AMPK inhibition in health and disease

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093

WIP1, a Homeostatic Regulator of the DNA Damage Response, Is Targeted by HIPK2 for Phosphorylation and Degradation

Choi, D. W., Na, W., Kabir, M. H., Yi, E., Kwon, S., Yeom, J., Ahn, J.-W., Choi, H.-H., Lee, Y., Seo, K., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.010 · Cited by 61

Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish

Yang, B., Zhai, G., Gong, Y., Su, J., Peng, X., Shang, G.-H., Han, D. H., Jin, J., Liu, H., Du, Z., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00227.2017 · Cited by 64

Indole Derivatives Isolated from Brown Alga Sargassum thunbergii Inhibit Adipogenesis through AMPK Activation in 3T3-L1 Preadipocytes

Kang, M., Ding, Y., Kim, E.-A. L., Choi, Y. K., Araujo, T. D., Heo, S., & Lee, S. (2017) · Marine Drugs · doi:10.3390/md15040119 · Cited by 60

Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1

Hu, L., Tian, K., Zhang, T., Fan, C., Zhou, P., Zeng, D., Zhao, S., Li, L., Smith, H. S., Li, J., et al. (2019) · Molecules · doi:10.3390/molecules24183231 · Cited by 60

Nutrient Excess in AMPK Downregulation and Insulin Resistance.

Coughlan, K. A., Valentine, R. J., Ruderman, N. B., & Saha, A. K. (2013) · PubMed · Cited by 59

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice

Hughey, C. C., James, F. D., Bracy, D. P., Donahue, E. P., Young, J. D., Viollet, B., Foretz, M., & Wasserman, D. H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.811547 · Cited by 56

TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism

Shepard, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.613639 · Cited by 62

Critical role for free radicals on sprint exercise-induced CaMKII and AMPKα phosphorylation in human skeletal muscle

Morales‐Álamo, D., Ponce‐González, J. G., Guadalupe‐Grau, A., Rodríguez‐García, L., Santana, A., Cussó, R., Guerrero, M., Dorado, C., Guerra, B., & Calbet, J. A. L. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01246.2012 · Cited by 59

Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions

Anandhan, A., Lei, S., Levytskyy, R. M., Pappa, A., Panayiotidis, M. I., Cerny, R. L., Khalimonchuk, O., Powers, R., & Franco, R. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9906-2 · Cited by 60

Mitochondrial metabolism and energy sensing in tumor progression

Iommarini, L., Ghelli, A. M., Gasparre, G., & Porcelli, A. M. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.02.006 · Cited by 58

AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators

Moreno-Arriola, E., Hafidi, M. E., Ortega-Cuéllar, D., & Carvajal, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148089 · Cited by 57

mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons

Lee, H.-K., Kwon, B., Lemere, C. A., de la Monte, S., Itamura, K., Ha, A. Y., & Querfurth, H. W. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161029 · Cited by 57

Adiponectin improves the osteointegration of titanium implant under diabetic conditions by reversing mitochondrial dysfunction via the AMPK pathway in vivo and in vitro

Hu, X., Wang, L. Q., Lu, Y., Xiang, G., Wu, Z., Yan, Y., Zhang, Y., Zhao, X., Zang, Y., Shi, L., et al. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.06.020 · Cited by 57

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture

Mot, A. I., Liddell, J. R., White, A. R., & Crouch, P. J. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.08.029 · Cited by 55

Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway

Samuels, J. S., Shashidharamurthy, R., & Rayalam, S. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0277-8 · Cited by 57

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Maqdasy, S., Lecoutre, S., Renzi, G., Frendo‐Cumbo, S., Rizo‐Roca, D., Möritz, T., Juvany, M., Hodek, O., Gao, H., Couchet, M., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00525-9 · Cited by 54

Implication of AMP-Activated Protein Kinase in Transient Receptor Potential Vanilloid Type 1-Mediated Activation of Endothelial Nitric Oxide Synthase

Ching, L., Chen, C., Su, K., Hou, H., Shyue, S., Kou, Y. R., & Lee, T. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00461 · Cited by 54

Substances of Interest That Support Glaucoma Therapy

Saccà, S. C., Corazza, P., Gandolfi, S., Ferrari, D., Sukkar, S. G., Iorio, E. L., & Traverso, C. E. (2019) · Nutrients · doi:10.3390/nu11020239 · Cited by 55

Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients

Dai, Y., Amenov, A., Ignatyeva, N., Koschinski, A., Xu, H., Soong, P. L., Tiburcy, M., Linke, W. A., Zaccolo, M., Hasenfuss, G. P., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-56597-3 · Cited by 57

AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer

Choudhury, Y., Yang, Z., Ahmad, I., Nixon, C., Salt, I. P., & Leung, H. Y. (2014) · Oncoscience · doi:10.18632/oncoscience.49 · Cited by 54

Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance

Garbacz, W. G., Lu, P., Miller, T. M., Poloyac, S. M., Eyre, N. S., Mayrhofer, G., Xu, M., Ren, S., & Xie, W. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00138-16 · Cited by 54

Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes

Sukumaran, A., Choi, K., & Dasgupta, B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00671 · Cited by 62

The pharmacogenetics of antipsychotic-induced adverse events

Müller, D. J., Chowdhury, N. I., & Zai, C. C. H. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835dc9da · Cited by 54

All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK Signaling Pathway

Zhang, J., Deng, B., Jiang, X., Cai, M., Liu, N., Zhang, S., Tan, Y., Huang, G., Jin, W., Liu, B., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00485 · Cited by 53

Pharmacodynamic effects of direct AMP kinase activation in humans with insulin resistance and non-alcoholic fatty liver disease: A phase 1b study

Fouqueray, P., Bolze, S., Dubourg, J., Hallakou‐Bozec, S., Theurey, P., Grouin, J., Chevalier, C., Dagorn, P. G., Moller, D. E., & Cusi, K. J. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100474 · Cited by 52

AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis

Gumá, M., Wang, Y., Viollet, B., & Liu‐Bryan, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140452 · Cited by 52

AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy

Ljubicic, V., & Jasmin, B. J. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.07.002 · Cited by 53

NADPH Oxidase 4 (NOX4) in Cancer: Linking Redox Signals to Oncogenic Metabolic Adaptation

Szántó, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052702 · Cited by 52

Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells

Mouhieddine, T. H., Nokkari, A., Itani, M. M., Chamaa, F., Bahmad, H. F., Monzer, A., El‐Merahbi, R., Daoud, G., Eid, A. A., Kobeissy, F. H., et al. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00442 · Cited by 49

Therapeutic targets of Traditional Chinese Medicine for colorectal cancer

Wei-dong, L., Li, C., Honggang, Z., Guohong, C., & Baojin, H. (2016) · 中医杂志：英文版 · doi:10.1016/s0254-6272(16)30034-6 · Cited by 50

Genomic Characterization of Metformin Hepatic Response

Luizon, M. R., Eckalbar, W. L., Wang, Y., Jones, S. L., Smith, R. P., Megan, L., Lin, L., Gallins, P. J., Etheridge, A. S., Wright, F. A., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006449 · Cited by 52

Sphingolipid accumulation causes mitochondrial dysregulation and cell death

Knupp, J., Martínez-Montañés, F., den Bergh, F. V., Cottier, S., Schneiter, R., Beard, D. A., & Chang, A. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.128 · Cited by 48

Brain-specific suppression of AMPKα2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2α phosphorylation

Yang, W., Zhou, X., Zimmermann, H. R., & Ma, T. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0739-z · Cited by 48

Mechanism of Zinc Excitotoxicity: A Focus on AMPK

Kim, Y. H., Eom, J.-W., & Koh, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.577958 · Cited by 48

AMP-Activated Protein Kinase

Harada, M., Nattel, S. N., & Nattel, S. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.112.972265 · Cited by 49

Metabolic Regulation of Insulin Secretion

Keane, K. N., & Newsholme, P. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800174-5.00001-6 · Cited by 52

Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet

Zhao, G., Yang, L., Zhong, W., Hu, Y., Tan, Y., Ren, Z., Ban, Q., Yang, C. S., Wang, Y., & Wang, Z. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.857879 · Cited by 49

Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells

Sanli, T., Storozhuk, Y., Linher‐Melville, K., Bristow, R. G., Laderoute, K. R., Viollet, B., Wright, J. R., Singh, G., & Tsakiridis, T. K. (2012) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2011.11.014 · Cited by 47

Impact of nutrient overload on metabolic homeostasis

Qiu, H., & Schlegel, V. L. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy023 · Cited by 51

Quzhou Fructus Aurantii Extract suppresses inflammation via regulation of MAPK, NF-κB, and AMPK signaling pathway

Li, L., Chen, J., Lin, L., Pan, G., Zhang, S., Chen, H., Zhang, M., Xuan, Y., Wang, Y., & You, Z. (2020) · Scientific Reports · doi:10.1038/s41598-020-58566-7 · Cited by 47

Sensing and responding to energetic stress: Evolution of the AMPK network

Craig, P. M., Moyes, C. D., & LeMoine, C. M. R. (2018) · Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2017.11.001 · Cited by 46

Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity

Wang, H., Lin, C., Yao, J., Shi, H., Zhang, C., Wei, Q., Lu, Y., Chen, Z., Xing, G., & Cao, X. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1858-9 · Cited by 48

Role of AMP-activated protein kinase on cardio-metabolic abnormalities in the development of diabetic cardiomyopathy: A molecular landscape

Haye, A., Ansari, M. A., Rahman, S. O., Shamsi, Y., Ahmed, D., & Sharma, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173376 · Cited by 47

AMPK pathway: an emerging target to control diabetes mellitus and its related complications

Kakoti, B. B., Alom, S., Deka, K., & Halder, R. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01420-8 · Cited by 50

AMPK-dependent and independent effects of AICAR and compound C on T-cell responses

Rao, E., Zhang, Y., Li, Q., Hao, J., Egilmez, N. K., Suttles, J., & Li, B. (2016) · Oncotarget · doi:10.18632/oncotarget.9277 · Cited by 45

Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth

Fritz, V., Benfodda, Z., Henriquet, C., Huré, S., Cristol, J., Michel, F., Carbonneau, M.-A., Casas, F., & Lluis Fajas, A. (2012) · Oncogene · doi:10.1038/onc.2012.523 · Cited by 44

5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis

Kumar, A., Giri, S., & Kumar, A. (2016) · Cellular Microbiology · doi:10.1111/cmi.12625 · Cited by 44

ATP‐citrate lyase is an epigenetic regulator to promote obesity‐related kidney injury

Chen, Y., Deb, D. K., Fu, X., Yi, B., Liang, Y., Du, J., He, L., & Li, Y. C. (2019) · The FASEB Journal · doi:10.1096/fj.201900213r · Cited by 43

Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication

Bagga, S., Rawat, S., Ajenjo, M., & Bouchard, M. J. (2016) · Virology · doi:10.1016/j.virol.2016.08.006 · Cited by 41

Angiotensin II affects inflammation mechanisms via AMPK-related signalling pathways in HL-1 atrial myocytes

Kim, N., Jung, Y., Nam, M., Sun Kang, M., Lee, M. K., Cho, Y., Choi, E.-K., Hwang, G.-S., & Soo Kim, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-09675-3 · Cited by 39

Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes

Li, B., Lee, D., Kang, Y. J., Yao, N.-Q., An, R., & Kim, Y. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.12.016 · Cited by 39

AMP‐activated protein kinase is involved in induction of protective autophagy in astrocytes exposed to oxygen‐glucose deprivation

Gabryel, B., Kost, A., Liśkiewicz, D., Liber, S., Machnik, G., Wiaderkiewicz, R., & Łabuzek, K. (2014) · Cell Biology International · doi:10.1002/cbin.10299 · Cited by 39

AMP-Activated Protein Kinase α1 Regulates Cardiac Gap Junction Protein Connexin 43 and Electrical Remodeling Following Pressure Overload

Alesutan, I., Voelkl, J. G. J., Stöckigt, F., Mia, S., Feger, M., Primeßnig, U., Sopjani, M., Muñoz, C., Borst, O., Gawaz, M., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369706 · Cited by 39

AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation

Hoogendijk, A. J., Pinhanços, S. S., van der Poll, T., & Wieland, C. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.413138 · Cited by 38

Effect of 6-gingerol on AMPK- NF-κB axis in high fat diet fed rats

Hashem, R. M., Rashed, L. A., Hassanin, K. M. A., Hetta, M. H., & Ahmed, A. O. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.035 · Cited by 38

Caloric restriction can improve learning and memory in C57/BL mice probably via regulation of the AMPK signaling pathway

Ma, L., Wang, R., Dong, W., & Zhao, Z. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.11.013 · Cited by 38

Germ‐free mice are not protected against diet‐induced obesity and metabolic dysfunction

Moretti, C. H., Schiffer, T. A., Li, X., Weitzberg, E., Carlström, M., & Lundberg, J. O. (2020) · Acta Physiologica · doi:10.1111/apha.13581 · Cited by 38

Metabolic functions of AMPK: Aspects of structure and of natural mutations in the regulatory gamma subunits

Moffat, C., & Harper, M. (2010) · IUBMB Life · doi:10.1002/iub.387 · Cited by 38

Metformin augments doxorubicin cytotoxicity in mammary carcinoma through activation of adenosine monophosphate protein kinase pathway

El‐Ashmawy, N. E., Khedr, N. F., El‐Bahrawy, H. A., & Mansour, H. E. A. (2017) · Tumor Biology · doi:10.1177/1010428317692235 · Cited by 38

Pharmacological and physiological activation of AMPK improves the spliceopathy in DM1 mouse muscles

Ravel‐Chapuis, A., Al-Rewashdy, A., Bélanger, G., & Jasmin, B. J. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy245 · Cited by 41

Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population

Song, H., Kim, H. N., Kweon, S., Choi, J., Shim, H. J., Cho, S., Chung, I. J., Park, Y., Kim, S. H., Choi, Y., et al. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22063 · Cited by 36

Modulatory effects of bombyxin on ecdysteroidogenesis in Bombyx mori prothoracic glands

Gu, S., Chen, C., Hsieh, Y.-C., Lin, P., & Young, S.-C. (2014) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2014.11.007 · Cited by 36

Metformin enhances cisplatin induced inhibition of cholangiocarcinoma cells via AMPK-mTOR pathway

Wandee, J., Prawan, A., Senggunprai, L., Kongpetch, S., Tusskorn, O., & Kukongviriyapan, V. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.05.046 · Cited by 36

Delayed Exercise Training Improves Obesity-Induced Chronic Kidney Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice

Juszczak, F., Vlassembrouck, M., Botton, O., Zwakhals, T., Decarnoncle, M., Tassin, A., Caron, N., & Declèves, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010350 · Cited by 35

Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels: pivotal roles in hemichannel-mediated cell injury

Chi, Y., Gao, K., Li, K., Nakajima, S., Kira, S., Takeda, M., & Yao, J. Q. (2014) · Journal of Cell Science · doi:10.1242/jcs.139089 · Cited by 36

Development of a model describing regulation of casein synthesis by the mammalian target of rapamycin (mTOR) signaling pathway in response to insulin, amino acids, and acetate

Castro, J. J., Apelo, S. I. A., Appuhamy, J. A. D. R. N., & Hanigan, M. D. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10591 · Cited by 35

Anti‐Tumorigenic Potential of a Novel Orlistat‐AICAR Combination in Prostate Cancer Cells

Wright, C. A., Iyer, A. K. V., Kaushik, V., & Azad, N. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26033 · Cited by 35

Pharmacological treatment of MASLD: contemporary treatment and future perspectives

Drygalski, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136518 · Cited by 39

Role of downregulated miR-133a-3p expression in bladder cancer: a bioinformatics study

Gao, L., Li, S., Tian, Y., Zhu, Q., Chen, G., Pang, Y., & Hu, X. T. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s137433 · Cited by 34

AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-κB Pathway in RAW264.7 Macrophages

Kumase, F., Takeuchi, K., Morizane, Y., Suzuki, J., Matsumoto, H., Kataoka, K., Al‐Moujahed, A., Maidana, D. E., Miller, J. W., & Vavvas, D. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147279 · Cited by 34

Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells

Ma, S., Jia, R., Li, D., & Shen, B. (2015) · BioMed Research International · doi:10.1155/2015/453986 · Cited by 32

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors

Matheson, C. J., Casalvieri, K. A., Backos, D. S., Minhajuddin, M., Jordan, C. T., & Reigan, P. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112316 · Cited by 32

Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions

Liu, B., Gan, X., Zhao, Y., Gao, J., & Yu, H. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00784-2 · Cited by 30

Growth inhibition of colon cancer cells by compounds affecting AMPK activity

Lea, M. A. (2014) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v6.i7.244 · Cited by 30

Lipopolysaccharide-Induced Loss of Cultured Rat Myenteric Neurons - Role of AMP-Activated Protein Kinase

Voss, U., & Ekblad, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114044 · Cited by 32

Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer

Tailor, D., Going, C. C., Resendez, A., Kumar, V., Nambiar, D. K., Li, Y., Dheeraj, A., LaGory, E. L., Ghoochani, A., Birk, A. M., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01137-4 · Cited by 31

Intermittent fasting—the future treatment in NASH patients?

Minciună, I., Gallage, S., Heikenwälder, M. F., Zelber‐Sagi, S., & Dufour, J. (2023) · Hepatology · doi:10.1097/hep.0000000000000330 · Cited by 31

Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier

Martínez-Zamora, A., Meseguer, S., Esteve, J. M., Villarroya, M., Aguado, C., Enrı́quez, J. A., Knecht, E., & Armengod, M. ‐. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144273 · Cited by 31

Pharmacological AMP kinase activators target the nucleolar organization and control cell proliferation

Kodiha, M., Salimi, A., Wang, Y. M., & Stochaj, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088087 · Cited by 29

Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson’s Disease

Mishra, A. K., Mishra, S., Rajput, C., Rasheed, M. S. U., Patel, D. K., & Singh, M. P. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9800-3 · Cited by 28

Leptin antagonism inhibits prostate cancer xenograft growth and progression

Philp, L., Rockstroh, A., Sadowski, M. C., Fard, A. T., Lehman, M., Tevž, G., Libério, M. S., Bidgood, C. L., Gunter, J. H., McPherson, S. J., et al. (2021) · Endocrine Related Cancer · doi:10.1530/erc-20-0405 · Cited by 29

Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain

de Souza, R. P., Tiwari, A. K., Chowdhury, N. I., Ceddia, R. B., Lieberman, J. A., Meltzer, H. Y., Kennedy, J. L., & Müller, D. J. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.010 · Cited by 29

Functional profile of oral plaque microbiome: Further insight into the bidirectional relationship between type 2 diabetes and periodontitis

Favale, N., Fariña, R., Carrieri, A., Simonelli, A., Severi, M., Sabbioni, S., Trombelli, L., & Scapoli, C. (2023) · Molecular Oral Microbiology · doi:10.1111/omi.12418 · Cited by 31

Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via β3-adrenergic Receptor-p38 MAPK Signaling Pathway

Manigandan, S., & Yun, J. W. (2020) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-020-0149-8 · Cited by 28

Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP

Zhang, Q., Li, W., Zhu, Y., Wang, Q., Zhai, C., Shi, W., Feng, W., Wang, J., Yan, X., Chai, L., et al. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04131-3 · Cited by 28

AMP-Activated Protein Kinase Regulates Intraocular Pressure, Extracellular Matrix, and Cytoskeleton in Trabecular Meshwork

Chatterjee, A., Villarreal, G., Oh, D., Kang, M. H., & Rhee, D. J. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12755 · Cited by 28

Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response

Lin, K.-C., Huang, D.-Y., Huang, D.-W., Tzeng, S., & Lin, W. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1339-2 · Cited by 26

Dual inhibiting OCT4 and AKT potently suppresses the propagation of human cancer cells

Li, W., Zhou, Y., Zhang, X., Yang, Y., Dan, S., Su, T., She, S., Dong, W., Zhao, Q. D., Jia, J., et al. (2017) · Scientific Reports · doi:10.1038/srep46246 · Cited by 25

Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling

Bi, X., He, X., Xu, M., Zhao, M. F., Yu, X., Lu, X., & Zang, W. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1060383 · Cited by 27

Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes

Rallis, C., Townsend, S., & Bähler, J. (2017) · Scientific Reports · doi:10.1038/srep44257 · Cited by 23

Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase

Dong, S., Baranwal, S., García, A., Serrano-Gomez, S. J., Eastlack, S. C., Iwakuma, T., Mercante, D. E., Mauvais‐Jarvis, F., & Alahari, S. K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784256 · Cited by 25

Mutual promotion of FGF21 and PPARγ attenuates hypoxia-induced pulmonary hypertension

Cai, G., Liu, J., Wang, M., Su, L., Cai, M., Huang, K., Li, X., Li, M., Wang, L., & Huang, X. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219828692 · Cited by 26

Linking cellular energy state to atrial fibrillation pathogenesis: Potential role of adenosine monophosphate–activated protein kinase

Chakraborty, P., Nattel, S., & Nanthakumar, K. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.03.025 · Cited by 27

Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy

Wang, L., Zhao, D., Tang, L., Li, H., Liu, Z., Gao, J., Edin, M. L., Zhang, H., Zhang, K., Chen, J., et al. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.12.013 · Cited by 26

A new role for AMP ‐activated protein kinase in the circadian regulation of L‐type voltage‐gated calcium channels in late‐stage embryonic retinal photoreceptors

Huang, C. C., Shi, L., Lin, C., Kim, A. J., Ko, M. L., & Ko, G. Y. ‐. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13349 · Cited by 27

Differential regulation of the fiber type-specific gene expression of the sarcoplasmic reticulum calcium-ATPase isoforms induced by exercise training

Morissette, M., Susser, S. E., Stammers, A. N., O’Hara, K. A., Gardiner, P. F., Sheppard, P. C., Moffatt, T. L., & Duhamel, T. A. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00092.2014 · Cited by 26

Protective effect of irbesartan against doxorubicin-induced nephrotoxicity in rats: implication of AMPK, PI3K/Akt, and mTOR signaling pathways

Mohamed, E. A., Ahmed, H. I., & Zaky, H. S. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0259 · Cited by 26

Inhibition of AMP Deaminase Activity Does Not Improve Glucose Control in Rodent Models of Insulin Resistance or Diabetes

Admyre, T., Amrot-Fors, L., Andersson, M., Bauer, M., Bjursell, M., Drmota, T., Hallén, S., Hartleib‐Geschwindner, J., Lindmark, B., Liu, J., et al. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.011 · Cited by 26

Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design: Miniperspective

Miglianico, M., Nicolaes, G. A. F., & Neumann, D. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01201 · Cited by 24

Small Molecule Modulators of AMP-Activated Protein Kinase (AMPK) Activity and Their Potential in Cancer Therapy

Strang, J. E., Astridge, D. D., Nguyen, V., & Reigan, P. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02354 · Cited by 27

Page /1 19 AMPK inhibition in health and disease

Rev, C., Mol, B., Viollet, B., Horman, R., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andréelli, F. (2015)

AMPK in Health and Disease

Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,672

Maintaining Energy Balance in Health and Disease: Role of the AMP-Activated Protein Kinase

Scott, J. W. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6382-6_9 · Cited by 2

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.004 · Cited by 485

AMPK: a metabolic gauge regulating whole-body energy homeostasis

Lage, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.007 · Cited by 512