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Post-traumatic stress disorder: the neurobiological impact of psychological trauma
Open accessAbstract
The classic fight-or-flight response to perceived threat is a reflexive nervous phenomenon thai has obvious survival advantages in evolutionary terms. However, the systems that organize the constellation of reflexive survival behaviors following exposure to perceived threat can under some circumstances become dysregulated in the process. Chronic dysregulation of these systems can lead to functional impairment in certain individuals who become "psychologically traumatized" and suffer from post-traumatic stress disorder (PTSD), A body of data accumulated over several decades has demonstrated neurobiological abnormalities in PTSD patients. Some of these findings offer insight into the pathophysiology of PTSD as well as the biological vulnerability of certain populations to develop PTSD, Several pathological features found in PTSD patients overlap with features found in patients with traumatic brain injury paralleling the shared signs and symptoms of these clinical syndromes.
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“In hippocampal activation, deficits occur while solving the tasks relating to verbal declarative memory (Bremner et al., 2003;Sherin and Nemeroff, 2011).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Sherin and Nemeroff, 2011
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Metadata
- Authors
- Sherin, J. E., & Nemeroff, C. B.
- Affiliations
- University of Miami (US)
- Corresponding author
- Sherin, Jonathan E.
- ORCID
- Nemeroff, Charles B.
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2011-09-30
- Volume
- 13
- Issue
- 3
- Pages
- 263-278
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- PMC
- PMC3182008
- OpenAlex
- W1548863913
- Cited by
- 750
- References
- 95
- Citations by year
- 2026: 56 · 2025: 76 · 2024: 86 · 2023: 67 · 2022: 55 · 2021: 71 · 2020: 38 · 2019: 54 · 2018: 59 · 2017: 54 · 2016: 40 · 2015: 43 · 2014: 30 · 2013: 15 · 2012: 6
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, psychological trauma, fight-or-flight response, threat perception, biological vulnerability, pathophysiology, traumatic brain injury
- MeSH terms
- Endocrine System, Humans, Hypothalamo-Hypophyseal System, Neurobiology, Neurochemistry, Risk Factors, Stress Disorders, Post-Traumatic, Stress, Psychological
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