 · see citing works
Demir, N., & Yildirim, O. A. (2023) · Psychiatry and Clinical Psychopharmacology · doi:10.5152/pcp.2022.22447 · Cited by 3 · see citing works
Kozłowska, E., Brzezińska‐Błaszczyk, E., Wysokiński, A., & Żelechowska, P. (2021) · Journal of Investigative Medicine · doi:10.1136/jim-2020-001523 · Cited by 3 · see citing works
Familial Mediterranean fever association with schizophrenia: insights from big data analysis
Sharif, Κ., Watad, ., Bragazzi, N. L., Yavne, Y., Bridgewood, C., McGonagle, D., Comanhester, D., Cohen, A. D., & Amital, H. (2020) · Archives of Medical Science · doi:10.5114/aoms.2020.95463 · Cited by 3 · see citing works
C-Reactive Protein and Aggression in Patients with Schizophrenia
Kachouchi, A. (2019) · International Journal of Psychological and Brain Sciences · doi:10.11648/j.ijpbs.20190402.11 · Cited by 3 · see citing works
Mourad, B. H. (2020) · Toxicology and Industrial Health · doi:10.1177/0748233720923504 · Cited by 3 · see citing works
Characterization of Anemia among Hospitalized Patients with Psychiatric Disorders
Ali, E., Zaitoun, N. A., Embaby, A., Zaitoun, N. A., & Ibrahim, D. (2022) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2022.271901 · Cited by 2 · see citing works
Schizophrenia spectrum disorders
(2023) · Advances in magnetic resonance technology and applications · doi:10.1016/b978-0-323-91771-1.00008-3 · Cited by 2 · see citing works
Arya, S., Kamyab, A., Sanatkar, S. A., Pourmehdiardebili, M., Ebrahimi, A., Kamyab, P., Alavi, K., Zarei, Z., & Ahmadkhaniha, H. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05234-5 · Cited by 3 · see citing works
Sommerfeld, D. H., Brunner, A., Glorioso, D., Lee, E., Ibarra, C., Zunshine, E., Daly, R. E., Zoumas, C., & Jeste, D. V. (2022) · Administration and Policy in Mental Health and Mental Health Services Research · doi:10.1007/s10488-022-01189-z · Cited by 2 · see citing works
Self-citationSakai, Y., Larsen, J. B., & Reitan, S. K. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e08992 · Cited by 2 · see citing works
Su, Q., Wang, J., Ge, H., Li, M., Sun, X., Wang, S., Xuekelaiti, Z., Feng, Z., Xu, Y., Qiu, Y., et al. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116604 · Cited by 1 · see citing works
Lee, J.-Y., Liu, Y.-H., Hsieh, C. L., & Lung, F. (2025) · Science Progress · doi:10.1177/00368504251405328 · Cited by 1 · see citing works
Chapter 11. Schizophrenia Spectrum and Other Psychotic Disorders
Graham, S. A., Adamowicz, D. H., Jeste, D. V., & Lee, E. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds11 · Cited by 1 · see citing works
Self-citationHeil, M., Edlinger, M., Biedermann, F., Schurr, T., & Hofer, A. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1644428 · Cited by 2 · see citing works
Exploring the link between inflammation and mental disorders
Effendy, E. (2018) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/125/1/012187 · Cited by 1 · see citing works
Oxidative Stress Index and Peripheral Biomarkers for Schizophrenia: A Revisited Approach.Preprint
Wasti, A. Z., Jabeen, F., Rasheed, S., Shah, N., Khan, D., Zehra, Z., Aziz, F., Riaz, A., Ahmed, S. L., Ahmed, N., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3879201/v1 · Cited by 1 · see citing works
Response to Xuerong Luo et al., Letter to the Editor
Aas, M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.006
Liu, J., He, Y., & Luo, X. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.007
Biological Changes in Older People with Schizophrenia
Centorino, M. B., & Schultz, S. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108539593.006
Mahmuddin, P. M., Effendy, E., & Amin, M. M. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.6305
A literature survey on the biomarkers of cardiovascular disease
Pavithra, R., Sangeetha, T., Velayuthaprabhu, S., & Anand, A. V. (2021) · International Journal of Academic Medicine · doi:10.4103/ijam.ijam_80_20
- Authors
- Joseph, J., Depp, C., Martin, A. S., Daly, R. E., Glorioso, D. K., Palmer, B. W., & Jeste, D. V.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Jeste, Dilip V.
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 168
- Issue
- 1-2
- Pages
- 456-460
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC4591213
- OpenAlex
- W2142231500
- Cited by
- 109
- References
- 55
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 8 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 15 · 2016: 13
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (MH019934, R01MH094151, T32MH019934)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- high-sensitivity C-reactive protein, schizophrenia
- MeSH terms
- Adult, Aged, C-Reactive Protein, Female, Humans, Longitudinal Studies, Male, Metabolic Diseases, Middle Aged, Outpatients, Psychotic Disorders, Risk Factors, Schizophrenia, Sex Characteristics, Biomarkers, Comorbidity
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