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A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease
Open accessAbstract
Oxidative stress, inflammation, and increased cholesterol levels are all mechanisms that have been associated with Alzheimer's disease (AD) pathology. Several epidemiologic studies have reported a decreased risk of AD with fish consumption. This pilot study was designed to evaluate the effects of supplementation with omega-3 fatty acids alone (ω-3) or omega-3 plus alpha lipoic acid (ω-3 + LA) compared to placebo on oxidative stress biomarkers in AD. The primary outcome measure was peripheral F2-isoprostane levels (oxidative stress measure). Secondary outcome measures included performance on: Mini-Mental State Examination (MMSE), Activities of Daily Living/Instrumental Activities of Daily Living (ADL/IADL), and Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-cog). Thirty-nine AD subjects were randomized to one of three groups: 1) placebo, 2) ω-3, or 3) ω-3 + LA for a treatment duration of 12 months. Eighty seven percent (34/39) of the subjects completed the 12-month intervention. There was no difference between groups at 12 months in peripheral F2-isoprostane levels (p = 0.83). The ω-3 + LA and ω-3 were not significantly different than the placebo group in ADAS-cog (p = 0.98, p = 0.86) and in ADL (p = 0.15, p = 0.82). Compared to placebo, the ω-3 + LA showed less decline in MMSE (p < 0.01) and IADL (p = 0.01) and the ω-3 group showed less decline in IADL (p < 0.01). The combination of ω-3 + LA slowed cognitive and functional decline in AD over 12 months. Because the results were generated from a small sample size, further evaluation of the combination of omega-3 fatty acids plus alpha-lipoic acid as a potential treatment in AD is warranted.
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“Moreover, preclinical studies and investigations in individuals affected by Alzheimer’s disease [132] provided evidence that ALA may promote neurocognitive enhancement via pleiotropic mechanisms, including antioxidant mitochondrial activity and anti-inflammatory properties [133]”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [132]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
A new rating scale for Alzheimer's disease
(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1356 · Cited by 4,175
An Inventory to Assess Activities of Daily Living for Clinical Trials in Alzheimerʼs Disease
Galasko, D., Bennett, D. A., Sano, M., Ernesto, C., Thomas, R., Grundman, M., & Ferris, S. H. (1997) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199700112-00005 · Cited by 1,198
Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135
Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
Shay, K. P., Moreau, R. F., Smith, E. J., Smith, A. R., & Hagen, T. M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.026 · Cited by 976
Dietary fat intake and the risk of incident dementia in the Rotterdam study
Kalmijn, S., Launer, L. J., Ott, A., Witteman, J. C. M., Hofman, A., & Breteler, M. M. B. (1997) · Annals of Neurology · doi:10.1002/ana.410420514 · Cited by 895 · cited 1×
“A number of epidemiologic studies have observed a consistent association of a decreased risk for AD and greater fish consumption [5–7].”
BackgroundThe pharmacology of the antioxidant lipoic acid
Biewenga, G. P., Haenen, G. R. M. M., & Bast, A. (1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(96)00474-0 · Cited by 848
Galasko, D. R., Bennett, D., Sano, M., Ernesto, C., Thomas, R., Grundman, M., & Ferris, S. H. (1997) · PubMed · Cited by 767
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial
Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764
Self-citationFreund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751
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Items 101–200 of 289
Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, M. M., & Chirumbolo, S. (2019) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2019.03.019 · Cited by 46
Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders
Chitre, N. M., Moniri, N. H., & Murnane, K. S. (2019) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527318666191114093749 · Cited by 54
Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
Zhu, H., Dronamraju, V., Xie, W., & More, S. S. (2021) · Medicinal Chemistry Research · doi:10.1007/s00044-020-02687-1 · Cited by 46
Chu, C., Hung, C., Ponnusamy, V. K., Chen, K.-C., & Chen, N.-C. (2022) · Nutrients · doi:10.3390/nu14061159 · Cited by 45
Andriambelo, B., Stiffel, M., Roke, K., & Plourde, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101835 · Cited by 49
Kaur, K., Narang, R. K., & Singh, S. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230726145447 · Cited by 43
Shen, Y., Zhang, G., Wei, C., Zhao, P., Wang, Y., Li, M., & Sun, L. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01343 · Cited by 44
Morgen, K., & Frölich, L. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1377-5 · Cited by 43
Ghasemi-Tarie, R., Kiasalari, Z., Fakour, M., Khorasani, M., Keshtkar, S., Baluchnejadmojarad, T., & Roghani, M. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00949-y · Cited by 45
Dieter, F., Esselun, C., & Eckert, G. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169186 · Cited by 42
Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review
de Sousa, C. N. S., Leite, C. M. G. D. S., Medeiros, I. D. S., Vasconcelos, L. C., Cabral, L. M., Patrocínio, C. F. V., Patrocínio, M. L. V., Mouaffak, F., Kébir, O., Macêdo, D. S., et al. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0344-x · Cited by 42
Mitochondrial Agents for Bipolar Disorder
Pereira, C. L., Chavarria, V., Vian, J., Ashton, M. M., Berk, M., Marx, W., & Dean, O. M. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy018 · Cited by 41
Araya‐Quintanilla, F., Gutiérrez‐Espinoza, H., Sánchez-Montoya, U., Muñoz-Yánez, M. J., Baeza-Vergara, A., Petersen-Yanjarí, M., & Fernández-Lecaros, L. (2020) · Neurología (English Edition) · doi:10.1016/j.nrleng.2017.07.014 · Cited by 41
Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy
Varesi, A., Campagnoli, L. I. M., Carrara, A., Pola, I., Floris, E., Ricevuti, G., Chirumbolo, S., & Pascale, A. (2023) · Antioxidants · doi:10.3390/antiox12010180 · Cited by 51
de Melo, A. D., Freire, V. A. F., Diogo, Í. L., Santos, H. D. L., Barbosa, L. A., & Carvalho‐Tavares, J. (2023) · Antioxidants · doi:10.3390/antiox12071397 · Cited by 40
Dubey, S., & Singh, E. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01173-5 · Cited by 39
Tseng, P., Zeng, B., Suen, M., Wu, Y., Correll, C. U., Zeng, B., Kuo, J. S., Chen, Y.-W., Chen, T., Tu, Y.-K., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.04.017 · Cited by 39
Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders
Badaeva, A. V., Danilov, A. B., Clayton, P., Moskalev, A., Karasev, A. V., Tarasevich, A. F., Vorobyeva, Y. D., & Novikov, V. N. (2023) · Nutrients · doi:10.3390/nu15112505 · Cited by 42
Bulaj, G. W., Ahern, M., Kuhn, A. K., Judkins, Z., Bowen, R. C., & Chen, Y. (2016) · Current Clinical Pharmacology · doi:10.2174/1574884711666160603012237 · Cited by 41
Čuperlović‐Culf, M., & Badhwar, A. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1674808 · Cited by 40
Gregori, M. D., Muscoli, C., Schatman, M. E., Stallone, T., Intelligente, F., Rondanelli, M., Franceschi, F., Arranz, L. I., Cebrián, S. L., Salamone, M., et al. (2016) · Journal of Pain Research · doi:10.2147/jpr.s115068 · Cited by 38
Liu, Z., Patil, I., Sancheti, H., Yin, F., & Cadenas, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-05217-z · Cited by 39
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review
Lewis, J. E., Poles, J., Shaw, D. P., Karhu, E., Khan, S. A., Lyons, A. E., Sacco, S. B., & McDaniel, H. R. (2021) · Journal of Clinical and Translational Research · doi:10.18053/jctres.07.202104.014 · Cited by 37
Fernández, S. S. M., Ivanauskas, T. M., & Ribeiro, S. M. L. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.06.015 · Cited by 36
New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders
Wilkins, H., & Morris, J. K. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612822666161230144517 · Cited by 34
Solfrizzi, V., Agosti, P., Lozupone, M., Custodero, C., Schilardi, A., Valiani, V., Santamato, A., Sardone, R., Dibello, V., Lena, L. D., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.10.022 · Cited by 38
Zhang, Y., Yan, X.-Z., Xu, S., Pang, Z., Li, L., Yang, Y., Fan, Y., Wang, Z., Yu, X., Guo, C., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00262 · Cited by 35
Towards Personalized Intervention for Alzheimer’s Disease
Peng, X., Xing, P., Li, X., Qian, Y., Song, F., Bai, Z., Han, G., & Lei, H. (2016) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.01.006 · Cited by 34
Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
Peng, P., Zhang, X., Qi, T., Cheng, H., Kong, Q., Liu, L., Cao, X., & Ding, Z. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12820 · Cited by 35
Comprehensive Review of Nutraceuticals against Cognitive Decline Associated with Alzheimer’s Disease
Reza-Zaldívar, E. E., & Jacobo‐Velázquez, D. A. (2023) · ACS Omega · doi:10.1021/acsomega.3c04855 · Cited by 39
Zhang, S., Zhao, J., Quan, Z., Li, H., & Qing, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.853911 · Cited by 35
Sanadgol, N., Golab, F., Askari, H., Moradi, F., Ajdary, M., & Mehdizadeh, M. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0099-9 · Cited by 31
Dietary Interventions to Prevent or Delay Alzheimer’s Disease: What the Evidence Shows
Bartochowski, Z., Conway, J., Wallach, Y., Chakkamparambil, B., Alakkassery, S., & Grossberg, G. T. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00333-1 · Cited by 31
Mitochondrial Disorders in Alzheimer’s Disease
Sukhorukov, V. S., Mudzhiri, N. M., Voronkova, A. S., Baranich, T. I., Glinkina, V. V., & Illarioshkin, S. N. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921060055 · Cited by 30
Botchway, B. O., Okoye, F. C., Chen, Y., Arthur, W. E., & Fang, M. (2022) · Aging and disease · doi:10.14336/ad.2021.0616 · Cited by 32
Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal!
Cardoso, S., Correia, S. C., Carvalho, C., & Moreira, P. I. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_3 · Cited by 29
Nair, D. V., Rani, M. U., Reddy, A. G., Kumar, B., Reddy, M. A., Lakshman, M., & RAJKUMAR, U. (2020) · Veterinary World · doi:10.14202/vetworld.2020.188-196 · Cited by 29
Pagano, G., Talamanca, A. A., Castello, G., Cordero, M. D., d’Ischia, M., Gadaleta, M. N., Pallardó, F. V., Petrović, S. Ž., Tiano, L., & Zatterale, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151120169 · Cited by 26
In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors
Telpoukhovskaia, M. A., Patrick, B. O., Rodríguez‐Rodríguez, C., & Orvig, C. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.01.080 · Cited by 27
Fraga, V. G., Ferriani, M. D. G. C., Caramelli, P., Sousa, L. P., & Gomes, K. B. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.07.005 · Cited by 26
Pagano, G., Pallardó, F. V., Lyakhovich, A., Tiano, L., Fittipaldi, M. R., Toscanesi, M., & Trifuoggi, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197060 · Cited by 27
Role of Omega-3 PUFAs in Neurobiological Health
Grant, R., & Guest, J. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_13 · Cited by 28
Safeguarding the brain from oxidative damage
Lee, K. H., Kim, U. J., Lee, B. H., & Cha, M. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.019 · Cited by 25
Circulating MicroRNA Profile Associated with Obstructive Sleep Apnea in Alzheimer’s Disease
Targa, A., Dakterzada, F., Benitez, I. D., de Gonzalo‐Calvo, D., Moncusí‐Moix, A., Ortega, R. L., Pujol, M., Arias, A. M., de Batlle, J., Sánchez‐de‐la‐Torre, M., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02031-z · Cited by 24
Validation of a Dietary Questionnaire to Screen Omega-3 Fatty Acids Levels in Healthy Adults
Shen, W., Weaver, A. M., Salazar, C., Samet, J. M., Díaz-Sánchez, D., & Tong, H. (2019) · Nutrients · doi:10.3390/nu11071470 · Cited by 23
Apolinário, L. M., De Carvalho, S. C., Santo Neto, H., & Marques, M. J. (2015) · The Anatomical Record · doi:10.1002/ar.23177 · Cited by 22
Sarezky, D., Raquib, A. R., Dunaief, J. L., & Kim, B. B. (2016) · Clinical ophthalmology · doi:10.2147/opth.s115900 · Cited by 23
Alpha lipoic acid supplementation improved antioxidant enzyme activities in hemodialysis patients
Mahdavi, R., Khabbazi, T., & Safa, J. (2019) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000552 · Cited by 22
Tong, J., Satyanarayanan, S. K., & Su, H. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.027 · Cited by 24
Moreira, S. C., Jansen, A. K., & Silva, F. M. (2020) · Dementia & Neuropsychologia · doi:10.1590/1980-57642020dn14-030008 · Cited by 23
Chen, P., Li, F.-M., Zhou, Y., Qian, C., Li, J., Jiang, L., & Qian, Z. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.09.011 · Cited by 21
Protective effects of alpha lipoic acid (ALA) are mediated by hormetic mechanisms
Calabrese, E. J., Agathokleous, E., Dhawan, G., Kapoor, R., & Calabrese, V. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113805 · Cited by 22
Sasaki, K., Geribaldi‐Doldán, N., Wu, Q., Davies, J., Szele, F. G., & Isoda, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.600575 · Cited by 20
Dietary phytochemicals that influence gut microbiota: Roles and actions as anti-Alzheimer agents
Wang, Y., Lim, Y. Y., He, Z., Wong, W., & Lai, W. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1882381 · Cited by 23
Castellanos-Perilla, N., Borda, M. G., Aarsland, D., & Barreto, G. E. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2313547 · Cited by 25
Erve, T. J. V. ‘. (2018) · Redox Biology · doi:10.1016/j.redox.2018.05.003 · Cited by 23
Dietary Fatty Acid Factors in Alzheimer’s Disease: A Review
Zhang, T., Han, X., Zhang, X., Chen, Z., Mi, Y., & Gou, X. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200558 · Cited by 21
Development and Sensory Evaluation of Omega-3-Rich Nile Perch Fish Oil-Fortified Yogurt
Murage, M. W., Muge, E. K., Mbatia, B. N., & Mwaniki, M. W. (2021) · International Journal of Food Science · doi:10.1155/2021/8838043 · Cited by 20
Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights
Wang, Y., Jiang, S., He, Y., Pang, P., & Shan, H. (2025) · Molecules · doi:10.3390/molecules30091972 · Cited by 21
A Systematic Review of Omega-3 Consumption and Neuroprotective Cognitive Outcomes
Sherzai, A. Z., Sherzai, D., & Sherzai, D. (2022) · American Journal of Lifestyle Medicine · doi:10.1177/15598276221117102 · Cited by 20
Neuronutrition: An Emerging Concept
Topçuoğlu, M. A., & Arsava, E. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-53171-7_10 · Cited by 19
Concerning the “repression” of ω -3 polyunsaturated fatty acids by adepts of evidence-based medicine
Torshin, I. Y., Громова, О. А., & Kobalava, Z. D. (2019) · FARMAKOEKONOMIKA Modern Pharmacoeconomics and Pharmacoepidemiology · doi:10.17749/2070-4909.2019.12.2.91-114 · Cited by 20
Acquaah-Mensah, G. K., & Taylor, R. C. (2016) · Gene · doi:10.1016/j.gene.2016.03.045 · Cited by 20
Martinez, E. C., Saji, S. Z., Ore, J. V. S., Borges-Sosa, O. A., Srinivas, S., Mareddy, N. S. R., Manzoor, T., Vanna, M. D., Shanableh, Y. A., Taneja, R., et al. (2024) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12455 · Cited by 27
Pakdaman, H., Harandi, A. A., Hatamian, H., Tabatabaee, M., Kasmaei, H. D., Ghassemi, A., Gharagozli, K., Ashrafi, F., Naeini, P. E., Tavakolian, M., et al. (2015) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000375295 · Cited by 18
Fernandes, D. P. D. S., Rezende, F. A. C., Rocha, G. P., Filgueiras, M. D. S., Moreira, P. R. S., & Alfenas, R. D. C. G. (2015) · PubMed · doi:10.3305/nh.2015.32.2.9111 · Cited by 19
Pei, X., Hu, F., Luo, F., Huang, X., Li, X., Xing, S., & Long, D. (2021) · Journal of Applied Toxicology · doi:10.1002/jat.4213 · Cited by 18
Mendes, D., Peixoto, F., Oliveira, M. M., Andrade, P. B., & Videira, R. A. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.05.001 · Cited by 18
Kocatürk, R. R., Temizyürek, A., Özcan, Ö. Ö., Erguzel, T. T., Karahan, M., Konuk, M., & Tarhan, N. (2022) · International Journal of Neuroscience · doi:10.1080/00207454.2022.2079506 · Cited by 17
Nguyen, T. T., Vo, T. K., & Vo, G. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55035-6_13 · Cited by 18
Challenges to determining whether DHA can protect against age-related cognitive decline
Hennebelle, M., Harbeby, E., Tremblay, S., Chouinard‐Watkins, R., Pifferi, F., Plourde, M., Guesnet, P., & Cunnane, S. C. (2015) · Clinical Lipidology · doi:10.2217/clp.14.61 · Cited by 16
Barros, M. I., Brandão, T. R. S., Irving, S. C., Alves, P., Gomes, F., & Correia, M. (2025) · Nutrients · doi:10.3390/nu17183002 · Cited by 19
Basile, G. A., Iannuzzo, F., Xerra, F., Genovese, G., Pandolfo, G., Cedro, C., Muscatello, M. R. A., & Bruno, A. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20032358 · Cited by 17
Li, S., Wei, Y., Liang, Z., Guo, L., Hao, X., & Zhang, Y. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250150 · Cited by 16
Pagano, G., Pallardó, F. V., Lyakhovich, A., Tiano, L., & Trifuoggi, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04007-1 · Cited by 15
[Contribution of omega-3 fatty acids for memory and cognitive function].
Waitzberg, D. L., & Garla, P. (2014) · PubMed · doi:10.3305/nh.2014.30.3.7632 · Cited by 16
Borrego-Ruiz, A., & Borrego, J. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188849 · Cited by 17
Nikolaeva, N. S., Yandulova, E. Y., Aleksandrova, Y. R., Starikov, A. S., & Неганова, М. Е. (2022) · Acta Naturae · doi:10.32607/actanaturae.11723 · Cited by 15
Neurodegenerative disease and antioxidant biomarkers: A bidirectional Mendelian randomization study
Zhang, Q., Li, Q., Zhao, H., Shu, M., Luo, M., Li, Y., Ding, Y., Shi, S., Cheng, X., & Niu, Q. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1158366 · Cited by 14
Application of fatty acid and lipid measurements in neuropsychiatry
Grela, A., Rachel, W., Cole, M., Zyss, T., Zięba, A., & Piekoszewski, W. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2015-0394 · Cited by 14
Kalamara, T.-V., Dodos, K., Georgakopoulou, V., Fotakopoulos, G., Spandidos, D. A., & Καπουκρανίδου, Δ. (2025) · Biomedical Reports · doi:10.3892/br.2025.1940 · Cited by 19
Inan, S., Wilson, R. P., & Tükel, Ç. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107693 · Cited by 15
Li, S., Sun, L., Huang, H., Wei, X., Lu, Y., Qian, K., & Wu, Y. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106789 · Cited by 15
Lifestyle and Alzheimer’s Disease
Bartolotti, N., & Lazarov, O. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802851-3.00007-3 · Cited by 13
Brain Lipids in the Pathophysiology and Treatment of Alzheimer’s Disease
Torres, M., Busquets, X., & Escribá, P. V. (2016) · InTech eBooks · doi:10.5772/64757 · Cited by 14
Lipids in the Treatment of Neurodegenerative Diseases
Lange, K. W. (2020) · Wiley eBooks · doi:10.1002/047167849x.bio118 · Cited by 12
Omega-3 polyunsaturated fatty acids in neurodegenerative disorders: Mixed designs = mixed results
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Metadata
- Authors
- Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L., & Kaye, J.
- Affiliations
- Oregon Health & Science University (US)
- University of Washington (US)
- Corresponding author
- Shinto, Lynne
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2013-10-29
- Volume
- 38
- Issue
- 1
- Pages
- 111-120
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC3886557
- OpenAlex
- W1528771930
- Cited by
- 288
- References
- 38
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 19 · 2023: 30 · 2022: 20 · 2021: 25 · 2020: 32 · 2019: 16 · 2018: 19 · 2017: 19 · 2016: 24 · 2015: 25 · 2014: 13
- FWCI
- 19.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc)
- PubMed Central (acceptedVersion, cc-by-nc)
- Funders
- National Institutes of Health (AG‐08017)
- National Institute on Aging (AG 08017, P30AG008017, R21AG023805)
- National Center for Research Resources (M01RR00334, M01RR000334, UL1RR024140)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, omega-3 fatty acids
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Cognition Disorders, Double-Blind Method, Female, Humans, Thioctic Acid, Male, Mental Status Schedule, Middle Aged, Pilot Projects, Fatty Acids, Omega-3, Outcome Assessment, Health Care, F2-Isoprostanes
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