Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study
Open accessAbstract
Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.
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PTSD symptoms correlate with activation in the ventromedial prefrontal cortex (vmPFC).
“PTSD symptoms correlate with activation in the ventromedial prefrontal cortex (vmPFC) (Hopper et al., 2007;Kemp et al., 2007;Shin et al., 2005;Williams et al., 2006).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Kemp et al., 2007
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The Neurocircuitry of Fear, Stress, and Anxiety Disorders
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Reformulating PTSD for<i>DSM‐V</i>: Life after Criterion A
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Neural correlates of trauma-unrelated emotional processing in war veterans with PTSD
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- Authors
- Kemp, A. H., Felmingham, K., Das, P., Hughes, G., Peduto, A. S., Bryant, R. A., & Williams, L. M.
- Affiliations
- The University of Sydney (AU)
- Westmead Hospital (AU)
- Corresponding author
- Kemp, Andrew H.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 155
- Issue
- 3
- Pages
- 265-269
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W1975965564
- Cited by
- 57
- References
- 2
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- post-traumatic stress disorder, depression, comorbidities, fear, amygdala, medial prefrontal cortex, fear processing
- MeSH terms
- Adult, Amygdala, Major Depressive Disorder, Depressive Disorder, Major, Facial Expression, Fear, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Surveys and Questionnaires, Severity of Illness Index, Stress Disorders, Post-Traumatic, Comorbidity, Prefrontal Cortex
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