The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Midlife and Late-Life Body Mass Index and Late-Life Dementia: Results from a Prospective Population-Based Cohort
Abstract
BACKGROUND: Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged. OBJECTIVE: The aim of this study was to investigate the association of midlife and late-life body mass index (BMI) with late-life dementia/Alzheimer's disease (AD) and whether the association was independent of other obesity-related co-morbidities. METHODS: The association between midlife BMI (mean age 50.2, SD 6.0) and late-life BMI (mean age 71.2, SD 4.0) and incident dementia later in life (mean age 75.7, SD 5.0) were investigated among 1,304 participants of the longitudinal population-based Cardiovascular risk factors, Aging and Dementia (CAIDE) study, conducted in Eastern Finland. The duration of follow-up was 26 years. The diagnosis of dementia was based on DSM-IV criteria and the probable and possible AD on the NINCDS-ADRDA criteria. RESULTS: Higher midlife BMI was associated with higher risk of incident dementia (adjusted HR, 95% CI 1.07, 1.00-1.14). However, decrease in BMI from midlife to late-life was associated with higher risk of dementia (1.14, 1.03-1.25 for one-unit decrease) and AD (1.20, 1.09-1.33). High late-life BMI was associated with lower risk of AD (0.89, 0.81-0.98) but the association with dementia was less evident (0.94, 0.86-1.03). CONCLUSION: Higher midlife BMI is related to higher risk of dementia and AD, independently of obesity-related risk factors and co-morbidities. Steeper decrease of BMI and low late-life BMI are associated with higher risk of dementia and AD. These findings highlight the importance of life-course perspective when assessing the association between BMI and cognition.
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Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
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Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders
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Body Mass Index in Midlife and Risk of Alzheimer Disease and Vascular Dementia
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Cited by
A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012
Langa, K. M., Larson, E. B., Crimmins, E. M., Faul, J. D., Levine, D. A., Kabeto, M. U., & Weir, D. R. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.6807 · Cited by 910
The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention
Zhang, X.-X., Tian, Y., Wang, Z.-T., Ma, Y.-H., Tan, L., & Yu, J.-T. (2021) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.15 · Cited by 789
Pedditizi, E., Peters, R., & Beckett, N. (2016) · Age and Ageing · doi:10.1093/ageing/afv151 · Cited by 474
Body mass index and risk of dementia: analysis of individual-level data from 1·3 million individuals
Kivimäki, M., Luukkonen, R., Batty, G. D., Ferrie, J. E., Pentti, J., Nyberg, S. T., Shipley, M. J., Alfredsson, L., Fransson, E. I., Goldberg, M., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.09.016 · Cited by 440
Self-citationObesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II study
Singh‐Manoux, A., Dugravot, A., Shipley, M., Brunner, E. J., Elbaz, A., Sabia, S., & Kivimaki, M. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.06.2637 · Cited by 401
Metadata
- Authors
- Tolppanen, A.-M., Ngandu, T., Kåreholt, I., Laatikainen, T., Rusanen, M., Soininen, H., & Kivipelto, M.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2013-10-29
- Volume
- 38
- Issue
- 1
- Pages
- 201-209
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2167825457
- Cited by
- 251
- References
- 10
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tolppanen, A.-M., Ngandu, T., Kåreholt, I., Laatikainen, T., Rusanen, M., Soininen, H., & Kivipelto, M. (2013). Midlife and Late-Life Body Mass Index and Late-Life Dementia: Results from a Prospective Population-Based Cohort. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-130698
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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