Cited by 387Metabolism, Diabetes, and CancerBiochemical and Molecular ResearchPeroxisome Proliferator-Activated Receptors

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AMPK inhibition in health and disease

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Viollet, Benoit, Horman, Sandrine, Leclerc, Jocelyne, Lantier, Louise, Foretz, Marc, Billaud, Marc, Giri, Shailendra, Andreelli, Fabrizio·2010·Critical Reviews in Biochemistry and Molecular Biology

DOI 10.3109/10409238.2010.488215PMC PMC3132561

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Abstract

All living organisms depend on dynamic mechanisms that repeatedly reassess the status of amassed energy, in order to adapt energy supply to demand. The AMP-activated protein kinase (AMPK) alphabetagamma heterotrimer has emerged as an important integrator of signals managing energy balance. Control of AMPK activity involves allosteric AMP and ATP regulation, auto-inhibitory features and phosphorylation of its catalytic (alpha) and regulatory (beta and gamma) subunits. AMPK has a prominent role not only as a peripheral sensor but also in the central nervous system as a multifunctional metabolic regulator. AMPK represents an ideal second messenger for reporting cellular energy state. For this reason, activated AMPK acts as a protective response to energy stress in numerous systems. However, AMPK inhibition also actively participates in the control of whole body energy homeostasis. In this review, we discuss recent findings that support the role and function of AMPK inhibition under physiological and pathological states.

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Kovacic, S., Soltys, C.-L. M., Barr, A., Shiojima, I., Walsh, K. X., & Dyck, J. R. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305371200 · Cited by 412
Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo.
Woods, A., Munday, M. R., Scott, J., Yang, X., Carlson, M., & Carling, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32198-1 · Cited by 409
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release
Salt, I. P., JOHNSON, G., Ashcroft, S. J. H., & Hardie, D. G. (1998) · Biochemical Journal · doi:10.1042/bj3350533 · Cited by 408
Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?
Febbraio, M. A., & Pedersen, B. K. (2005) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200507000-00003 · Cited by 402
Insulin Resistance and Type 2 Diabetes Are Not Related to Resistin Expression in Human Fat Cells or Skeletal Muscle
Nagaev, I., & Smith, U. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5173 · Cited by 380
Role of resistin in diet-induced hepatic insulin resistance
Muse, E. D., Obici, S., Bhanot, S., Monia, B. P., McKay, R. A., Rajala, M. W., Scherer, P. E., & Rossetti, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21270 · Cited by 375
Functional Domains of the α1 Catalytic Subunit of the AMP-activated Protein Kinase
Crute, B. E., Seefeld, K. J., Gamble, J., Kemp, B. E., & Witters, L. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35347 · Cited by 370
AMP-Activated Protein Kinase: An Ultrasensitive System for Monitoring Cellular Energy Charge
HARDIE, D. G., SALT, I. P., HAWLEY, S. A., & DAVIES, S. P. (1999) · Biochemical Journal · doi:10.1042/bj3380717 · Cited by 362
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2006 · Cited by 359
Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase
McGarry, J., Woeltje, K. F., Kuwajima, M., & Foster, D. W. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050305 · Cited by 359
A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
Xie, M., Zhang, D., Dyck, J. R. B., Li, Y., Zhang, H., Morishima, M., Mann, D. L., Taffet, G. E., Baldini, A., Khoury, D. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604708103 · Cited by 358
AMP-Activated Protein Kinase in the Heart
Arad, M., Seidman, C. E., & Seidman, J. G. (2007) · Circulation Research · doi:10.1161/01.res.0000258446.23525.37 · Cited by 357
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
Fogarty, S., & Hardie, D. G. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.09.012 · Cited by 357
Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491
Horman, S., Vertommen, D., Heath, R. B., Neumann, D., Mouton, V., Woods, A., Schlattner, U., Wallimann, T., Carling, D., Hue, L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506850200 · Cited by 355
Self-citation
AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation
Chen, Z., McConell, G. K., Michell, B. J., Snow, R. J., Canny, B. J., & Kemp, B. E. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1202 · Cited by 342
AMP-Activated Protein Kinase is Highly Expressed in Neurons in the Developing Rat Brain and Promotes Neuronal Survival Following Glucose Deprivation
Culmsee, C., monnig, J., Kemp, B. E., & Mattson, M. P. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:1:45 · Cited by 340
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias
Hudson, E. R., Pan, D. A., James, J., Lucocq, J. M., Hawley, S. A., Green, K. A., Baba, O., Terashima, T., & Hardie, D. G. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00249-5 · Cited by 332
Anti-lipolytic Action of AMP-activated Protein Kinase in Rodent Adipocytes
Daval, M., DUPUY, F., Bazin, R., Hainault, I., Viollet, B., Vaulont, S., Hajduch, É., Ferré, P., & Foufelle, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414222200 · Cited by 331
Self-citation
AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
Nagata, D., Mogi, M., & Walsh, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300643200 · Cited by 331 · cited 2×
“In addition, AMPK also produces its regulatory effects in the peripheral vasculature through vascular endothelial growth factor (VEGF)-mediated endothelial angiogenesis (Nagata et al., 2003; Ouchi et al., 2005; Stahmann et al., 2010).”
Background
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes
Tamás, P., Hawley, S. A., Clarke, R. G., Mustard, K. J., Green, K., Hardie, D. G., & Cantrell, D. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052469 · Cited by 328
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
Choi, C. S., Savage, D. B., Abu-Elheiga, L., Liu, Z.-X., Kim, S., Kulkarni, A., Distefano, A., Hwang, Y.-J., Reznick, R. M., Codella, R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706794104 · Cited by 325
Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells
Ido, Y., Carling, D., & Ruderman, N. B. (2002) · Diabetes · doi:10.2337/diabetes.51.1.159 · Cited by 323
Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
Ponticos, M., Lu, Q. L., Morgan, J. E., Hardie, D. G., Partridge, T. A., & Carling, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1688 · Cited by 317
C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase
Kim, E. K., Miller, I., Aja, S. M., Landree, L. E., Pinn, M. L., McFadden, J. M., Kuhajda, F. P., Moran, T. H., & Ronnett, G. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402165200 · Cited by 313
Macrophage-secreted factors induce adipocyte inflammation and insulin resistance
Permana, P. A., Menge, C., & Reaven, P. D. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.012 · Cited by 307
Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction
Opie, L. H. (1975) · The American Journal of Cardiology · doi:10.1016/0002-9149(75)90086-7 · Cited by 304
Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
Zhao, X., Zmijewski, J. W., Lorne, E., Liu, G., Park, Y.-J., Tsuruta, Y., & Abraham, E. H. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90210.2008 · Cited by 303
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
Sakamoto, K., Göransson, O., Hardie, D. G., & Alessi, D. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2004 · Cited by 299
Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle
Birk, J. B., & Wojtaszewski, J. F. P. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120972 · Cited by 293
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.
Kelly, M., Keller, C., Avilucea, P. R., Keller, P., Luo, Z., Xiang, X., Giralt, M., Hidalgo, J., Saha, A. K., Pedersen, B. K., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.188 · Cited by 289
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy
Lee, M.-J., Féliers, D., Mariappan, M. M., Sataranatarajan, K., Mahimainathan, L., Musi, N., Foretz, M., Viollet, B., Weinberg, J. M., Choudhury, G. G., et al. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00278.2006 · Cited by 287
Self-citation
Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle
Martin, T. L., Alquier, T., Asakura, K., Furukawa, N., Preitner, F., & Kahn, B. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512831200 · Cited by 287
Role of AMP-activated Protein Kinase in Cyclic AMP-dependent Lipolysis In 3T3-L1 Adipocytes
Wu, Y., Mu, J., & Birnbaum, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308484200 · Cited by 286
PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis
Djouder, N., Tuerk, R. D., Suter, M., Chiabotti, P. S., Thali, R. F., Scholz, R., Vaahtomeri, K., Auchli, Y., Rechsteiner, H., Brunisholz, R., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.339 · Cited by 285
Self-citation
Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization
Warden, S. M., Richardson, C. A., O’Donnell, J. B., Stapleton, D., Kemp, B. E., & Witters, L. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540275 · Cited by 284
Insulin signalling in the heart
Bertrand, L., Horman, S., Beauloye, C., & Vanoverschelde, J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn093 · Cited by 280
Self-citation
Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats
Satoh, H., Nguyen, M. T., Miles, P. D. G., Imamura, T., Usui, I., & Olefsky, J. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20785 · Cited by 271
Cellular Distribution and Developmental Expression of AMP‐Activated Protein Kinase Isoforms in Mouse Central Nervous System
Turnley, A. M., Stapleton, D., Mann, R. J., Witters, L. A., Kemp, B. E., & Bartlett, P. F. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721707.x · Cited by 270
An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts.
Lopaschuk, G. D., Wambolt, R. B., & Barr, R. L. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10243-7 · Cited by 266
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
Chen, Z., Peng, I.-C., Sun, W., Su, M.-I., Hsu, P.-H., Fu, Y., Zhu, Y., DeFea, K., Pan, S., Tsai, M.-D., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.187567 · Cited by 264 · cited 1×
“, 1999), Ser633 (Chen et al., 2009b) and by promoting its association with heat shock protein 90 (Davis et al.”
Background
Regulation of AMP-activated Protein Kinase by Multisite Phosphorylation in Response to Agents That Elevate Cellular cAMP
Hurley, R. L., Barré, L. K., Wood, S. D., Anderson, K. A., Kemp, B. E., Means, A. R., & Witters, L. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606676200 · Cited by 264
Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle
Wojtaszewski, J. F. P., Jørgensen, S. B., Hellsten, Y., Hardie, D. G., & Richter, E. A. (2002) · Diabetes · doi:10.2337/diabetes.51.2.284 · Cited by 261
Molecular mechanisms for the control of translation by insulin
Proud, C. G., & DENTON, M. R. (1997) · Biochemical Journal · doi:10.1042/bj3280329 · Cited by 257
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
Xavier, G. D. S., Leclerc, I., Váradi, A., Tsuboi, T., MOULE, S. K., & Rutter, G. A. (2003) · Biochemical Journal · doi:10.1042/bj20021812 · Cited by 255
Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia
Kudo, N., Gillespie, J. G., Kung, L., Witters, L. A., Schulz, R., Clanachan, A. S., & Lopaschuk, G. D. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00013-6 · Cited by 246
AMP-activated Protein Kinase Is Activated as a Consequence of Lipolysis in the Adipocyte
Gauthier, M., Miyoshi, H., Souza, S. C., Cacicedo, J. M., Saha, A. K., Greenberg, A. S., & Ruderman, N. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708177200 · Cited by 245
AMP-Activated Protein Kinase Signaling Stimulates VEGF Expression and Angiogenesis in Skeletal Muscle
Ouchi, N., Shibata, R., & Walsh, K. X. (2005) · Circulation Research · doi:10.1161/01.res.0000163633.10240.3b · Cited by 244
Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia.
Lopaschuk, G. D., Spafford, M. A., Davies, N. J., & Wall, S. R. (1990) · Circulation Research · doi:10.1161/01.res.66.2.546 · Cited by 243
Identification of Phosphorylation Sites in AMP-activated Protein Kinase (AMPK) for Upstream AMPK Kinases and Study of Their Roles by Site-directed Mutagenesis
Woods, A., Vertommen, D., Neumann, D., Tuerk, R. D., Bayliss, J., Schlattner, U., Wallimann, T., Carling, D., & Rider, M. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303946200 · Cited by 242
The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading
Jørgensen, S. B., Nielsen, J. N., Birk, J. B., Olsen, G. S., Viollet, B., Andreelli, F., Schjerling, P., Vaulont, S., Hardie, D. G., Hansen, B. F., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3074 · Cited by 241
Self-citation
AMPK inhibits fatty acid-induced increases in NF-κB transactivation in cultured human umbilical vein endothelial cells
Cacicedo, J. M., Yagihashi, N., Keaney, J. F., Ruderman, N. B., & Ido, Y. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.177 · Cited by 236
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury
Nagoshi, T., Matsui, T., Aoyama, T., Leri, A., Anversa, P., Li, L., Ogawa, W., del Monte, F., Gwathmey, J. K., Grazette, L. P., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23073 · Cited by 229
Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.
Witters, L. A., & Kemp, B. E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50663-9 · Cited by 228
Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling
Shi, H., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403886200 · Cited by 223
Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle
Glund, S., Deshmukh, A., Long, Y. C., Moller, T., Koistinen, H. A., Caidahl, K., Zierath, J. R., & Krook, A. (2007) · Diabetes · doi:10.2337/db06-1733 · Cited by 219
Neuroprotective Effects of Adenosine Monophosphate- Activated Protein Kinase Inhibition and Gene Deletion in Stroke
Li, J., Zeng, Z., Viollet, B., Ronnett, G. V., & McCullough, L. D. (2007) · Stroke · doi:10.1161/strokeaha.107.490904 · Cited by 216
Self-citation
Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase
Suzuki, A., Okamoto, S., Lee, S. P., Saito, K., Shiuchi, T., & Minokoshi, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02222-06 · Cited by 213
Sustained activation of AMP‐activated protein kinase induces c‐Jun N‐terminal kinase activation and apoptosis in liver cells
Meisse, D., de Casteele, M. V., Beauloye, C., Hainault, I., Kefas, B. A., Rider, M. H., Foufelle, F., & Hue, L. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03110-1 · Cited by 205
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression
Xavier, G. D. S., Leclerc, I., Salt, I. P., Doiron, B., Hardie, D. G., Kahn, A., & Rutter, G. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4023 · Cited by 203
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
Chen, L., Jiao, Z., Zheng, L., Zhang, Y., Xie, S.-T., Wang, Z., & Wu, J. (2009) · Nature · doi:10.1038/nature08075 · Cited by 200
Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation
Kato, K., Ogura, T., Kishimoto, A., Minegishi, Y., Nakajima, N., Miyazaki, M., & Esumi, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205737 · Cited by 197
Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization
Warden, S. M., RICHARDSON, C., O’Donnell, J. B., et al. (2001) · Biochemical Journal · doi:10.1042/bj3540275 · Cited by 195
Interleukin-6 Regulation of AMP-Activated Protein Kinase
Ruderman, N. B., Keller, C., Richard, A.-M. T., Saha, A. K., Luo, Z., Xiang, X., Giralt, M., Ritov, V. B., Menshikova, E. V., Kelley, D. E., et al. (2006) · Diabetes · doi:10.2337/db06-s007 · Cited by 191
Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Calcium Signaling in O2-sensing Cells?
Evans, A. M., Mustard, K. J. W., Wyatt, C. N., Peers, C., Dipp, M., Kumar, P., Kinnear, N. P., & Hardie, D. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510040200 · Cited by 191
Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase
Townley, R. A., & Shapiro, L. S. (2007) · Science · doi:10.1126/science.1137503 · Cited by 190
S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase
Aguilar, V. M., Alliouachene, S., Sotiropoulos, A., Sobering, A. K., Athéa, Y., Djouadi, F., Miraux, S., Thiaudière, E., Foretz, M., Viollet, B., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.006 · Cited by 189
Self-citation
Phospho-Dependent Functional Modulation of GABAB Receptors by the Metabolic Sensor AMP-Dependent Protein Kinase
Kuramoto, N., Wilkins, M. E., Fairfax, B. P., Revilla-Sanchez, R., Terunuma, M., Tamaki, K., Takarada‐Iemata, M., Warren, N. A., Couve, A., Calver, A. R., et al. (2007) · Neuron · doi:10.1016/j.neuron.2006.12.015 · Cited by 184
The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic β-Cells
Gleason, C. E., Lu, D., Witters, L. A., Newgard, C. B., & Birnbaum, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610631200 · Cited by 182
Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase
Hardie, D. G. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90001-c · Cited by 181
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion
Leclerc, I., Woltersdorf, W. W. W., Xavier, G. D. S., Rowe, R. L., Cross, S. E., Korbutt, G. S., Rajotte, R. V., Smith, R. M., & Rutter, G. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00532.2003 · Cited by 173
Downregulation of AMP‐activated protein kinase by Cidea‐mediated ubiquitination and degradation in brown adipose tissue
Qi, J., Gong, J., Zhao, T., Zhao, J., Lam, P., Ye, J., Li, J. Z., Wu, J., Hai‐Meng, Z. H. O. U., & Li, P. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.92 · Cited by 172
Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscle.
Derave, W., Ai, H., Ihlemann, J., Witters, L. A., Kristiansen, S., Richter, E. A., & Ploug, T. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1281 · Cited by 168
Induced Adiposity and Adipocyte Hypertrophy in Mice Lacking the AMP-Activated Protein Kinase-α2 Subunit
Villena, J. A., Viollet, B., Andreelli, F., Kahn, A., Vaulont, S., & Sul, H. S. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2242 · Cited by 164
Self-citation
Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle
McGee, S. L., Howlett, K. F., Starkie, R. L., Cameron-Smith, D., Kemp, B. E., & Hargreaves, M. (2003) · Diabetes · doi:10.2337/diabetes.52.4.926 · Cited by 160
Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart
Ko, H. J., Zhang, Z., Jung, D. Y., Jun, J. Y., Ma, Z., Jones, K. E., Chan, S. Y., & Kim, J. K. (2009) · Diabetes · doi:10.2337/db08-1361 · Cited by 160
Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells
Pang, T., Zhang, Z., Gu, M., Qiu, B., Yu, L.-F., Cao, P.-R., Shao, W., Su, M., Li, J.-Y., Nan, F., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710114200 · Cited by 159
Posttranslational Modifications of the 5′-AMP-activated Protein Kinase β1 Subunit
Mitchelhill, K. I., Michell, B. J., House, C. M., Stapleton, D., Dyck, J. R. B., Gamble, J., Ullrich, C., Witters, L. A., & Kemp, B. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24475 · Cited by 158
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.008 · Cited by 156
Fatal Congenital Heart Glycogenosis Caused by a Recurrent Activating R531Q Mutation in the γ2-Subunit of AMP-Activated Protein Kinase (PRKAG2), Not by Phosphorylase Kinase Deficiency
Burwinkel, B., Scott, J. W., Bührer, C., van Landeghem, F. K. H., Cox, G. F., Wilson, C. J., Hardie, D. G., & Kilimann, M. W. (2005) · The American Journal of Human Genetics · doi:10.1086/430840 · Cited by 155
Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats
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Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition
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See all 387

Authors: Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F.
Affiliations: UCLouvain (BE)
Inserm (FR)
Centre National de la Recherche Scientifique (FR)
Mayo Clinic (US)
ORCID: Horman, Sandrine
Lantier, Louise
Foretz, Marc
Billaud, Marc
Giri, Shailendra
Venue: Critical Reviews in Biochemistry and Molecular Biology
Publisher: Informa UK Limited
Published: 2010-06-04
Volume: 45
Issue: 4
Pages: 276-295
ISSN: 0045-6411 (ISSN-L)
1040-9238
1549-7798
DOI: 10.3109/10409238.2010.488215
PMC: PMC3132561
OpenAlex: W2015171350
Cited by: 383
References: 226
Citations by year: 2026: 14 · 2025: 15 · 2024: 11 · 2023: 18 · 2022: 22 · 2021: 23 · 2020: 39 · 2019: 22 · 2018: 34 · 2017: 33 · 2016: 38 · 2015: 30 · 2014: 27 · 2013: 25 · 2012: 19
FWCI: 1.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion, other-oa)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Funders: European Commission
Agence Nationale de la Recherche (ANR-06-PHYS-0026)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: AMPK, AMPK inhibition, energy homeostasis, allosteric regulation, protein phosphorylation, central nervous system metabolism
MeSH terms: Animals, Energy Metabolism, Enzyme Activation, Humans, Down-Regulation, AMP-Activated Protein Kinases

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