The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
AMPK inhibition in health and disease
Open accessAbstract
All living organisms depend on dynamic mechanisms that repeatedly reassess the status of amassed energy, in order to adapt energy supply to demand. The AMP-activated protein kinase (AMPK) alphabetagamma heterotrimer has emerged as an important integrator of signals managing energy balance. Control of AMPK activity involves allosteric AMP and ATP regulation, auto-inhibitory features and phosphorylation of its catalytic (alpha) and regulatory (beta and gamma) subunits. AMPK has a prominent role not only as a peripheral sensor but also in the central nervous system as a multifunctional metabolic regulator. AMPK represents an ideal second messenger for reporting cellular energy state. For this reason, activated AMPK acts as a protective response to energy stress in numerous systems. However, AMPK inhibition also actively participates in the control of whole body energy homeostasis. In this review, we discuss recent findings that support the role and function of AMPK inhibition under physiological and pathological states.
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“It comprises three sub-units, each of which have multiple isoforms and confer tissue specificity (549).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [549]
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5 retracted
Activation of the AMP-activated Protein Kinase by the Anti-diabetic Drug Metformin in Vivo
Zou, M., Kirkpatrick, S. S., Davis, B. J., Nelson, J. S., Wiles, W. G., Schlattner, U., Neumann, D., Brownlee, M., Freeman, M. B., & Goldman, M. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404421200 · Cited by 480
RetractedActivation of Protein Phosphatase 2A by Palmitate Inhibits AMP-activated Protein Kinase
Wu, Y., Song, P., Xu, J., Zhang, M., & Zou, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608310200 · Cited by 283
RetractedRopelle, E. R., Pauli, J. R., Fernandes, M. F., Rocco, S. A., Marin, R. M., Morari, J., Souza, K. K., Dias, M. M., Gomes‐Marcondes, M. C. C., Gontijo, J. A. R., et al. (2007) · Diabetes · doi:10.2337/db07-0573 · Cited by 214
RetractedDual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
Nieto-Vazquez, I., Fernández-Veledo, S., de Alvaro, C., & Lorenzo, M. (2008) · Diabetes · doi:10.2337/db07-1062 · Cited by 209
RetractedWang, S., Xu, J. C., Song, P., Viollet, B., & Zou, M. (2009) · Diabetes · doi:10.2337/db09-0267 · Cited by 137
Self-citationRetractedUnderstanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Research works printed but not linked: 18
- Arad M, 2002, J Clin Invest, 109, 357, 10.1172/JCI0214571 · DOI
- Bai A, 2010, J Pharmacol Exp Ther. (in press).
- Billaud M, 2008, Metformin: Mechanistic Insights Towards New Applications
- Bradley EA, 2010, Arterioscler Thromb Vasc Biol 30: 1137-1142.
- Brochu M, 2001, J Clin Endocrinol Metab, 86, 1020
- Fogarty S, 2009, Biochim Biophys Acta 1804: 581-591.
- 10.1152/ajpregu.90971.2008 · DOI
- Lee JH, 2007, Nature 447:1017-1020.
- Lopaschuk GD, 1990, Circ Res, 66, 546, 10.1161/01.RES.66.2.546 · DOI
- Muse ED, 2004, J Clin Invest, 114, 232, 10.1172/JCI200421270 · DOI
- Olson DP, 2010, Proc Natl Acad Sci USA.
- Osuka K, 2009, J Neurotrauma 26: 1157-1165
- Proud CG, 1997, Biochem J, 328, 329, 10.1042/bj3280329 · DOI
- 10.1042/bj3340177 · DOI
- 10.1042/bj3350533 · DOI
- Scott JW, 2004, J Clin Invest, 113, 274, 10.1172/JCI19874 · DOI · Paper page
- Viollet B, 2003, J Clin Invest, 111, 91, 10.1172/JCI16567 · DOI · Paper page
- Viollet B, 2003, J Clin Invest, 111, 91, 10.1172/JCI16567 · DOI · Paper page
Cited by
Sorted by citations
AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Structural basis of AMPK regulation by small molecule activators
Xiao, B., Sanders, M. J., Carmena, D., Bright, N. J., Haire, L. F., Underwood, E., Patel, B. R., Heath, R. B., Walker, P. A., Hallén, S., et al. (2013) · Nature Communications · doi:10.1038/ncomms4017 · Cited by 566
Pinkosky, S. L., Newton, R. S., Day, E. A., Ford, R. J., Lhotak, S., Austin, R. C., Birch, C. M., Smith, B. K., Filippov, S., Groot, P. H. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms13457 · Cited by 498
Chronic inflammation and the hallmarks of aging
Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471
Metadata
- Authors
- Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F.
- Affiliations
- UCLouvain (BE)
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Mayo Clinic (US)
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2010-06-04
- Volume
- 45
- Issue
- 4
- Pages
- 276-295
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- PMC
- PMC3132561
- OpenAlex
- W2015171350
- Cited by
- 383
- References
- 226
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 11 · 2023: 18 · 2022: 22 · 2021: 23 · 2020: 39 · 2019: 22 · 2018: 34 · 2017: 33 · 2016: 38 · 2015: 30 · 2014: 27 · 2013: 25 · 2012: 19
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Funders
- European Commission
- Agence Nationale de la Recherche (ANR-06-PHYS-0026)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- AMPK, AMPK inhibition, energy homeostasis, allosteric regulation, protein phosphorylation, central nervous system metabolism
- MeSH terms
- Animals, Energy Metabolism, Enzyme Activation, Humans, Down-Regulation, AMP-Activated Protein Kinases
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