Monitoring the menstrual cycle: Comparison of urinary and serum reproductive hormones referenced to true ovulation
Abstract
Objective The aim of the study was to examine relationships and interindividual variations in urinary and serum reproductive hormone levels relative to ultrasound-observed ovulation in menstrual cycles of apparently normally menstruating women.Methods This was a prospective study of normally menstruating women (no known subfertility), aged 18–40 years (n = 40), who collected daily urine samples and attended the study centre for blood samples and transvaginal ultrasound during one complete menstrual cycle. Serum luteinising hormone (LH), progesterone, estradiol, urinary LH, pregnanediol-3- glucuronide (P3G) and estrone-3-glucuronide were measured. Ultrasound was conducted by two physicians and interpreted by central expert review.Results Menstrual cycle length varied from 22 to 37 days (median 27 days). Ovulation by ultrasound ranged from day 8 to day 26 (median day 15). Serum and urinary hormone profiles showed excellent agreement. Estrogen and LH hormone peaks in urine and serum showed a range of signal characteristics across the study group before and after ovulation. The rise in estrogen and LH always occurred before ovulation; the progesterone rise from baseline always occurred after ovulation.Conclusions Urinary and serum reproductive hormones showed excellent agreement and may be used interchangeably. The beginning of the surge in serum and urinary LH was an excellent predictor of ovulation. The rise in progesterone and P3G above baseline was a consistent marker of luteinisation confirming ovulation. Both LH and progesterone surges delivered clear, sharp signals in all volunteers, allowing reliable detection and confirmation of ovulation.Chinese Abstract摘要目的 检验正常行经女性在月经周期中,尿液与血清生殖激素水平与经阴道超声所观察到的排卵的关系及个体差异。方法 这是一个对年龄为18-40岁( n = 40)的正常行经妇女(无已知生育能力低下) 进行的前瞻性研究,在一个完整的月经周期中,受试者采集自己的尿样并到研究中心采集血样和进行阴道超声测试。检测血清黄体生成素(LH),孕酮,雌二醇,尿液LH,雌酮3葡糖苷酸(P3G)及3-葡糖苷酸孕二酮水平。由两名医生进行超声检查,中心专家评审判读结果.结果 月经周期长度22至37天不等(中位时间为27天)。超声所监测到的排卵从第八天至第26天不等(中位时间为第15天)。血清和尿液的荷尔蒙的描绘显示了高度的契合。尿液和血清中雌激素和LH荷尔蒙的峰值在研究受试者群体中表现出排卵前后的一系列信号特征。雌激素和LH水平往往在排卵前升高;孕酮从基线值升高往往发生在排卵后。结论 尿液和血清中的生殖激素表明了高度的一致性,且可能可交换使用。血清和尿液中LH波峰的出现是对排卵期极佳的预测。 孕酮和P3G超出基线值的升高是黄素化的一致性标记,这证实了排卵。LH和孕酮的波峰在受试者中都表达了清晰尖锐的信号,使得排卵期的可靠探测和确证成为可能。关键词雌二醇;雌酮-3-葡糖苷酸(E3G);黄体生成素(LH);排卵;3-葡糖苷酸孕二醇(P3G);孕酮;生殖激素;经阴道超声
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The peak fertility result refers to the LH surge and can be mapped chronologically as 1 day before ovulation.
“The peak fertility result refers to the LH surge and can be mapped chronologically as 1 day before ovulation (Johnson et al. 2015; Roos et al. 2015).”
From Real-life insights on menstrual cycles and ovulation using big data (2020) · cites this paper as Roos et al. 2015
Ovulation tests typically measure luteinising hormone (LH) that surges ~1 day before ovulation.
“Ovulation tests typically measure luteinising hormone (LH) that surges ~1 day before ovulation (Johnson et al. 2015; Roos et al. 2015).”
From Real-life insights on menstrual cycles and ovulation using big data (2020) · cites this paper as Roos et al. 2015
Some ovulation tests also measure estrone-3-glucuronide (E3G), which rises prior to the LH surge and marks the onset of the fertile window.
“Some ovulation tests also measure the oestrogen metabolite, estrone-3-glucuronide (E3G), which rises prior to the LH surge and marks the onset of the fertile window (Johnson et al. 2015; Roos et al. 2015).”
From Real-life insights on menstrual cycles and ovulation using big data (2020) · cites this paper as Roos et al. 2015
Cites
VARIATION OF THE HUMAN MENSTRUAL CYCLE THROUGH REPRODUCTIVE LIFE
TRELOAR, A. E., BOYNTON, R. E., BEHN, B. G., & BROWN, B. W. (1968) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-196801000-00019 · Cited by 1,018 · see citing works
Definition and prevalence of subfertility and infertility
Gnoth, C., Godehardt, E., Frank-Herrmann, P., Friol, K., Tigges, J., & Freundl, G. (2005) · Human Reproduction · doi:10.1093/humrep/deh870 · Cited by 603 · see citing works
Self-citationOvarian antral folliculogenesis during the human menstrual cycle: A review
Baerwald, A. R., Adams, G. P., & Pierson, R. A. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr039 · Cited by 487 · see citing works
The normal menstrual cycle in women
Mihm, M., Gangooly, S., & Muttukrishna, S. (2011) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2010.08.030 · Cited by 448 · see citing works
Stricker, R., Eberhart, R., Chevailler, M.-C., Quinn, F. A., Bischof, P., & Stricker, R. (2006) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2006.160 · Cited by 392 · see citing works
Behre, H. M., Kuhlage, J., Gaβner, C., Sonntag, B., Schem, C., Schneider, H. P. G., & Nieschlag, E. (2000) · Human Reproduction · doi:10.1093/humrep/15.12.2478 · Cited by 238 · see citing works
World Health Organization, T. F. O. M. F. T. D. O. T. F. P., & Special Programme of Research, D. A. R. T. I. H. R. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90133-7 · Cited by 208 · see citing works
Frank‐Herrmann, P., Heil, J., Gnoth, C., Toledo, E., Baur, S., Pyper, C., Jenetzky, E., Strowitzki, T., & Freundl, G. (2007) · Human Reproduction · doi:10.1093/humrep/dem003 · Cited by 201 · see citing works
Self-citationPauerstein, C. J., Eddy, C. A., Croxatto, H. D., Hess, R., Siler-Khodr, T. M., & Croxatto, H.-D. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90264-8 · Cited by 183 · see citing works
How regular is regular? An analysis of menstrual cycle regularity
Creinin, M. D., Keverline, S., & Meyn, L. A. (2004) · Contraception · doi:10.1016/j.contraception.2004.04.012 · Cited by 168 · see citing works
The normal variabilities of the menstrual cycle
Cole, L. A., Ladner, D. G., & Byrn, F. W. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.11.073 · Cited by 152 · see citing works
Direito, A., Bailly, S., Mariani, A., & Écochard, R. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.047 · Cited by 145 · see citing works
Howards, P. P., Schisterman, E. F., Wactawski-Wende, J., Reschke, J. E., Frazer, A. A., & Hovey, K. M. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn287 · Cited by 113 · see citing works
Menstrual Bleeding Patterns Among Regularly Menstruating Women
Dasharathy, S. S., Mumford, S. L., Pollack, A. Z., Perkins, N. J., Mattison, D. R., Wactawski‐Wende, J., & Schisterman, E. F. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr356 · Cited by 107 · see citing works
The influence of sporadic anovulation on hormone levels in ovulatory cycles
Hambridge, H. L., Mumford, S. L., Mattison, D. R., Ye, A., Pollack, A. Z., Bloom, M. S., Mendola, P., Lynch, K. L., Wactawski‐Wende, J., & Schisterman, E. F. (2013) · Human Reproduction · doi:10.1093/humrep/det090 · Cited by 79 · see citing works
Johnson, S., Weddell, S., Godbert, S., Freundl, G., Roos, J., & Gnoth, C. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-1087 · Cited by 61 · see citing works
Self-citationSensitivity and specificity of ultrasound indices of ovulation in spontaneous cycles
Écochard, R., Marret, H., Rabilloud, M., Bradaï, R., Boehringer, H., Girotto, S., & Barbato, M. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(99)00249-3 · Cited by 55 · see citing works
Cycle characteristics after discontinuation of oral contraceptives
Gnoth, C., Frank‐Herrmann, P., Schmoll, A., Godehardt, E., & Freundl, G. (2002) · Gynecological Endocrinology · doi:10.1080/gye.16.4.307.317 · Cited by 54 · see citing works
Self-citationJohnson, S. R., Miro, F., Barrett, S., & Ellis, J. E. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990902743935 · Cited by 54 · see citing works
Self-citationBlackwell, L. F., Brown, J. B., & Cooke, D. G. (1998) · Steroids · doi:10.1016/s0039-128x(97)00117-7 · Cited by 40 · see citing works
Blackwell, L. F., Pilar Vigil, P., Cooke, D. G., d’Arcangues, C., & Brown, J. B. (2013) · Human Reproduction · doi:10.1093/humrep/det389 · Cited by 40 · see citing works
Ovulation detection in the human.
Kerin, J. F. (1982) · PubMed · Cited by 36 · see citing works
Blockeel, C., Knez, J., Polyzos, N. P., Vos, M. D., Camus, M., & Tournaye, H. J. (2014) · Human Reproduction · doi:10.1093/humrep/deu022 · Cited by 36 · see citing works
Accuracy of perception of ovulation day in women trying to conceive
Zinaman, M., Johnson, S., Ellis, J., & Ledger, W. (2012) · Current Medical Research and Opinion · doi:10.1185/03007995.2012.681638 · Cited by 33 · see citing works
Self-citationConception probabilities at different days of menstrual cycle in Chinese women
Bilian, X., Heng, Z., Shang-chun, W., Jing, X., He, C.-H., Wen-qi, S., & Lei, Z.-W. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.05.054 · Cited by 24 · see citing works
Miró, F., Coley, J., Gani, M. M., Perry, P., Talbot, D. C. S., & Aspinall, L. (2004) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2004.210 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neuroimaging the menstrual cycle: A multimodal systematic review
Dubol, M., Epperson, C. N., Sacher, J., Pletzer, B. A., Derntl, B., Lanzenberger, R. R., Poromaa, I. S., & Comasco, E. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100878 · Cited by 193 · see citing works
The Effect of Steroid Hormones on Ovarian Follicle Development
Chou, C.-H., & Chen, M. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.01.013 · Cited by 141 · see citing works
Parisi, F., Fenizia, C., Introini, A., Zavatta, A., Scaccabarozzi, C., Biasin, M., & Savasi, V. M. (2023) · Human Reproduction Update · doi:10.1093/humupd/dmad016 · Cited by 127 · see citing works
Can apps and calendar methods predict ovulation with accuracy?
Johnson, S., Marriott, L., & Zinaman, M. (2018) · Current Medical Research and Opinion · doi:10.1080/03007995.2018.1475348 · Cited by 115 · see citing works
Self-citationFavre, M., & Serrador, J. M. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00474.2018 · Cited by 87 · see citing works
Period tracker applications: What menstrual cycle information are they giving women?
Worsfold, L., Marriott, L., Johnson, S., & Harper, J. C. (2021) · Women s Health · doi:10.1177/17455065211049905 · Cited by 78 · see citing works
Self-citationReal-life insights on menstrual cycles and ovulation using big data
Soumpasis, I., Grace, B., & Johnson, S. (2020) · Human Reproduction Open · doi:10.1093/hropen/hoaa011 · Cited by 76 · see citing works
“Ovulation tests typically measure luteinising hormone (LH) that surges ∼1 day before ovulation (Johnson et al. 2015; Roos et al. 2015).”
BackgroundInfluentialSelf-citationApter, D., Zimmerman, Y., Beekman, L., Mawet, M., Maillard, C., Foidart, J.-M., & Coelingh Bennink, H. J. T. (2016) · Contraception · doi:10.1016/j.contraception.2016.04.015 · Cited by 77 · see citing works
Erden, M., Mümüşoğlu, S., Polat, M., Ozbek, I. Y., Esteves, S. C., Humaidan, P., & Yaralı́, H. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmac012 · Cited by 69 · see citing works
Reproductive Hormones and Female Mental Wellbeing
Wieczorek, K., Targonskaya, A., & Maslowski, K. (2023) · Women · doi:10.3390/women3030033 · Cited by 61 · see citing works
Menstrual patterns in the first gynecological year: a systematic review
Gunn, H. M., Tsai, M.-C., McRae, A., & Steinbeck, K. S. (2018) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2018.07.009 · Cited by 60 · see citing works
Mihajlovic, J., Leutner, M., Hausmann, B., Köhl, G., Schwarz, J., Röver, H., Stimakovits, N. M., Wolf, P. S., Maruszczak, K., Bastian, M., et al. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15517 · Cited by 54 · see citing works
Estradiol modulation of the renin–angiotensin system and the regulation of fear extinction
Parrish, J. N., Bertholomey, M. L., Pang, H. W., Speth, R. C., & Torregrossa, M. M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0374-0 · Cited by 47 · see citing works
Grant, A. D., Newman, M. S., & Kriegsfeld, L. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-76236-6 · Cited by 48 · see citing works
Peña, A. S., Doherty, D. A., Atkinson, H. C., Hickey, M., Norman, R. J., & Hart, R. (2018) · Archives of Disease in Childhood · doi:10.1136/archdischild-2017-312968 · Cited by 47 · see citing works
Newman, M. S., Pratt, S. M., Curran, D. A., & Stanczyk, F. Z. (2019) · BMC Chemistry · doi:10.1186/s13065-019-0539-1 · Cited by 43 · see citing works
Anckaert, E., Jank, A., Petzold, J., Rohsmann, F., Paris, R., Renggli, M., Schönfeld, K., Schiettecatte, J., & Kriner, M. (2021) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2021.e00211 · Cited by 42 · see citing works
Avila‐Varela, D. S., Hidalgo‐Lopez, E., Dagnino, P. C., Acero-Pousa, I., del Agua, E., Deco, G., Pletzer, B. A., & Escrichs, A. (2024) · npj Women s Health · doi:10.1038/s44294-024-00012-4 · Cited by 39 · see citing works
Türkgeldi, E., Yıldız, Ş., Cekic, S. G., Shakerian, B., Keleş, İ., & Ata, B. (2020) · Human Fertility · doi:10.1080/14647273.2020.1794060 · Cited by 37 · see citing works
Johnson, S., Stanford, J. B., Warren, G., Bond, S., Bench-Capon, S., & Zinaman, M. J. (2019) · Journal of Women s Health · doi:10.1089/jwh.2019.7850 · Cited by 34 · see citing works
Self-citationGnoth, C., Roos, J., Broomhead, D., Schiffner, J., Godehardt, E. A. J., Freundl, G., & Johnson, S. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.08.027 · Cited by 33 · see citing works
Self-citationChang, K., Su, Y.-T., Tsai, Y.-R., Lan, K., Hsuuw, Y.-D., Kang, H., Chan, W., & Huang, F. (2021) · Biomedical Journal · doi:10.1016/j.bj.2021.01.004 · Cited by 32 · see citing works
Groenewoud, E. R., Macklon, N., Cohlen, B. J., Al‐Oraiby, A., Brinkhuis, E. A., Broekmans, F. J., de Bruin, J. P., van den Dool, G., Fleisher, K., Friederich, J., et al. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.02.008 · Cited by 32 · see citing works
Establishing a Gold Standard for Quantitative Menstrual Cycle Monitoring
Bouchard, T. P., Yong, P. J., & Doyle–Baker, P. K. (2023) · Medicina · doi:10.3390/medicina59091513 · Cited by 30 · see citing works
Bouchard, T. P., Fehring, R. J., & Mu, Q. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.2000393 · Cited by 30 · see citing works
Blackwell, L. F., Cooke, D. G., & Brown, S. B. (2018) · Frontiers in Public Health · doi:10.3389/fpubh.2018.00153 · Cited by 29 · see citing works
Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS
Jarrett, B. Y., & Lujan, M. E. (2016) · Reproduction · doi:10.1530/rep-16-0385 · Cited by 29 · see citing works
Leiva, R. A., McNamara-Kilian, M., Niezgoda, H., Écochard, R., & Bouchard, T. P. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028496 · Cited by 26 · see citing works
Gildner, T. E. (2020) · American Journal of Human Biology · doi:10.1002/ajhb.23535 · Cited by 24 · see citing works
Hart, R. J., D’Hooghe, T. M., Dancet, E. A. F., Aurell, R., Lunenfeld, B., Orvieto, R., Pellicer, A., Polyzos, N. P., & Zheng, W. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00754-5 · Cited by 22 · see citing works
EndoTime: non-categorical timing estimates for luteal endometrium
Lipecki, J., Mitchell, A. E., Muter, J., Lucas, E. S., Makwana, K., Fishwick, K. J., Odendaal, J., Hawkes, A., Vrljicak, P., Brosens, J. J., et al. (2022) · Human Reproduction · doi:10.1093/humrep/deac006 · Cited by 22 · see citing works
Development of Smartphone-Based Lateral Flow Device for the Quantification of LH and E3G Hormones
Thakur, R., Akram, F., Rastogi, V., Mitra, A., Nawani, R., Av, V., Dubey, S. K., & Shakher, C. (2020) · IEEE Sensors Journal · doi:10.1109/jsen.2020.3008566 · Cited by 21 · see citing works
Poulsen, L. L. C., Englund, A. L. M., Andersen, A. S., Bøtkjær, J. A., Mamsen, L. S., Damdimopoulou, P., Østrup, O., Grøndahl, M. L., & Andersen, C. Y. (2020) · Molecular Human Reproduction · doi:10.1093/molehr/gaaa013 · Cited by 21 · see citing works
Predicting serum hormone concentration by estimation of urinary hormones through a home-use device
Pattnaik, S., Das, D., Venkatesan, V. A., & Rai, A. (2022) · Human Reproduction Open · doi:10.1093/hropen/hoac058 · Cited by 20 · see citing works
Gadsby, R., Ivanova, D., Trevelyan, E., Hutton, J. L., & Johnson, S. (2020) · British Journal of General Practice · doi:10.3399/bjgp20x710885 · Cited by 19 · see citing works
Self-citationBlackwell, L. F., Pilar Vigil, P., Alliende, M. E., Brown, S. B., Festin, M., & Cooke, D. G. (2015) · Human Reproduction · doi:10.1093/humrep/dev303 · Cited by 18 · see citing works
Validation of urinary reproductive hormone measurements using a novel smartphone connected reader
Pattnaik, S., Das, D., & Venkatesan, V. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-36539-w · Cited by 18 · see citing works
Pyra, M. N., Lingappa, J. R., Heffron, R. A., Erikson, D. W., Blue, S. W., Patel, R. C., Nanda, K., Rees, H., Mugo, N., Davis, N. L., et al. (2018) · Contraception · doi:10.1016/j.contraception.2018.01.011 · Cited by 18 · see citing works
Dragutinovic, B., Moser, F., Notbohm, H. L., Ihalainen, J. K., Bloch, W., & Schumann, M. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00198.2024 · Cited by 17 · see citing works
Wegrzynowicz, A. K., Beckley, A., Eyvazzadeh, A. D., Levy, G., Park, J., & Klein, J. (2022) · Medicina · doi:10.3390/medicina58121853 · Cited by 17 · see citing works
Schiffner, J., Roos, J., Broomhead, D., van Helden, J., Godehardt, E. A. J., Fehr, D., Freundl, G., Johnson, S., & Gnoth, C. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0609 · Cited by 17 · see citing works
Self-citationAguree, S., Bethancourt, H. J., Taylor, L. A., Rosinger, A. Y., & Gernand, A. D. (2020) · Physiological Reports · doi:10.14814/phy2.14418 · Cited by 17 · see citing works
Foo, L. F., Johnson, S., Marriott, L., Bourne, T., Bennett, P. R., & Lees, C. C. (2020) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12613 · Cited by 14 · see citing works
Self-citationNagpal, A., Schmalenberger, K. M., Barone, J., Mulligan, E. M., Stumper, A., Knol, L., Failenschmid, J. I., Kiesner, J., Peters, J. R., & Eisenlohr-Moul, T. A. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107584 · Cited by 16 · see citing works
Heller, C., Güllmar, D., Čolić, L., Pritschet, L., Gell, M., Javaheripour, N., de la Cruz, F., Rojczyk, P., Koeppel, C. J., Larsen, B., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02066-2 · Cited by 15 · see citing works
Wegrzynowicz, A. K., Eyvazzadeh, A. D., & Beckley, A. (2024) · Seminars in Reproductive Medicine · doi:10.1055/s-0044-1791190 · Cited by 24 · see citing works
Timed intercourse for couples trying to conceive
Gibbons, T., Reavey, J. J., Georgiou, E. X., & Becker, C. M. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011345.pub3 · Cited by 12 · see citing works
Han, L. L., Creinin, M. D., Hemon, A., Glasier, A. F., Chen, M. J., & Edelman, A. B. (2022) · Contraception · doi:10.1016/j.contraception.2022.03.016 · Cited by 12 · see citing works
A Comparison of Two Hormonal Fertility Monitoring Systems for Ovulation Detection: A Pilot Study
Mu, Q., & Fehring, R. J. (2023) · Medicina · doi:10.3390/medicina59020400 · Cited by 12 · see citing works
Stanford, J. B., Schliep, K. C., Chang, C.-P. E., O'Sullivan, J., & Porucznik, C. A. (2020) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12642 · Cited by 12 · see citing works
Gifford, R. M., Howie, F. A., Wilson, K. S., Johnston, N. R., Todisco, T., Crane, M., Greeves, J. P., Skorupskaite, K., Woods, D. R., Reynolds, R. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-36051-6 · Cited by 11 · see citing works
Alliende, M. E., Arraztoa, J. A., Guajardo, U., & Mellado, F. (2018) · Frontiers in Public Health · doi:10.3389/fpubh.2018.00147 · Cited by 11 · see citing works
Aydın, T., Köroğlu, N., Albayrak, N., & İnsel, M. A. (2023) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-023-02864-2 · Cited by 9 · see citing works
Influence of Menstrual Phase and Symptoms on Match Running in Professional Footballers
Brown, G. A., & Duffield, R. (2024) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14734 · Cited by 9 · see citing works
Mizrachi, Y., Weissman, A., Rozen, G., Rogers, P. A. W., Stern, C. J., & Polyakov, A. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.03.021 · Cited by 9 · see citing works
Dinh, T. V., Thompson, M. E., & Gangestad, S. W. (2022) · doi:10.1016/j.evolhumbehav.2022.08.001 · Cited by 9 · see citing works
Barron, M. L., VanderKolk, K. J., & Raviele, K. M. (2018) · MCN The American Journal of Maternal/Child Nursing · doi:10.1097/nmc.0000000000000422 · Cited by 7 · see citing works
Zyklus-Apps zur Verhütung – sicher oder Gesellschaftsspiel?
Frank‐Herrmann, P., Freis, A., Freundl-Schütt, T., Wallwiener, L.-M., Baur, S., Freundl, G., Raith-Paula, E., & Strowitzki, T. (2018) · Der Gynäkologe · doi:10.1007/s00129-018-4358-6 · Cited by 7 · see citing works
Self-citationHandelsman, D. J., Nimmagadda, R., Desai, R., Handelsman, T. D., Whittle, B., Skorupskaite, K., & Anderson, R. A. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105900 · Cited by 7 · see citing works
Svenstrup, L., Möller, S., Fedder, J., Pedersen, D. E., Erb, K., Andersen, C. Y., & Humaidan, P. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.04.019 · Cited by 8 · see citing works
Satwik, R., Majumdar, A., Gupta, S. M., Tiwari, N., Majumdar, G., & Kochhar, M. (2021) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2021.06.005 · Cited by 7 · see citing works
Hormonal Smartphone Diagnostics
Matías‐García, P. R., Martinez-Hurtado, J. L., Beckley, A., Schmidmayr, M., & Seifert‐Klauss, V. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_38 · Cited by 7 · see citing works
Tran, D., Thompson, M. E., & Gangestad, S. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105276 · Cited by 5 · see citing works
Luteinising hormone profiles in conception and non-conception natural cycles
Johnson, S., Schiffner, J., Freundl, G., Bachmann, N., & Gnoth, C. (2019) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/13625187.2019.1590697 · Cited by 6 · see citing works
Self-citationAACC Guidance Document on the Use of Point-of-Care Testing in Fertility and Reproduction
Nichols, J. H., Ali, M., Anetor, J. I., Chen, L. S., Chen, Y., Collins, S. P., Das, S., Devaraj, S., Fu, L., Karon, B. S., et al. (2022) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfac042 · Cited by 6 · see citing works
Grebe, N. M., Eckardt, W., Stoinski, T. S., Umuhoza, R., Santymire, R. M., & Rosenbaum, S. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114351 · Cited by 6 · see citing works
Usala, S. J., & Trindade, A. A. (2020) · Medicina · doi:10.3390/medicina56110555 · Cited by 6 · see citing works
Rosetta, L., Thalabard, J., Tanniou, J., Ducot, B., Maitrot‐Mantelet, L., Rousset‐Jablonski, C., Bohet, A., Bouyer, J., Chimènes, A., & Slama, R. (2017) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/13625187.2017.1410881 · Cited by 5 · see citing works
Cordova-Gomez, A., Wong, A. P., Sims, L. B., Doncel, G. F., & Dorflinger, L. J. (2023) · Frontiers in Reproductive Health · doi:10.3389/frph.2023.1210083 · Cited by 5 · see citing works
Li, Y., Zeng, H., & Fu, J. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01495-0 · Cited by 5 · see citing works
Usala, S. J., Alliende, M. E., & Trindade, A. A. (2021) · Medicina · doi:10.3390/medicina57020134 · Cited by 5 · see citing works
Johnson, S., Bond, S., Grace, B., & Marriott, L. (2022) · Women s Health Reports · doi:10.1089/whr.2021.0102 · Cited by 5 · see citing works
Self-citationGonadotropin and Ovarian Hormone Monitoring: Lateral Flow Assays for Clinical Decision Making
Targonskaya, A., & Maslowski, K. (2023) · Women · doi:10.3390/women3040036 · Cited by 4 · see citing works
Binnie, J. E., Cooke, D. G., & Blackwell, L. F. (2016) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2016.1236730 · Cited by 4 · see citing works
Ivanović, K., Tulić, L., Tulic, I., Ivanovic, S., Stojnić, J., Bila, J. S., Dosev, T., Vuković, Ž., & Milošević, B. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14175965 · Cited by 3 · see citing works
Simonneaux, M., & Simonneaux, V. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70101 · Cited by 3 · see citing works
Brown, G. A., Fullagar, H. H. K., & Duffield, R. (2025) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2024-0295 · Cited by 3 · see citing works
Effectiveness of a Postpartum Breastfeeding Protocol for Avoiding Pregnancy
Schneider, M., Fehring, R. J., & Bouchard, T. P. (2023) · The Linacre Quarterly · doi:10.1177/00243639231167235 · Cited by 3 · see citing works
Brown, S. B., Cooke, D. G., & Blackwell, L. F. (2020) · Open Health · doi:10.1515/openhe-2020-0001 · Cited by 3 · see citing works
Gudmand‐Hoeyer, J., & Ottesen, J. T. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.04.003 · Cited by 3 · see citing works
Dozortsev, D. I., Pellicer, A., & Diamond, M. P. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.05.107 · Cited by 3 · see citing works
Shenouda, N., Stock, J. M., Chouramanis, N. V., Lincoln, Z. R., Wenner, M. M., Chirinos, J. A., & Edwards, D. G. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00363.2024 · Cited by 2 · see citing works
Neuronal Dynamics of Menstrually Related Migraine
Peng, K., Mehnert, J., & May, A. (2025) · Neurology · doi:10.1212/wnl.0000000000214234 · Cited by 2 · see citing works
Stumper, A., Schmalenberger, K. M., Eisenlohr-Moul, T. A., & Peters, J. R. (2026) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-061724-083756 · Cited by 2 · see citing works
Familienplanung mit Zyklus-Apps – ein Update
Frank‐Herrmann, P., Freundl-Schütt, T., Wallwiener, L.-M., Baur, S., & Strowitzki, T. (2021) · Gynäkologische Endokrinologie · doi:10.1007/s10304-021-00391-w · Cited by 2 · see citing works
Karanfil, E., & Görğü, M. (2024) · Aesthetic Surgery Journal · doi:10.1093/asj/sjae044 · Cited by 2 · see citing works
Are there any differences in pain thresholds during the menstrual cycle?
Savic, A., Savanov, B., Subic, L., Popović, D., Aleksandrić, T., & Knežević, A. (2024) · Medicinski pregled · doi:10.2298/mpns2408228s · Cited by 2 · see citing works
Raith-Paula, E., & Frank‐Herrmann, P. (2020) · Springer eBooks · doi:10.1007/978-3-662-59311-0_14 · Cited by 2 · see citing works
Chang, H., Wu, Q., Ge, H., Li, J., Zhu, M., Luo, X., Han, Y., Wang, C. C., & Wu, X. (2021) · Research Square · doi:10.21203/rs.3.rs-146920/v1 · Cited by 2 · see citing works
Pattnaik, S., Das, D., & Venkatesan, V. A. (2021) · medRxiv · doi:10.1101/2021.05.11.21257023 · Cited by 2 · see citing works
Bouchard, T. P., Fehring, R. J., Meyers, M., Stujenske, T. M., Boychuk, L., Smith, A., Schweinsberg, K., Scarpa, B., & Schneider, M. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-02184-w · Cited by 1 · see citing works
Hansen, L. Y., Fujisawa, T., Povlsen, B. B., Laursen, R., Jensen, M. B., Humaidan, P., & Alsbjerg, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110795 · Cited by 1 · see citing works
Estradiol, Emotion Regulation, and the Limbic System: Effects on Gray Matter Volume
Denninger, A. F., Rehbein, E., Poromaa, I. S., Derntl, B., & Kogler, L. (2026) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2026.100709 · Cited by 1 · see citing works
Fertility and pregnancy detection - how the pharmacist can help?
Trávník, P. (2017) · Praktické lékárenství · doi:10.36290/lek.2017.062 · Cited by 1 · see citing works
Natürlicher Zyklus und Spontanschwangerschaftsraten
Gnoth, C., Freundl-Schütt, T., & Freundl, G. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-57636-6_11 · Cited by 1 · see citing works
Self-citationFehring, R. J., & Barron, M. L. (2018) · The Linacre Quarterly · doi:10.1177/0024363918792542 · Cited by 1 · see citing works
Zyklus-Apps: zur Verhütung, zum Kinderwunsch oder doch nur Menstruationskalender?
Frank‐Herrmann, P., Freis, A., Freundl-Schütt, T., Wallwiener, L.-M., Baur, S., & Strowitzki, T. (2021) · Journal für Gynäkologische Endokrinologie/Österreich · doi:10.1007/s41974-020-00171-7 · Cited by 1 · see citing works
Endogenous Hormones and Cognitive Decline in Women: Unveiling the Complex Interplay
Targonskaya, A., Wieczorek, K., & Maslowski, K. (2024) · Women · doi:10.3390/women4020009 · Cited by 1 · see citing works
Brown, G. A., Fullagar, H. H. K., & Duffield, R. (2025) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.70011 · Cited by 2 · see citing works
Pennanen, T. M., Lindeberg, H., Mononen, J., Vepsäläinen, J., Hujo, M., & Viitala, S. M. (2025) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2025.107973 · Cited by 1 · see citing works
- Authors
- Roos, J., Johnson, S., Weddell, S., Godehardt, E., Schiffner, J., Freundl, G., & Gnoth, C.
- Affiliations
- University of Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Gnoth, Christian
- Venue
- The European Journal of Contraception & Reproductive Health Care
- Publisher
- Informa UK Limited
- Published
- 2015-05-27
- Volume
- 20
- Issue
- 6
- Pages
- 438-450
- ISSN
- 1362-5187 (ISSN-L)
- 1473-0782
- OpenAlex
- W2156455308
- Cited by
- 126
- References
- 26
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 10 · 2023: 13 · 2022: 12 · 2021: 14 · 2020: 17 · 2019: 8 · 2018: 13 · 2017: 4 · 2016: 4 · 2015: 3
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The European Journal of Contraception & Reproductive Health Care (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- ovulation detection, menstrual cycle, serum reproductive hormones, luteinizing hormone surge, luteinization, pregnanediol-3-glucuronide, estrone-3-glucuronide, estradiol, luteal phase, ovulation prediction, interindividual variability, transvaginal ultrasound
- MeSH terms
- Adolescent, Adult, Estradiol, Estrone, Female, Ovarian Follicle, Humans, Luteinizing Hormone, Menstrual Cycle, Monitoring, Physiologic, Ovulation, Ovulation Detection, Predictive Value of Tests, Pregnanediol, Progesterone, Prospective Studies, Time Factors, Biomarkers, Endosonography, Young Adult
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