Psychiatric disorders in individuals with high-functioning autism and Asperger's disorder: Similarities and differences
Abstract
OBJECTIVES: To investigate and compare the rate and type of psychiatric co-morbidity in individuals with diagnosis of high functioning autism (HFA) and Asperger's disorder (AS). METHODS: This study includes 30 children and adolescents with diagnosis of HFA and 30 with diagnosis of AS. Diagnoses of HFA and AS were made using strict DSM-IV criteria. Psychiatric co-morbidity was assessed using the Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL-T). RESULTS: The rate of comorbid psychiatric disorders was very high in both groups (93.3% in HFA and 100% in AS). The most common disorder in both groups was attention deficit hyperactivity disorder. There was no statistically significant difference between groups in the rate of associated psychiatric disorders, except for major depressive disorder (P = 0.029) and ADHD-combined type (P = 0.030). The AS group displayed greater comorbidity with depressive disorders and ADHD-CT. CONCLUSION: From a clinical perspective, it could be concluded that both disorders involve a high risk for developing psychiatric disorders, with AS patients at greater risk for depression. From a nosological perspective, the substantial similarities in terms of psychiatric comorbidity may support the idea that both disorders are on the same spectrum and differs in some aspects.
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ASD is characterised by deficits in expression of feelings and thoughts, and anxiety is the most prevalent comorbidity.
“Furthermore, ASD is characterised with deficits in expression of feelings and thoughts [10] and anxiety is the most prevalent comorbidity [10, 13].”
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148 · see citing works
Frith, C., & Frith, U. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.041 · Cited by 3,494 · see citing works
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318179964f · Cited by 3,399 · see citing works
Adult outcome for children with autism
Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00215.x · Cited by 1,813 · see citing works
Comorbid psychiatric disorders in children with autism: interview development and rates of disorders
Leyfer, O. T., Folstein, S. E., Bacalman, S., Davis, N. O., Dinh, E., Morgan, J., Tager-Flusberg, H., & Lainhart, J. E. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0123-0 · Cited by 1,637 · see citing works
The Prevalence of Anxiety and Mood Problems among Children with Autism and Asperger Syndrome
Kim, J. A., Szatmári, P., Bryson, S. E., Streiner, D. L., & Wilson, F. (2000) · Autism · doi:10.1177/1362361300004002002 · Cited by 885 · see citing works
Howlin, P. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1022270118899 · Cited by 563 · see citing works
“Theory of Mind” in Asperger's Syndrome Dermot M. Bowler
Bowler, D. M. (1992) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1992.tb01962.x · Cited by 534 · see citing works
Presentation of depression in autism and Asperger syndrome: A review
Stewart, M. E., Barnard, L., Pearson, J., Hasan, R., & O’Brien, G. (2006) · Autism · doi:10.1177/1362361306062013 · Cited by 515 · see citing works
Ronald, A., Simonoff, E., Kuntsi, J., Asherson, P., & Plomin, R. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01857.x · Cited by 466 · see citing works
Comorbidity of Asperger syndrome: a preliminary report
Ghaziuddin, M., Weidmer‐Mikhail, E., & Ghaziuddin, N. (1998) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1998.tb01647.x · Cited by 414 · see citing works
Comorbid anxiety symptoms in children with pervasive developmental disorders
Muris, P., Steerneman, P., Merckelbach, H., Holdrinet, I., & Meesters, C. (1998) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(98)00022-x · Cited by 368 · see citing works
Ozonoff, S. J., South, M., & Miller, J. N. (2000) · Autism · doi:10.1177/1362361300004001003 · Cited by 285 · see citing works
Pervasive Developmental Disorders
(2011) · Springer eBooks · doi:10.1007/978-0-387-79061-9_4496 · Cited by 247 · see citing works
Lee, D. O., & Ousley, O. Y. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.737 · Cited by 239 · see citing works
Asperger's Syndrome and Autism: Differences in Behavior, Cognition, and Adaptive Functioning
Szatmári, P., Archer, L. A., Fisman, S., Streiner, D. L., & Wilson, F. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199512000-00017 · Cited by 222 · see citing works
Shtayermman, O. (2007) · Issues in Comprehensive Pediatric Nursing · doi:10.1080/01460860701525089 · Cited by 203 · see citing works
Yoshida, Y., & Uchiyama, T. (2004) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-004-0391-1 · Cited by 195 · see citing works
Pedantic speaking style differentiates asperger syndrome from high-functioning autism
Ghaziuddin, M., & Gerstein, L. (1996) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172348 · Cited by 193 · see citing works
Baron‐Cohen, S., Scahill, V. L., Izaguirre, J., Hornsey, H., & Robertson, M. M. (1999) · Psychological Medicine · doi:10.1017/s003329179900896x · Cited by 180 · see citing works
Behavioural and Emotional Disturbance in High-Functioning Autism and Asperger Syndrome
Tonge, B. J., Brereton, A. V., Gray, K. M., & Einfeld, S. (1999) · Autism · doi:10.1177/1362361399003002003 · Cited by 145 · see citing works
Hedley, D., & Young, R. (2006) · Autism · doi:10.1177/1362361306062020 · Cited by 139 · see citing works
New-onset psychiatric disorders in individuals with autism
Hutton, J., Goode, S., Murphy, M., Le Couteur, A., & Rutter, M. (2008) · Autism · doi:10.1177/1362361308091650 · Cited by 139 · see citing works
Szatmari, P., Bryson, S., Duku, E., Vaccarella, L., Zwaigenbaum, L., Bennett, T., & Boyle, M. H. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02123.x · Cited by 136 · see citing works
Munesue, T., Ono, Y., Mutoh, K., Shimoda, K., Nakatani, H., & Kikuchi, M. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.02.015 · Cited by 120 · see citing works
Cognitive and symptom profiles in Asperger’s syndrome and high‐functioning autism
Koyama, T., Tachimori, H., Osada, H., Takeda, T., & Kurita, H. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01617.x · Cited by 103 · see citing works
Gökler, B., Ünal, F., Pehlivantürk, B., Kültür, Ç. E., Akdemir, D., & Taner, Y. I. (2004) · Çocuk ve Gençlik Ruh Sağlığı Dergisi / Turkish Journal of Child and Adolescent Mental Health · Cited by 88 · see citing works
Thede, L. L., & Coolidge, F. L. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0212-0 · Cited by 75 · see citing works
High rates of psychiatric co-morbidity in individuals with Asperger's disorder
Mukaddes, N. M., & Fateh, R. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970902789130 · Cited by 70 · see citing works
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Lai, M.-C., Kassee, C., Besney, R., Bonato, S., Hull, L., Mandy, W., Szatmari, P., & Ameis, S. H. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30289-5 · Cited by 1,892 · see citing works
Anxiety Disorders in Children and Adolescents with Autistic Spectrum Disorders: A Meta-Analysis
van Steensel, F. J. A., Bögels, S. M., & Perrin, S. (2011) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-011-0097-0 · Cited by 1,463 · see citing works
“After contacting the author, data from one presentation abstract (Herguner and Motavalli 2009) were found to display considerable overlap with the data from the published article of Mukaddes et al. (2010), and this abstract was therefore excluded.”
MethodLever, A. G., & Geurts, H. M. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2722-8 · Cited by 572 · see citing works
“…focused on co-occurring symptoms and disorders in childhood (de Bruin et al. 2007; Leyfer et al. 2006; Lundstro¨m et al. 2015; Mattila et al. 2010; Mukaddes et al. 2010; Simonoff et al. 2008; Sinzig et al. 2009; van Steensel et al. 2013; Verheij et al. 2015), recently a steadily increasing…”
Rommelse, N. N. J., Geurts, H. M., Franke, B., Buitelaar, J. K., & Hartman, C. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.015 · Cited by 429 · see citing works
Salazar, F., Baird, G., Chandler, S., Tseng, E., O’sullivan, T., Howlin, P., Pickles, A., & Simonoff, E. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2361-5 · Cited by 364 · see citing works
Rong, Y., Yang, C.-J., Jin, Y., & Wang, Y. (2021) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2021.101759 · Cited by 316 · see citing works
Psychiatric comorbidities in Asperger syndrome and high functioning autism: diagnostic challenges
Mazzone, L., Ruta, L., & Reale, L. (2012) · Annals of General Psychiatry · doi:10.1186/1744-859x-11-16 · Cited by 213 · see citing works
Joshi, G., Faraone, S. V., Wozniak, J., Tarko, L., Fried, R., Galdo, M., Furtak, S. L., & Biederman, J. (2017) · Journal of Attention Disorders · doi:10.1177/1087054714543368 · Cited by 155 · see citing works
Tan, B. W. Z., Pooley, J. A., & Speelman, C. P. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2854-x · Cited by 157 · see citing works
“Furthermore, given that comorbidity between the two disorders is reported to be as high as over 80 % of the cases (e.g., Joshi et al. 2010; Mukaddes et al. 2010), it is not known if exercise can be used as an effective intervention in improving aspects of cognitive functions in these clinical…”
BackgroundMatson, J. L., Rieske, R. D., & Williams, L. W. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2013.05.021 · Cited by 124 · see citing works
Mental Health Services for Individuals with High Functioning Autism Spectrum Disorder
Lake, J. K., Perry, A., & Lunsky, Y. (2014) · Autism Research and Treatment · doi:10.1155/2014/502420 · Cited by 72 · see citing works
Adamo, N., Huo, L., Adelsberg, S., Petkova, E., Castellanos, F. X., & Di Martino, A. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-013-0428-4 · Cited by 55 · see citing works
Huntjens, A., van den Bosch, L. M. C. W., Sizoo, B., Kerkhof, A., Huibers, M. J. H., & van der Gaag, M. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02531-1 · Cited by 50 · see citing works
Muratori, F., Turi, M., Prosperi, M., Narzisi, A., Valeri, G., Guerrera, S., Santocchi, E., Apicella, F., Lattarulo, C., Calderoni, S., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00107 · Cited by 29 · see citing works
- Authors
- Mukaddes, N. M., Hergüner, S., & Tanidir, C.
- Affiliations
- Istanbul University (TR)
- ORCID
- Hergüner, Sabri
- Venue
- The World Journal of Biological Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2010-08-24
- Volume
- 11
- Issue
- 8
- Pages
- 964-971
- ISSN
- 1562-2975 (ISSN-L)
- 1814-1412
- OpenAlex
- W2084177190
- Cited by
- 96
- References
- 30
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 14 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 10
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The World Journal of Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- high-functioning autism, Asperger syndrome, psychiatric comorbidity, attention deficit hyperactivity disorder, major depressive disorder, children and adolescents, autism spectrum disorder
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Mental Disorders, Child, Major Depressive Disorder, Female, Humans, Intelligence, Male, Turkey, Comorbidity, Asperger Syndrome
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