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Cited by 604

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Understanding weight gain at menopause

Open access
Davis, S. R., Castelo-Branco, C., Chedraui, P., Lumsden, M. A., Nappi, R. E., Shah, D., Villaseca, P., as the Writing Group of the International Menopause Society for World Menopause Day 2012·2012·Climacteric
DOI 10.3109/13697137.2012.707385
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Abstract

OBJECTIVE: The aim of this review was to summarize the literature regarding the impact of the menopause transition on body weight and body composition. METHODS: We conducted a search of the literature using Medline (Ovid, 1946-present) and PubMed (1966-2012) for English-language studies that included the following search terms: 'menopause', 'midlife', 'hormone therapy' or 'estrogen' combined with 'obesity', 'body weight' or 'body composition'. RESULTS: Whereas weight gain per se cannot be attributed to the menopause transition, the change in the hormonal milieu at menopause is associated with an increase in total body fat and an increase in abdominal fat. Weight excess at midlife is not only associated with a heightened risk of cardiovascular and metabolic disease, but also impacts adversely on health-related quality of life and sexual function. Animal and human studies indicate that this tendency towards central abdominal fat accumulation is ameliorated by estrogen therapy. Studies mostly indicate a reduction in overall fat mass with estrogen and estrogen-progestin therapy, improved insulin sensitivity and a lower rate of development of type 2 diabetes. CONCLUSION: The hormonal changes across the perimenopause substantially contribute to increased abdominal obesity which leads to additional physical and psychological morbidity. There is strong evidence that estrogen therapy may partly prevent this menopause-related change in body composition and the associated metabolic sequelae. However, further studies are required to identify the women most likely to gain metabolic benefit from menopausal hormone therapy in order to develop evidence-based clinical recommendations.

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Metadata

Authors
Davis, S. R., Castelo-Branco, C., Chedraui, P., Lumsden, M. A., Nappi, R. E., Shah, D., Villaseca, P., & as the Writing Group of the International Menopause Society for World Menopause Day 2012
Venue
Climacteric
Publisher
Informa UK Limited
Published
2012-09-15
Volume
15
Issue
5
Pages
419-429
ISSN
  • 1369-7137 (ISSN-L)
  • 1473-0804
DOI
10.3109/13697137.2012.707385
OpenAlex
W2128849535
Cited by
604
References
21
FWCI
21.63
Type
journal article
Language
en
Open access
bronze

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