AMPK inhibition in health and disease

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093

Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension

Xiong, P. Y., Potus, F., Chan, W. W. Y., & Archer, S. L. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.08824 · Cited by 27

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation

Quenneville, S., Labouèbe, G., Basco, D., Metref, S., Viollet, B., Foretz, M., & Thorens, B. (2020) · Diabetes · doi:10.2337/db20-0577 · Cited by 24

Comparative analyses of liver transcriptomes reveal the effect of exercise on growth-, glucose metabolism-, and oxygen transport-related genes and signaling pathways in grass carp (Ctenopharyngodon idella)

Zhang, L., Li, X., Yu, Y., Zhang, L., Dong, L., Gan, J., Mao, T., Liu, T., Peng, J., & He, L. (2021) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2021.111081 · Cited by 24

Leptin Influence Cholelithiasis Formation by Regulating Bile Acid Metabolism

Wen, J., Yu, J., Lei, Z.-M., He, J., Ye, M., & Fu, W. (2020) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2020.19594 · Cited by 24

Effects of moderate exercise on hepatic amino acid and fatty acid composition, liver transcriptome, and intestinal microbiota in channel catfish (Ictalurus punctatus)

Zhang, L., Yu, Y., Dong, L., Gan, J., Mao, T., Liu, T., Li, X., & He, L. (2021) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2021.100921 · Cited by 24

3,3′-Diindolylmethane Protects against Cardiac Hypertrophy via 5′-Adenosine Monophosphate-Activated Protein Kinase-α2

Zong, J., Deng, W., Zhou, H., Bian, Z., Dai, J., Yuan, Y., Zhang, J., Zhang, R., Zhang, Y., Wu, Q., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053427 · Cited by 24

Mice lacking AMP-activated protein kinase α1 catalytic subunit have increased bone remodelling and modified skeletal responses to hormonal challenges induced by ovariectomy and intermittent PTH treatment

Jeyabalan, J., Shah, M., Viollet, B., Roux, J. P., Chavassieux, P., Korbonits, M., & Chenu, C. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0184 · Cited by 24

L‐rhamnose induces browning in 3T3‐L1 white adipocytes and activates HIB1B brown adipocytes

Choi, M., Mukherjee, S., Kang, N. H., Lone, J. B., Parray, H. A., & Yun, J. W. (2018) · IUBMB Life · doi:10.1002/iub.1750 · Cited by 25

AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170

Yashirogi, S., Nagao, T., Nishida, Y., Takahashi, Y., Qaqorh, T., Yazawa, I., Katayama, T., Kioka, H., Matsui, T. S., Saito, S., et al. (2020) · EMBO Reports · doi:10.15252/embr.202050949 · Cited by 21

‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects

Schmidt, M. C., & O’Donnell, A. F. (2020) · Current Genetics · doi:10.1007/s00294-020-01122-7 · Cited by 24

Triggering receptor expressed on myeloid cells and 5’adenosine monophosphate-activated protein kinase in the inflammatory response: a potential therapeutic target

Thankam, F. G., Dilisio, M. F., Dougherty, K. A., Dietz, N. E., & Agrawal, D. K. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1196138 · Cited by 22

Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism

Kaphalia, L., Srinivasan, M. P., Kakumanu, R. D., Kaphalia, B. S., & Calhoun, W. J. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14131 · Cited by 22

Obesity-induced miR-802 directly targets AMPK and promotes nonalcoholic steatohepatitis in mice

Sun, H., Seok, S., Jung, H.-K., KEMPER, B. W., & Kemper, J. K. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101603 · Cited by 22

Electroacupuncture inhibits weight gain in diet-induced obese rats by activating hypothalamicLKB1-AMPK signaling

Xu, J., Chen, L., Tang, L., Chang, L., Liu, S., Tan, J., Chen, Y., Ren, Y., Liang, F., & Cui, J. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0667-7 · Cited by 22

Differential regulation of AMPK activation in leptin‐and creatine‐deficient mice

Stockebrand, M. C., Sauter, K., Neu, A. D., Isbrandt, D., & Choe, C. (2013) · The FASEB Journal · doi:10.1096/fj.12-225136 · Cited by 22

AutophagySMDB: a curated database of small molecules that modulate protein targets regulating autophagy

Nanduri, R., Kalra, R., Bhagyaraj, E., Chacko, A. P., Ahuja, N., Tiwari, D., Kumar, S. R., Jain, M., Parkesh, R., & Gupta, P. K. (2019) · Autophagy · doi:10.1080/15548627.2019.1571717 · Cited by 22

Mogrol attenuates lipopolysaccharide (LPS)-induced memory impairment and neuroinflammatory responses in mice

Wang, H., Meng, G., Zhang, C., Wang, H., Hu, M. Y., Long, Y., Hong, H., & Tang, S. (2019) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2019.1642878 · Cited by 22

Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells

Kwon, B., Gamache, T., Lee, H., & Querfurth, H. W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.05.012 · Cited by 23

Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence

Grabowska, W., Mosieniak, G., Achtabowska, N., Czochara, R., Litwinienko, G., Bojko, A., Sikora, E., & Bielak-Żmijewska, A. (2019) · Biogerontology · doi:10.1007/s10522-019-09825-2 · Cited by 22

CD47 Deficiency Attenuates Isoproterenol-Induced Cardiac Remodeling in Mice

Zuo, Z., Ji, M., Zhao, K., Su, Z., Li, P., Hou, D., & Li, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7121763 · Cited by 21

Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement

HEINONEN, I. H. A., Sorop, O., van Dalen, B. M., Wüst, R. C. I., van de Wouw, J., de Beer, V. J., Octavia, Y., van Duin, R. W. B., Hoogstrate, Y., Blonden, L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-68637-4 · Cited by 21

Genipin and insulin combined treatment improves implant osseointegration in type 2 diabetic rats

Zhang, J., Wang, Y., Jia, T., Huang, H., Zhang, D., & Xu, X. (2021) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-021-02210-1 · Cited by 21

Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders

Su, K., & Dai, C. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2291-1 · Cited by 22

Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo

Duivenvoorden, W., Beatty, L. K., Lhoták, Š., Hill, B., Mak, I. W. Y., Paulin, G. A., Gallino, D., Popović, S., Austin, R. C., & Pinthus, J. H. (2013) · British Journal of Cancer · doi:10.1038/bjc.2012.574 · Cited by 20

Nucleobindin‑2 enhances the epithelial‑mesenchymal transition in renal cell carcinoma

Tao, R., Niu, W., Dou, P., Ni, S., Yu, Y., Cai, L., Wang, X., Li, S., Zhang, C., & Luo, Z. (2020) · Oncology Letters · doi:10.3892/ol.2020.11526 · Cited by 20

Estrogen regulates energy metabolic pathway and upstream adenosine 5′‐monophosphate‐activated protein kinase and phosphatase enzyme expression in dorsal vagal complex metabolosensory neurons during glucostasis and hypoglycemia

Tamrakar, P., Ibrahim, B. A., Gujar, A. D., & Briski, K. P. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23481 · Cited by 20

Toll-Like Receptor 9–Dependent AMPKα Activation Occurs via TAK1 and Contributes to RhoA/ROCK Signaling and Actin Polymerization in Vascular Smooth Muscle Cells

McCarthy, C. G., Wenceslau, C. F., Ogbi, S. N., Szasz, T., & Webb, R. C. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.245746 · Cited by 20

AICAR prolongs corneal allograft survival via the AMPK-mTOR signaling pathway in mice

Li, J., Liu, T., Xie, L., Ouyang, C., Ji, J., & Huang, T. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.019 · Cited by 20

The role of AMPK signaling pathway in the pathogenesis of type 2 diabetes mellitus with its complications and related metabolic disorders

Tesfa, K. H., Gebeyehu, C. D., Ewunetie, A. T., Gugsa, E., Zewdie, A. N., Dessie, G., & Endale, H. T. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100397 · Cited by 28

Compound C, a Broad Kinase Inhibitor Alters Metabolic Fingerprinting of Extra Cellular Matrix Detached Cancer Cells

Mohammed, M. R. S., Alghamdi, R., Alzahrani, A. M., Zamzami, M. A., Choudhry, H., & Khan, M. I. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.612778 · Cited by 20

ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model

Zhan, Z., Li, A., Zhang, W., Wu, X., He, J., Li, Z., Li, Y., Sun, J. H., & Zhang, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.914865 · Cited by 19

The rational design of a novel potent analogue of the 5′-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity

Machrouhi, F., Ouhamou, N., Laderoute, K. R., Calaoagan, J. M., Bukhtiyarova, M., Ehrlich, P. J., & Klon, A. E. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.09.088 · Cited by 19

Innovative Approach of Non-Thermal Plasma Application for Improving the Growth Rate in Chickens

Zhang, J., Wang, X., Kwon, T., Huynh, D. L., Chandimali, N., Kim, N., Kang, T. Y., Ghosh, M., Gera, M., Lee, S. B., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082301 · Cited by 19

Xiaokeyinshui extract combination, a berberine-containing agent, exerts anti-diabetic and renal protective effects on rats in multi-target mechanisms

Zhou, J., Pan, J., Xiang, Z.-N., Wang, Q., Tong, Q., Fang, J., Wan, L.-S., & Chen, J. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113098 · Cited by 19

Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies

du Toit‐Thompson, T., Leck, L. Y. W., Gillson, J., Pavlakis, N., Gill, A. J., Samra, J. S., Mittal, A., & Sahni, S. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115647 · Cited by 20

Regulation of brain-type creatine kinase by AMP-activated protein kinase: Interaction, phosphorylation and ER localization

Ramírez‐Ríos, S., Lamarche, F., Cottet‐Rousselle, C., Klaus, A., Tuerk, R. D., Thali, R. F., Auchli, Y., Brunisholz, R., Neumann, D., Barret, L. G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.03.020 · Cited by 18

Pharmacological Approaches to Decelerate Aging: A Promising Path

Hassani, B., Goshtasbi, G., Nooraddini, S., & Firouzabadi, N. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4201533 · Cited by 19

Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitis

Feng, Q., Li, Y., Zhang, H., Wang, Z., Nie, X., Yao, D., Lu, H., Chen, W., & Wang, Y. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.09.018 · Cited by 19

Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis

Liao, J., Yu, X., Chen, J., Wu, Z., He, Q., Zhang, Y., Song, W., Luo, J., & Tao, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1063018 · Cited by 19

Hypoxia and its effect on the cellular system

Rahane, D., Dhingra, T., Chalavady, G., Datta, A., Ghosh, B., Rana, N., Borah, A., Saraf, S., & Bhattacharya, P. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3940 · Cited by 20

Optimal control strategies of eradicating invisible glioblastoma cells after conventional surgery

Reyes, A. A. D. L., V, Jung, E., & Kim, Y. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.1392 · Cited by 18

AMP-activated protein kinase α1 in Megalobrama amblycephala: Molecular characterization and the transcriptional modulation by nutrient restriction and glucose and insulin loadings

Xu, C., Li, X., Shi, H., Liu, J., Zhang, L., & Liu, W. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.05.030 · Cited by 18

Knockout model reveals the role of Nischarin in mammary gland development, breast tumorigenesis and response to metformin treatment

Dong, S., Ruiz‐Calderon, B., Rathinam, R., Eastlack, S. C., Maziveyi, M., & Alahari, S. K. (2019) · International Journal of Cancer · doi:10.1002/ijc.32690 · Cited by 18

Induction of mitophagy in C2C12 cells by electrical pulse stimulation involves increasing the level of the mitochondrial receptor FUNDC1 through the AMPK-ULK1 pathway.

Gao, J., Liang, Y., Wang, Z., Wang, R., & Liu, X. (2020) · PubMed · Cited by 18

Tetraspanins stimulate protein synthesis in myeloma cell lines

Zismanov, V., Drucker, L., Attar‐Schneider, O., Matalon, S. T., Pasmanik‐Chor, M., & Lishner, M. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24126 · Cited by 17

AMPK-α2is involved in exercise training-induced adaptations in insulin-stimulated metabolism in skeletal muscle following high-fat diet

Abbott, M. J., & Turcotte, L. P. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01380.2013 · Cited by 17

AMP-activated protein kinase α1-sensitive activation of AP-1 in cardiomyocytes

Voelkl, J. G. J., Alesutan, I., Primeßnig, U., Feger, M., Mia, S., Jungmann, A., Castor, T., Viereck, R., Stöckigt, F., Borst, O., et al. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.04.009 · Cited by 18

Effect of palmitoylethanolamide on inner retinal function in glaucoma: a randomized, single blind, crossover, clinical trial by pattern-electroretinogram

Rossi, G. C. M., Scudeller, L., Lumini, C., Bettio, F., Picasso, E., Ruberto, G., Briola, A., Mirabile, A. V., Paviglianiti, A., Pasinetti, G. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67527-z · Cited by 16

Prepubertal exposure to Pb alters autophagy in the brain of aging mice: A time-series based model

Bai, L., Wu, Y., Wang, R., Liu, R., Liu, M., Li, Q., Ba, Y., Zhang, H., Zhou, G., Yu, F., et al. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.08.013 · Cited by 16

Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice

Hughey, C. C., Bracy, D. P., Rome, F. I., Goelzer, M., Donahue, E. P., Viollet, B., Foretz, M., & Wasserman, D. H. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00289.2023 · Cited by 15

Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases

Yang, C., Rubin, L., Yu, X., Lazarovici, P., & Zheng, W. (2024) · Medicinal Research Reviews · doi:10.1002/med.22014 · Cited by 16

6-Gingerol microneedle promotes diabetic wound healing by regulating macrophage polarization

Ling, Y., He, Q., Zhang, Y., Luo, H., Xiang, W. D., Deng, C., Li, C., Li, X., Yao, L., Ke, D., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114288 · Cited by 17

Inhibition by fluoxetine of LH-stimulated cyclic AMP synthesis in tumor Leydig cells partly involves AMPK activation

Nguyen, T. M. D., Klett, D., Filliatreau, L., & Combarnous, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217519 · Cited by 16

Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents

Huet, C., Boudaba, N., Guigas, B., Viollet, B., & Foretz, M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010244 · Cited by 18

AMPKα2 controls the anti-atherosclerotic effects of fish oils by modulating the SUMOylation of GPR120

Yan, C., Liu, H., Tian, X.-X., Li, J., Ye, D., Li, Y., Mei, Z., Zou, M., & Han, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-34996-x · Cited by 15

Impact of AMP-Activated Protein Kinase α1 Deficiency on Tissue Injury following Unilateral Ureteral Obstruction

Mia, S., Federico, G., Feger, M., Pakladok, T., Meissner, A., Voelkl, J. G. J., Gröne, H., Alesutan, I., & Lang, F. J. W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135235 · Cited by 15

Astragalus polysaccharide alleviates transport stress-induced heart injury in newly hatched chicks via ERS-UPR-autophagy dependent pathway

Chen, J., Tang, Y.-X., Kang, J.-X., Xu, Y., Elsherbeni, A. I. A., Gharib, H. B., & Li, J. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102030 · Cited by 17

Stress-Induced Premature Senescence Related to Oxidative Stress in the Developmental Programming of Nonalcoholic Fatty Liver Disease in a Rat Model of Intrauterine Growth Restriction

Keshavjee, B., Lambelet, V., Coppola, H., Viertl, D., Prior, J. O., Kappeler, L., Armengaud, J.-B., Chouraqui, J.-P., Chehade, H., Vanderriele, P., et al. (2022) · Antioxidants · doi:10.3390/antiox11091695 · Cited by 17

Reactive Oxygen Species: Friends and Foes of Signal Transduction

Retta, S. F., Chiarugi, P., Trabalzini, L., Pinton, P., & Belkin, A. M. (2012) · Journal of Signal Transduction · doi:10.1155/2012/534029 · Cited by 16

Growth and male reproduction improvement of non-thermal dielectric barrier discharge plasma treatment on chickens

Zhang, J., Huynh, D. L., Chandimali, N., Kang, T. Y., Kim, N., Mok, Y. S., Kwon, T., & Jeong, D. K. (2018) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/aabd9a · Cited by 15

Insulin-sensitizing and insulin-mimetic activities of Sarcopoterium spinosum extract

Rozenberg, K., Smirin, P., Sampson, S. R., & Rosenzweig, T. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.05.030 · Cited by 14

Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells

Monleón, D. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.802 · Cited by 14

Antiobesity effects of a–lipoic acid supplementation

Fernández‐Galilea, M., Prieto-Hontoria, P. L., Martínez, J. A., & Moreno-Aliaga, M. J. (2013) · Clinical Lipidology · doi:10.2217/clp.13.19 · Cited by 15

AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms

Kopsiaftis, S., Hegde, P., Taylor, J. A., & Claffey, K. P. (2016) · Translational Oncology · doi:10.1016/j.tranon.2016.07.007 · Cited by 14

Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK

Morita, N., Hosaka, T., Kitahara, A., Murashima, T., Onuma, H., Sumitani, Y., Takahashi, K., Tanaka, T., Kondo, T., & Ishida, H. (2018) · Journal of Diabetes Research · doi:10.1155/2018/9256482 · Cited by 15

MUL1 E3 ligase regulates the antitumor effects of metformin in chemoresistant ovarian cancer cells via AKT degradation

Lee, J., An, S., Jung, J. H., Kim, K., Kim, J. E., An, I., & Bae, S. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4730 · Cited by 14

Inactivated AMPK-α2 promotes the progression of diabetic brain damage by Cdk5 phosphorylation at Thr485 site

Li, Y., Xiang, Q., Yao, Y.-H., Li, J., Wang, Y., & Li, X.-H. (2019) · Biochimie · doi:10.1016/j.biochi.2019.11.010 · Cited by 14

Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice

Tokarska-Schlattner, M., Kay, L., Perret, P., Isola, R., Attia, S., Lamarche, F., Tellier, C., Cottet‐Rousselle, C., Uneisi, A., Hininger‐Favier, I., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.731015 · Cited by 13

Targeting AMPK for Therapeutic Intervention in Type 2 Diabetes

Kodiha, M., & Stochaj, U. (2011) · InTech eBooks · doi:10.5772/20930 · Cited by 14

Modulations in human neutrophil metabolome and S-glutathionylation of glycolytic pathway enzymes during the course of extracellular trap formation

Awasthi, D., Nagarkoti, S., Sadaf, S., Aggarwal, H., Gupta, S. K., Chandra, T., Kumar, Y., Kumar, S., & Dikshit, M. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166581 · Cited by 13

Shikonin Inhibits Fin Regeneration in Zebrafish Larvae

Cao, Z., Guo, C., Chen, G., Liu, J., Ni, H., Liu, F., Xiong, G., Liao, X., & Lu, H. (2022) · Cells · doi:10.3390/cells11203187 · Cited by 11

Current insights in molecular characterization of non-alcoholic fatty liver disease and treatment

Che, W., Zhao, M., Li, X., Li, C., Cho, W. C. S., & Yu, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1002916 · Cited by 12

Screening methods for AMP-activated protein kinase modulators: a patent review

Kim, J., Shin, J., & Ha, J. (2014) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2014.995626 · Cited by 13

STING signalling: an emerging common pathway in autoimmunity and cancer

McCaffary, D. (2017) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2017.1350704 · Cited by 13

Dietary Technologies to Optimize Healing from Injury-Induced Inflammation

Sears, B., Perry, M., & Saha, A. K. (2020) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523019666200512114210 · Cited by 13

Loss of family with sequence similarity 107, member A (FAM107A) induces browning in 3T3-L1 adipocytes

Manigandan, S., Mukherjee, S., & Yun, J. W. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108885 · Cited by 12

Dihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cells

Hernandez, A., Sonavane, M., Smith, K. R., Seiger, J., Migaud, M. E., & Gassman, N. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278516 · Cited by 12

Primary Cilia Bend LKB1 and mTOR to Their Will

Aznar, N., & Billaud, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.11.016 · Cited by 12

Regulatory role of cardiomyocyte metabolism via AMPK activation in modulating atrial structural, contractile, and electrical properties following atrial fibrillation

Brown, S. M., Larsen, N. K., Thankam, F. G., & Agrawal, D. K. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0313 · Cited by 12

Short-chain C2 ceramide induces heme oxygenase-1 expression by upregulating AMPK and MAPK signaling pathways in rat primary astrocytes

Jung, J.-S., Choi, M. J., Ko, H.-M., & Kim, H.-S. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.02.004 · Cited by 12

Study of AMPK-Regulated Metabolic Fluxes in Neurons Using the Seahorse XFe Analyzer

Marinangeli, C., Kluza, J., Marchetti, P., Buée, L., & Vingtdeux, V. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7598-3_19 · Cited by 11

Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type-1 receptor and adiponectin receptor-1

Zha, D., Yao, T., Bao, L., Gao, P. H., & Wu, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.044 · Cited by 11

Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance

Vera, D. M., López-Gambero, A. J., Navarro, J. A., Sanjuan, C., Baixerás, E., Decara, J. M., & de Fonseca, F. R. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.379015 · Cited by 10

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

Tong, W., Allison, B. J., Brain, K. L., Patey, O. V., Niu, Y., Botting, K. J., Ford, S. G., Garrud, T. A. C., Wooding, F. B. P., Lyu, Q., et al. (2025) · The Journal of Physiology · doi:10.1113/jp287897 · Cited by 14

Stimulation of Cardiomyogenesis of Embryonic Stem Cells by Nitric Oxide Downstream of AMP-Activated Protein Kinase and mTOR Signaling Pathways

Padmasekar, M., Sharifpanah, F., Finkensieper, A., Wartenberg, M., & Sauer, H. (2011) · Stem Cells and Development · doi:10.1089/scd.2010.0581 · Cited by 10

Irradiation of carotid baroreceptor with low‐intensity pulsed ultrasound exerts different metabolic protection in perirenal, epididymal white adipose tissue and interscapular brown adipose tissue of obese rats

Cao, Q., Liu, L., Hu, Y., Jiang, N., Wang, Y., Chen, J., Zhou, Q. S., & Guo, R. (2020) · The FASEB Journal · doi:10.1096/fj.202001550r · Cited by 10

Putative Role of AMPK in Fetal Adaptive Brain Shut-Down: Linking Metabolism and Inflammation in the Brain

Frasch, M. G. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00150 · Cited by 10

Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism

Novikova, D., Garabadzhiu, A. V., Melino, G., Barlev, N. A., & Tribulovich, V. G. (2015) · Russian Chemical Bulletin · doi:10.1007/s11172-015-1036-x · Cited by 10

Effect of consuming endophyte-infected fescue seed on transcript abundance in the mammary gland of lactating and dry cows, as assessed by RNA sequencing

Capuco, A. V., Bickhart, D. M., Li, C., Evock-Clover, C. M., Choudhary, R. K., Grossi, P., Bertoni, G., Trevisi, E., Aiken, G. E., McLeod, K. R., et al. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-14735 · Cited by 10

Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?

Kim, W. (2015) · International Neurourology Journal · doi:10.5213/inj.2015.19.2.55 · Cited by 11

Tryptanthrin Regulates Vascular Smooth Muscle Cell Phenotypic Switching in Atherosclerosis by AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Signaling Pathway

Shi, X., Zhang, Y., Han, J., Peng, W., Fang, Z., Qin, Y., Xu, X., Lin, J., Xiao, F., Zhao, L., et al. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001008 · Cited by 10

The role and function of lncRNA in ageing-associated liver diseases

Zarandi, P. K., Ghiasi, M., & Heiat, M. (2024) · RNA Biology · doi:10.1080/15476286.2024.2440678 · Cited by 10

Sustained AMPK Activation and Proline Metabolism Play Critical Roles in the Survival of Matrix-Deprived Transformed Cells

Saha, M., Deshpande, N., Dubey, A., Pal, D., Atreya, H. S., & Rangarajan, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.771366 · Cited by 11

A novel network-based approach for discovering dynamic metabolic biomarkers in cardiovascular disease

Baumgärtner, C., Spath-Blass, V., Niederkofler, V., Bergmoser, K. M., Langthaler, S., Lassnig, A., Rienmüller, T. M., Baumgartner, D., Asnani, A. H., & Gerszten, R. E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208953 · Cited by 9

AMPK activation; a potential strategy to mitigate TKI-induced cardiovascular toxicity

Safaie, N., Idari, G., Ghasemi, D., Hajiabbasi, M., Alivirdiloo, V., Masoumi, S., Zavvar, M., Majidi, Z., & Faridvand, Y. (2024) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2024.2426494 · Cited by 8

Cytochrome P450 2F2 (CYP2F2) negatively regulates browning in 3T3-L1 white adipocytes

Dang, T. T. H., Choi, M., Pham, H. G., & Yun, J. W. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174318 · Cited by 8

Defining the short-term effects of pharmacological 5′-AMP activated kinase modulators on mitochondrial polarization, morphology and heterogeneity

Kodiha, M., Flamant, E. M., Wang, Y. M., & Stochaj, U. (2018) · PeerJ · doi:10.7717/peerj.5469 · Cited by 8

The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus

Aydın, S., Tekinalp, S. G., Tuzcu, B., Çam, F., Sevik, M. O., Tatar, E., Kalaskar, D. M., & Çam, M. E. (2024) · Obesity Medicine · doi:10.1016/j.obmed.2024.100577 · Cited by 8

In Vivo Two-Photon Imaging Analysis of Dynamic Degradation of Hepatic Lipid Droplets in MS-275-Treated Mouse Liver

Lee, C.-G., Lee, S., Park, S., Choi, S., Song, M., Lee, H. W., Kim, H. J., KANG, Y. Y., Lee, K. W., Kim, H. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179978 · Cited by 7

Competing endogenous RNAs in human astrocytes: crosstalk and interacting networks in response to lipotoxicity

Gil‐Jaramillo, N., Aristizábal-Pachón, A. F., Aleman, M. A. L., Gómez, V. G., Hurtado, H. D. E., Pinto, L. C. G., Camacho, J. S. J., Rojas-Cruz, A. F., González‐Giraldo, Y., Pinzón, A. M., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1195840 · Cited by 7

Page /1 19 AMPK inhibition in health and disease

Rev, C., Mol, B., Viollet, B., Horman, R., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andréelli, F. (2015)

AMPK in Health and Disease

Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,672

Maintaining Energy Balance in Health and Disease: Role of the AMP-Activated Protein Kinase

Scott, J. W. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6382-6_9 · Cited by 2

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.004 · Cited by 485

AMPK: a metabolic gauge regulating whole-body energy homeostasis

Lage, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.007 · Cited by 512