The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Methicillin Resistance in Staphylococcus Aureus: Mechanisms and Modulation
Open accessAbstract
Staphylococcus aureus is a major pathogen both within hospitals and in the community. Methicillin, a β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs) that are involved in the synthesis of peptidoglycan, an essential mesh-like polymer that surrounds the cell. S. aureus can become resistant to methicillin and other β-lactam antibiotics through the expression of a foreign PBP, PBP2a, that is resistant to the action of methicillin but which can perform the functions of the host PBPs. Methicillin-resistant S. aureus isolates are often resistant to other classes of antibiotics (through different mechanisms) making treatment options limited, and this has led to the search for new compounds active against these strains. An understanding of the mechanism of methicillin resistance has led to the discovery of accessory factors that influence the level and nature of methicllin resistance. Accessory factors, such as Fem factors, provide possible new targets, while compounds that modulate methicillin resistance such as epicatechin gallate, derived from green tea, and corilagin, provide possible lead compounds for development of inhibitors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications
Chambers, H. F. (1997) · Clinical Microbiology Reviews · doi:10.1128/cmr.10.4.781 · Cited by 1,127
Katayama, Y., Ito, T., & Hiramatsu, K. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.6.1549-1555.2000 · Cited by 1,038
Bactericidal catechins damage the lipid bilayer
Ikigai, H., Nakae, T., Hara, Y., & Shimamura, T. (1993) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(93)90323-r · Cited by 644
Antibiotic resistance in staphylococci
Livermore, D. M. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(00)00299-5 · Cited by 471
Evidence for a Clonal Origin of Methicillin Resistance in Staphylococcus aureus
Kreiswirth, B., Kornblum, J., Arbeit, R. D., Eisner, W., Maslow, J. N., McGeer, A., Low, D. E., & Novick, R. P. (1993) · Science · doi:10.1126/science.8093647 · Cited by 409
Zhao, W.-H., Hu, Z.-Q., Okubo, S., Hara, Y., & Shimamura, T. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.6.1737-1742.2001 · Cited by 395
Pinho, M. G., de Lencastre, H., & Tomasz, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191260798 · Cited by 384
Antimicrobial properties of tea (Camellia sinensis L.)
Hamilton-Miller, J. M. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.11.2375 · Cited by 380
Staphylococcal Cell Wall: Morphogenesis and Fatal Variations in the Presence of Penicillin
Giesbrecht, P., Kersten, T., Maidhof, H., & Wecke, J. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1371-1414.1998 · Cited by 304
Song, M. D., Wachi, M., Doi, M., Ishino, F., & Matsuhashi, M. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80373-3 · Cited by 302
Cited by
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,637
Molecular mechanisms of antibiotic resistance revisited
Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00820-y · Cited by 1,398
Tannins as an alternative to antibiotics
Farha, A. K., Yang, Q.-Q., Kim, G., Li, H.-B., Zhu, F., Liu, H.-Y., Gan, R.-Y., & Corke, H. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100751 · Cited by 375
Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains
Miklasińska-Majdanik, M., Kępa, M., Wojtyczka, R. D., Idzik, D., & Wąsik, T. J. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15102321 · Cited by 367
Menz, B. D., Charani, E., Gordon, D. L., Leather, A. J., Moonesinghe, S. R., & Phillips, C. J. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s319780 · Cited by 118
Metadata
- Authors
- Stapleton, P. D., & Taylor, P. W.
- Venue
- Science Progress
- Publisher
- SAGE Publications
- Published
- 2002-02
- Volume
- 85
- Issue
- 1
- Pages
- 57-72
- ISSN
- 0036-8504 (ISSN-L)
- 2047-7163
- OpenAlex
- W1976780773
- Cited by
- 416
- References
- 38
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Methicillin Resistance in Staphylococcus Aureus: Mechanisms and Modulation. https://app.cochat.ai/papers/10.3184/003685002783238870
- The paper
- Stapleton, P. D., & Taylor, P. W. (2002). Methicillin Resistance in Staphylococcus Aureus: Mechanisms and Modulation. Science Progress. https://doi.org/10.3184/003685002783238870
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
