Interferon Consensus Sequence Binding Protein Confers Resistance against Yersinia enterocolitica

Hein, Joachim; Kempf, Volkhard A. J.; Diebold, Joachim; Bücheler, Nicole; Preger, Sonja; Horak, Ivan; Sing, Andreas; Kramer, Uwe; Autenrieth, Ingo B.

doi:10.1128/iai.68.3.1408-1417.2000

Cited by 39interferon and immune responsesImmune Response and InflammationImmunodeficiency and Autoimmune Disorders

Interferon Consensus Sequence Binding Protein Confers Resistance against Yersinia enterocolitica

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Hein, Joachim, Kempf, Volkhard A. J., Diebold, Joachim, Bücheler, Nicole, Preger, Sonja, Horak, Ivan, Sing, Andreas, Kramer, Uwe +1 more·2000·Infection and Immunity

DOI 10.1128/iai.68.3.1408-1417.2000PMC PMC97295

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Abstract

Interferon consensus sequence binding protein (ICSBP)-deficient mice display enhanced susceptibility to intracellular pathogens. At least two distinct immunoregulatory defects are responsible for this phenotype. First, diminished production of reactive oxygen intermediates in macrophages results in impaired intracellular killing of microorganisms. Second, defective early interleukin-12 (IL-12) production upon microbial challenge leads to a failure in gamma interferon (IFN-γ) induction and subsequently in T helper 1 immune responses. Here, we investigated the role of ICSBP in resistance against the extracellular bacterium Yersinia enterocolitica. ICSBP−/−mice failed to produce IL-12 and IFN-γ, but also IL-4, after Yersinia challenge. In addition, granuloma formation was highly disturbed in infected ICSBP−/−mice, leading to multiple necrotic abscesses in affected organs. Consequently, ICSBP−/−mice rapidly succumbed to acute Yersinia infection. In vitro treatment of spleen cells from ICSBP−/−mice with recombinant IL-12 (rIL-12) or rIL-18 in combination with a second stimulus resulted in IFN-γ induction. In experimental therapy of infected ICSBP−/−mice, we observed that administration of rIL-12 induced IFN-γ production which was associated with improved resistance to Yersinia. In contrast, treatment with rIL-18 failed to enhance endogenous IFN-γ production but nevertheless reduced bacterial burden in ICSBP−/−mice. Although cytokine therapy with rIL-12 or rIL-18 ameliorated the course of Yersinia infection in ICSBP−/−mice, both cytokines failed to completely restore impaired immunity. Taken together, the results indicate that the transcription factor ICSBP is essential for efficient host immune defense against Yersinia. These results are important for understanding the complex host immune responses in bacterial infections.

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ICSBP-/- mice are immunodeficient and susceptible to various pathogens.
“ICSBP 2 / 2 mice are immunodeficient and susceptible to various pathogens.”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [39]

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Cloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,602 · see citing works
Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants
Hueck, C. J. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.379-433.1998 · Cited by 2,384 · see citing works
Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice
Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80543-9 · Cited by 911 · see citing works
The Virulence Plasmid ofYersinia, an Antihost Genome
Cornelis, G. R., Boland, A., Boyd, A., Geuijen, C., Iriarte, M., Neyt, C., Sory, M., & Stainier, I. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1315-1352.1998 · Cited by 793 · see citing works
IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB
Robinson, D. S., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., KASTELEIN, R. A., Bazán, F., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80378-7 · Cited by 720 · see citing works
Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene
Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644 · see citing works
Self-citation
The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells
Cornelis, G. R., & Wolf‐Watz, H. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.2731623.x · Cited by 559 · see citing works
The growing family of interferon regulatory factors
Nguyen, H., Hiscott, J., & Pitha, P. M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00019-1 · Cited by 480 · see citing works
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447 · see citing works
Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death
Monack, D. M., Mecsas, J. C., Ghori, N., & Falkow, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10385 · Cited by 409 · see citing works
Inhibition of the Mitogen-Activated Protein Kinase Kinase Superfamily by a Yersinia Effector
Orth, K., Palmer, L. E., Bao, Z., Stewart, S., Rudolph, A. E., Bliska, J. B., & Dixon, J. E. (1999) · Science · doi:10.1126/science.285.5435.1920 · Cited by 402 · see citing works
M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells
Clark, M. A., Hirst, B. H., & Jepson, M. A. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.1237-1243.1998 · Cited by 363 · see citing works
Iron, Infections, and Anemia of Inflammation
Jurado, R. L. (1997) · Clinical Infectious Diseases · doi:10.1086/515549 · Cited by 358 · see citing works
An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.
Driggers, P. H., Ennist, D. L., Gleason, S. L., Mak, W. H., Marks, M. S., Levi, B. Z., Flanagan, J. R., Appella, E., & Ozato, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3743 · Cited by 356 · see citing works
Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1
Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, S., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, S., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80443-4 · Cited by 353 · see citing works
YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF‐α production and downregulation of the MAP kinases p38 and JNK
Palmer, L. E., Hobbie, S., Galán, J. E., & Bliska, J. B. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00740.x · Cited by 294 · see citing works
Interferon Regulatory Factor-1 Is Required for a T Helper 1 Immune Response In Vivo
Lohoff, M. D., Ferrick, D. A., Mittrücker, H., Duncan, G. S., Bischof, S., Röllinghoff, M., & Mak, T. W. (1997) · Immunity · doi:10.1016/s1074-7613(00)80444-6 · Cited by 286 · see citing works
The yopJ locus is required for Yersinia‐mediated inhibition of NF‐κB activation and cytokine expression: YopJ contains a eukaryotic SH2‐like domain that is essential for its repressive activity
Schesser, K., Spiik, A., Dukuzumuremyi, J., Neurath, M. F., Pettersson, S., & Wolf‐Watz, H. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00851.x · Cited by 280 · see citing works
Involvement of M cells in the bacterial invasion of Peyer's patches: a common mechanism shared by Yersinia enterocolitica and other enteroinvasive bacteria.
Grützkau, A., HANSKI, C., Hahn, H. H., & Riecken, E. O. (1990) · Gut · doi:10.1136/gut.31.9.1011 · Cited by 265 · see citing works
A single DNA response element can confer inducibility by both alpha- and gamma-interferons.
Reid, L. E., Brasnett, A. H., Gilbert, C. S., Porter, A. C. G., Gewert, D. R., Stark, G. R., & Kerr, I. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.840 · Cited by 257 · see citing works
Association between virulence of Yersinia pestis and suppression of gamma interferon and tumor necrosis factor alpha
Nakajima, R., & Brubaker, R. R. (1993) · Infection and Immunity · doi:10.1128/iai.61.1.23-31.1993 · Cited by 247 · see citing works
Yersinia-induced Apoptosis In Vivo Aids in the Establishment of a Systemic Infection of Mice
Monack, D. M., Mecsas, J. C., Bouley, D. M., & Falkow, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.2127 · Cited by 240 · see citing works
Yersinia enterocolitica Impairs Activation of Transcription Factor NF-κB: Involvement in the Induction of Programmed Cell Death and in the Suppression of the Macrophage Tumor Necrosis Factor α Production
Ruckdeschel, K., Harb, S., Roggenkamp, A., Hornef, M. W., Zumbihl, R., Köhler, S., Heesemann, J., & Rouot, B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.7.1069 · Cited by 239 · see citing works
IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.
Osaki, T., Péron, J., Cai, Q., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., & Tahara, H. (1998) · PubMed · Cited by 231 · see citing works
IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice.
Bohn, E., Sing, A., Zumbihl, R., Bielfeldt, C., Okamura, H., Kurimoto, M., Heesemann, J., & Autenrieth, I. B. (1998) · PubMed · Cited by 230 · see citing works
Self-citation
The V‐antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation
Pettersson, J., Holmström, A., Hill, J., Leary, S. E. C., Frithz‐Lindsten, E., Euler‐Matell, A. V., Carlsson, E., Titball, R. W., Försberg, Å., & Wolf‐Watz, H. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01408.x · Cited by 228 · see citing works
Electron microscopic evidence for in vivo extracellular localization of Yersinia pseudotuberculosis harboring the pYV plasmid
Simonet, M., Richard, S., & Berche, P. (1990) · Infection and Immunity · doi:10.1128/iai.58.3.841-845.1990 · Cited by 220 · see citing works
Interferon Consensus Sequence Binding Protein–deficient Mice Display Impaired Resistance to Intracellular Infection Due to a Primary Defect in Interleukin 12 p40 Induction
Scharton-Kersten, T., Contursi, C., Masumi, A., Sher, A., & Ozato, K. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1523 · Cited by 217 · see citing works
Role of YopP in Suppression of Tumor Necrosis Factor Alpha Release by Macrophages duringYersiniaInfection
Boland, A., & Cornelis, G. R. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.1878-1884.1998 · Cited by 214 · see citing works
Critical roles of neutrophils in host defense against experimental systemic infections of mice by Listeria monocytogenes, Salmonella typhimurium, and Yersinia enterocolitica
Conlan, J. W. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.630-635.1997 · Cited by 208 · see citing works
IL-18 (IFN-γ-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice
Bohn, E., Sing, A., Zumbihl, R., Bielfeldt, C., Okamura, H., Kurimoto, M., Heesemann, J., & Autenrieth, I. B. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.299 · Cited by 204 · see citing works
Self-citation
Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis
Ruckdeschel, K., Roggenkamp, A., Lafont, V., Mangeat, P. H., Heesemann, J., & Rouot, B. (1997) · Infection and Immunity · doi:10.1128/iai.65.11.4813-4821.1997 · Cited by 203 · see citing works
Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization
Nakajima, R., Motin, V. L., & Brubaker, R. R. (1995) · Infection and Immunity · doi:10.1128/iai.63.8.3021-3029.1995 · Cited by 198 · see citing works
Penetration of M cells and destruction of Peyer's patches by Yersinia enterocolitica: an ultrastructural and histological study
Autenrieth, I. B., & Firsching, R. (1996) · Journal of Medical Microbiology · doi:10.1099/00222615-44-4-285 · Cited by 197 · see citing works
Self-citation
IFN-γ-Inducing Factor/IL-18 Administration Mediates IFN-γ- and IL-12-Independent Antitumor Effects
Osaki, T., Péron, J., Cai, Q., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., & Tahara, H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.4.1742 · Cited by 194 · see citing works
IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production
Kawakami, K., Qureshi, M. H., Zhang, T., Okamura, H., Kurimoto, M., & Saitô, A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.11.5528 · Cited by 193 · see citing works
Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.
Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588 · Cited by 192 · see citing works
Interferon Consensus sequence-Binding Protein, a Member of the Interferon Regulatory Factor Family, Suppresses Interferon-Induced Gene Transcription
Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588-599.1993 · Cited by 192 · see citing works
Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon
Autenrieth, I. B., Beer, M., Bohn, E., Kaufmann, S. H. E., & Heesemann, J. (1994) · Infection and Immunity · doi:10.1128/iai.62.6.2590-2599.1994 · Cited by 191 · see citing works
Self-citation
Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype O8 with intestinal mucosa during experimental enteritis
HANSKI, C., Kutschka, U., Schmoranzer, H., Naumann, M., Stallmach, A., Hahn, H. H., Menge, H., & Riecken, E. O. (1989) · Infection and Immunity · doi:10.1128/iai.57.3.673-678.1989 · Cited by 183 · see citing works
TheYersiniaDeadly Kiss
Cornelis, G. R. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.21.5495-5504.1998 · Cited by 176 · see citing works
PU.1, Interferon Regulatory Factor 1, and Interferon Consensus Sequence-binding Protein Cooperate to Increase gp91 Expression
Eklund, E. A., Jalava, A., & Kakar, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13957 · Cited by 176 · see citing works
Virulence of Yersinia enterocolitica is closely associated with siderophore production, expression of an iron‐repressible outer membrane polypeptide of 65 000 Da and pesticin sensitivity
Heesemann, J., Hantke, K., Vocke, T., Saken, E., Rakin, A., Stojiljković, I., & Berner, R. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01583.x · Cited by 173 · see citing works
Interleukin-18 Protects Mice against Acute Herpes Simplex Virus Type 1 Infection
Fujioka, N., Akazawa, R., Ohashi, K., Fujii, M., Ikeda, M., & Kurimoto, M. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.2401-2409.1999 · Cited by 169 · see citing works
Targeting of the Yersinia pestis YopM protein into HeLa cells and intracellular trafficking to the nucleus
Skrzypek, E., Cowan, C., & Straley, S. C. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01135.x · Cited by 169 · see citing works
Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.
Bovolenta, C., Driggers, P. H., Marks, M. S., Medin, J. A., Politis, A. D., Vogel, S. N., Levy, D. E., Sakaguchi, K., Appella, E., & Coligan, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5046 · Cited by 167 · see citing works
Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA
Sharf, R., Meraro, D., Azriel, A., Thornton, A. M., Ozato, K., Petricoin, E. F., Larner, A. C., Schaper, F., Hauser, H., & Levi, B.-Z. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9785 · Cited by 162 · see citing works
Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis
Fehr, T., Schoedon, G., Odermatt, B., Holtschke, T., Schneemann, M., Bachmann, M. F., Mak, T. W., Horak, I., & Zinkernagel, R. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.921 · Cited by 162 · see citing works
Self-citation
Interferon (IFN) Consensus Sequence-binding Protein, a Transcription Factor of the IFN Regulatory Factor Family, Regulates Immune Responses In Vivo through Control of Interleukin 12 Expression
Giese, N. A., Gabriele, L., Doherty, T. M., Klinman, D. M., Tadesse-Heath, L., Contursi, C., Epstein, S. L., & Morse, H. C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1535 · Cited by 160 · see citing works
Construction of a mobilizable Yersinia enterocolitica virulence plasmid
Heesemann, J., & Laufs, R. (1983) · Journal of Bacteriology · doi:10.1128/jb.155.2.761-767.1983 · Cited by 159 · see citing works
The Yersinia Yop Virulon: LcrV Is Required for Extrusion of the Translocators YopB and YopD
Sarker, M. R., Neyt, C., Stainier, I., & Cornelis, G. R. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.5.1207-1214.1998 · Cited by 157 · see citing works
Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils
Ruckdeschel, K., Roggenkamp, A., Schubert, S., & Heesemann, J. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.724-733.1996 · Cited by 156 · see citing works
Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
Weisz, A., Marx, P., Sharf, R., Appella, E., Driggers, P. H., Ozato, K., & Levi, B. Z. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74081-2 · Cited by 152 · see citing works
Yersinia enterocolitica Promotes Deactivation of Macrophage Mitogen-activated Protein Kinases Extracellular Signal-regulated Kinase-1/2, p38, and c-Jun NH2-terminal Kinase
Ruckdeschel, K., Machold, J., Roggenkamp, A., Schubert, S., Pierre, J., Zumbihl, R., Liautard, J., Heesemann, J., & Rouot, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15920 · Cited by 151 · see citing works
Virulence Role of V Antigen ofYersinia pestisat the Bacterial Surface
Fields, K. A., Nilles, M. L., Cowan, C., & Straley, S. C. (1999) · Infection and Immunity · doi:10.1128/iai.67.10.5395-5408.1999 · Cited by 138 · see citing works
Correlation analysis between frequencies of circulating antigen-specific IgG-bearing memory B cells and serum titers of antigen-specific IgG
Leyendeckers, H., Odendahl, M., Löhndorf, A., Irsch, J., Spangfort, M. D., Miltenyi, S., Hunzelmann, N., Assenmacher, M., Radbruch, A., & Schmitz, J. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199904)29:04 · Cited by 135 · see citing works
IL-12 is essential for resistance against Yersinia enterocolitica by triggering IFN-γ production in NK cells and CD4+ T cells
Bohn, E., & Autenrieth, I. B. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.4.1458 · Cited by 128 · see citing works
Self-citation
Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence–Binding Protein
Gabriele, L., Phung, J., Fukumoto, J., Segal, D., Wang, I.-M., Giannakakou, P., Giese, N. A., Ozato, K., & Morse, H. C. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.3.411 · Cited by 114 · see citing works
Differential clearance and host-pathogen interactions of YopE- and YopK- YopL- Yersinia pestis in BALB/c mice
Straley, S. C., & Cibull, M. L. (1989) · Infection and Immunity · doi:10.1128/iai.57.4.1200-1210.1989 · Cited by 110 · see citing works
Defense mechanisms in Peyer's patches and mesenteric lymph nodes against Yersinia enterocolitica involve integrins and cytokines
Autenrieth, I. B., Kempf, V. A. J., Sprinz, T., Preger, S., & Schnell, A. (1996) · Infection and Immunity · doi:10.1128/iai.64.4.1357-1368.1996 · Cited by 109 · see citing works
Self-citation
YopJ of Yersinia spp. Is Sufficient To Cause Downregulation of Multiple Mitogen-Activated Protein Kinases in Eukaryotic Cells
Palmer, L. E., Pancetti, A. R., Greenberg, S., & Bliska, J. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.708-716.1999 · Cited by 107 · see citing works
Molecular Genetics of Chronic Granulomatous Disease
Orkin, S. H. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001425 · Cited by 106 · see citing works
Roles of IFN Consensus Sequence Binding Protein and PU.1 in Regulating IL-18 Gene Expression
Kim, Y.-M., Kang, H.-S., Paik, S., Pyun, K.-H., Anderson, K. L., Torbett, B. E., & Choi, I. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2000 · Cited by 104 · see citing works
T lymphocytes mediate protection against Yersinia enterocolitica in mice: characterization of murine T-cell clones specific for Y. enterocolitica
Autenrieth, I. B., Tingle, A., Reske-Kunz, A. B., & Heesemann, J. (1992) · Infection and Immunity · doi:10.1128/iai.60.3.1140-1149.1992 · Cited by 104 · see citing works
Self-citation
Functional Domain Analysis of Interferon Consensus Sequence Binding Protein (ICSBP) and Its Association with Interferon Regulatory Factors
Sharf, R., Azriel, A., Lejbkowicz, F., Winograd, S. S., Ehrlich, R., & Levi, B.-Z. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13063 · Cited by 100 · see citing works
In vivo neutralization of tumor necrosis factor-alpha and interferon-gamma abrogates resistance to Yersinia enterocolitica infection in mice
Autenrieth, I. B., & Heesemann, J. (1992) · Medical Microbiology and Immunology · doi:10.1007/bf00191545 · Cited by 97 · see citing works
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Experimental Yersinia enterocolitica infection in euthymic and T-cell-deficient athymic nude C57BL/6 mice: comparison of time course, histomorphology, and immune response
Autenrieth, I. B., Vogel, U. F., Preger, S., Heymer, B., & Heesemann, J. (1993) · Infection and Immunity · doi:10.1128/iai.61.6.2585-2595.1993 · Cited by 91 · see citing works
Self-citation
Differential Expression and Distinct Functions of IFN Regulatory Factor 4 and IFN Consensus Sequence Binding Protein in Macrophages
Marecki, S., Atchison, M. L., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2713 · Cited by 87 · see citing works
Early gamma interferon mRNA expression is associated with resistance of mice against Yersinia enterocolitica
Bohn, E., Heesemann, J., Ehlers, S., & Autenrieth, I. B. (1994) · Infection and Immunity · doi:10.1128/iai.62.7.3027-3032.1994 · Cited by 86 · see citing works
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Gallant, T., Freedman, M. H., Vellend, H., & Francombe, W. H. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606193142515 · Cited by 86 · see citing works
Modulation of interferon consensus sequence binding protein mRNA in murine peritoneal macrophages. Induction by IFN-gamma and down-regulation by IFN-alpha, dexamethasone, and protein kinase inhibitors
Politis, A. D., Sivo, J., Driggers, P. H., Ozato, K., & Vogel, S. N. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.3.801 · Cited by 68 · cited 1× · see citing works
“ICSBP is exclusively expressed in hematopoietically derived cells and predominantly induced by IFN-g (25, 55).”
Background
Humoral and cellular defense against intestinal murine infection with Yersinia enterocolitica
HANSKI, C., Naumann, M., Grützkau, A., Pluschke, G., Friedrich, B., Hahn, H. H., & Riecken, E. O. (1991) · Infection and Immunity · doi:10.1128/iai.59.3.1106-1111.1991 · Cited by 65 · see citing works
Regulation of IFN Consensus Sequence Binding Protein Expression in Murine Macrophages
Kantakamalakul, W., Politis, A. D., Marecki, S., Sullivan, T., Ozato, K., Fenton, M. J., & Vogel, S. N. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.12.7417 · Cited by 61 · see citing works
Yersinia Sepsis in Patients with Iron Overload Treated with Deferoxamine
(1986) · New England Journal of Medicine · doi:10.1056/nejm198606193142514 · Cited by 54 · see citing works
Roles of V antigen in promoting virulence in Yersiniae.
Une, T., Nakajima, R., & Brubaker, R. R. (1987) · PubMed · Cited by 51 · see citing works
IFN consenus sequence binding protein (ICSBP) is a conditional repressor of IFN inducible promoters
Welsz, A., Kirchhoff, S., & Levi, B.-Z. (1994) · International Immunology · doi:10.1093/intimm/6.8.1125 · Cited by 50 · see citing works
Ambiguous Role of Interleukin-12 inYersinia enterocoliticaInfection in Susceptible and Resistant Mouse Strains
Bohn, E., Schmitt, E., Bielfeldt, C., Noll, A., Schulte, R., & Autenrieth, I. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.2213-2220.1998 · Cited by 47 · see citing works
Self-citation
AML and Ets proteins regulate the Iα1 germ-line promoter
Xie, X., Pardali, E., Holm, M., Sideras, P., & Grundström, T. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199902)29:02 · Cited by 46 · see citing works
Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-gamma.
Wu, C. Y., Maeda, H., Contursi, C., Ozato, K., & Seder, R. A. (1999) · PubMed · Cited by 38 · see citing works
Differential Requirement of IFN Consensus Sequence Binding Protein for the Production of IL-12 and Induction of Th1-Type Cells in Response to IFN-γ
Wu, C.-Y., Maeda, H., Contursi, C., Ozato, K., & Seder, R. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.2.807 · Cited by 31 · see citing works
Analysis of the antagonist effect of IFN-alpha on IFN-gamma-induced interferon consensus sequence binding protein messenger RNA in murine macrophages.
Fultz, M. J., & Vogel, S. (1998) · PubMed · Cited by 7 · see citing works

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The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259 · see citing works
Type 1/Type 2 Immunity in Infectious Diseases
Spellberg, B. J., & Edwards, J. E. (2001) · Clinical Infectious Diseases · doi:10.1086/317537 · Cited by 904 · see citing works
The role of gamma interferon in antimicrobial immunity
Shtrichman, R., & Samuel, C. E. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00199-5 · Cited by 334 · see citing works
Roles of interferon-regulatory factors in T-helper-cell differentiation
Lohoff, M. D., & Mak, T. W. (2005) · Nature reviews. Immunology · doi:10.1038/nri1552 · Cited by 216 · see citing works
Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells
Tamura, T., & Ozato, K. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452755 · Cited by 183 · see citing works
The Plague Virulence Protein YopM Targets the Innate Immune Response by Causing a Global Depletion of NK Cells
Kerschen, E. J., Cohen, D. A., Kaplan, A. M., & Straley, S. C. (2004) · Infection and Immunity · doi:10.1128/iai.72.8.4589-4602.2004 · Cited by 160 · see citing works
TLR-Independent Type I Interferon Induction in Response to an Extracellular Bacterial Pathogen via Intracellular Recognition of Its DNA
Charrel-Dennis, M., Latz, E., Halmen, K. A., Trieu‐Cuot, P., Fitzgerald, K. A., Kasper, D. L., & Golenbock, D. T. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.11.002 · Cited by 136 · see citing works
Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases
Salem, S., Salem, D., & Gros, P. (2020) · Human Genetics · doi:10.1007/s00439-020-02154-2 · Cited by 124 · see citing works
ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro
Tsujimura, H., Tamura, T., Gongora, C., Aliberti, J., Sousa, C. R. E., Sher, A., & Ozato, K. (2003) · Blood · doi:10.1182/blood-2002-05-1327 · Cited by 114 · see citing works
Alternate interferon signaling pathways
Kalvakolanu, D. V. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00070-6 · Cited by 106 · see citing works
Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2
Burchert, A. (2003) · Blood · doi:10.1182/blood-2003-08-2970 · Cited by 101 · see citing works
Transcription factors that regulate growth and differentiation of myeloid cells.
Nagamura-Inoue, T., Tamura, T., & Ozato, K. (2001) · International Reviews of Immunology · doi:10.3109/08830180109056724 · Cited by 94 · see citing works
The Most Important Virulence Markers of Yersinia enterocolitica and Their Role during Infection
Bancerz‐Kisiel, A., Pieczywek, M., Łada, P., & Szweda, W. (2018) · Genes · doi:10.3390/genes9050235 · Cited by 85 · see citing works
IFN Consensus Sequence Binding Protein/IFN Regulatory Factor-8 Guides Bone Marrow Progenitor Cells Toward the Macrophage Lineage
Tsujimura, H., Nagamura‐Inoue, T., Tamura, T., & Ozato, K. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1261 · Cited by 82 · see citing works
Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis
Marquis, J.-F., Kapoustina, O., Langlais, D., Ruddy, R., Dufour, C. R., Kim, B.-H., MacMicking, J. D., Giguère, V., & Gros, P. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002097 · Cited by 73 · see citing works
A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation
Wang, H., Yan, M., Sun, J., Jain, S., Yoshimi, R., Abolfath, S. M., Ozato, K., Coleman, W. G., Ng, A. P., Metcalf, D., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301939 · Cited by 71 · see citing works
Quantification of Murine IFN‐γ mRNA and Protein Expression: Impact of Real‐Time Kinetic RT–PCR Using SYBR Green I Dye
Hein, J., Schellenberg, U., Bein, G., & Hackstein, H. (2001) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2001.00928.x · Cited by 59 · see citing works
Self-citation
Histamine signaling through the H 2 receptor in the Peyer’s patch is important for controlling Yersinia enterocolitica infection
Handley, S. A., Dube, P. H., & Miller, V. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510414103 · Cited by 56 · see citing works
Expressed sequence tags analysis of Atlantic halibut (Hippoglossus hippoglossus) liver, kidney and spleen tissues following vaccination against Vibrio anguillarum and Aeromonas salmonicida
Park, K. C., Osborne, J. A., Tsoi, S. C. ‐., Brown, L. L., & Johnson, S. C. (2005) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2004.10.003 · Cited by 51 · see citing works
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Berghout, J., Langlais, D., Radovanovic, I., Tam, M., MacMicking, J. D., Stevenson, M. M., & Gros, P. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003491 · Cited by 49 · see citing works
Characterization of immune response elicited by the recombinant outer membrane protein OmpF of Aeromonas hydrophila, a potential vaccine candidate in murine model
Yadav, S. K., Sahoo, P. K., & Dixit, A. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3033-9 · Cited by 48 · see citing works
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Turcotte, K., Gauthier, S., Malo, D., Tam, M., Stevenson, M. M., & Gros, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2467 · Cited by 46 · see citing works
Interaction between Interferon Consensus Sequence-binding Protein and COP9/Signalosome Subunit CSN2 (Trip15)
Cohen, H., Azriel, A., Cohen, T., Meraro, D., Hashmueli, S., Bech-Otschir, D., Kraft, R., Dubiel, W., & Levi, B.-Z. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004900200 · Cited by 45 · see citing works
Y. enterocolitica and Y. pseudotuberculosis
Carniel, É., Autenrieth, I. B., Cornelis, G. R., Fukushima, H., Guinet, F., Isberg, R. R., Pham, J. N., Prentice, M. B., Simonet, M., Skurnik, M., et al. (2006) · Springer eBooks · doi:10.1007/0-387-30746-x_13 · Cited by 44 · see citing works
Self-citation
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Salem, S., & Gros, P. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6111-1_3 · Cited by 42 · see citing works
Regulation of T helper cell differentiation by interferon regulatory factor family members
Zhang, R., Chen, K., Peng, L., & Xiong, H. (2012) · Immunologic Research · doi:10.1007/s12026-012-8328-0 · Cited by 34 · see citing works
Y. enterocolitica and Y. pseudotuberculosis
(2011) · SpringerReference · doi:10.1007/springerreference_3816 · Cited by 18 · see citing works
Gene expression profile of CD4+ T cells reveals an interferon signaling suppression associated with progression of experimental Schistosoma japonicum infection
Ji, M., Su, C., Wu, H., Zhu, X., Cai, X.-P., Li, C.-L., Li, G., Wang, Y., Zhang, Z., & Wu, G. (2003) · Cellular Immunology · doi:10.1016/j.cellimm.2003.08.001 · Cited by 17 · see citing works
Yersinia enterocolitica in Crohn’s disease
Xue, F., Kang, L., Qiu, Y.-F., Li, Z., & Bai, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1129996 · Cited by 15 · see citing works
Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenicYersinia
Hein, J., Sing, A., Genaro, M. S. D., & Autenrieth, I. B. (2001) · Microbial Pathogenesis · doi:10.1006/mpat.2001.0458 · Cited by 13 · see citing works
Self-citation
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Zhang, Y., Tam, J. W., Mena, P., van der Velden, A. W. M., & Bliska, J. B. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005167 · Cited by 11 · see citing works
Clostridium perfringens beta toxin DNA prime-protein boost elicits enhanced protective immune response in mice
Solanki, A. K., Bhatia, B., Kaushik, H., Deshmukh, S. K., Dixit, A., & Garg, L. C. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8333-2 · Cited by 8 · see citing works
Interleukin-12p40 contributes to protection against lung injury after oral Yersinia enterocolitica infection
Gutiérrez, J. G., Valdez, S. R., Genaro, S. D., & Gómez, N. N. (2008) · Inflammation Research · doi:10.1007/s00011-008-7162-2 · Cited by 8 · see citing works
Functional Identification and Genetic Analysis of O-Antigen Gene Clusters of Food-Borne Pathogen Yersinia enterocolitica O:10 and Other Uncommon Serotypes, Further Revealing Their Virulence Profiles
Hu, B., Wang, J., Li, L., Wang, Q., Qin, J., Chi, Y., Yan, J., Sun, W., Cao, B., & Guo, X. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2402.02044 · Cited by 3 · see citing works
Strains of Inbred Mice Infection in Three Different enterocolitica Yersinia Characterization of Oral
Miller, V. L., Handley, S. A., Dube, P. H., & Revell, P. A. (2014) · Cited by 1 · see citing works
Interferon Regulatory Factors: Role in Transcriptional Regulation of Macrophage Plasticity and Activation
Eames, H. L., & Udalova, I. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_22 · Cited by 1 · see citing works
Comparative pangenome analysis of Yersinia enterocolitica in a one health approach
Martins, B. T. F., Rodrigues, R. D. S., & Nero, L. A. (2025) · BMC Genomics · doi:10.1186/s12864-025-12420-0
Papel das Yops de yersinia pseudotuberculosis na modulação da resposta imune celular durante infecção experimental
Monnazzi, L. G. S. (2007) · Americanae (AECID Library)

Interferon Consensus Sequence Binding Protein–deficient Mice Display Impaired Resistance to Intracellular Infection Due to a Primary Defect in Interleukin 12 p40 Induction
Scharton-Kersten, T., Contursi, C., Masumi, A., Sher, A., & Ozato, K. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1523 · Cited by 217 · see citing works
Ambiguous Role of Interleukin-12 inYersinia enterocoliticaInfection in Susceptible and Resistant Mouse Strains
Bohn, E., Schmitt, E., Bielfeldt, C., Noll, A., Schulte, R., & Autenrieth, I. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.2213-2220.1998 · Cited by 47 · see citing works
Self-citation
IL-12 is essential for resistance against Yersinia enterocolitica by triggering IFN-γ production in NK cells and CD4+ T cells
Bohn, E., & Autenrieth, I. B. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.4.1458 · Cited by 128 · see citing works
Self-citation
Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression
Expression, I., Giese, A., Gabriele, L., Doherty, T. M., Klinman, D. M., Taddesse-Heath, L., Contursi, C., Epstein, S. L., & Morse, H. C., III (1997)
Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenicYersinia
Hein, J., Sing, A., Genaro, M. S. D., & Autenrieth, I. B. (2001) · Microbial Pathogenesis · doi:10.1006/mpat.2001.0458 · Cited by 13 · see citing works
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Authors: Hein, J., Kempf, V. A. J., Diebold, J., Bücheler, N., Preger, S., Horak, I., Sing, A., Kramer, U., & Autenrieth, I. B.
Affiliations: Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie (DE)
Pathologisches Institut (DE)
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie1 and
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (DE)
ORCID: Kempf, Volkhard A. J.
Diebold, Joachim
Horak, Ivan
Sing, Andreas
Autenrieth, Ingo B.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2000-03
Volume: 68
Issue: 3
Pages: 1408-1417
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.68.3.1408-1417.2000
PMC: PMC97295
OpenAlex: W2075365138
Cited by: 39
References: 83
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 1
FWCI: 1.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords: Yersinia enterocolitica, IL-12, IL-18, interferon-gamma, granuloma formation, cytokine therapy, T helper 1 response, IL-4
MeSH terms: Interferon Regulatory Factor-8, Animals, Interferon-gamma, Mice, Inbred C57BL, Repressor Proteins, Yersinia enterocolitica, Yersinia Infections, Mice, Knockout, Interleukin-12, Interleukin-18, Interferon Regulatory Factors, Mice

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Interferon Consensus Sequence Binding Protein Confers Resistance against Yersinia enterocolitica

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