Cited by 127Hip and Femur FracturesNutrition and Health in AgingBone health and osteoporosis research

Effects of protein-rich supplementation and nandrolone in lean elderly women with femoral neck fractures

Tidermark, Jan, Ponzer, Sari, Carlsson, Pronoti, Söderqvist, Anita, Brismar, Kerstin, Tengstrand, Birgitta, Cederholm, Tommy·2004·Clinical Nutrition

Abstract

Aim To evaluate the effects of a protein-rich liquid supplementation, alone or in combination with the anabolic steroid nandrolone decanoate, on body composition, activities of daily living (ADL) status and the health-related quality of life (HRQoL) after a femoral neck fracture. Methods Sixty women, aged 83 +/- 5 years (mean +/- SD), BMI < 24 kg/m2 (20.4 +/- 2 kg/m2 ) and capable of co-operating, with a femoral neck fracture treated with internal fixation, were randomised to open treatment during 6 months with a protein-rich liquid formula alone (PR, Fortimel, 200 ml/day, 20 g protein/day) or in combination with nandrolone decanoate (PR/N, Deca-Durabol 25 mg i.m./3 weeks) or to a control group (C). The patients were re-examined after 6 and 12 months regarding body weight (BW), lean body mass (LBM, DXA), ADL status according to Katz, HRQoL according to EQ 5-D and fracture healing. Results LBM decreased in the C (-1.2 +/- 2 kg) and PR groups (-1.2 +/- 1 kg) but remained the same in the PR/N group (0.3 +/- 1 kg) (P < 0.05 between groups). ADL remained at a high level in the two intervention groups but declined significantly in the C group (P < 0.005 between groups). The decline in HRQoL was least pronounced in the PR/N group at 6 months (P < 0.05 between groups). Patients with fracture healing complications lost more BW (P < 0.05) and LBM (P < 0.01) than patients with uneventful fracture healing. Conclusion Protein-rich liquid supplementation in combination with nandrolone given for 6 months to lean elderly women after a femoral neck fracture may positively affect LBM, ADL and HRQoL.

Integrity signals

Registry

Crossref · 10.1016/j.clnu.2003.10.006

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

4 of the 49 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Tidermark, J., Ponzer, S., Carlsson, P., Söderqvist, A., Brismar, K., Tengstrand, B., & Cederholm, T.
Affiliations
  • Karolinska Institutet (SE)
  • Karolinska University Hospital (SE)
Corresponding author
Tidermark, Jan
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2004-08
Volume
23
Issue
4
Pages
587-596
ISSN
0261-5614 (ISSN-L)
OpenAlex
W2057430676
Cited by
127
References
49
Citations by year
2026: 3 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 7 · 2012: 6
FWCI
6.09
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Hip and Femur Fractures
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
femoral neck fracture, nandrolone decanoate, lean body mass, body composition, activities of daily living, health-related quality of life, fracture healing complications, internal fixation, anabolic steroids
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Body Composition, Dietary Proteins, Female, Femoral Neck Fractures, Food, Formulated, Humans, Nandrolone, Nutritional Status, Quality of Life, Nutrition Assessment, Treatment Outcome, Fracture Healing, Anabolic Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review