AMPK inhibition in health and disease

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093

AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860

Placental Origins of Chronic Disease

Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717

Structural basis of AMPK regulation by small molecule activators

Xiao, B., Sanders, M. J., Carmena, D., Bright, N. J., Haire, L. F., Underwood, E., Patel, B. R., Heath, R. B., Walker, P. A., Hallén, S., et al. (2013) · Nature Communications · doi:10.1038/ncomms4017 · Cited by 566

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Pinkosky, S. L., Newton, R. S., Day, E. A., Ford, R. J., Lhotak, S., Austin, R. C., Birch, C. M., Smith, B. K., Filippov, S., Groot, P. H. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms13457 · Cited by 498

Chronic inflammation and the hallmarks of aging

Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471

AMP-activated protein kinase: nature's energy sensor

Carling, D., Mayer, F. V., Sanders, M. J., & Gamblin, S. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.610 · Cited by 387

AMP-activated protein kinase: new regulation, new roles?

Carling, D., Thornton, C., Woods, A., & Sanders, M. J. (2012) · Biochemical Journal · doi:10.1042/bj20120546 · Cited by 390

Targeting AMPK for cancer prevention and treatment

Li, W., Saud, S. M., Young, M. R., Chen, G., & Hua, B. (2015) · Oncotarget · doi:10.18632/oncotarget.3629 · Cited by 361

The Crosstalk between the Gut Microbiota and Mitochondria during Exercise

Clark, A. P., & Mach, N. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00319 · Cited by 345

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

Zhao, P., Sun, X., Chaggan, C., Liao, Z., Wong, K. I., He, F., Singh, S., Loomba, R. S., Karin, M., Witztum, J. L., et al. (2020) · Science · doi:10.1126/science.aay0542 · Cited by 312

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Querfurth, H., & Lee, H.-K. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00428-5 · Cited by 288

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

Liu, X., Chhipa, R. R., Nakano, I., & Dasgupta, B. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0579 · Cited by 288

SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction

Lai, Y.-C., Tabima, D. M., Dube, J. J., Hughan, K. S., Vanderpool, R. R., Goncharov, D. A., St. Croix, C. M., Garcia-Ocaña, A., Goncharova, E. A., Tofovic, S. P., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.018935 · Cited by 270

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., & Saltiel, A. R. (2018) · Cell · doi:10.1016/j.cell.2018.01.007 · Cited by 250

AMP-activated protein kinase, stress responses and cardiovascular diseases

Wang, S., Song, P., & Zou, M. (2012) · Clinical Science · doi:10.1042/cs20110625 · Cited by 251

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

Uittenbogaard, M. N., & Chiaramello, A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140305224906 · Cited by 246

AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression

Sun, X., Yang, Q., Rogers, C. J., Du, ‬., & Zhu, M. J. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.14 · Cited by 241

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK

Liu, X., Chhipa, R. R., Pooya, S., Wortman, M. D., Yachyshin, S., Chow, L. M. L., Kumar, A., Zhou, X., Sun, Y. H., Quinn, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311121111 · Cited by 232

AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway

Sanli, T., Steinberg, G. R., Singh, G., & Tsakiridis, T. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.26726 · Cited by 220

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

Nandipati, K. C., Subramanian, S., & Agrawal, D. K. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2878-8 · Cited by 214

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.003 · Cited by 212

The relationship of autophagy defects to cartilage damage during joint aging in a mouse model

Caramés, B., Olmer, M., Kiosses, W. B., & Lotz, M. K. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39073 · Cited by 204

The role of AMPK in macrophage metabolism, function and polarisation

Cui, Y., Chen, J., Zhang, Z., Shi, H., Sun, W., & Yi, Q. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04772-6 · Cited by 213

Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling

Antonopoulos, A. S., Margaritis, M., Verheule, S., Récalde, A., Sanna, F., Herdman, L., Psarros, C. T., Nasrallah, H. M., Coutinho, P., Akoumianakis, I., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.307856 · Cited by 173

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Zong, Y., Zhang, C., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J.-W., Tian, X., Qu, Q., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0163-6 · Cited by 168

Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

Jiang, P., Ren, L., Li, Z., Yu, Z., Lv, F., Xu, F., Peng, W., Bai, X., Cheng, K., Quan, L., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.008 · Cited by 170

SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy

Zhao, W., Zhang, L., Chen, R., Lu, H., Sui, M., Zhu, Y., & Zeng, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01526 · Cited by 155

Emerging Role of Adipocytokines in Type 2 Diabetes as Mediators of Insulin Resistance and Cardiovascular Disease

Jaganathan, R., Ravindran, R., & Dhanasekaran, S. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.040 · Cited by 154

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

Pinkosky, S. L., Scott, J. W., Desjardins, E. M., Smith, B. K., Day, E. A., Ford, R. J., Langendorf, C. G., Ling, N. X. Y., Nero, T. L., Loh, K., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0245-2 · Cited by 145

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

Prasad, S., Sajja, R. K., Kaisar, M. A., Park, J. H., Villalba, H., Liles, T., Abbruscato, T. J., & Cucullo, L. (2017) · Redox Biology · doi:10.1016/j.redox.2017.02.007 · Cited by 138

A Metabolic Roadmap for Somatic Stem Cell Fate

Ly, C., Lynch, G. S., & Ryall, J. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.022 · Cited by 144

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Juszczak, F., Caron, N., Mathew, A. V., & Declèves, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217994 · Cited by 140

Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease

Sid, B., Verrax, J., & Calderón, P. B. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.007 · Cited by 141

A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats

Lindholm, C. R., Ertel, R. L., Bauwens, J. D., Schmuck, E. G., Mulligan, J. D., & Saupe, K. W. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0199-2 · Cited by 136

Hyporesponsiveness to the anti-inflammatory action of interleukin-10 in type 2 diabetes

Barry, J., Shakibakho, S., Durrer, C. G., Simtchouk, S., Jawanda, K. K., Cheung, S. T., Mui, A., & Little, J. P. (2016) · Scientific Reports · doi:10.1038/srep21244 · Cited by 136

Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes

Lee, S. G., Parks, J. S., & Kang, H. W. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.12.018 · Cited by 130

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M. K., Reue, K., van Marken Lichtenbelt, W. D., Olivecrona, G., Rensen, P. C., et al. (2015) · eLife · doi:10.7554/elife.08428 · Cited by 114

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965

Dite, T. A., Langendorf, C. G., Hoque, A., Galić, S., Rebello, R. J., Ovens, A. J., Lindqvist, L., Ngoei, K. R. W., Ling, N. X. Y., Furic, L., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003547 · Cited by 132

On the Clinical Pharmacology of Reactive Oxygen Species

Casas, A. I., Nogales, C., Mucke, H. A., Petraina, A., Cuadrado, A., Rojo, A. I., Ghezzi, P., Jaquet, V., Augsburger, F., Dufrasne, F., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019422 · Cited by 131

SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway

Zhang, M., Deng, Y., Zhang, J., Liu, J., Li, Y., Su, H., & Qu, Q. (2018) · Aging and Disease · doi:10.14336/ad.2017.0517 · Cited by 126

Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress

Zhuo, X., Wu, Y., Ni, Y.-J., Liu, J.-H., Gong, M., Wang, X.-H., Feng, W., Wang, T., Yuan, Z., Ma, A.-Q., et al. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0843-5 · Cited by 121

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

Dasgupta, B., & Chhipa, R. R. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.11.007 · Cited by 121

Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress

Gratia, S., Kay, L., Potenza, L., Seffouh, A., Novel-Chaté, V., Schnebelen, C., Sestili, P., Schlattner, U., & Tokarska-Schlattner, M. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs134 · Cited by 123

Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts

Lu, J., Shi, J., Li, M., Gui, B., Fu, R., Yao, G., Duan, Z., Lv, Z., Yang, Y., Chen, Z., et al. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.01.042 · Cited by 119

Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis

Moreira, D., Rodrigues, V., Abengózar, M. Á., Rivas, L., Rial, E., Laforge, M., Li, X., Foretz, M., Viollet, B., Estaquier, J., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004684 · Cited by 125

Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders

Pinkosky, S. L., Groot, P. H. E., Lalwani, N. D., & Steinberg, G. R. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.09.001 · Cited by 118

Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems

Song, P., & Zou, M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.025 · Cited by 122

MaternalPRKAA1andEDNRAgenotypes are associated with birth weight, andPRKAA1with uterine artery diameter and metabolic homeostasis at high altitude

Bigham, A. W., Julian, C. G., Wilson, M. J., Vargas, E., Browne, V. A., Shriver, M. D., & MOORE, L. G. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00063.2014 · Cited by 114

AMP-activated protein kinase: A target for old drugs against diabetes and cancer

Russo, G. L., Russo, M., & Ungaro, P. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.023 · Cited by 116

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

Yavari, A., Stocker, C. J., Ghaffari, S., Wargent, E. T., Steeples, V., Czibik, G., Pintér, K., Bellahcene, M., Woods, A., de Morentin, P. B. M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.003 · Cited by 114

Protection against cardiac hypertrophy by geniposide involves the GLP‐1 receptor / AMPKα signalling pathway

Ma, Z., Dai, J., Zhang, W., Yuan, Y., Liao, H., Zhang, N., Bian, Z., & Tang, Q. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13449 · Cited by 109

Leishmania survival in the macrophage: where the ends justify the means

Duque, G. A., & Descoteaux, A. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.04.007 · Cited by 116

AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition

Lee, J. H., Kim, J. H., Kim, J. S., Chang, J. W., Kim, S. B., Park, J. S., & Lee, S. K. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00148.2012 · Cited by 107

mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management

Cetrullo, S., D’Adamo, S., Tantini, B., Borzı̀, R. M., & Flamigni, F. (2015) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2015012975 · Cited by 109

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C. L., Graham, D., Richter, E. A., Viollet, B., Touyz, R. M., Palmer, T. M., & Salt, I. P. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.010 · Cited by 106

Glycogen metabolism in cancer

Zois, C. E., Favaro, E., & Harris, A. L. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.09.001 · Cited by 102

Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway

Gui, D., Cui, Z., Zhang, L., Chang, Y., Yao, D., Xu, M., Chen, M., Wu, P., Li, G., Wang, L., et al. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-017-0477-4 · Cited by 100

Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells

Chen, R. R., Yung, M. M. H., Yang, X., Zhan, S., Leung, L. L., Liang, R. R., Leung, T. H. Y., Yang, H., Xu, D., Sharma, R., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0508-1 · Cited by 97

From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases

Zhao, P., & Saltiel, A. R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011356 · Cited by 106

Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK

Hill, K., Yuan, H., Wang, X., & Sha, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0782-16.2016 · Cited by 97

AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability

Ye, D., Zhang, M., Zhang, W., Lu, Q., Cai, Z., Song, P., Okon, I. S., Xiao, L., & Zou, M. (2016) · Circulation Research · doi:10.1161/circresaha.116.308689 · Cited by 96

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

Zha, Q.-B., Wei, H.-X., Li, C.-G., Liang, Y.-D., Xu, L.-H., Bai, W.-J., Pan, H., He, X.-H., & Ouyang, D.-Y. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00597 · Cited by 95

AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization

Asby, D. J., Cuda, F., Beyaert, M., Houghton, F. D., Cagampang, F. R. A., & Tavassoli, A. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.06.008 · Cited by 91

Interactions between dietary carbohydrate and metformin: Implications on energy sensing, insulin signaling pathway, glycolipid metabolism and glucose tolerance in blunt snout bream Megalobrama amblycephala

Xu, C., Liu, W., Zhang, D., Cao, X., Shi, H., & Li, X. (2017) · Aquaculture · doi:10.1016/j.aquaculture.2017.10.022 · Cited by 91

A synbiotic consisting of Lactobacillus plantarum S58 and hull-less barley β-glucan ameliorates lipid accumulation in mice fed with a high-fat diet by activating AMPK signaling and modulating the gut microbiota

Tang, T., Song, J., Li, J., Wang, H., Zhang, Y., & Suo, H. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116398 · Cited by 89

Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease

Satriano, J. A., Sharma, K., Blantz, R. C., & Deng, A. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00293.2013 · Cited by 87

Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats

He, M. X., Zhang, Q., Deng, C., Wang, H., Lian, J., & Huang, X. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.018 · Cited by 93

Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice

Zimmermann, H. R., Yang, W., Kasica, N. P., Zhou, X., Wang, X., Beckelman, B. C., Lee, J., Furdui, C. M., Keene, C. D., & Ma, T. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133982 · Cited by 86

The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization

Ye, W., Wang, J., Lin, D., & Ding, Z. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.028 · Cited by 86

Six types of tea reduce high-fat-diet-induced fat accumulation in mice by increasing lipid metabolism and suppressing inflammation

Liu, C., Guo, Y., Sun, L., Lai, X., Li, Q., Zhang, W., Xiang, L., Sun, S., & Cao, F. (2019) · Food & Function · doi:10.1039/c8fo02334d · Cited by 86

AMP-Activated Protein Kinase and Host Defense against Infection

Silwal, P., Kim, J. K., Yuk, J., & Jo, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113495 · Cited by 82

Quercetin induces bladder cancer cells apoptosis by activation of AMPK signaling pathway.

Su, Q., Peng, M., Zhang, Y., Xu, W., Darko, K. O., Tao, T., Huang, Y., Tao, X., & Yang, X. (2016) · PubMed Central · Cited by 83

Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK), RSVA314 and RSVA405, Inhibit Adipogenesis

Vingtdeux, V., Chandakkar, P., Zhao, H., Davies, P., & Marambaud, P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00163 · Cited by 81

Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal

Mesubi, O. O., & Anderson, M. E. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw002 · Cited by 81

Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study

Cusi, K. J., Alkhouri, N., Harrison, S. A., Fouqueray, P., Moller, D. E., Hallakou‐Bozec, S., Bolze, S., Grouin, J., Megnien, S. J., Dubourg, J., et al. (2021) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(21)00300-9 · Cited by 80

Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury

Jian, M., ALEXEYEV, M. F., Wolkowicz, P. E., Zmijewski, J. W., & Creighton, J. R. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00173.2013 · Cited by 78

Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss

Gautam, J., Khedgikar, V., Kushwaha, P., Choudhary, D., Nagar, G. K., Dev, K., Dixit, P., Singh, D. R., Maurya, R., & Trivedi, R. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517000149 · Cited by 78

Metformin Decreases GnRH- and Activin-Induced Gonadotropin Secretion in Rat Pituitary Cells: Potential Involvement of Adenosine 5' Monophosphate-Activated Protein Kinase (PRKA)

Tosca, L., Froment, P., Ramé, C., McNEILLY, J. R., McNeilly, A. S., Maillard, V., & Dupont, J. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.087023 · Cited by 83

Arrhythmia causes lipid accumulation and reduced glucose uptake

Lenski, M., Schleider, G., Kohlhaas, M., Adrian, L., Adam, O., Tian, X. Y., Kaestner, L., Lipp, P., Lehrke, M., Maack, C., et al. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0497-2 · Cited by 76

Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C-glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome

Johnson, R., de Beer, D., Dludla, P. V., Ferreira, D., Muller, C. J. F., & Joubert, E. (2018) · Planta Medica · doi:10.1055/s-0044-100622 · Cited by 79

The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence

Assefa, B. T., Tafere, G. G., Wondafrash, D. Z., & Gidey, M. T. (2020) · BioMed Research International · doi:10.1155/2020/9895121 · Cited by 76

AMP-activated protein kinase: Structure, function, and role in pathological processes

Novikova, D., Garabadzhiu, A. V., Melino, G., Barlev, N. A., & Tribulovich, V. G. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915020017 · Cited by 77

Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin

Kwon, B., & Querfurth, H. W. (2015) · Biochimie · doi:10.1016/j.biochi.2015.09.006 · Cited by 77

A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer

Khan, A., & Frigo, D. E. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2016.272 · Cited by 74

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

Lee, M.-S., Han, H.-J., Han, S. Y., Kim, I. Y., Chae, S., Lee, C.-S., Kim, S. E., Yoon, S. G., Park, J.-W., Kim, J.-H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05721-4 · Cited by 75

New Insights into AMPK, as a Potential Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease and Hepatic Fibrosis

An, H., Jang, Y., Choi, J.-I., Hur, J., Kim, S., & Kwon, Y. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.188 · Cited by 75

Hypoxia, AMPK activation and uterine artery vasoreactivity

Skeffington, K. L., Higgins, J. S., Mahmoud, A. D., Evans, A. M., Sferruzzi‐Perri, A. N., Fowden, A. L., Yung, H. W., Burton, G. J., Giussani, D. A., & Moore, L. G. (2016) · The Journal of Physiology · doi:10.1113/jp270995 · Cited by 69

5′-AMP-activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors

Laderoute, K. R., Calaoagan, J. M., Chao, W., Dinh, D., Denko, N. C., Duellman, S. J., Kalra, J., Liu, X., Papandreou, I., Sambucetti, L. C., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.576371 · Cited by 69

Nuclear Transport: A Switch for the Oxidative Stress—Signaling Circuit?

Kodiha, M., & Stochaj, U. (2011) · Journal of Signal Transduction · doi:10.1155/2012/208650 · Cited by 72

A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies

von Loeffelholz, C., Coldewey, S. M., & Birkenfeld, A. L. (2021) · Cells · doi:10.3390/cells10071822 · Cited by 70

Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs

Chung, M.-M., Nicol, C. J., Cheng, Y.-C., Lin, K.-H., Chen, Y.-L., Pei, D., Lin, C.-H., Shih, Y.-N., Yen, C.-H., Chen, S.-J., et al. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.01.017 · Cited by 66

AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals

Kim, S. Y., Jeong, S., Jung, E., Baik, K.-H., Chang, M. H., Kim, S. A., Shim, J.-H., Chun, E., & Lee, K. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.95 · Cited by 66

AMP-activated protein kinase: a therapeutic target in intestinal diseases

Sun, X., & Zhu, M. J. (2017) · Open Biology · doi:10.1098/rsob.170104 · Cited by 68

AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation

Saha, M., Kumar, S., Bukhari, S., Andugulapati, S. B., Kumar, P., Hindupur, S. K., & Rangarajan, A. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2090 · Cited by 66

Profile of Circulatory Metabolites in an Animal Model of Multiple Sclerosis using Global Metabolomics

Mangalam, A. K. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000150 · Cited by 65

Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?

Finelli, C. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i46.6790 · Cited by 63

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release

Scott, J. W., Galić, S., Graham, K. L., Foitzik, R. C., Ling, N. X. Y., Dite, T. A., Issa, S. M. A., Langendorf, C. G., Weng, Q. P., Thomas, H. E., et al. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.05.011 · Cited by 61

AMPK Inhibition Blocks ROS-NFκB Signaling and Attenuates Endotoxemia-Induced Liver Injury

Guo, Y., Zhang, Y., Hong, K. M., Luo, F., Gu, Q., Lü, N., & Bai, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086881 · Cited by 61

Page /1 19 AMPK inhibition in health and disease

Rev, C., Mol, B., Viollet, B., Horman, R., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andréelli, F. (2015)

AMPK in Health and Disease

Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,672

Maintaining Energy Balance in Health and Disease: Role of the AMP-Activated Protein Kinase

Scott, J. W. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6382-6_9 · Cited by 2

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.004 · Cited by 485

AMPK: a metabolic gauge regulating whole-body energy homeostasis

Lage, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.007 · Cited by 512