Association between C reactive protein level and depressive symptoms in an elderly Korean population: Korean Social Life, Health and Aging Project
Open accessAbstract
OBJECTIVE: The relationship between inflammatory markers and depressive symptoms has been reported inconsistently. Moreover, there were only a few studies conducted in an Asian population. The purpose of this study was to examine the association between C reactive protein (CRP) and depressive symptoms in an elderly Korean population. DESIGN, SETTING AND PARTICIPANTS: This study used data from the Korean Social Life, Health and Aging Project Health Examination Cohort, which started in 2011. Among participants aged 60 or over recruited from a rural community, 569 (224 men and 345 women) without a history of stroke, angina pectoris, myocardial infarction or CRP≥20 mg/L were employed for cross-sectional analyses. As a marker of systemic inflammation, CRP was measured. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression analysis was used to investigate the relationship between CRP and depressive symptoms. RESULTS: In men, CRP levels had significant associations with depressive symptoms before (β=0.420, p=0.010) and after (β=0.336, p=0.025) adjusting for age, body mass index, systolic blood pressure, number of comorbidities, smoking status, alcohol intake, marital status, education and sleep duration. However, in women, the association between CRP and depressive symptoms was not significant before (p=0.250) and after (p=0.256) adjustment. CONCLUSIONS: Our findings suggest that elevated CRP levels are independently associated with the presence of depressive symptoms in elderly Korean men.
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In 596 participants, elevated CRP levels were independently associated with depressive symptoms in elderly Koreans, but this association was observed only in men both before and after adjusting for covariates.
“Similar findings were found in another Korean cross-sectional study, in which 596 participants (224 men and 345 women) from the Korean Social life, Health and Aging Project Health Examination (KSHAP-HE) cohort, were assessed for depressive symptoms through the CES-D and for serum CRP levels [71]. The authors reported that elevated CRP levels were independently associated with depressive symptoms”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [71]
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- Authors
- Song, B. M., Lee, J.-M., Choi, W., Youm, Y., Chu, S. H., Park, Y.-R., & Kim, H. C.
- Affiliations
- Yonsei University (KR)
- Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea
- Kangnam University (KR)
- Corresponding author
- Kim, Hyeon Chang
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2015-02
- Volume
- 5
- Issue
- 2
- Pages
- e006429
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC4342593
- OpenAlex
- W1991713930
- Cited by
- 33
- References
- 33
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 3
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Open (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Research Foundation
- Yonsei University
- National Research Foundation of Korea (NRF-2011-330-B00137)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- C-reactive protein, depressive symptoms, systemic inflammation, older adults, sex differences, Korean older adults, rural population, comorbidities, sleep duration
- MeSH terms
- Aged, Aged, 80 and over, Aging, C-Reactive Protein, Depression, Female, Health Surveys, Humans, Inflammation, Longitudinal Studies, Male, Surveys and Questionnaires, Risk Factors, Rural Population, Socioeconomic Factors, Biomarkers, Comorbidity, Odds Ratio, Asian People, Republic of Korea
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