Prediction of ovulation by urinary hormone measurements with the home use ClearPlan fertility monitor: comparison with transvaginal ultrasound scans and serum hormone measurements
Abstract
The timing of sexual intercourse in relation to ovulation strongly influences the chance of conception. Daily serum LH measurements or transvaginal ultrasonography are not practical to determine ovulation in consecutive cycles for an individual. A prospective study was initiated to test the home use performance of the ClearPlan Fertility Monitor (CPFM) in ovulation prediction compared with transvaginal ultrasonography and serum hormone measurements. A total of 53 women aged 18-39 years with a normal uterus and at least one ovary, cycle length between 21-42 days and not using medication which interferes with ovarian function contributed 150 cycles for analysis. One cycle was anovulatory and no LH surge, indicating peak fertility, was detected by the monitor. Of the remaining 149 cycles, 135 (90.6%) had a monitor LH surge and ultrasonographically confirmed ovulation. Ovulation was detected in 91.1% of cycles during the 2 days of CPFM peak fertility. Ovulation was observed in 51.1% of cycles 1 day and in 43.2% of cycles 2 days after the surge in serum LH. Ovulation never occurred before CPFM peak fertility or the serum LH surge day. CPFM can help women who desire pregnancy to time intercourse. It may also have potential as a diagnostic aid and for monitoring the treatment of infertility.
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Variation in luteal phase lengths has previously been observed in controlled clinical studies.
“Variation in luteal phase lengths has previously been observed in controlled clinical studies7,24,28”
From Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles (2019) · cites this paper as [24]
Home urinary luteinising hormone tests may be used to determine fertile days or used as input to BBT methods to improve the accuracy of ovulation detection.
“Home urinary luteinising hormone (LH) tests may also be used to determine fertile days24 or used as input to BBT methods to improve the accuracy of ovulation detection.20”
From Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles (2019) · cites this paper as [24]
Imprecision of ±1 day has been reported for the assay used to assign ovulation day.
“However, imprecision of ±1 day has been reported for this assay (Behre et al. 2000).”
From Real-life insights on menstrual cycles and ovulation using big data (2020) · cites this paper as Behre et al. 2000
Ovulation day was assigned as the day following the LH surge, as comparisons between the assays used by the connected ovulation tests and transvaginal ultrasonography have indicated that this is the average relationship between the measures.
“In this study, ovulation day was assigned as the day following the LH surge, as comparisons between the assays used by the connected ovulation tests and transvaginal ultrasonography have indicated that this is the average relationship between the measures.”
From Real-life insights on menstrual cycles and ovulation using big data (2020) · cites this paper as Behre et al. 2000
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- Authors
- Behre, H. M., Kuhlage, J., Gaβner, C., Sonntag, B., Schem, C., Schneider, H. P. G., & Nieschlag, E.
- Affiliations
- University of Münster (DE)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-12
- Volume
- 15
- Issue
- 12
- Pages
- 2478-2482
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2144853611
- Cited by
- 238
- References
- 17
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 12 · 2019: 20 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 12 · 2014: 15 · 2013: 15 · 2012: 8
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- ovulation prediction, urinary luteinizing hormone, luteinizing hormone surge, transvaginal ultrasound, serum LH, timing of intercourse, conception
- MeSH terms
- Adolescent, Adult, Estradiol, Estrone, Female, Fertility, Ovarian Follicle, Humans, Luteinizing Hormone, Menstrual Cycle, Ovulation Detection, Prospective Studies, Reagent Strips, Ultrasonography
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